SAMEER DHAWAN - Academia.edu (original) (raw)

Papers by SAMEER DHAWAN

Research paper thumbnail of Designer Peptides as Versatile Building Blocks for Functional Materials

Bioorganic & Medicinal Chemistry Letters

Research paper thumbnail of CCDC 1816299: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of Spectroscopic investigation of linear and branched tryptophan-containing peptides

Journal of Photochemistry and Photobiology A: Chemistry, 2019

Intrinsic fluorescence from amino acid tryptophan (Trp) is used extensively to monitor conformati... more Intrinsic fluorescence from amino acid tryptophan (Trp) is used extensively to monitor conformational dynamics and inter/intra-molecular interactions in proteins and related systems. Peptide systems with varied number of Trp residues are desirable model compounds for understanding fluorescence behaviour of Trp under different conditions. Investigations through model peptides will provide deep insight into photophysical properties of the Trp in a complex protein environment. In this work, three aspartic acid-based peptidic molecules possessing one, two and three Trp units are designed and synthesized for their detailed photophysical and fluorescence quenching investigations within polar-protic methanol, polar-aprotic acetonitrile, and apolar ethyl acetate. From various UV–vis absorbance and steady-state/time-resolved fluorescence measurements, relevant photophysical parameters, such as, absorbance and fluorescence emission maxima, molar absorptivity, fluorescence quantum yield, stead...

Research paper thumbnail of Pseudopeptidic Polymer Microsphere-Filled Liquid Crystals as High-Performance Light-Scattering Switches

Research paper thumbnail of Supersensitive Detection of Anions in Pure Organic and Aqueous Media by Amino Acid Conjugated Ellman’s Reagent

The last few decades witnessed a remarkable advancement in the field of molecular anion receptors... more The last few decades witnessed a remarkable advancement in the field of molecular anion receptors. A variety of anion binding motifs have been discovered, and large number of designer molecular ani...

Research paper thumbnail of Unprecedented formation of reverse micellar vesicles from psuedopeptidic bottlebrush polymers

Chemical Communications

Self-assembly of psuedopeptidic polymers to vesicles is reported and the mechanism of this spheri... more Self-assembly of psuedopeptidic polymers to vesicles is reported and the mechanism of this spherical assembly has also been delineated.

Research paper thumbnail of Organic field effect transistors based on self-assembling core-modified peptidic polymers

Molecular Systems Design & Engineering

Self-assembling hybrid peptide-based organic field effect transistors are reported that showed hi... more Self-assembling hybrid peptide-based organic field effect transistors are reported that showed high mobilities up to 9.3 cm2 V−1 s−1 and significant air stability.

Research paper thumbnail of Self‐assembling polymeric dendritic peptide as functional osteogenic matrix for periodontal regeneration scaffolds—an in vitro study

Journal of Periodontal Research

Research paper thumbnail of Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis

Research paper thumbnail of Glutamic Acid-Based Dendritic Peptides for Scaffold-free Cartilage Tissue Engineering

Research paper thumbnail of Redox Sensitive Self-Assembling Dipeptide for Sustained Intracellular Drug Delivery

Research paper thumbnail of Synthetic Osteogenic Matrix using Polymeric Dendritic Peptides for treating Human Periodontal defects – design and in vitro evaluation

Materials Today: Proceedings

Research paper thumbnail of Maximizing RNA loading for gene silencing using porous silicon nanoparticles

ACS Applied Materials & Interfaces

Research paper thumbnail of Polymersomes from hybrid peptide-based bottlebrush homopolymers

Research paper thumbnail of Spectroscopic investigation of linear and branched tryptophan-containing peptides

Journal of Photochemistry and Photobiology A: Chemistry

Research paper thumbnail of Designer Peptide Dendrons and Dendrimers Based Soft Materials Through Self-Assembly

Research paper thumbnail of Lipidated psuedopeptides with mutable self-assembly: fibres to flowers

Research paper thumbnail of Vesicles: self-assembly beyond biological lipids

RSC Adv.

This review presents an overview of synthetic systems that self-assemble to form vesicles.

Research paper thumbnail of Peptide dendrons as thermal stability amplifiers for IgG1 monoclonal antibody biotherapeutics

Bioconjugate Chemistry

Biotherapeutics such as monoclonal antibodies (mAbs) have a major share of the pharmaceutical ind... more Biotherapeutics such as monoclonal antibodies (mAbs) have a major share of the pharmaceutical industry for treatment of life-threatening chronic diseases such as cancer, skin ailments, and immune disorders. Instabilities such as aggregation, fragmentation, oxidation, and reduction have resulted in the practice of storing these products at low temperatures (-80 to -20 °C). However, reliable storage at these temperatures can be a challenge, particularly in developing and underdeveloped countries; hence, lately, there has been a renewed interest in creating formulations that would offer stability at higher temperatures (25 to 55 °C). Most therapeutic formulations contain excipients such as salts, sugars, amino acids, surfactants, and polymers to provide stability to the biotherapeutic, but their efficacy at high temperatures is limited. The current work proposes the use of peptide dendrons of different generations to create formulations that would be stable at high temperature. Among these dendrons, third-generation lysine dendron L6 has been identified to provide the highest stability to mAbs, as demonstrated by a host of analytical techniques such as size-exclusion chromatography (SEC), dynamic light scattering (DLS), Nanoparticle tracking Analysis (NTA), and circular dichroism (CD). The biocompatibility of these dendrons was confirmed by hemolytic activity tests. Non-interference of the dendrons with the activity of the mAb was confirmed using a surface plasmon resonance (SPR) based activity assay. We hope that this study will stimulate utilization of such higher-generation dendrons for enhancing the thermal stability of mAbs.

Research paper thumbnail of Novel peptidylated surfaces for interference-free electrochemical detection of cardiac troponin I

Biosensors and Bioelectronics

Research paper thumbnail of Designer Peptides as Versatile Building Blocks for Functional Materials

Bioorganic & Medicinal Chemistry Letters

Research paper thumbnail of CCDC 1816299: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Research paper thumbnail of Spectroscopic investigation of linear and branched tryptophan-containing peptides

Journal of Photochemistry and Photobiology A: Chemistry, 2019

Intrinsic fluorescence from amino acid tryptophan (Trp) is used extensively to monitor conformati... more Intrinsic fluorescence from amino acid tryptophan (Trp) is used extensively to monitor conformational dynamics and inter/intra-molecular interactions in proteins and related systems. Peptide systems with varied number of Trp residues are desirable model compounds for understanding fluorescence behaviour of Trp under different conditions. Investigations through model peptides will provide deep insight into photophysical properties of the Trp in a complex protein environment. In this work, three aspartic acid-based peptidic molecules possessing one, two and three Trp units are designed and synthesized for their detailed photophysical and fluorescence quenching investigations within polar-protic methanol, polar-aprotic acetonitrile, and apolar ethyl acetate. From various UV–vis absorbance and steady-state/time-resolved fluorescence measurements, relevant photophysical parameters, such as, absorbance and fluorescence emission maxima, molar absorptivity, fluorescence quantum yield, stead...

Research paper thumbnail of Pseudopeptidic Polymer Microsphere-Filled Liquid Crystals as High-Performance Light-Scattering Switches

Research paper thumbnail of Supersensitive Detection of Anions in Pure Organic and Aqueous Media by Amino Acid Conjugated Ellman’s Reagent

The last few decades witnessed a remarkable advancement in the field of molecular anion receptors... more The last few decades witnessed a remarkable advancement in the field of molecular anion receptors. A variety of anion binding motifs have been discovered, and large number of designer molecular ani...

Research paper thumbnail of Unprecedented formation of reverse micellar vesicles from psuedopeptidic bottlebrush polymers

Chemical Communications

Self-assembly of psuedopeptidic polymers to vesicles is reported and the mechanism of this spheri... more Self-assembly of psuedopeptidic polymers to vesicles is reported and the mechanism of this spherical assembly has also been delineated.

Research paper thumbnail of Organic field effect transistors based on self-assembling core-modified peptidic polymers

Molecular Systems Design & Engineering

Self-assembling hybrid peptide-based organic field effect transistors are reported that showed hi... more Self-assembling hybrid peptide-based organic field effect transistors are reported that showed high mobilities up to 9.3 cm2 V−1 s−1 and significant air stability.

Research paper thumbnail of Self‐assembling polymeric dendritic peptide as functional osteogenic matrix for periodontal regeneration scaffolds—an in vitro study

Journal of Periodontal Research

Research paper thumbnail of Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis

Research paper thumbnail of Glutamic Acid-Based Dendritic Peptides for Scaffold-free Cartilage Tissue Engineering

Research paper thumbnail of Redox Sensitive Self-Assembling Dipeptide for Sustained Intracellular Drug Delivery

Research paper thumbnail of Synthetic Osteogenic Matrix using Polymeric Dendritic Peptides for treating Human Periodontal defects – design and in vitro evaluation

Materials Today: Proceedings

Research paper thumbnail of Maximizing RNA loading for gene silencing using porous silicon nanoparticles

ACS Applied Materials & Interfaces

Research paper thumbnail of Polymersomes from hybrid peptide-based bottlebrush homopolymers

Research paper thumbnail of Spectroscopic investigation of linear and branched tryptophan-containing peptides

Journal of Photochemistry and Photobiology A: Chemistry

Research paper thumbnail of Designer Peptide Dendrons and Dendrimers Based Soft Materials Through Self-Assembly

Research paper thumbnail of Lipidated psuedopeptides with mutable self-assembly: fibres to flowers

Research paper thumbnail of Vesicles: self-assembly beyond biological lipids

RSC Adv.

This review presents an overview of synthetic systems that self-assemble to form vesicles.

Research paper thumbnail of Peptide dendrons as thermal stability amplifiers for IgG1 monoclonal antibody biotherapeutics

Bioconjugate Chemistry

Biotherapeutics such as monoclonal antibodies (mAbs) have a major share of the pharmaceutical ind... more Biotherapeutics such as monoclonal antibodies (mAbs) have a major share of the pharmaceutical industry for treatment of life-threatening chronic diseases such as cancer, skin ailments, and immune disorders. Instabilities such as aggregation, fragmentation, oxidation, and reduction have resulted in the practice of storing these products at low temperatures (-80 to -20 °C). However, reliable storage at these temperatures can be a challenge, particularly in developing and underdeveloped countries; hence, lately, there has been a renewed interest in creating formulations that would offer stability at higher temperatures (25 to 55 °C). Most therapeutic formulations contain excipients such as salts, sugars, amino acids, surfactants, and polymers to provide stability to the biotherapeutic, but their efficacy at high temperatures is limited. The current work proposes the use of peptide dendrons of different generations to create formulations that would be stable at high temperature. Among these dendrons, third-generation lysine dendron L6 has been identified to provide the highest stability to mAbs, as demonstrated by a host of analytical techniques such as size-exclusion chromatography (SEC), dynamic light scattering (DLS), Nanoparticle tracking Analysis (NTA), and circular dichroism (CD). The biocompatibility of these dendrons was confirmed by hemolytic activity tests. Non-interference of the dendrons with the activity of the mAb was confirmed using a surface plasmon resonance (SPR) based activity assay. We hope that this study will stimulate utilization of such higher-generation dendrons for enhancing the thermal stability of mAbs.

Research paper thumbnail of Novel peptidylated surfaces for interference-free electrochemical detection of cardiac troponin I

Biosensors and Bioelectronics