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Papers by SACHIN PATIL

Research paper thumbnail of A Simple and Efficient Approach to Quinazolinones under Mild Copper-Catalyzed Conditions

Angewandte Chemie International Edition, 2009

Quinazolinone (Q) is a key core structure that occurs in natural products such as luotonin A from... more Quinazolinone (Q) is a key core structure that occurs in natural products such as luotonin A from Peganum nigellastrum, [1a] 2-methyl-4(3H)-quinazolinone from Bacillus cereus, [1b] 2-(4-hydroxybutyl)quinazolin-4-one from Dichroa febrifuga, [1c] and bouchardatine from Bouchardatia neurococca (Figure 1). [1d] Quinazolinone derivatives are now known to have useful biological and medicinal activities; they can be used as hypnotic, sedative, analgesic, anticonvulsant, antitussive, antibacterial, antidiabetic, anti-inflammatory, and antitumor agents. [2, 3] Additionally, some therapeutic agents containing this core structure have been on the market or are in clinical trials for the treatment of cancer. [4] Although some methods for the synthesis of quinazolinone derivatives [2, 5, 6] have been developed, they depend on the availability of the requisite ortho-amino-or-nitrobenzoic

Research paper thumbnail of A Simple and Efficient Approach to Quinazolinones under Mild Copper-Catalyzed Conditions

Angewandte Chemie International Edition, 2009

Quinazolinone (Q) is a key core structure that occurs in natural products such as luotonin A from... more Quinazolinone (Q) is a key core structure that occurs in natural products such as luotonin A from Peganum nigellastrum, [1a] 2-methyl-4(3H)-quinazolinone from Bacillus cereus, [1b] 2-(4-hydroxybutyl)quinazolin-4-one from Dichroa febrifuga, [1c] and bouchardatine from Bouchardatia neurococca (Figure 1). [1d] Quinazolinone derivatives are now known to have useful biological and medicinal activities; they can be used as hypnotic, sedative, analgesic, anticonvulsant, antitussive, antibacterial, antidiabetic, anti-inflammatory, and antitumor agents. [2, 3] Additionally, some therapeutic agents containing this core structure have been on the market or are in clinical trials for the treatment of cancer. [4] Although some methods for the synthesis of quinazolinone derivatives [2, 5, 6] have been developed, they depend on the availability of the requisite ortho-amino-or-nitrobenzoic