SAAD MALIK - Academia.edu (original) (raw)

Papers by SAAD MALIK

Arabian Journal of Geosciences

Journal of Investigative Medicine High Impact Case Reports

Complete occlusion of the sinoatrial node artery can be a complication of percutaneous interventi... more Complete occlusion of the sinoatrial node artery can be a complication of percutaneous intervention (PCI) to the right coronary artery (RCA). When this happens, dysfunction of the sinus node may follow resulting in sinus arrest. When this occurs, it is usually transient and as such, is typically not accompanied by hemodynamic instability. Permanent sinus arrest and shock state may, however, occur on rare occasions. The presence of junctional rhythms on the electrocardiogram (ECG) may predict the occurrence of these permanent arrhythmias and cardiogenic shock. In this case report, we present a 78-year-old woman who developed cardiogenic shock secondary to sinus arrest following PCI to RCA. Her ECG showed junctional rhythm, and she went on to require permanent ventricular pacing. This illustrates a known but rare complication of PCI to RCA.

IGARSS 2019 - 2019 IEEE International Geoscience and Remote Sensing Symposium

Hydrological cycle is comprised of many constituents, the most important of which is precipitatio... more Hydrological cycle is comprised of many constituents, the most important of which is precipitation. Simulation results greatly depend upon the quality of precipitation data as it is entered as the primary input for hydrological model simulations. Due to its chronological and spatial unpredictability, rainfall is considered as one of the most unreliable and irregular atmospheric parameters and therefore rain gauges serve as the main resource of measurement of rainfall. Rain-gauge network is the most commonly used source for rainfall measurement as it works by offering direct measurements of precipitation intensity and time duration at individual point sites. The collected information is further used by Meteorologists, hydrologists and weather reporters who subsequently report how much rain was received in a specific area in an individual event as well as in a particular span of time. Over the years, researchers have been trying to overcome the difficulties faced in the installation of rain gauge networks. The main reason for the errors occurring in the aerial rainfall data for a region is inadequate gauge density. Due to rapidly increasing urbanization and climate change, critical attention is being paid not only to rainfall monitoring but also to the urban waterlogging. Siting selection methods that are used conventionally do not contemplate the environmental surroundings and spatial-temporal scale to choose a site for rain gauge networks. Therefore, the objective of this study was to observe and calculate the need of additional numbers of rain gauges in an area of interest. To execute the intended purpose, the technique of "Estimation of Optimum number of Rain Gauges proposed by Das & Saikia" is used, whereas the appropriate site selection for rain gauges in study area is determined using "Multi-criteria Decision Analysis (MCDA)" using Geographic Information System (GIS). The variables which were incorporated for multi criteria assessment include; elevation, slope, rainfall data (2010), land use/cover, and exiting number of rain gauges in study area. A scale ranges from 1 to 3, "1" being the least suitable, "2" being mildly suitable and "3" being the highly suitable. A site suitability map of the study area is drawn by overlaying these layers in GIS. Results of the experiment exhibit that the suggested methods are appropriate for site selection for rain gauges in urban areas which will also play an important role in the selection of the sites for hydrological facilities, such as water gauge.

Progress in Transplantation

The ongoing burden of COVID-19 in persons with end stage liver failure necessitates the developme... more The ongoing burden of COVID-19 in persons with end stage liver failure necessitates the development of sound and rational policies for organ transplantation in this population. Following our initial experience with two COVID-19 recovered recipients who died shortly after transplant, we adjusted our center policies, re-evaluated outcomes, and retrospectively analyzed the clinical course of the subsequent seven COVID-19 recovered recipients. There were two early deaths and 5 successful outcomes. Both deceased patients shared common characteristics in that they had positive SARS-CoV2 PCR tests proximal to transplant (7-17 days), had acute on chronic liver failure, and suffered thromboembolic phenomena. After a careful review of clinical and virological outcome predictors, we instituted policy changes to avoid transplantation in these circumstances. We believe that our series offers useful insights into the unique challenges that confront transplant centers in the COVID-19 era and could...

Pakistan BioMedical Journal, 2022

To determine the relation between consanguinity and keratoconus (KC). Study Design: Comparative ... more To determine the relation between consanguinity and keratoconus (KC). Study Design: Comparative cross sectional study. Place and duration of study: Ophthalmology department of The University of Lahore Teaching Hospital, Lahore from 12th February to 18th June, 2021. Methods:A comparative cross sectional study was carried out to find the relation between consanguinity and keratoconus. 30 KC diagnosed patients were included in the study according to sample size. A self administered questionnaire was made to collect information about demographic data, various KC findings, clinical signs andnature of marriage between the parents of the participants. Results:Out of 30recruitedKC patients with age ranging between 10-30 years, 13 subjects were male and 17 were female. 56.7% of patients reported with first parental cousin marriage, 26.7% with second, 6.7% with third and 10% with out of family parental marriages. Relation between consanguinity and KC was obtained with P< 0.05, showing the...

2020 IEEE 92nd Vehicular Technology Conference (VTC2020-Fall), 2020

Day by day innovation in wireless communications and micro-technology has evolved in the developm... more Day by day innovation in wireless communications and micro-technology has evolved in the development of wireless sensor networks. This technology has applications such as healthcare supervision, home security, battlefield surveillance and many more. However, due to the use of small batteries with low power this technology faces the issue of power and target monitoring. There is much research done to overcome these issues with the development of different architecture and algorithms. In this paper, a scheduling machine learning algorithm called adaptive learning automata algorithm(ALAA) is used. It provides an efficient scheduling technique. Such that each sensor node in the network has been equipped with learning automata, and with this, they can select their proper state at any given time. The state of the sensor is either active or sleep. For the experiment, different parameters are used to check the consistency of the algorithm to schedule the sensor node such that it can cover all the targets with the use of less power. The results obtained from the experiments show that the proposed algorithm is an efficient way to schedule the sensor nodes to monitor all the targets with use of less power. On the whole, this paper manages to achieve its goal by contributing to the related research on wireless sensor networks with a new design of a learning automata scheduling algorithm. The ability of this proposed algorithm to use the minimum number of sensors to be in active state verified to reduce the use of power in the network. Thus, achieving the goal by enhancing the lifetime of wireless sensor networks.

Transplantation Direct, 2021

Background. Outcomes of liver transplantation (LT) from donation after circulatory death (DCD) ha... more Background. Outcomes of liver transplantation (LT) from donation after circulatory death (DCD) have been improving; however, ischemic cholangiopathy (IC) continues to be a problem. In 2014, measures to minimize donor hepatectomy time (DHT) and cold ischemic time (CIT) have been adopted to improve DCD LT outcomes. Methods. Retrospective review of all patients who underwent DCD LT between 2005 and 2017 was performed. We compared outcomes of patients who were transplanted before 2014 (historic group) with those who were transplanted between 2014 and 2017 (modern group). Results. We identified 112 patients; 44 were in the historic group and 68 in the modern group. Donors in the historic group were younger (26.5 versus 33, P = 0.007) and had a lower body mass index (26.2 versus 28.2, P = 0.007). DHT (min) and CIT (h) were significantly longer in the historic group (21.5 versus 14, P < 0.001 and 5.3 versus 4.2, P < 0.001, respectively). Fourteen patients (12.5%) developed IC, with a significantly higher incidence in the historic group (23.3% versus 6.1%, P = 0.02). There was no difference in graft and patient survival between both groups. Conclusion. In appropriately selected recipients, minimization of DHT and CIT may decrease the incidence of IC. These changes can potentially expand the DCD donor pool.

2019 Sixth International Conference on Aerospace Science and Engineering (ICASE), 2019

In this study a multi-criteria analysis model of GIS has been developed to map the susceptibility... more In this study a multi-criteria analysis model of GIS has been developed to map the susceptibility of coral reef based on various environmental indicators. For this there is a need to understand the pattern of coral susceptibility to environmental indicators including sea surface temperature (SST) which is continuously changing due to the global climate. The Northern Indian Ocean (NIO) has been selected as the study area which includes waters of Arabian Sea and Bay of Bengal. The purpose of this study is to highlight most vulnerable areas of coral bleaching in the NIO by using multicriteria analysis (MCA). Remotely sensed environmental indicators including SST, aragonite saturation state, bathymetry, photosynthetic active radiation (PAR), wind velocity, and reef slope were used to observe the susceptibility of coral reefs in NIO. Existing bleaching sites of corals were overlaid with susceptibility map obtained by MCA. The coast of Sri Lanka, South India, Maldives, Oman and British Indian ocean territory were found to be in the highly susceptible zone of coral bleaching. GIS-based MCA proved to be an efficient technique to analyze the suitable or unsuitable conditions for coral reef susceptibility.

Iraqi journal of science, 2016

The rising temperatures are the most significant aspect in the period of climate variability. In ... more The rising temperatures are the most significant aspect in the period of climate variability. In this study PRECIS model data and observed data are used for assessing the temperature change scenarios of Sindh province during the first half of the present century. Observed data from various meteorological stations of Sindh are the primary source for temperature change detection. The current scenario (1961– 1990) and future one (2010-2050) are acted by the PRECIS Regional Climate Model at a spatial resolution of 25 * 25 km. Regional Climate Model (RCM) can yield reasonably suitable projections to be used in the climate scenario. The main objective of the study is to prepare maps. The simulated temperature as obtained from climate model-PRECIS and their comparison with observed temperatures. The analysis is done on all the districts of Sindh in order to have a more precise picture of temperature change scenarios. According to the results the temperature is likely to increase by 1.5 2.1...

World Academy of Science, Engineering and Technology, International Journal of Mechanical and Mechatronics Engineering, 2017

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih... more Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2018.This work is a student project of the Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.The History of Turkey course (HIST200) is a requirement for all Bilkent undergraduates. It is designed to encourage students to work in groups on projects concerning any topic of their choice that relates to the history of Turkey. It is designed as an interactive course with an emphasis on research and the objective of investigating events, chronologically short historical periods, as well as historic representations. Students from all departments prepare and present final projects for examination by a committee, with 10 projects chosen to receive awards.Includes bibliographical references (page 11).by Burcu Feyzullahoğlu

Transplantation, 2018

Introduction: Significant progress in percutaneous interventional correction of complications in ... more Introduction: Significant progress in percutaneous interventional correction of complications in children after liver transplantation was achieved during the period from May 2015 to October 2017. The method was established to be an effective technique of miniinvasive surgical care for children who developed complications after liver transplantation.

Cancer, 2020

AUTHOR CONTRIBUTIONS Rajshekhar Chakraborty: Designed the study, collected data by screening abst... more AUTHOR CONTRIBUTIONS Rajshekhar Chakraborty: Designed the study, collected data by screening abstracts and full-text of selected articles, and wrote the initial draft. Irbaz Bin Riaz: Designed the study, performed the statistical analysis, critically reviewed the first draft, and approved the final version of the article. Saad Ullah Malik: Designed the study and performed the statistical analysis. Naimisha Marneni: Collected data by screening abstracts and full-text of selected articles. Alex Mejia Garcia: Critically reviewed the first draft and approved the final version of the article. Faiz Anwer: Critically reviewed the first draft and approved the final version of the article. Alok A. Khorana: Critically reviewed the first draft and approved the final version of the article. S. Vincent Rajkumar: Critically reviewed the first draft and approved the final version of the article. Shaji Kumar: Critically reviewed the first draft and approved the final version of the article. M. Hassan Murad: Critically reviewed the first draft and approved the final version of the article. Zhen Wang: Critically reviewed the first draft and approved the final version of the article. Safi U. Khan: Critically reviewed the first draft and approved the final version of the article. Navneet S. Majhail: Designed the study, critically reviewed the first draft and approved the final version of the article.

Journal of Clinical Oncology, 2018

e20048Background: Primary plasma cell leukemia (pPCL) is rare but aggressive disease with median ... more e20048Background: Primary plasma cell leukemia (pPCL) is rare but aggressive disease with median overall survival (mOS) of less than one year. Our aim is to review its unique biology, efficacy of a...

Journal of Clinical Oncology, 2019

6596 Background: Several previous systematic reviews and meta-analyses have attempted to summariz... more 6596 Background: Several previous systematic reviews and meta-analyses have attempted to summarize toxicity of Immune checkpoint inhibitors (ICIs). However, very soon after each one of these reviews has been published, it became outdated. ICIs are currently used in 14 different cancers and data is rapidly evolving from new clinical trials. A living Systematic review, which is defined as a systematic review that is continually updated to incorporate relevant new evidence as it becomes available, is necessary in this situations. Therefore, we performed an updated systematic review and a meta-analysis which will serve as a foundation of a living Systematic review. Methods: MEDLINE, EMBASE and Cochrane were searched to identify phase 2 and 3 RCTs of PD-1/PD-L1 ICIs. Included studies compared either immunotherapy alone or combination with existing standard of care treatment and reported data for AE’s of interest. DerSimonian-Laird random effects Meta-Analysis was performed to derive pool...

Journal of Clinical Oncology, 2019

e13119 Background: Tyrosine kinase inhibitors (TKIs) are routinely used in the treatment of metas... more e13119 Background: Tyrosine kinase inhibitors (TKIs) are routinely used in the treatment of metastatic RCC and Sunitinib is approved for the use in adjuvant setting. Arterial thromboembolic events (ATEs) have been described with these agents, although the overall risk remains unclear. We did a systematic review and meta-analysis to determine the incidence associated with the use of FDA approved TKIs used in treatment of RCC. Methods: PubMed, EMBASE, Cochrane Central and Scopus databases were searched to identify phase 2 and 3 RCTs of TKI therapy in RCC. Trials were included if they reported ATEs defined as arterial thrombosis, cerebral ischemia or infarction, myocardial ischemia and myocardial infarction. The DerSimonian-Laird random effects meta-analysis was performed using CMAv3 software to derive pooled estimates of incidence rates of ATEs with its 95% confidence interval (CI). I2 statistic was computed to express the percentage of the total observed variability due to study hete...

Journal of Clinical Oncology, 2019

e13096 Background: Several studies have reported the association between atrial fibrillation (AF)... more e13096 Background: Several studies have reported the association between atrial fibrillation (AF) and malignant cancer. Recently, results from a large cohort within the Women’s Health Study showed increased incident risk of breast, colon and lung cancer in patients with AF. Therefore, we performed a systematic review to assess the available evidence and a meta-analysis to define the strength of this association. Methods: MEDLINE, Cochrane and Scopus databases were searched for all prospective studies that reported the association between AF and presence of cancer. The HR for incident risk of common cancers was recorded (Breast, Lung, Colorectal) in patients with and without AF. Lung cancer was excluded because the data required for the analysis was not consistently reported. The DerSimonian-Laird random effects meta-analysis was performed to derive pooled Hazard Ratio (HR) estimates for incident risk of colorectal and breast cancer in patients with AF. Q-test was used to assess betw...

Journal of Clinical Oncology, 2019

263 Background: In non-metastatic CRPC with short PSA doubling time, APA or ENZA with ADT have sh... more 263 Background: In non-metastatic CRPC with short PSA doubling time, APA or ENZA with ADT have shown to slow development of metastasis. We performed an indirect comparison of APA and ENZA clinical effectiveness (efficacy and side effects) using network meta-analysis. Methods: A search of Medline, Embase, Cochrane Library, and Cochrane Central Register of Controlled Trials was performed to identify relevant RCTs. Collected data included hazard ratio (HR) and confidence interval (CI) for primary outcome of median time to metastasis free survival (MFS) and secondary outcomes of median time to overall survival (OS), PSA progression, initiation of cytotoxic therapy and number of adverse events (AE) in each study arm. Risk for bias was assessed using the Cochrane Collaboration’s tool. We used a fixed effects model using Bayesian approach to generate pooled estimates. Results: Two randomized trials (n=2608) were analyzed. SPARTAN trial compared APA plus ADT to ADT alone and PROSPER compare...

Biology of Blood and Marrow Transplantation, 2018

When comparing group 4 (median OS >9 years) to the other groups (median OS <9 years), younger age... more When comparing group 4 (median OS >9 years) to the other groups (median OS <9 years), younger age at MM diagnosis, frontline SCT, treatment at a high-volume cancer center, no associated comorbidities, female sex, insured, and median household income were associated with long-term survival in a multivariate analysis. The Table 2 shows univariate and multivariate odds ratio for long-term MM survival. Conclusion: Among patients with MM diagnosed between 2004 and 2006, 1 in 8 patients were long-term survivors (OS > 3X the median). Although differences in the underlying disease biology could not be assessed, key differences in socio-demographic characteristics, patient volume at treatment facility and use of SCT were associated with longterm survival. While some features at MM diagnosis cannot be changed (age, sex, associated comorbidities), early use of SCT and treatment at a high-volume cancer center at the time of diagnosis might impact long-term OS.

International Journal of Plant & Soil Science, 2017

Wheat, the world's third important cereal, is cultivated in Pakistan both in irrigated and rainfe... more Wheat, the world's third important cereal, is cultivated in Pakistan both in irrigated and rainfed areas. One of the major constraints of wheat production in rainfed area is drought that needs to be addressed. Although many genotypes were released that were tolerant to drought stress by improving various physiological traits but there is a need to lessen the effects of drought to boost wheat productivity. The present study was designed to identify genotype(s) suitable under drought stress by analyzing various physiological traits such as relative water content, cell membrane stability, proline content and chlorophyll content under drought stress. The research material consisted of sixteen different wheat genotypes. The experiment was planted during winter 2013-14 following RCBD with three replications. Drought stress was induced by withholding water during heading and anthesis stages. High heritability, observed for relative water content, proline content and cell membrane stability, indicated that selection would be effective for these traits as they are heritable to next generation. Correlation analysis revealed that cell membrane stability and proline Original Research Article

Arabian Journal of Geosciences

Journal of Investigative Medicine High Impact Case Reports

Complete occlusion of the sinoatrial node artery can be a complication of percutaneous interventi... more Complete occlusion of the sinoatrial node artery can be a complication of percutaneous intervention (PCI) to the right coronary artery (RCA). When this happens, dysfunction of the sinus node may follow resulting in sinus arrest. When this occurs, it is usually transient and as such, is typically not accompanied by hemodynamic instability. Permanent sinus arrest and shock state may, however, occur on rare occasions. The presence of junctional rhythms on the electrocardiogram (ECG) may predict the occurrence of these permanent arrhythmias and cardiogenic shock. In this case report, we present a 78-year-old woman who developed cardiogenic shock secondary to sinus arrest following PCI to RCA. Her ECG showed junctional rhythm, and she went on to require permanent ventricular pacing. This illustrates a known but rare complication of PCI to RCA.

IGARSS 2019 - 2019 IEEE International Geoscience and Remote Sensing Symposium

Hydrological cycle is comprised of many constituents, the most important of which is precipitatio... more Hydrological cycle is comprised of many constituents, the most important of which is precipitation. Simulation results greatly depend upon the quality of precipitation data as it is entered as the primary input for hydrological model simulations. Due to its chronological and spatial unpredictability, rainfall is considered as one of the most unreliable and irregular atmospheric parameters and therefore rain gauges serve as the main resource of measurement of rainfall. Rain-gauge network is the most commonly used source for rainfall measurement as it works by offering direct measurements of precipitation intensity and time duration at individual point sites. The collected information is further used by Meteorologists, hydrologists and weather reporters who subsequently report how much rain was received in a specific area in an individual event as well as in a particular span of time. Over the years, researchers have been trying to overcome the difficulties faced in the installation of rain gauge networks. The main reason for the errors occurring in the aerial rainfall data for a region is inadequate gauge density. Due to rapidly increasing urbanization and climate change, critical attention is being paid not only to rainfall monitoring but also to the urban waterlogging. Siting selection methods that are used conventionally do not contemplate the environmental surroundings and spatial-temporal scale to choose a site for rain gauge networks. Therefore, the objective of this study was to observe and calculate the need of additional numbers of rain gauges in an area of interest. To execute the intended purpose, the technique of "Estimation of Optimum number of Rain Gauges proposed by Das & Saikia" is used, whereas the appropriate site selection for rain gauges in study area is determined using "Multi-criteria Decision Analysis (MCDA)" using Geographic Information System (GIS). The variables which were incorporated for multi criteria assessment include; elevation, slope, rainfall data (2010), land use/cover, and exiting number of rain gauges in study area. A scale ranges from 1 to 3, "1" being the least suitable, "2" being mildly suitable and "3" being the highly suitable. A site suitability map of the study area is drawn by overlaying these layers in GIS. Results of the experiment exhibit that the suggested methods are appropriate for site selection for rain gauges in urban areas which will also play an important role in the selection of the sites for hydrological facilities, such as water gauge.

Progress in Transplantation

The ongoing burden of COVID-19 in persons with end stage liver failure necessitates the developme... more The ongoing burden of COVID-19 in persons with end stage liver failure necessitates the development of sound and rational policies for organ transplantation in this population. Following our initial experience with two COVID-19 recovered recipients who died shortly after transplant, we adjusted our center policies, re-evaluated outcomes, and retrospectively analyzed the clinical course of the subsequent seven COVID-19 recovered recipients. There were two early deaths and 5 successful outcomes. Both deceased patients shared common characteristics in that they had positive SARS-CoV2 PCR tests proximal to transplant (7-17 days), had acute on chronic liver failure, and suffered thromboembolic phenomena. After a careful review of clinical and virological outcome predictors, we instituted policy changes to avoid transplantation in these circumstances. We believe that our series offers useful insights into the unique challenges that confront transplant centers in the COVID-19 era and could...

Pakistan BioMedical Journal, 2022

To determine the relation between consanguinity and keratoconus (KC). Study Design: Comparative ... more To determine the relation between consanguinity and keratoconus (KC). Study Design: Comparative cross sectional study. Place and duration of study: Ophthalmology department of The University of Lahore Teaching Hospital, Lahore from 12th February to 18th June, 2021. Methods:A comparative cross sectional study was carried out to find the relation between consanguinity and keratoconus. 30 KC diagnosed patients were included in the study according to sample size. A self administered questionnaire was made to collect information about demographic data, various KC findings, clinical signs andnature of marriage between the parents of the participants. Results:Out of 30recruitedKC patients with age ranging between 10-30 years, 13 subjects were male and 17 were female. 56.7% of patients reported with first parental cousin marriage, 26.7% with second, 6.7% with third and 10% with out of family parental marriages. Relation between consanguinity and KC was obtained with P< 0.05, showing the...

2020 IEEE 92nd Vehicular Technology Conference (VTC2020-Fall), 2020

Day by day innovation in wireless communications and micro-technology has evolved in the developm... more Day by day innovation in wireless communications and micro-technology has evolved in the development of wireless sensor networks. This technology has applications such as healthcare supervision, home security, battlefield surveillance and many more. However, due to the use of small batteries with low power this technology faces the issue of power and target monitoring. There is much research done to overcome these issues with the development of different architecture and algorithms. In this paper, a scheduling machine learning algorithm called adaptive learning automata algorithm(ALAA) is used. It provides an efficient scheduling technique. Such that each sensor node in the network has been equipped with learning automata, and with this, they can select their proper state at any given time. The state of the sensor is either active or sleep. For the experiment, different parameters are used to check the consistency of the algorithm to schedule the sensor node such that it can cover all the targets with the use of less power. The results obtained from the experiments show that the proposed algorithm is an efficient way to schedule the sensor nodes to monitor all the targets with use of less power. On the whole, this paper manages to achieve its goal by contributing to the related research on wireless sensor networks with a new design of a learning automata scheduling algorithm. The ability of this proposed algorithm to use the minimum number of sensors to be in active state verified to reduce the use of power in the network. Thus, achieving the goal by enhancing the lifetime of wireless sensor networks.

Transplantation Direct, 2021

Background. Outcomes of liver transplantation (LT) from donation after circulatory death (DCD) ha... more Background. Outcomes of liver transplantation (LT) from donation after circulatory death (DCD) have been improving; however, ischemic cholangiopathy (IC) continues to be a problem. In 2014, measures to minimize donor hepatectomy time (DHT) and cold ischemic time (CIT) have been adopted to improve DCD LT outcomes. Methods. Retrospective review of all patients who underwent DCD LT between 2005 and 2017 was performed. We compared outcomes of patients who were transplanted before 2014 (historic group) with those who were transplanted between 2014 and 2017 (modern group). Results. We identified 112 patients; 44 were in the historic group and 68 in the modern group. Donors in the historic group were younger (26.5 versus 33, P = 0.007) and had a lower body mass index (26.2 versus 28.2, P = 0.007). DHT (min) and CIT (h) were significantly longer in the historic group (21.5 versus 14, P < 0.001 and 5.3 versus 4.2, P < 0.001, respectively). Fourteen patients (12.5%) developed IC, with a significantly higher incidence in the historic group (23.3% versus 6.1%, P = 0.02). There was no difference in graft and patient survival between both groups. Conclusion. In appropriately selected recipients, minimization of DHT and CIT may decrease the incidence of IC. These changes can potentially expand the DCD donor pool.

2019 Sixth International Conference on Aerospace Science and Engineering (ICASE), 2019

In this study a multi-criteria analysis model of GIS has been developed to map the susceptibility... more In this study a multi-criteria analysis model of GIS has been developed to map the susceptibility of coral reef based on various environmental indicators. For this there is a need to understand the pattern of coral susceptibility to environmental indicators including sea surface temperature (SST) which is continuously changing due to the global climate. The Northern Indian Ocean (NIO) has been selected as the study area which includes waters of Arabian Sea and Bay of Bengal. The purpose of this study is to highlight most vulnerable areas of coral bleaching in the NIO by using multicriteria analysis (MCA). Remotely sensed environmental indicators including SST, aragonite saturation state, bathymetry, photosynthetic active radiation (PAR), wind velocity, and reef slope were used to observe the susceptibility of coral reefs in NIO. Existing bleaching sites of corals were overlaid with susceptibility map obtained by MCA. The coast of Sri Lanka, South India, Maldives, Oman and British Indian ocean territory were found to be in the highly susceptible zone of coral bleaching. GIS-based MCA proved to be an efficient technique to analyze the suitable or unsuitable conditions for coral reef susceptibility.

Iraqi journal of science, 2016

The rising temperatures are the most significant aspect in the period of climate variability. In ... more The rising temperatures are the most significant aspect in the period of climate variability. In this study PRECIS model data and observed data are used for assessing the temperature change scenarios of Sindh province during the first half of the present century. Observed data from various meteorological stations of Sindh are the primary source for temperature change detection. The current scenario (1961– 1990) and future one (2010-2050) are acted by the PRECIS Regional Climate Model at a spatial resolution of 25 * 25 km. Regional Climate Model (RCM) can yield reasonably suitable projections to be used in the climate scenario. The main objective of the study is to prepare maps. The simulated temperature as obtained from climate model-PRECIS and their comparison with observed temperatures. The analysis is done on all the districts of Sindh in order to have a more precise picture of temperature change scenarios. According to the results the temperature is likely to increase by 1.5 2.1...

World Academy of Science, Engineering and Technology, International Journal of Mechanical and Mechatronics Engineering, 2017

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih... more Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2018.This work is a student project of the Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.The History of Turkey course (HIST200) is a requirement for all Bilkent undergraduates. It is designed to encourage students to work in groups on projects concerning any topic of their choice that relates to the history of Turkey. It is designed as an interactive course with an emphasis on research and the objective of investigating events, chronologically short historical periods, as well as historic representations. Students from all departments prepare and present final projects for examination by a committee, with 10 projects chosen to receive awards.Includes bibliographical references (page 11).by Burcu Feyzullahoğlu

Transplantation, 2018

Introduction: Significant progress in percutaneous interventional correction of complications in ... more Introduction: Significant progress in percutaneous interventional correction of complications in children after liver transplantation was achieved during the period from May 2015 to October 2017. The method was established to be an effective technique of miniinvasive surgical care for children who developed complications after liver transplantation.

Cancer, 2020

AUTHOR CONTRIBUTIONS Rajshekhar Chakraborty: Designed the study, collected data by screening abst... more AUTHOR CONTRIBUTIONS Rajshekhar Chakraborty: Designed the study, collected data by screening abstracts and full-text of selected articles, and wrote the initial draft. Irbaz Bin Riaz: Designed the study, performed the statistical analysis, critically reviewed the first draft, and approved the final version of the article. Saad Ullah Malik: Designed the study and performed the statistical analysis. Naimisha Marneni: Collected data by screening abstracts and full-text of selected articles. Alex Mejia Garcia: Critically reviewed the first draft and approved the final version of the article. Faiz Anwer: Critically reviewed the first draft and approved the final version of the article. Alok A. Khorana: Critically reviewed the first draft and approved the final version of the article. S. Vincent Rajkumar: Critically reviewed the first draft and approved the final version of the article. Shaji Kumar: Critically reviewed the first draft and approved the final version of the article. M. Hassan Murad: Critically reviewed the first draft and approved the final version of the article. Zhen Wang: Critically reviewed the first draft and approved the final version of the article. Safi U. Khan: Critically reviewed the first draft and approved the final version of the article. Navneet S. Majhail: Designed the study, critically reviewed the first draft and approved the final version of the article.

Journal of Clinical Oncology, 2018

e20048Background: Primary plasma cell leukemia (pPCL) is rare but aggressive disease with median ... more e20048Background: Primary plasma cell leukemia (pPCL) is rare but aggressive disease with median overall survival (mOS) of less than one year. Our aim is to review its unique biology, efficacy of a...

Journal of Clinical Oncology, 2019

6596 Background: Several previous systematic reviews and meta-analyses have attempted to summariz... more 6596 Background: Several previous systematic reviews and meta-analyses have attempted to summarize toxicity of Immune checkpoint inhibitors (ICIs). However, very soon after each one of these reviews has been published, it became outdated. ICIs are currently used in 14 different cancers and data is rapidly evolving from new clinical trials. A living Systematic review, which is defined as a systematic review that is continually updated to incorporate relevant new evidence as it becomes available, is necessary in this situations. Therefore, we performed an updated systematic review and a meta-analysis which will serve as a foundation of a living Systematic review. Methods: MEDLINE, EMBASE and Cochrane were searched to identify phase 2 and 3 RCTs of PD-1/PD-L1 ICIs. Included studies compared either immunotherapy alone or combination with existing standard of care treatment and reported data for AE’s of interest. DerSimonian-Laird random effects Meta-Analysis was performed to derive pool...

Journal of Clinical Oncology, 2019

e13119 Background: Tyrosine kinase inhibitors (TKIs) are routinely used in the treatment of metas... more e13119 Background: Tyrosine kinase inhibitors (TKIs) are routinely used in the treatment of metastatic RCC and Sunitinib is approved for the use in adjuvant setting. Arterial thromboembolic events (ATEs) have been described with these agents, although the overall risk remains unclear. We did a systematic review and meta-analysis to determine the incidence associated with the use of FDA approved TKIs used in treatment of RCC. Methods: PubMed, EMBASE, Cochrane Central and Scopus databases were searched to identify phase 2 and 3 RCTs of TKI therapy in RCC. Trials were included if they reported ATEs defined as arterial thrombosis, cerebral ischemia or infarction, myocardial ischemia and myocardial infarction. The DerSimonian-Laird random effects meta-analysis was performed using CMAv3 software to derive pooled estimates of incidence rates of ATEs with its 95% confidence interval (CI). I2 statistic was computed to express the percentage of the total observed variability due to study hete...

Journal of Clinical Oncology, 2019

e13096 Background: Several studies have reported the association between atrial fibrillation (AF)... more e13096 Background: Several studies have reported the association between atrial fibrillation (AF) and malignant cancer. Recently, results from a large cohort within the Women’s Health Study showed increased incident risk of breast, colon and lung cancer in patients with AF. Therefore, we performed a systematic review to assess the available evidence and a meta-analysis to define the strength of this association. Methods: MEDLINE, Cochrane and Scopus databases were searched for all prospective studies that reported the association between AF and presence of cancer. The HR for incident risk of common cancers was recorded (Breast, Lung, Colorectal) in patients with and without AF. Lung cancer was excluded because the data required for the analysis was not consistently reported. The DerSimonian-Laird random effects meta-analysis was performed to derive pooled Hazard Ratio (HR) estimates for incident risk of colorectal and breast cancer in patients with AF. Q-test was used to assess betw...

Journal of Clinical Oncology, 2019

263 Background: In non-metastatic CRPC with short PSA doubling time, APA or ENZA with ADT have sh... more 263 Background: In non-metastatic CRPC with short PSA doubling time, APA or ENZA with ADT have shown to slow development of metastasis. We performed an indirect comparison of APA and ENZA clinical effectiveness (efficacy and side effects) using network meta-analysis. Methods: A search of Medline, Embase, Cochrane Library, and Cochrane Central Register of Controlled Trials was performed to identify relevant RCTs. Collected data included hazard ratio (HR) and confidence interval (CI) for primary outcome of median time to metastasis free survival (MFS) and secondary outcomes of median time to overall survival (OS), PSA progression, initiation of cytotoxic therapy and number of adverse events (AE) in each study arm. Risk for bias was assessed using the Cochrane Collaboration’s tool. We used a fixed effects model using Bayesian approach to generate pooled estimates. Results: Two randomized trials (n=2608) were analyzed. SPARTAN trial compared APA plus ADT to ADT alone and PROSPER compare...

Biology of Blood and Marrow Transplantation, 2018

When comparing group 4 (median OS >9 years) to the other groups (median OS <9 years), younger age... more When comparing group 4 (median OS >9 years) to the other groups (median OS <9 years), younger age at MM diagnosis, frontline SCT, treatment at a high-volume cancer center, no associated comorbidities, female sex, insured, and median household income were associated with long-term survival in a multivariate analysis. The Table 2 shows univariate and multivariate odds ratio for long-term MM survival. Conclusion: Among patients with MM diagnosed between 2004 and 2006, 1 in 8 patients were long-term survivors (OS > 3X the median). Although differences in the underlying disease biology could not be assessed, key differences in socio-demographic characteristics, patient volume at treatment facility and use of SCT were associated with longterm survival. While some features at MM diagnosis cannot be changed (age, sex, associated comorbidities), early use of SCT and treatment at a high-volume cancer center at the time of diagnosis might impact long-term OS.

International Journal of Plant & Soil Science, 2017

Wheat, the world's third important cereal, is cultivated in Pakistan both in irrigated and rainfe... more Wheat, the world's third important cereal, is cultivated in Pakistan both in irrigated and rainfed areas. One of the major constraints of wheat production in rainfed area is drought that needs to be addressed. Although many genotypes were released that were tolerant to drought stress by improving various physiological traits but there is a need to lessen the effects of drought to boost wheat productivity. The present study was designed to identify genotype(s) suitable under drought stress by analyzing various physiological traits such as relative water content, cell membrane stability, proline content and chlorophyll content under drought stress. The research material consisted of sixteen different wheat genotypes. The experiment was planted during winter 2013-14 following RCBD with three replications. Drought stress was induced by withholding water during heading and anthesis stages. High heritability, observed for relative water content, proline content and cell membrane stability, indicated that selection would be effective for these traits as they are heritable to next generation. Correlation analysis revealed that cell membrane stability and proline Original Research Article