SANA FATIMA - Academia.edu (original) (raw)
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Senior Subject Specialist, Govt. Higher Sec. School, Hassan Abdal, Disst. Attock, Pakistan
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![Research paper thumbnail of 3-(4-Chlorophenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione](https://attachments.academia-assets.com/79257181/thumbnails/1.jpg)
](Acta Crystallographica Section E Structure Reports Online, 2009
Diabetes is one of the major causes of disease related deaths in these modern times and the peopl... more Diabetes is one of the major causes of disease related deaths in these modern times and the people in Southeast Asia and Western Pacific are being the most at risk (Tiwari et al., 2002). To cure the disease sulfonyl ureas are the most frequently used antidiabetic drugs (DeFronzo, 1999; Feinglos & Bethel, 1998). An important complication related to this disease is the cataract formation and imidazolidine-2,4-diones have been found as aldose reductase inhibitors (Murakami et al., 1997). The combination of the two scaffolds, i.e. the sulfonyl urea and the imidazolidine-2,4-dione, in one molecule may be a useful combination to cure the disease and associated complications, especially the cataract formation. With this hypothesis in mind, we synthesized a number of N-arylsulfonylimidazolidine-2,4-diones and evaluated their antidiabetic activity (Hussain
New York: Academic, 1979
There has been a curious gap between theoretical debate and quantitative research on social inequ... more There has been a curious gap between theoretical debate and quantitative research on social inequality throughout the history of sociology. The theoretical debates on inequality have above all revolved around the concept of class, and in particular around the adequacy of the Marxist theory of class. From Weber, to Parsons, to Dahrendorf and Giddens, the point of departure of theorizing the nature of inequality has been an assessment of Marx's contribution. Quantitative research on inequality, on the other hand, has been almost totally oblivious to the Marxist analysis of class as a structure of domination and conflict. And Marxists, for their part, have tended to be suspicious of quantitative, multivariate approaches to the study of social reality and thus have also done little to link the theoretical debate to quantitative research.
Acta Crystallographica Section E Structure Reports Online, 2009
Diabetes is one of the major causes of disease related deaths in these modern times and the peopl... more Diabetes is one of the major causes of disease related deaths in these modern times and the people in Southeast Asia and Western Pacific are being the most at risk (Tiwari et al., 2002). To cure the disease sulfonyl ureas are the most frequently used antidiabetic drugs (DeFronzo, 1999; Feinglos & Bethel, 1998). An important complication related to this disease is the cataract formation and imidazolidine-2,4-diones have been found as aldose reductase inhibitors (Murakami et al., 1997). The combination of the two scaffolds, i.e. the sulfonyl urea and the imidazolidine-2,4-dione, in one molecule may be a useful combination to cure the disease and associated complications, especially the cataract formation. With this hypothesis in mind, we synthesized a number of N-arylsulfonylimidazolidine-2,4-diones and evaluated their antidiabetic activity (Hussain
New York: Academic, 1979
There has been a curious gap between theoretical debate and quantitative research on social inequ... more There has been a curious gap between theoretical debate and quantitative research on social inequality throughout the history of sociology. The theoretical debates on inequality have above all revolved around the concept of class, and in particular around the adequacy of the Marxist theory of class. From Weber, to Parsons, to Dahrendorf and Giddens, the point of departure of theorizing the nature of inequality has been an assessment of Marx's contribution. Quantitative research on inequality, on the other hand, has been almost totally oblivious to the Marxist analysis of class as a structure of domination and conflict. And Marxists, for their part, have tended to be suspicious of quantitative, multivariate approaches to the study of social reality and thus have also done little to link the theoretical debate to quantitative research.