Süleyman SALMAN - Academia.edu (original) (raw)
Papers by Süleyman SALMAN
Journal of Academic Research in Medicine
Cukurova Medical Journal, 2022
The most common clinical symptom of HPV is the condyloma acuminata, characterized by type 6 and 1... more The most common clinical symptom of HPV is the condyloma acuminata, characterized by type 6 and 11 and constitutes 90% of the infections. However, 12% of the smear specimens were found to have HPV types 16 and 18, which are actually oncogenic. This virüs which frequently infects external genitalia, infects mucocutaneous component much less frequently likewise urethra as a part of mucocutaneous component. We present a case of A 58-year-old menapousal woman consulted with gynecological and obstetrics department due to pathology report of condyloma accumunata of previously excited mass from anal region by a general surgeon. At the examination of the patient, two white clitoral condyloma with white colored tiny condyloma on the right side of the urethra were seen, both HPV 16 and 18 were detected aftetwards. Urethral condyloma acuminata of atypical location at urethral mucosa which coincided with vulvar condyloma, can be a clue for oncogenic HPV infection. We aimed to discuss the mucosa...
Journal of Obstetrics and Gynaecology Research, 2022
ObjectiveApical prolapse constitutes an important part of pelvic organ prolapse. In this study, o... more ObjectiveApical prolapse constitutes an important part of pelvic organ prolapse. In this study, our aim was to investigate the effectiveness of laparoscopic pectopexy that we made by preserving the uterus in the surgical treatment of apical prolapse.MethodsA total of 36 patients with apical prolapse who wanted to preserve their uterus underwent laparoscopic rectopexy. Apical prolapse and sexual function of the patients were evaluated preoperatively and 12 months after surgery using the Pelvic Organ Prolapse Quantification (POP‐Q) scale and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ‐12) sexual questionnaire form. Preoperative medical records and postoperative clinical results were recorded.ResultsThere were no intraoperative or postoperative complications in the patients who underwent laparoscopic pectopexy. The average duration of surgery was 48.7 ± 9.8 min. Two patients had a recurrence of apical prolapse. In the Aa, Ba, C, and D points in the POP‐Q stagi...
Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy, 2021
Objective: Vaginoscopic office hysteroscopy (VOH) is a gold standard diagnostic method for many u... more Objective: Vaginoscopic office hysteroscopy (VOH) is a gold standard diagnostic method for many uterine disorders. However, it may result in patient discomfort. This study aimed to investigate the effect of the Trendelenburg lithotomy (TL) position, in respect of the level of pain and procedure time during the VOH for diagnostic purposes. Methods: This study included 157 patients between the ages of 20 and 65 years, of whom 74 underwent diagnostic VOH with the lithotomy position (group 1) and 83 with the TL position (group 2). Subsequent evaluation that was conducted on both groups included visual analog scale scores of patients, procedure duration, and the attitudinal Likert-type survey of doctors. Results: A significant difference was found between groups 1 and 2 in pain scores (p<0.001), procedure duration (p<0.001), and attitudinal Likert-type survey of doctors (p=0.002). Group 2 reported lower pain scores than group 1 (3.34±2.37 and 5.69±2.33, respectively). Similarly, the procedure duration in group 2 was significantly reduced (60.11±26.3 and 83.3±29.5, respectively). The attitudinal Likert-type survey of doctors also showed significant improvement in group 2 (3.48±0.97 vs. 3.03±0.86, respectively). Conclusion: VOH with the TL position lowered the pain scores in patients and reduced the procedure duration. The TL position is a good way of increasing the patients' compliance and tolerance. Likewise, it makes the procedure easier for the doctor without any additional price.
The New Indian Journal of OBGYN, 2020
To draw attention to the clinical approach in terms of early diagnosis in the trocar entry site h... more To draw attention to the clinical approach in terms of early diagnosis in the trocar entry site hernias which are rare complications after laparoscopic operations. A 47 years old female patient was admitted to our clinic with complaint of ongoing pelvic pain and the patient was scheduled for laparoscopic cystectomy. On the 13th day postoperatively, the patient was referred to our clinic again with ileus clinic. In the CT scan, incarcerated intestinal herniation was detected at the 5 mm trocar entry site. As the trocar site hernias can occur even in incisions smaller than 10 mm,early diagnosis and treatment is of vital importance.
Geburtshilfe und Frauenheilkunde, 2019
Objective The aim of this study was to determine the effectiveness of a newly developed anchoring... more Objective The aim of this study was to determine the effectiveness of a newly developed anchoring system for unilateral sacrospinous ligament fixation (USSLF) and bilateral sacrospinous ligament fixation (BSSLF) procedures. Material and Methods Ninety-three patients with pelvic prolapse who were treated surgically with the Anchorsure System® between 2013 and 2018 were included in the study. USSLF was performed in 52 patients (group 1), and BSSLF was performed in 41 patients (group 2). Pelvic organ prolapse was assessed preoperatively and 6 months postoperatively. Results There were no significant differences between groups 1 and 2 with regard to age, parity, and demographic characteristics. Anatomical improvement rates were similar, irrespective of the type of SSLF used. No bleeding requiring blood transfusion or organ injuries occurred in any patient. Three patients in the group that received BSSLF developed small asymptomatic cystoceles (grade 1 to 2); there was no recurrence of r...
Proceedings in Obstetrics and Gynecology, 2016
Background: In recent years the rate of cesarean section has significantly increased.To determine... more Background: In recent years the rate of cesarean section has significantly increased.To determine the efficacy of prophylactic antibiotics in reducing infectious morbidity after cesarean section. Objectives: In our study, we aimed to evaluate the efficiency of prophylactic antibiotic administration by comparing three groups using single, multiple and no prophylactic antibiotic therapy. Materials and Methods: Our study is a prospective, randomized controlled study including emergent cases, that developed cesarean indication while in active labor, and elective cesarean cases. A total of 90 patients were included in the study, including 30 patients who underwent cesarean delivery and did not undergo an antibiotic prophylaxis (Group 1), 30 patients who underwent a single dose antibiotic prophylaxis (Group II) and 30 patients who underwent multiple dose antibiotic prophylaxis (Group III). Results: The incidence of wound infection was significantly higher in cases that were not using antibiotics at postoperative days 3, 5 and 7 compared to the cases using single and multiple antibiotics. There was not a significant difference between groups in terms of endometritis. Conclusion: Administration of prophylactic antibiotics prevent wound infection but does not prevent development of endometritis.
Balkan medical journal, Jan 26, 2017
In addition to pain caused by uterine contractions in labor, continuous and severe back pain is o... more In addition to pain caused by uterine contractions in labor, continuous and severe back pain is observed in 33% of women. Several pharmacological and nonpharmacological methods are available for managing this pain. Sterile water injection is considered to be an alternative method for nonpharmacological management. The aim of this study was to assess the satisfaction level and effectiveness of sterile water injection for back pain among women in labor. This was a randomized controlled trial. A total of 168 term, healthy women with labor pain and severe back pain were randomized into 4× 0.1 mL of sterile water (study) and 4× dry injection (placebo) groups. Injections were applied to the rhombus of Michaelis in the sacral area. Pain scores were assessed at 10, 30, 60, 120, and 180 min with the visual analog scale. Additionally, the need for epidural analgesia, Apgar score, mode of delivery, time of delivery, maternal satisfaction, and breastfeeding scores were all assessed. The mean ba...
Journal of Academic Research in Medicine, 2016
Apert syndrome, craniosynostosis, mid-face hypoplasia, symmetric syndactyly of the hands and feet... more Apert syndrome, craniosynostosis, mid-face hypoplasia, symmetric syndactyly of the hands and feet, and varying degrees of mental retardation, and is characterized by congenital heart defects. Although the mode of inheritance is autosomal dominant, it creates new mutations in the majority of cases. In this study, an atrial septal defect cases of Apert syndrome, concomitant potential for congenital heart defects, in order to emphasize further investigation, we were willing to offer.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2012
eterotopic pregnancy, defined as the simultaneous development of an extrauterine along with an in... more eterotopic pregnancy, defined as the simultaneous development of an extrauterine along with an intrauterine pregnancy, is a very rare event, even in the context of ectopic pregnancy. Duverney first described this diagnosis in 1708 in autopsy findings of a patient who expired from an ectopic pregnancy. 1 The incidence of heterotopic pregnancy varies between 1/30.000 and 1/40.000 but the prevalence of heterotopic pregnancies has been reported to rise to as high as 1-2% due to the use of assisted reproductive technology and ovulation-inducing agents. 2,3 The ectopic pregnancy can be tubal, ovarian, cervical, cornual or abdominal. 4 Tubal ectopic pregnancies are the most common. Abdominal pregnancy affects 1 in 10.000 deliveries. The maternal mortality rate is nearly 6%, and the clinical pres
Journal of Academic Research in Medicine, 2015
Objective: Evaluation of the uterus is one of the indispensable components of routine infertility... more Objective: Evaluation of the uterus is one of the indispensable components of routine infertility examinations. The aim of this study is to evaluate the utility of endometrial screening with contrast media during the assessment of the uterus with transvaginal ultrasonography (TvUSG) in infertility researches. Methods: One hundred and two infertile patients who were referred to Süleymaniye Obstetrics and Gynecology Hospital because of infertility underwent saline infusion sonohysterography (SIS) at our clinic. The cases were informed about the procedure, and consent forms were obtained. Data was collected prospectively. Results were compared with a large patient cohort that was evaluated with only hysterography (HSG) and TvUSG for uterus assessment. Results: Abnormal intracavitary findings were observed in 20.5% of the 102 infertile patients who had undergone SIS. This rate was 7.4% in the control group. Total abnormal intracavitary finding rate of the SIS group was significantly higher (p<0.01). The rates of the uterine anomalies were similar in two groups; 4.9% in the SIS group and 5.03% in the control group. There was no statistically significant difference between the uterine anomaly rates of the groups (p>0.05). Conclusion: SIS is a practical, low-cost method that does not require specific equipment; in addition to these advantages, it is effective in the detection of intrauterine pathologies and for making differential diagnosis. In consideration of the higher frequency of uterine pathologies in infertile patients, SIS can be used as a routine test in infertility researches.
Journal of Academic Research in Medicine, 2015
Objective: The objective of this study was to determine under the view literature, the indication... more Objective: The objective of this study was to determine under the view literature, the indications, findings, and complications of diagnostic and operative laparoscopy performed at a teaching hospital. Methods: A total of 503 cases for which the laparoscopy was performed for diagnostic and operative purposes was included into this study. Demographic characteristics, length of operative time, length of hospital stay, conversion rate to open procedure, and complication rates were evaluated. Results: In our clinic, operative laparoscopy was performed in 405 out of 503 cases. The mean age, gravida, parity, and living child numbers of cases were 32.97±7.29 years, 1.06±1.72, 0.47±1.11, and 0.6±1.15, respectively. Indications of patients undergoing laparoscopy were as follows: diagnostic purpose, tubal obstructions, polycystic ovary syndrome, myoma uteri, adnexial mass, habitual abortion, tubal ligation, adhesions, ectopic pregnancy, amenorrhea, decensus uteri, intrauterine device extraction, chronic pelvic pain, repair of uterine perforation, which occurred during hysteroscopy. Laparotomy was required in seven cases while performing laparoscopy. The complications were reported in 17 of 503 patients with diagnostic and operative laparoscopy. Conclusion: Laparoscopic procedures have become the choice of treatment for most gynecological diseases. Avoidance of laparotomy, smaller incisions, lesser perioperative problems, minimal tissue damage, and shorter duration of hospitalization are well-known advantages of laparoscopy. However, the physician must be an expert in its application and must have adequate knowledge to overcome complications.
International journal of fertility & sterility, 2011
In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clon... more In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically. A total of 36 albino Wistar rats were divided into the following six groups: 0.075 mg/kg clonidine group; 100 mg/kg methyldopa group; 2 mg/kg amlodipine group; 2.5 mg/kg ramipril group; 0.5 mg/kg rilmenidine group; and the healthy group. Rats underwent chronic drug administration for 30 days and at the end, biochemical and histopathological examinations were performed. All data were subjected to one-way ANOVA test. We divided these drugs into the following three groups according to their effects on rat uteri: (I) mild negative effects (clonidine), (II) moderate negative effects (rilmenidine, methyldopa) and (III) drugs which had severe negative effects (amlodipine, ramipril). These data may...
Journal of Academic Research in Medicine, 2015
Objective: The purpose of this study was to evaluate the results of our experience with 83 patien... more Objective: The purpose of this study was to evaluate the results of our experience with 83 patients who underwent total laparoscopic hysterectomy (TLH). Methods: The subjects included 83 patients operated in Gaziosmanpaşa Taksim Training and Research Hospital, Department of Obstetrics and Gynecology. Total laparoscopic hysterectomies were performed for various indications between January 2013 and October 2014. Indications of total laparoscopic hysterectomy, method of operation, intraoperative and postoperative complications, duration of the operation, length of hospital stay, and blood loss in patients who underwent total laparoscopic hysterectomies were retrospectively evaluated. Results: In total, 83 patients were included in our study. The mean age was 49.3 years. The most common indication for total laparoscopic hysterectomy was menorrhagia. The mean body mass index (BMI) was 28.7±4.3. The mean operation time was 132.16±48.5 min, mean hospital stay was 3.38±1.6 days, and mean blood loss was 2 g/dL. The overall complication rate was 6%. Conclusion: Total laparoscopic hysterectomy is a preferred method to abdominal hysterectomy because it is associated with a more favorable surgical outcome. The laparoscopic approach is an acceptable treatment modality in the current gynecological practice. Total laparoscopic hysterectomy is more beneficial to patients because of low estimated blood loss, less analgesia use, low intraoperative and postoperative complication rates, less postoperative pain, more rapid recovery, and short hospital stays. However, the percentage of total laparoscopic hysterectomies is still very low. The longer operation time in total laparoscopic hysterectomy, an unfavorable learning curve, and extensive training of surgeons and the whole surgical team are often cited as reasons.
Iranian journal of reproductive medicine, 2012
Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and c... more Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate. Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn't prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn't prevent osteoporosis in ovariectomised rats.
International journal of fertility & sterility, 2012
The effects of moclobemide on damaged ovarian tissue induced by ischemia- reperfusion and damaged... more The effects of moclobemide on damaged ovarian tissue induced by ischemia- reperfusion and damaged contralateral ovarian tissue were investigated in rats, biochemically and histologically. In this experimental study, 40 rats were equally divided into four groups: 10 mg/kg moclobemide, 20 mg/kg moclobemide, ischemia/reperfusion control, and intact control groups. A 2-2.5-cm-long vertical incision was made in the lower abdomen of each rat in order to reach the ovaries, after which a vascular clip was placed on the lower side of the right ovary of each animal in the two treatment groups and the ischemia-reperfusion control group, but not in the healthy (intact control) animal group. The purpose of this procedure was to create ischemia over the course of three hours, then the clips were unclamped to provide reperfusion for the next two hours. At the end of the two hours of reperfusion, all the animals were killed by high-dose anaesthesia and their ovaries were taken and subjected to hist...
Journal of Academic Research in Medicine, 2014
Amaç: Bizim bu çalışmadaki amacımız, laparoskopik olarak tedavi edilen matür kistik teratom olgul... more Amaç: Bizim bu çalışmadaki amacımız, laparoskopik olarak tedavi edilen matür kistik teratom olgularının retrospektif olarak değerlendirip sunmak ve kist içerği batına dökülen hastalarda ne gibi komplikasyonlar gelişebileceğini irdelemekti Yöntemler: Kliniğimizde 2008 ile 2014 yılları arasında laparoskopik olarak tedavi edilen matür kistik teratom olguları retrospektif olarak analiz edildi. Laparoskopi sırasında kistektomi yada ooferektomi yapıldığı ve hangi hastalarda kist rüptürü oluştuğuna bakıldı. Kist rüptürü oluşan hastalarda posoperatif komplikasyon oluşup oluşmadığına bakıldı. Postoperatif komlikasyonların nasıl yönetldiğine bakıldı. Bulgular: Toplam 22 hastanın 15'ine laparoskopik kistektomi yapılırken 7 hastaya laparoskopik ooferektomi uygulandı. Laparoskopik kist eksizyonu yapılan toplam 8 hastanın kist içeriği batına döküldü, bu hastalardan Sadece 1 tanesinde postoperatif komplikasyon gelişti, bu hasta hospitalize edilip medikal olarak tedavi edildi. Sonuç: Laparoskopik yöntem dermoid kist vakalarında tercih edilecek tedavi yöntemidir. Bizim çalışmamızda 15 hastaya laparoskopik kist eksizyonu uygulanırken 7 hastaya laparoskopik ooferektomi uygulandı. Kistektomi uygulanan 8 hastada kist rüptürü oluştu. Kist rüptürü oluşan 1 hastada postoperatif komplikasyon gelişti ve medikal olarak tedavi edildi. Kist içeriği batına dökülecek olursa iyice temizlenmelidir ve batın serum fizyolojik ile yıkanmalıdır. Eksize edilen kistin endobag kullanarak dışarıya çıkarılması kist içeriğinin batın içine dökülmesine engel olabilir. Laparoskopik yöntem matür kistik teratomların tedavisinde seçilecek ilk yöntem olmalıdır. Genç hastalarda overler mümkün olduğunca korunmaya çalışılmalıdır. İnfertilitesini tamamlamış perimenapozal hastalarda ooferektomi yapılabilir.
International Journal of Cancer, 2009
In this study, the anticancer effect of prednisolone was investigated using rats with normal endo... more In this study, the anticancer effect of prednisolone was investigated using rats with normal endogen adrenaline levels (intact), reduced adrenaline levels (metyrosine-induced) and adrenaline deficiency (adrenalectomized) via gastric adenocarcinoma model. Gastric adenocarcinoma was induced with N-methyl-N 0-nitro-N-nitrosoguanidine (MNNG). According to our experimental results, prednisolone could not prevent MNNG-induced adenocarcinoma when used alone in intact rats. There were neither macroscopic nor microscopic signs of cancer in the rat groups that received metyrosine and prednisolone. However, dysplasia occurred in the stomachs of 2 of 10 rats that received metyrosine and prednisolone. There was no adenocarcinoma genesis in the stomachs of adrenalectomized rats that received prednisolone alone. However, yohimbine (a selective blocker of a2adrenoreceptors) pretreatment in adrenalectomized rats negated the anticancer effect of prednisolone. In conclusion, prednisolone was shown not to be an anticancer agent in intact rats when used alone; however, it has anticancer effects in rats whose adrenaline levels were reduced via adrenalectomy or metyrosine, which is a catecholamine synthesis inhibitor.
Gynecological Endocrinology, 2011
In this study, effects of chronic antihypertensive drug (clonidine, methyldopa, amlodipine, ramip... more In this study, effects of chronic antihypertensive drug (clonidine, methyldopa, amlodipine, ramipril, and rilmenidine) treatment on antioxidant-oxidant parameters were investigated in rat ovarian tissue. Chronic drug administration for 30 days and at the end, biochemical examinations (total glutathione (tGSH), glutathione peroxidase (GPO), glutathione reductase (GR), glutathione s-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO), catalase (CAT), malondialdehyde (MDA), and myeloperoxidase (MPO) analyses) were performed. The levels of glutathione (GSH) and NO, and the activities of GPO, GR, GST, SOD, and CAT were measured the lowest in ramiprile group. Also in ramiprile group, the level of MDA and the activity of MPO was the highest. We divided the drugs into four groups according to their biochemical side effect potentials in ovarian tissue: (I) Drugs which have no clear negative effect on ovarian tissue: clonidine, rilmenidine; (II) Drugs which have mild negative effect on ovarian tissue: methyldopa; (III) Drugs which have moderate negative effect on ovarian tissue: amlodipine; (IV) Drugs which have severe negative effect on ovarian tissue: ramipril. These data might be useful in the selection of the least toxic antihypertensive drug in pregnant and/or normal females.
BMC Gastroenterology, 2009
Background Although many drugs are available for the treatment of gastric ulcers, often these dru... more Background Although many drugs are available for the treatment of gastric ulcers, often these drugs are ineffective. Many antidepressant drugs have been shown to have antiulcer activity in various models of experimental ulcer. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in oxidant, parameters. To date, however, there is no information available regarding the antiulcer activity for a similar antidepressant, fluvoxamine. This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants. Methods Groups of rats fasted for 24 h received fluvoxamine (25, 50, 100 and 200 mg/kg), ranitidine (50 mg/kg) or distilled water by oral gavage. Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent. Six hours after ulcer induction, the stomachs of the rats were excised and an ulcer index determined. Separate group...
Journal of Academic Research in Medicine
Cukurova Medical Journal, 2022
The most common clinical symptom of HPV is the condyloma acuminata, characterized by type 6 and 1... more The most common clinical symptom of HPV is the condyloma acuminata, characterized by type 6 and 11 and constitutes 90% of the infections. However, 12% of the smear specimens were found to have HPV types 16 and 18, which are actually oncogenic. This virüs which frequently infects external genitalia, infects mucocutaneous component much less frequently likewise urethra as a part of mucocutaneous component. We present a case of A 58-year-old menapousal woman consulted with gynecological and obstetrics department due to pathology report of condyloma accumunata of previously excited mass from anal region by a general surgeon. At the examination of the patient, two white clitoral condyloma with white colored tiny condyloma on the right side of the urethra were seen, both HPV 16 and 18 were detected aftetwards. Urethral condyloma acuminata of atypical location at urethral mucosa which coincided with vulvar condyloma, can be a clue for oncogenic HPV infection. We aimed to discuss the mucosa...
Journal of Obstetrics and Gynaecology Research, 2022
ObjectiveApical prolapse constitutes an important part of pelvic organ prolapse. In this study, o... more ObjectiveApical prolapse constitutes an important part of pelvic organ prolapse. In this study, our aim was to investigate the effectiveness of laparoscopic pectopexy that we made by preserving the uterus in the surgical treatment of apical prolapse.MethodsA total of 36 patients with apical prolapse who wanted to preserve their uterus underwent laparoscopic rectopexy. Apical prolapse and sexual function of the patients were evaluated preoperatively and 12 months after surgery using the Pelvic Organ Prolapse Quantification (POP‐Q) scale and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ‐12) sexual questionnaire form. Preoperative medical records and postoperative clinical results were recorded.ResultsThere were no intraoperative or postoperative complications in the patients who underwent laparoscopic pectopexy. The average duration of surgery was 48.7 ± 9.8 min. Two patients had a recurrence of apical prolapse. In the Aa, Ba, C, and D points in the POP‐Q stagi...
Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy, 2021
Objective: Vaginoscopic office hysteroscopy (VOH) is a gold standard diagnostic method for many u... more Objective: Vaginoscopic office hysteroscopy (VOH) is a gold standard diagnostic method for many uterine disorders. However, it may result in patient discomfort. This study aimed to investigate the effect of the Trendelenburg lithotomy (TL) position, in respect of the level of pain and procedure time during the VOH for diagnostic purposes. Methods: This study included 157 patients between the ages of 20 and 65 years, of whom 74 underwent diagnostic VOH with the lithotomy position (group 1) and 83 with the TL position (group 2). Subsequent evaluation that was conducted on both groups included visual analog scale scores of patients, procedure duration, and the attitudinal Likert-type survey of doctors. Results: A significant difference was found between groups 1 and 2 in pain scores (p<0.001), procedure duration (p<0.001), and attitudinal Likert-type survey of doctors (p=0.002). Group 2 reported lower pain scores than group 1 (3.34±2.37 and 5.69±2.33, respectively). Similarly, the procedure duration in group 2 was significantly reduced (60.11±26.3 and 83.3±29.5, respectively). The attitudinal Likert-type survey of doctors also showed significant improvement in group 2 (3.48±0.97 vs. 3.03±0.86, respectively). Conclusion: VOH with the TL position lowered the pain scores in patients and reduced the procedure duration. The TL position is a good way of increasing the patients' compliance and tolerance. Likewise, it makes the procedure easier for the doctor without any additional price.
The New Indian Journal of OBGYN, 2020
To draw attention to the clinical approach in terms of early diagnosis in the trocar entry site h... more To draw attention to the clinical approach in terms of early diagnosis in the trocar entry site hernias which are rare complications after laparoscopic operations. A 47 years old female patient was admitted to our clinic with complaint of ongoing pelvic pain and the patient was scheduled for laparoscopic cystectomy. On the 13th day postoperatively, the patient was referred to our clinic again with ileus clinic. In the CT scan, incarcerated intestinal herniation was detected at the 5 mm trocar entry site. As the trocar site hernias can occur even in incisions smaller than 10 mm,early diagnosis and treatment is of vital importance.
Geburtshilfe und Frauenheilkunde, 2019
Objective The aim of this study was to determine the effectiveness of a newly developed anchoring... more Objective The aim of this study was to determine the effectiveness of a newly developed anchoring system for unilateral sacrospinous ligament fixation (USSLF) and bilateral sacrospinous ligament fixation (BSSLF) procedures. Material and Methods Ninety-three patients with pelvic prolapse who were treated surgically with the Anchorsure System® between 2013 and 2018 were included in the study. USSLF was performed in 52 patients (group 1), and BSSLF was performed in 41 patients (group 2). Pelvic organ prolapse was assessed preoperatively and 6 months postoperatively. Results There were no significant differences between groups 1 and 2 with regard to age, parity, and demographic characteristics. Anatomical improvement rates were similar, irrespective of the type of SSLF used. No bleeding requiring blood transfusion or organ injuries occurred in any patient. Three patients in the group that received BSSLF developed small asymptomatic cystoceles (grade 1 to 2); there was no recurrence of r...
Proceedings in Obstetrics and Gynecology, 2016
Background: In recent years the rate of cesarean section has significantly increased.To determine... more Background: In recent years the rate of cesarean section has significantly increased.To determine the efficacy of prophylactic antibiotics in reducing infectious morbidity after cesarean section. Objectives: In our study, we aimed to evaluate the efficiency of prophylactic antibiotic administration by comparing three groups using single, multiple and no prophylactic antibiotic therapy. Materials and Methods: Our study is a prospective, randomized controlled study including emergent cases, that developed cesarean indication while in active labor, and elective cesarean cases. A total of 90 patients were included in the study, including 30 patients who underwent cesarean delivery and did not undergo an antibiotic prophylaxis (Group 1), 30 patients who underwent a single dose antibiotic prophylaxis (Group II) and 30 patients who underwent multiple dose antibiotic prophylaxis (Group III). Results: The incidence of wound infection was significantly higher in cases that were not using antibiotics at postoperative days 3, 5 and 7 compared to the cases using single and multiple antibiotics. There was not a significant difference between groups in terms of endometritis. Conclusion: Administration of prophylactic antibiotics prevent wound infection but does not prevent development of endometritis.
Balkan medical journal, Jan 26, 2017
In addition to pain caused by uterine contractions in labor, continuous and severe back pain is o... more In addition to pain caused by uterine contractions in labor, continuous and severe back pain is observed in 33% of women. Several pharmacological and nonpharmacological methods are available for managing this pain. Sterile water injection is considered to be an alternative method for nonpharmacological management. The aim of this study was to assess the satisfaction level and effectiveness of sterile water injection for back pain among women in labor. This was a randomized controlled trial. A total of 168 term, healthy women with labor pain and severe back pain were randomized into 4× 0.1 mL of sterile water (study) and 4× dry injection (placebo) groups. Injections were applied to the rhombus of Michaelis in the sacral area. Pain scores were assessed at 10, 30, 60, 120, and 180 min with the visual analog scale. Additionally, the need for epidural analgesia, Apgar score, mode of delivery, time of delivery, maternal satisfaction, and breastfeeding scores were all assessed. The mean ba...
Journal of Academic Research in Medicine, 2016
Apert syndrome, craniosynostosis, mid-face hypoplasia, symmetric syndactyly of the hands and feet... more Apert syndrome, craniosynostosis, mid-face hypoplasia, symmetric syndactyly of the hands and feet, and varying degrees of mental retardation, and is characterized by congenital heart defects. Although the mode of inheritance is autosomal dominant, it creates new mutations in the majority of cases. In this study, an atrial septal defect cases of Apert syndrome, concomitant potential for congenital heart defects, in order to emphasize further investigation, we were willing to offer.
Turkiye Klinikleri Journal of Gynecology and Obstetrics, 2012
eterotopic pregnancy, defined as the simultaneous development of an extrauterine along with an in... more eterotopic pregnancy, defined as the simultaneous development of an extrauterine along with an intrauterine pregnancy, is a very rare event, even in the context of ectopic pregnancy. Duverney first described this diagnosis in 1708 in autopsy findings of a patient who expired from an ectopic pregnancy. 1 The incidence of heterotopic pregnancy varies between 1/30.000 and 1/40.000 but the prevalence of heterotopic pregnancies has been reported to rise to as high as 1-2% due to the use of assisted reproductive technology and ovulation-inducing agents. 2,3 The ectopic pregnancy can be tubal, ovarian, cervical, cornual or abdominal. 4 Tubal ectopic pregnancies are the most common. Abdominal pregnancy affects 1 in 10.000 deliveries. The maternal mortality rate is nearly 6%, and the clinical pres
Journal of Academic Research in Medicine, 2015
Objective: Evaluation of the uterus is one of the indispensable components of routine infertility... more Objective: Evaluation of the uterus is one of the indispensable components of routine infertility examinations. The aim of this study is to evaluate the utility of endometrial screening with contrast media during the assessment of the uterus with transvaginal ultrasonography (TvUSG) in infertility researches. Methods: One hundred and two infertile patients who were referred to Süleymaniye Obstetrics and Gynecology Hospital because of infertility underwent saline infusion sonohysterography (SIS) at our clinic. The cases were informed about the procedure, and consent forms were obtained. Data was collected prospectively. Results were compared with a large patient cohort that was evaluated with only hysterography (HSG) and TvUSG for uterus assessment. Results: Abnormal intracavitary findings were observed in 20.5% of the 102 infertile patients who had undergone SIS. This rate was 7.4% in the control group. Total abnormal intracavitary finding rate of the SIS group was significantly higher (p<0.01). The rates of the uterine anomalies were similar in two groups; 4.9% in the SIS group and 5.03% in the control group. There was no statistically significant difference between the uterine anomaly rates of the groups (p>0.05). Conclusion: SIS is a practical, low-cost method that does not require specific equipment; in addition to these advantages, it is effective in the detection of intrauterine pathologies and for making differential diagnosis. In consideration of the higher frequency of uterine pathologies in infertile patients, SIS can be used as a routine test in infertility researches.
Journal of Academic Research in Medicine, 2015
Objective: The objective of this study was to determine under the view literature, the indication... more Objective: The objective of this study was to determine under the view literature, the indications, findings, and complications of diagnostic and operative laparoscopy performed at a teaching hospital. Methods: A total of 503 cases for which the laparoscopy was performed for diagnostic and operative purposes was included into this study. Demographic characteristics, length of operative time, length of hospital stay, conversion rate to open procedure, and complication rates were evaluated. Results: In our clinic, operative laparoscopy was performed in 405 out of 503 cases. The mean age, gravida, parity, and living child numbers of cases were 32.97±7.29 years, 1.06±1.72, 0.47±1.11, and 0.6±1.15, respectively. Indications of patients undergoing laparoscopy were as follows: diagnostic purpose, tubal obstructions, polycystic ovary syndrome, myoma uteri, adnexial mass, habitual abortion, tubal ligation, adhesions, ectopic pregnancy, amenorrhea, decensus uteri, intrauterine device extraction, chronic pelvic pain, repair of uterine perforation, which occurred during hysteroscopy. Laparotomy was required in seven cases while performing laparoscopy. The complications were reported in 17 of 503 patients with diagnostic and operative laparoscopy. Conclusion: Laparoscopic procedures have become the choice of treatment for most gynecological diseases. Avoidance of laparotomy, smaller incisions, lesser perioperative problems, minimal tissue damage, and shorter duration of hospitalization are well-known advantages of laparoscopy. However, the physician must be an expert in its application and must have adequate knowledge to overcome complications.
International journal of fertility & sterility, 2011
In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clon... more In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically. A total of 36 albino Wistar rats were divided into the following six groups: 0.075 mg/kg clonidine group; 100 mg/kg methyldopa group; 2 mg/kg amlodipine group; 2.5 mg/kg ramipril group; 0.5 mg/kg rilmenidine group; and the healthy group. Rats underwent chronic drug administration for 30 days and at the end, biochemical and histopathological examinations were performed. All data were subjected to one-way ANOVA test. We divided these drugs into the following three groups according to their effects on rat uteri: (I) mild negative effects (clonidine), (II) moderate negative effects (rilmenidine, methyldopa) and (III) drugs which had severe negative effects (amlodipine, ramipril). These data may...
Journal of Academic Research in Medicine, 2015
Objective: The purpose of this study was to evaluate the results of our experience with 83 patien... more Objective: The purpose of this study was to evaluate the results of our experience with 83 patients who underwent total laparoscopic hysterectomy (TLH). Methods: The subjects included 83 patients operated in Gaziosmanpaşa Taksim Training and Research Hospital, Department of Obstetrics and Gynecology. Total laparoscopic hysterectomies were performed for various indications between January 2013 and October 2014. Indications of total laparoscopic hysterectomy, method of operation, intraoperative and postoperative complications, duration of the operation, length of hospital stay, and blood loss in patients who underwent total laparoscopic hysterectomies were retrospectively evaluated. Results: In total, 83 patients were included in our study. The mean age was 49.3 years. The most common indication for total laparoscopic hysterectomy was menorrhagia. The mean body mass index (BMI) was 28.7±4.3. The mean operation time was 132.16±48.5 min, mean hospital stay was 3.38±1.6 days, and mean blood loss was 2 g/dL. The overall complication rate was 6%. Conclusion: Total laparoscopic hysterectomy is a preferred method to abdominal hysterectomy because it is associated with a more favorable surgical outcome. The laparoscopic approach is an acceptable treatment modality in the current gynecological practice. Total laparoscopic hysterectomy is more beneficial to patients because of low estimated blood loss, less analgesia use, low intraoperative and postoperative complication rates, less postoperative pain, more rapid recovery, and short hospital stays. However, the percentage of total laparoscopic hysterectomies is still very low. The longer operation time in total laparoscopic hysterectomy, an unfavorable learning curve, and extensive training of surgeons and the whole surgical team are often cited as reasons.
Iranian journal of reproductive medicine, 2012
Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and c... more Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate. Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn't prevent methylprednisolone +ovariectomised induced osteoporosis in rats. Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn't prevent osteoporosis in ovariectomised rats.
International journal of fertility & sterility, 2012
The effects of moclobemide on damaged ovarian tissue induced by ischemia- reperfusion and damaged... more The effects of moclobemide on damaged ovarian tissue induced by ischemia- reperfusion and damaged contralateral ovarian tissue were investigated in rats, biochemically and histologically. In this experimental study, 40 rats were equally divided into four groups: 10 mg/kg moclobemide, 20 mg/kg moclobemide, ischemia/reperfusion control, and intact control groups. A 2-2.5-cm-long vertical incision was made in the lower abdomen of each rat in order to reach the ovaries, after which a vascular clip was placed on the lower side of the right ovary of each animal in the two treatment groups and the ischemia-reperfusion control group, but not in the healthy (intact control) animal group. The purpose of this procedure was to create ischemia over the course of three hours, then the clips were unclamped to provide reperfusion for the next two hours. At the end of the two hours of reperfusion, all the animals were killed by high-dose anaesthesia and their ovaries were taken and subjected to hist...
Journal of Academic Research in Medicine, 2014
Amaç: Bizim bu çalışmadaki amacımız, laparoskopik olarak tedavi edilen matür kistik teratom olgul... more Amaç: Bizim bu çalışmadaki amacımız, laparoskopik olarak tedavi edilen matür kistik teratom olgularının retrospektif olarak değerlendirip sunmak ve kist içerği batına dökülen hastalarda ne gibi komplikasyonlar gelişebileceğini irdelemekti Yöntemler: Kliniğimizde 2008 ile 2014 yılları arasında laparoskopik olarak tedavi edilen matür kistik teratom olguları retrospektif olarak analiz edildi. Laparoskopi sırasında kistektomi yada ooferektomi yapıldığı ve hangi hastalarda kist rüptürü oluştuğuna bakıldı. Kist rüptürü oluşan hastalarda posoperatif komplikasyon oluşup oluşmadığına bakıldı. Postoperatif komlikasyonların nasıl yönetldiğine bakıldı. Bulgular: Toplam 22 hastanın 15'ine laparoskopik kistektomi yapılırken 7 hastaya laparoskopik ooferektomi uygulandı. Laparoskopik kist eksizyonu yapılan toplam 8 hastanın kist içeriği batına döküldü, bu hastalardan Sadece 1 tanesinde postoperatif komplikasyon gelişti, bu hasta hospitalize edilip medikal olarak tedavi edildi. Sonuç: Laparoskopik yöntem dermoid kist vakalarında tercih edilecek tedavi yöntemidir. Bizim çalışmamızda 15 hastaya laparoskopik kist eksizyonu uygulanırken 7 hastaya laparoskopik ooferektomi uygulandı. Kistektomi uygulanan 8 hastada kist rüptürü oluştu. Kist rüptürü oluşan 1 hastada postoperatif komplikasyon gelişti ve medikal olarak tedavi edildi. Kist içeriği batına dökülecek olursa iyice temizlenmelidir ve batın serum fizyolojik ile yıkanmalıdır. Eksize edilen kistin endobag kullanarak dışarıya çıkarılması kist içeriğinin batın içine dökülmesine engel olabilir. Laparoskopik yöntem matür kistik teratomların tedavisinde seçilecek ilk yöntem olmalıdır. Genç hastalarda overler mümkün olduğunca korunmaya çalışılmalıdır. İnfertilitesini tamamlamış perimenapozal hastalarda ooferektomi yapılabilir.
International Journal of Cancer, 2009
In this study, the anticancer effect of prednisolone was investigated using rats with normal endo... more In this study, the anticancer effect of prednisolone was investigated using rats with normal endogen adrenaline levels (intact), reduced adrenaline levels (metyrosine-induced) and adrenaline deficiency (adrenalectomized) via gastric adenocarcinoma model. Gastric adenocarcinoma was induced with N-methyl-N 0-nitro-N-nitrosoguanidine (MNNG). According to our experimental results, prednisolone could not prevent MNNG-induced adenocarcinoma when used alone in intact rats. There were neither macroscopic nor microscopic signs of cancer in the rat groups that received metyrosine and prednisolone. However, dysplasia occurred in the stomachs of 2 of 10 rats that received metyrosine and prednisolone. There was no adenocarcinoma genesis in the stomachs of adrenalectomized rats that received prednisolone alone. However, yohimbine (a selective blocker of a2adrenoreceptors) pretreatment in adrenalectomized rats negated the anticancer effect of prednisolone. In conclusion, prednisolone was shown not to be an anticancer agent in intact rats when used alone; however, it has anticancer effects in rats whose adrenaline levels were reduced via adrenalectomy or metyrosine, which is a catecholamine synthesis inhibitor.
Gynecological Endocrinology, 2011
In this study, effects of chronic antihypertensive drug (clonidine, methyldopa, amlodipine, ramip... more In this study, effects of chronic antihypertensive drug (clonidine, methyldopa, amlodipine, ramipril, and rilmenidine) treatment on antioxidant-oxidant parameters were investigated in rat ovarian tissue. Chronic drug administration for 30 days and at the end, biochemical examinations (total glutathione (tGSH), glutathione peroxidase (GPO), glutathione reductase (GR), glutathione s-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO), catalase (CAT), malondialdehyde (MDA), and myeloperoxidase (MPO) analyses) were performed. The levels of glutathione (GSH) and NO, and the activities of GPO, GR, GST, SOD, and CAT were measured the lowest in ramiprile group. Also in ramiprile group, the level of MDA and the activity of MPO was the highest. We divided the drugs into four groups according to their biochemical side effect potentials in ovarian tissue: (I) Drugs which have no clear negative effect on ovarian tissue: clonidine, rilmenidine; (II) Drugs which have mild negative effect on ovarian tissue: methyldopa; (III) Drugs which have moderate negative effect on ovarian tissue: amlodipine; (IV) Drugs which have severe negative effect on ovarian tissue: ramipril. These data might be useful in the selection of the least toxic antihypertensive drug in pregnant and/or normal females.
BMC Gastroenterology, 2009
Background Although many drugs are available for the treatment of gastric ulcers, often these dru... more Background Although many drugs are available for the treatment of gastric ulcers, often these drugs are ineffective. Many antidepressant drugs have been shown to have antiulcer activity in various models of experimental ulcer. One such drug, the antidepressant mirtazapine, has been reported to have an antiulcer effect that involves an increase in antioxidant, and a decrease in oxidant, parameters. To date, however, there is no information available regarding the antiulcer activity for a similar antidepressant, fluvoxamine. This study aimed to investigate the antiulcer effects of fluvoxamine and to determine its relationship with antioxidants. Methods Groups of rats fasted for 24 h received fluvoxamine (25, 50, 100 and 200 mg/kg), ranitidine (50 mg/kg) or distilled water by oral gavage. Indomethacin (25 mg/kg) was orally administered to the rats as an ulcerative agent. Six hours after ulcer induction, the stomachs of the rats were excised and an ulcer index determined. Separate group...