amruta SALVE - Academia.edu (original) (raw)

Papers by amruta SALVE

Research paper thumbnail of An analytical balance as tensiometer and densimeter

Journal of Chemical Education, 1991

Research paper thumbnail of SiO2.TTC: Efficient Catalyst for Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones/Thiones

Efficient method has been developed to synthesize various 3,4-dihydropyrimidinones. Dihydropyrimi... more Efficient method has been developed to synthesize various 3,4-dihydropyrimidinones. Dihydropyrimidinone derivatives were synthesized with excellent yield by using aldehyde, ethylacetoacetate and urea or thiourea with silica supported Titanium trichloride. The reaction carr ied out under room temperature. This method is a very easy and rapid for synthesis of dihydropyrimidinone derivatives.

Research paper thumbnail of Sharing Data Dynamically on Cloud Computing by Using Public Auditing and Public Revocation

International Journal of Advance Engineering and Research Development, 2017

The approach of the cloud computing makes reposting outsourcing grow to be a rising pattern that ... more The approach of the cloud computing makes reposting outsourcing grow to be a rising pattern that advances the safe remote data reviewing a remarkable issue that showed up at intervals the examination writing. As presently some exploration ponders the matter of secure and sensible public data general knowledge trait inspecting for shared half knowledge. On the alternative hand, these plans unit still not secure against the intrigue of cloud storage server and denied cluster users throughout user revocation in purposeful cloud storage framework. throughout this paper, we've a bent to be of the agreement assault at intervals the deed organize and provides a decent public trait reviewing organize with secure gathering shopper disclaimer taking into thought vector duty and verifier-neighbourhood repudiation bunch signature. We've a bent to rearrange a solid organize taking into thought our arrange definition. Our organize bolsters of us ordinarily checking and sensible shopper resignation what is more some sensible properties, as AN example, certainly, productivity, tally capability and traceability of secure gathering shopper disclaimer. At last, the protection and preliminary exam demonstrate that, contrasted and its pertinent arranges our set up is likewise secure and sensible.

Research paper thumbnail of The role of NK1 and NK2 receptors in nociceptive inputs to rat dorsal horn lamina I and laminae neurons

Neuropeptides, 1993

The non-specificity of the non-peptide NKI antagonist, (i)CP-96,345, has made interpretation of i... more The non-specificity of the non-peptide NKI antagonist, (i)CP-96,345, has made interpretation of its antinociceptive actions difficult. The present study compares the activity of (f)CP-96,345 with that of GR82334, (+z)CP-99,994 and (f)RP67580 in rodent nociceptive tests. All three non-peptide NKI receptor antagonists were effective in the acetylcholine-induced abdominal constriction test in mouse; EDJO values @mol/kg s.c.) were: (f)CP-99,994, 11; (f)CP-96,345, 6; (i)RP67580, 4. Intraperitoneal or subcutaneous administration of GR82334 (6.7pmolkg) was ineffective, although this compound is active after both I.C.V. and intrathecal administration. In the rat formalin test, (f)CP-96,345 produced a selective block of the second phase, whereas (f)RP67580 (0.6-63pmol/kg and (f)CP-99,994 (0.8-26pmol/kg s.c.) were inactive. (f)CP-99,994 (8Opmolkg s.c.) produced a non-significant 40% reduction of the second phase. Intrathecal administration of GR82334 produces a selective block of the second phase. Intraplantar injection of GR82334 (10 pg) was ineffective. In contrast to (f)CP-96,345 repeated administration of GR82334 (lpmobkg s.c.) and (i)CP-99,994 (10 pmol/kg s.c.) failed to alter mechanical hyperalgesia and oedema induced by carrageenan in rat. The results suggest that N& receptors may only be involved in certain nociceptive tests in rodents. However, it is likely that both specificity and the physicochemical properties of the antagonist under investigation will determine its profile of action in these tests.

Research paper thumbnail of Excitation of rat dorsal horn lamina I neurons by selective agonist at NK-2 but not NK-1 receptors

Research paper thumbnail of Evidence for a role of tachykinin NK2 receptors in mediating brief nociceptive inputs to rat dorsal horn (laminae III–V) neurons

European Journal of Pharmacology, 1993

Since the NK 2 receptor-selective tachykinin, neurokinin A is present in fine primary afferent ne... more Since the NK 2 receptor-selective tachykinin, neurokinin A is present in fine primary afferent neurons in addition to the NK 1 receptor-selective tachykinin, substance P, we have addressed the relative role of NK 1 and NK 2 receptors in somatosensory processing in spinal dorsal horn. Recording extracellularly from rat laminae III-V neurons whilst ionophoresing drugs nearby, the selective NK 1 receptor antagonists L 688,169, GR 82334 and [D-Proa,D-Trp7,91°Phell]substance P-(4-11) failed to influence neuronal responses to cutaneous pinch or noxious heat but often enhanced responses to innocuous brush. In contrast, the highly selective NK 2 receptor antagonist L 659,874 profoundly inhibited responses to noxious heat but not pinch or brush. Highly selective synthetic agonists for both NK 1 and NK 2 receptors ([N-acetyl-Arg6,Sar9,Met(O2)ll]substance P-(6-11) and GR 64349, respectively) and also NKA showed the inverse effects on sensory responses to those brought about by their antagonists. At higher ionophoretic currents, both NK 1 and NK 2 receptor agonists increased spontaneous activity. This increased basal firing induced by GR 64349 and neurokinin A (but not that due to [N-acetyl-Arg6,Sarg,Met(O2)ll]substance P-(6-11) appeared to partially preempt further excitatory responses to noxious heat. It is concluded that although both NK 1 and NK 2 receptors can clearly mediate excitation of dorsal horn neurons, it is not NK1, but rather NK 2 receptors that are important as the physiological transducer of brief thermal nociceptive inputs in this model.

Research paper thumbnail of Efficient CeO2 nanoparticles catalysed for Synthesis of heterocyclic Bis(Indolyl) methanes under mild conditions

There is need to develop simple, efficient & economically viable chemical pathways to synthesise ... more There is need to develop simple, efficient & economically viable chemical pathways to synthesise biologically active & commercially important heterocyclic Bis(indolyl) methanes1.The indole ring is an important constituent of many natural products, pharmaceuticals & other compounds of commercial importantance2. The literature survey shows that Bis(indolyl) methanes are known to increase estrogen metabolism in human beings and hence can be used for the treatment of breast cancer, also it exhibits antibacterial activities3,4,5. This wide range of applications has leaded the chemists to develop new methods to synthesise Bis (Indolyl) methanes. Various methods have been developed for their synthesis using Lewis acid catalysts6-12, ionicliquids13, trichloro-1,3,5-triazine14, and potassium hydrogen sulphate15.However, many of these reported methods suffer from one or other disadvantages such as harsh reaction conditions and reagents that are expensive, moisture sensitive. A mild and effic...

Research paper thumbnail of An analytical balance as tensiometer and densimeter

Journal of Chemical Education, 1991

Research paper thumbnail of SiO2.TTC: Efficient Catalyst for Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones/Thiones

Efficient method has been developed to synthesize various 3,4-dihydropyrimidinones. Dihydropyrimi... more Efficient method has been developed to synthesize various 3,4-dihydropyrimidinones. Dihydropyrimidinone derivatives were synthesized with excellent yield by using aldehyde, ethylacetoacetate and urea or thiourea with silica supported Titanium trichloride. The reaction carr ied out under room temperature. This method is a very easy and rapid for synthesis of dihydropyrimidinone derivatives.

Research paper thumbnail of Sharing Data Dynamically on Cloud Computing by Using Public Auditing and Public Revocation

International Journal of Advance Engineering and Research Development, 2017

The approach of the cloud computing makes reposting outsourcing grow to be a rising pattern that ... more The approach of the cloud computing makes reposting outsourcing grow to be a rising pattern that advances the safe remote data reviewing a remarkable issue that showed up at intervals the examination writing. As presently some exploration ponders the matter of secure and sensible public data general knowledge trait inspecting for shared half knowledge. On the alternative hand, these plans unit still not secure against the intrigue of cloud storage server and denied cluster users throughout user revocation in purposeful cloud storage framework. throughout this paper, we've a bent to be of the agreement assault at intervals the deed organize and provides a decent public trait reviewing organize with secure gathering shopper disclaimer taking into thought vector duty and verifier-neighbourhood repudiation bunch signature. We've a bent to rearrange a solid organize taking into thought our arrange definition. Our organize bolsters of us ordinarily checking and sensible shopper resignation what is more some sensible properties, as AN example, certainly, productivity, tally capability and traceability of secure gathering shopper disclaimer. At last, the protection and preliminary exam demonstrate that, contrasted and its pertinent arranges our set up is likewise secure and sensible.

Research paper thumbnail of The role of NK1 and NK2 receptors in nociceptive inputs to rat dorsal horn lamina I and laminae neurons

Neuropeptides, 1993

The non-specificity of the non-peptide NKI antagonist, (i)CP-96,345, has made interpretation of i... more The non-specificity of the non-peptide NKI antagonist, (i)CP-96,345, has made interpretation of its antinociceptive actions difficult. The present study compares the activity of (f)CP-96,345 with that of GR82334, (+z)CP-99,994 and (f)RP67580 in rodent nociceptive tests. All three non-peptide NKI receptor antagonists were effective in the acetylcholine-induced abdominal constriction test in mouse; EDJO values @mol/kg s.c.) were: (f)CP-99,994, 11; (f)CP-96,345, 6; (i)RP67580, 4. Intraperitoneal or subcutaneous administration of GR82334 (6.7pmolkg) was ineffective, although this compound is active after both I.C.V. and intrathecal administration. In the rat formalin test, (f)CP-96,345 produced a selective block of the second phase, whereas (f)RP67580 (0.6-63pmol/kg and (f)CP-99,994 (0.8-26pmol/kg s.c.) were inactive. (f)CP-99,994 (8Opmolkg s.c.) produced a non-significant 40% reduction of the second phase. Intrathecal administration of GR82334 produces a selective block of the second phase. Intraplantar injection of GR82334 (10 pg) was ineffective. In contrast to (f)CP-96,345 repeated administration of GR82334 (lpmobkg s.c.) and (i)CP-99,994 (10 pmol/kg s.c.) failed to alter mechanical hyperalgesia and oedema induced by carrageenan in rat. The results suggest that N& receptors may only be involved in certain nociceptive tests in rodents. However, it is likely that both specificity and the physicochemical properties of the antagonist under investigation will determine its profile of action in these tests.

Research paper thumbnail of Excitation of rat dorsal horn lamina I neurons by selective agonist at NK-2 but not NK-1 receptors

Research paper thumbnail of Evidence for a role of tachykinin NK2 receptors in mediating brief nociceptive inputs to rat dorsal horn (laminae III–V) neurons

European Journal of Pharmacology, 1993

Since the NK 2 receptor-selective tachykinin, neurokinin A is present in fine primary afferent ne... more Since the NK 2 receptor-selective tachykinin, neurokinin A is present in fine primary afferent neurons in addition to the NK 1 receptor-selective tachykinin, substance P, we have addressed the relative role of NK 1 and NK 2 receptors in somatosensory processing in spinal dorsal horn. Recording extracellularly from rat laminae III-V neurons whilst ionophoresing drugs nearby, the selective NK 1 receptor antagonists L 688,169, GR 82334 and [D-Proa,D-Trp7,91°Phell]substance P-(4-11) failed to influence neuronal responses to cutaneous pinch or noxious heat but often enhanced responses to innocuous brush. In contrast, the highly selective NK 2 receptor antagonist L 659,874 profoundly inhibited responses to noxious heat but not pinch or brush. Highly selective synthetic agonists for both NK 1 and NK 2 receptors ([N-acetyl-Arg6,Sar9,Met(O2)ll]substance P-(6-11) and GR 64349, respectively) and also NKA showed the inverse effects on sensory responses to those brought about by their antagonists. At higher ionophoretic currents, both NK 1 and NK 2 receptor agonists increased spontaneous activity. This increased basal firing induced by GR 64349 and neurokinin A (but not that due to [N-acetyl-Arg6,Sarg,Met(O2)ll]substance P-(6-11) appeared to partially preempt further excitatory responses to noxious heat. It is concluded that although both NK 1 and NK 2 receptors can clearly mediate excitation of dorsal horn neurons, it is not NK1, but rather NK 2 receptors that are important as the physiological transducer of brief thermal nociceptive inputs in this model.

Research paper thumbnail of Efficient CeO2 nanoparticles catalysed for Synthesis of heterocyclic Bis(Indolyl) methanes under mild conditions

There is need to develop simple, efficient & economically viable chemical pathways to synthesise ... more There is need to develop simple, efficient & economically viable chemical pathways to synthesise biologically active & commercially important heterocyclic Bis(indolyl) methanes1.The indole ring is an important constituent of many natural products, pharmaceuticals & other compounds of commercial importantance2. The literature survey shows that Bis(indolyl) methanes are known to increase estrogen metabolism in human beings and hence can be used for the treatment of breast cancer, also it exhibits antibacterial activities3,4,5. This wide range of applications has leaded the chemists to develop new methods to synthesise Bis (Indolyl) methanes. Various methods have been developed for their synthesis using Lewis acid catalysts6-12, ionicliquids13, trichloro-1,3,5-triazine14, and potassium hydrogen sulphate15.However, many of these reported methods suffer from one or other disadvantages such as harsh reaction conditions and reagents that are expensive, moisture sensitive. A mild and effic...