Sinan Atmaca - Academia.edu (original) (raw)
Papers by Sinan Atmaca
International Journal of Pediatric Otorhinolaryngology
Journal of Clinical Oncology
e17538 Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of... more e17538 Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer worldwide. In Turkey, 5538 new cases and 2340 deaths from head and neck cancer are estimated to occur every year. Tobacco and alcohol are the most important etiological risk factors but in the past three decads tobacco usage is decreased and Human Papilloma Virus (HPV) has changed HNSCC epidemiology. Many new reports suggests that almost 25% of all cases of HNSCC are related to HPV. But its prevelans shows a wide variation among different populations.Today in Turkey HPV positivity in HNSCC is currently not known and this retrospective study aimed to to evaluate the HPV infection in our HNSCC patients. Methods: We included 125 HNSCC patients diagnosed and treated in our hospital beween January 2010 and December 2016. Oral cavity, oropharyngeal, laryngeal and hypopharyngeal cancers were included. Nasopharyngeal and salivary gland cancers were exculuded. Head and neck cancer tissue ...
Journal of Craniofacial Surgery
The Turkish journal of pediatrics, 2017
Kemal Ö, Atmaca S, Bel-Çeçen A, Düzgün B, Aygün HC. The use of nasal trumpet as a non-invasive tr... more Kemal Ö, Atmaca S, Bel-Çeçen A, Düzgün B, Aygün HC. The use of nasal trumpet as a non-invasive treatment method in congenital nasal stenosis. Turk J Pediatr 2017; 59: 210-213. Newborns and infants are dependent on nasal respiration and therefore, nasal obstructions may lead to life-threatening outcomes in this age group. Although the most common cause of nasal obstruction in newborns are choanal atresia, soft tissue edema, congenital nasal bone anomalies such as narrowness of the apertura piriformis and midnasal stenosis should be kept in mind. A 5-day-old infant was referred to our clinic with the complaints of respiratory problems. Physical examination revealed nasal bone hypoplasia and saddle nose deformity. In the endoscopic examination, the septum was seen to be deviated in an `S` shape and the nasal passages were almost completely closed. The paranasal CT examination reported significant narrowing of the airway in the central part of the nasal cavity. After application of nasa...
Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology, 2016
Thyroglossal duct cyst (TGDC) is the most common congenital midline neck mass in children. It usu... more Thyroglossal duct cyst (TGDC) is the most common congenital midline neck mass in children. It usually becomes symptomatic following a respiratory tract infection and is usually diagnosed at 5 years of age. Thyroglossal duct cyst is rarely observed in less than 1-year-old infants. In this study, we present a 3-month-old infant with TGDC, who was administered multiple courses of antibiotic therapy for the hyperemic, draining, midline neck mass that had existed since he was 15 days old. Physical examination revealed an infrahyoid midline neck mass measuring 3×3 cm, which moved while swallowing and had a sinus opening in the overlying skin. The patient underwent Sistrunk operation under general anesthesia. Histopathologic examination revealed TGDC. One-year follow-up revealed no recurrence.
The Journal of Pediatric Research, 2016
Turkiye Klinikleri Kulak Burun Bogaz Ozel Dergisi, 2009
... Mehmet KOYUNCU, Sinan ATMACA, Meltem CEYHAN,1 Yeşim EROL ... Eur Arch Otorhinolaryngol 2003;2... more ... Mehmet KOYUNCU, Sinan ATMACA, Meltem CEYHAN,1 Yeşim EROL ... Eur Arch Otorhinolaryngol 2003;260:35-8. 6. Güney E, Yiğitbaşi OG, Canöz K, Oztürk M, Ersoy A. Functional neck dissection: cure and functional results. ...
The Journal of International Advanced Otology, 2016
The most important types of these factors are thought to be basic fibroblast growth factor (bFGF)... more The most important types of these factors are thought to be basic fibroblast growth factor (bFGF), keratinocyte growth factor-1 (KGF-1), and transforming growth factor-β 1 (TGF-β 1) [2-4]. bFGF is expressed by fibroblasts and endothelial cells, and it induces the proliferation of endothelial cells, keratinocytes, and fibroblasts as well as stimulates chemotaxis. It is one of the most important factors in vascularization. KGF-1 is synthesized in fibroblasts and stromal cells and acts only on keratinocytes because its target receptors are found only on keratinocyte membranes. KGF-1 stimulates the proliferation of keratinocytes and is chemotactic and mitogenic for epithelial cells. TGF-β 1 is expressed by macrophages, keratinocytes, fibroblasts, and platelets. It acts mainly in scar formation, stimulates the proliferation and migration of inflammatory cells, induces extracellular matrix formation, and increases mesenchymal tissue formation and vascularity [2, 5]. Mitomycin C (MMC) is an antineoplastic agent of the antibiotic subgroup, which is produced by a fungus called Streptomyces caespitosus. It blocks DNA and RNA replication by interfering in the G1 and S phases at the late stages of the cell cycle. Local application of MMC to the margins of perforations after myringotomy is reported to delay perforation closure [6, 7]. The aim of this study was to investigate the effects of locally applied MMC on the duration of TM healing and on the expression of bFGF, TGF-β 1 , and KGF-1 after perforations induced by myringotomy. MATERIALS and METHODS This experimental study was approved by the local animal use committee. Forty healthy (20 males and 20 females) adult Wistar albino rats with intact TMs weighing up to 250-300 g were equally divided into five randomized groups; each group contained four male and four female rats. All animals were anesthetized by the intraperitoneal administration of ketamine (50 mg/kg) and
Turk Plastik Rekonstruktif Ve Estetik Cerrahi Dergisi, Jan 5, 2011
GİRİŞ Konjenital retrognati ve glossopitozun birlikteli-ğine Pierre Robin ardılı denir.1 Beraberi... more GİRİŞ Konjenital retrognati ve glossopitozun birlikteli-ğine Pierre Robin ardılı denir.1 Beraberinde yarık da-mak da bulunabilir. Ardıl olarak isimlendirilmesinin sebebi mandibula küçüklüğünün dilin geri düşmesi-ne bazen de yarık damağa yol açmasıdır. Mikrogna-ti ve retrognatiye ...
Turkiye Klinikleri Kulak Burun Bogaz Ozel Dergisi, 2009
Journal of Experimental and Clinical Medicine, 2008
... in the benefit of RT after surgery in cases with infiltrative margins and large tumors in the... more ... in the benefit of RT after surgery in cases with infiltrative margins and large tumors in the floor of mouth. Gelifl Tarihi : 10.04.2008 Yayna kabul tarihi : 26.08.2008 Corresponding author : Sinan ATMACA, MD Assistant Professor of Otolaryngology Ondokuz Mayis Universitesi Tip ...
Journal of Experimental and Clinical Medicine, 2013
Yeditepe Medical Journal, 2009
ZET Frontal sinüs kolesteatomları nadir görülen, paranazal sinüslerin diğer inflamatuar (mukosel,... more ZET Frontal sinüs kolesteatomları nadir görülen, paranazal sinüslerin diğer inflamatuar (mukosel, pyosel, mukus retansiyon kisti gibi) ve neoplastik (fibrom, osteom, malign tümörler gibi) lezyonlarından klinik ve radyolojik olarak ayırıcı tanısı zor olan lezyonlardır. Bu tebliğde iki frontal sinüs kolesteatom olgusu sunulmuş ve lezyonların özellikle radyolojik bulgularının diğer paranazal sinüs lezyonlarından ayırıcı tanısı ve cerrahi tedavi üzerinde durulmuştur. Frontal sinüs kolesteatomları konvansiyonel radyogramlarda düzgün kenarlı kemik erozyonu ve bilgisayarlı tomografide (BT) kontrast tutulumu olmaması ile paranazal sinüs neoplazilerinden ayırdedilebilir; ancak BT ile mukosel ve kolesterol granülomlarının ekarte edilmeleri mümkün değildir. Kolesteatom ile en fazla karışan patolojilerden biri olan kolesterol granülomları, manyetik rezonans görüntülemede T1 ağırlıklı kesitlerde kolesteatomların hipointens, granülomların ise hiperintens sinyal vermeleri ile ayırdedilirler. Koles...
International Journal of Pediatric Otorhinolaryngology Extra, 2012
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
Angiofibroma of extranasopharyngeal origin is very rare. Although it is usually originated from a... more Angiofibroma of extranasopharyngeal origin is very rare. Although it is usually originated from any mucosal structure in the head and neck region, maxilla is the most common involvement site. The nasal septum is an exceptional anatomic site of an angiofibroma. Surgery is the best treatment modality and recurrence is very rare. Nasal septal angiofibromas must be considered in the differential diagnosis of nasal vascular masses arising from the nasal septum. In this article, we report a 37-year-old male case with nasal septal angiofibroma who underwent surgical resection of the tumor. This is the 16th case in the literature.
Journal of Experimental and Clinical Medicine, 2011
... Sinan Atmacaa*, Tahir Tulgaa, Emrah Gönülolb, Senem Çengel Kurnaza ... BT'de sağ sub... more ... Sinan Atmacaa*, Tahir Tulgaa, Emrah Gönülolb, Senem Çengel Kurnaza ... BT'de sağ submandibuler bölgeden başlayıp palatin tonsil ve yumuşak damağa uzanan, aşağıda ağız tabanı dü- zeyine kadar gelen angulus mandibula düzeyinde öne doğru dönerek mandibula lateral ...
International Journal of Pediatric Otorhinolaryngology, 2013
A prospective study was carried out to determine the sensitivity and specificity of reflux sympto... more A prospective study was carried out to determine the sensitivity and specificity of reflux symptoms and laryngeal findings to diagnose laryngopharyngeal reflux (LPR) and gastro-esophageal reflux (GER) in children with asthma by comparing the results of double probe pH monitorization and to determine the difference between controlled and uncontrolled asthma in terms of GER and LPR coexistence. Methods: A total of 50 patients (23 girls, mean age 10.8 AE 0.4 years) with mild to moderate persistent asthma were included in this study. The patients were divided in two groups according to the asthma control status as controlled (n = 27) vs. uncontrolled asthma (n = 23). All patients completed the reflux symptom questionnaire and then they underwent flexible fiberoptic laryngoscopy and 24 h double probe (pharyngeal and esophageal) pH monitorization. Laryngopharyngeal and gastroesophageal reflux were defined according to the double probe pH meter results. Results: The prevalences of LPR and GER were 70% and 46% in asthmatic patients, respectively. The reflux symptom score and LPR disease index were not useful to predict LPR or GER. There was no association between asthma control status and LPR and GER. Vocal nodule seems to be a valuable sign to evaluate LPR in asthmatic children. Conclusions: The reflux symptom score and LPR disease index do not seem reliable to diagnose LPR and GER in children with asthma. The frequency of LPR and GER are independent of asthma control, atopy and long acting beta agonist usage.
Journal of Experimental and Clinical Medicine, 2012
International Journal of Pediatric Otorhinolaryngology
Journal of Clinical Oncology
e17538 Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of... more e17538 Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of cancer worldwide. In Turkey, 5538 new cases and 2340 deaths from head and neck cancer are estimated to occur every year. Tobacco and alcohol are the most important etiological risk factors but in the past three decads tobacco usage is decreased and Human Papilloma Virus (HPV) has changed HNSCC epidemiology. Many new reports suggests that almost 25% of all cases of HNSCC are related to HPV. But its prevelans shows a wide variation among different populations.Today in Turkey HPV positivity in HNSCC is currently not known and this retrospective study aimed to to evaluate the HPV infection in our HNSCC patients. Methods: We included 125 HNSCC patients diagnosed and treated in our hospital beween January 2010 and December 2016. Oral cavity, oropharyngeal, laryngeal and hypopharyngeal cancers were included. Nasopharyngeal and salivary gland cancers were exculuded. Head and neck cancer tissue ...
Journal of Craniofacial Surgery
The Turkish journal of pediatrics, 2017
Kemal Ö, Atmaca S, Bel-Çeçen A, Düzgün B, Aygün HC. The use of nasal trumpet as a non-invasive tr... more Kemal Ö, Atmaca S, Bel-Çeçen A, Düzgün B, Aygün HC. The use of nasal trumpet as a non-invasive treatment method in congenital nasal stenosis. Turk J Pediatr 2017; 59: 210-213. Newborns and infants are dependent on nasal respiration and therefore, nasal obstructions may lead to life-threatening outcomes in this age group. Although the most common cause of nasal obstruction in newborns are choanal atresia, soft tissue edema, congenital nasal bone anomalies such as narrowness of the apertura piriformis and midnasal stenosis should be kept in mind. A 5-day-old infant was referred to our clinic with the complaints of respiratory problems. Physical examination revealed nasal bone hypoplasia and saddle nose deformity. In the endoscopic examination, the septum was seen to be deviated in an `S` shape and the nasal passages were almost completely closed. The paranasal CT examination reported significant narrowing of the airway in the central part of the nasal cavity. After application of nasa...
Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology, 2016
Thyroglossal duct cyst (TGDC) is the most common congenital midline neck mass in children. It usu... more Thyroglossal duct cyst (TGDC) is the most common congenital midline neck mass in children. It usually becomes symptomatic following a respiratory tract infection and is usually diagnosed at 5 years of age. Thyroglossal duct cyst is rarely observed in less than 1-year-old infants. In this study, we present a 3-month-old infant with TGDC, who was administered multiple courses of antibiotic therapy for the hyperemic, draining, midline neck mass that had existed since he was 15 days old. Physical examination revealed an infrahyoid midline neck mass measuring 3×3 cm, which moved while swallowing and had a sinus opening in the overlying skin. The patient underwent Sistrunk operation under general anesthesia. Histopathologic examination revealed TGDC. One-year follow-up revealed no recurrence.
The Journal of Pediatric Research, 2016
Turkiye Klinikleri Kulak Burun Bogaz Ozel Dergisi, 2009
... Mehmet KOYUNCU, Sinan ATMACA, Meltem CEYHAN,1 Yeşim EROL ... Eur Arch Otorhinolaryngol 2003;2... more ... Mehmet KOYUNCU, Sinan ATMACA, Meltem CEYHAN,1 Yeşim EROL ... Eur Arch Otorhinolaryngol 2003;260:35-8. 6. Güney E, Yiğitbaşi OG, Canöz K, Oztürk M, Ersoy A. Functional neck dissection: cure and functional results. ...
The Journal of International Advanced Otology, 2016
The most important types of these factors are thought to be basic fibroblast growth factor (bFGF)... more The most important types of these factors are thought to be basic fibroblast growth factor (bFGF), keratinocyte growth factor-1 (KGF-1), and transforming growth factor-β 1 (TGF-β 1) [2-4]. bFGF is expressed by fibroblasts and endothelial cells, and it induces the proliferation of endothelial cells, keratinocytes, and fibroblasts as well as stimulates chemotaxis. It is one of the most important factors in vascularization. KGF-1 is synthesized in fibroblasts and stromal cells and acts only on keratinocytes because its target receptors are found only on keratinocyte membranes. KGF-1 stimulates the proliferation of keratinocytes and is chemotactic and mitogenic for epithelial cells. TGF-β 1 is expressed by macrophages, keratinocytes, fibroblasts, and platelets. It acts mainly in scar formation, stimulates the proliferation and migration of inflammatory cells, induces extracellular matrix formation, and increases mesenchymal tissue formation and vascularity [2, 5]. Mitomycin C (MMC) is an antineoplastic agent of the antibiotic subgroup, which is produced by a fungus called Streptomyces caespitosus. It blocks DNA and RNA replication by interfering in the G1 and S phases at the late stages of the cell cycle. Local application of MMC to the margins of perforations after myringotomy is reported to delay perforation closure [6, 7]. The aim of this study was to investigate the effects of locally applied MMC on the duration of TM healing and on the expression of bFGF, TGF-β 1 , and KGF-1 after perforations induced by myringotomy. MATERIALS and METHODS This experimental study was approved by the local animal use committee. Forty healthy (20 males and 20 females) adult Wistar albino rats with intact TMs weighing up to 250-300 g were equally divided into five randomized groups; each group contained four male and four female rats. All animals were anesthetized by the intraperitoneal administration of ketamine (50 mg/kg) and
Turk Plastik Rekonstruktif Ve Estetik Cerrahi Dergisi, Jan 5, 2011
GİRİŞ Konjenital retrognati ve glossopitozun birlikteli-ğine Pierre Robin ardılı denir.1 Beraberi... more GİRİŞ Konjenital retrognati ve glossopitozun birlikteli-ğine Pierre Robin ardılı denir.1 Beraberinde yarık da-mak da bulunabilir. Ardıl olarak isimlendirilmesinin sebebi mandibula küçüklüğünün dilin geri düşmesi-ne bazen de yarık damağa yol açmasıdır. Mikrogna-ti ve retrognatiye ...
Turkiye Klinikleri Kulak Burun Bogaz Ozel Dergisi, 2009
Journal of Experimental and Clinical Medicine, 2008
... in the benefit of RT after surgery in cases with infiltrative margins and large tumors in the... more ... in the benefit of RT after surgery in cases with infiltrative margins and large tumors in the floor of mouth. Gelifl Tarihi : 10.04.2008 Yayna kabul tarihi : 26.08.2008 Corresponding author : Sinan ATMACA, MD Assistant Professor of Otolaryngology Ondokuz Mayis Universitesi Tip ...
Journal of Experimental and Clinical Medicine, 2013
Yeditepe Medical Journal, 2009
ZET Frontal sinüs kolesteatomları nadir görülen, paranazal sinüslerin diğer inflamatuar (mukosel,... more ZET Frontal sinüs kolesteatomları nadir görülen, paranazal sinüslerin diğer inflamatuar (mukosel, pyosel, mukus retansiyon kisti gibi) ve neoplastik (fibrom, osteom, malign tümörler gibi) lezyonlarından klinik ve radyolojik olarak ayırıcı tanısı zor olan lezyonlardır. Bu tebliğde iki frontal sinüs kolesteatom olgusu sunulmuş ve lezyonların özellikle radyolojik bulgularının diğer paranazal sinüs lezyonlarından ayırıcı tanısı ve cerrahi tedavi üzerinde durulmuştur. Frontal sinüs kolesteatomları konvansiyonel radyogramlarda düzgün kenarlı kemik erozyonu ve bilgisayarlı tomografide (BT) kontrast tutulumu olmaması ile paranazal sinüs neoplazilerinden ayırdedilebilir; ancak BT ile mukosel ve kolesterol granülomlarının ekarte edilmeleri mümkün değildir. Kolesteatom ile en fazla karışan patolojilerden biri olan kolesterol granülomları, manyetik rezonans görüntülemede T1 ağırlıklı kesitlerde kolesteatomların hipointens, granülomların ise hiperintens sinyal vermeleri ile ayırdedilirler. Koles...
International Journal of Pediatric Otorhinolaryngology Extra, 2012
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
Angiofibroma of extranasopharyngeal origin is very rare. Although it is usually originated from a... more Angiofibroma of extranasopharyngeal origin is very rare. Although it is usually originated from any mucosal structure in the head and neck region, maxilla is the most common involvement site. The nasal septum is an exceptional anatomic site of an angiofibroma. Surgery is the best treatment modality and recurrence is very rare. Nasal septal angiofibromas must be considered in the differential diagnosis of nasal vascular masses arising from the nasal septum. In this article, we report a 37-year-old male case with nasal septal angiofibroma who underwent surgical resection of the tumor. This is the 16th case in the literature.
Journal of Experimental and Clinical Medicine, 2011
... Sinan Atmacaa*, Tahir Tulgaa, Emrah Gönülolb, Senem Çengel Kurnaza ... BT'de sağ sub... more ... Sinan Atmacaa*, Tahir Tulgaa, Emrah Gönülolb, Senem Çengel Kurnaza ... BT'de sağ submandibuler bölgeden başlayıp palatin tonsil ve yumuşak damağa uzanan, aşağıda ağız tabanı dü- zeyine kadar gelen angulus mandibula düzeyinde öne doğru dönerek mandibula lateral ...
International Journal of Pediatric Otorhinolaryngology, 2013
A prospective study was carried out to determine the sensitivity and specificity of reflux sympto... more A prospective study was carried out to determine the sensitivity and specificity of reflux symptoms and laryngeal findings to diagnose laryngopharyngeal reflux (LPR) and gastro-esophageal reflux (GER) in children with asthma by comparing the results of double probe pH monitorization and to determine the difference between controlled and uncontrolled asthma in terms of GER and LPR coexistence. Methods: A total of 50 patients (23 girls, mean age 10.8 AE 0.4 years) with mild to moderate persistent asthma were included in this study. The patients were divided in two groups according to the asthma control status as controlled (n = 27) vs. uncontrolled asthma (n = 23). All patients completed the reflux symptom questionnaire and then they underwent flexible fiberoptic laryngoscopy and 24 h double probe (pharyngeal and esophageal) pH monitorization. Laryngopharyngeal and gastroesophageal reflux were defined according to the double probe pH meter results. Results: The prevalences of LPR and GER were 70% and 46% in asthmatic patients, respectively. The reflux symptom score and LPR disease index were not useful to predict LPR or GER. There was no association between asthma control status and LPR and GER. Vocal nodule seems to be a valuable sign to evaluate LPR in asthmatic children. Conclusions: The reflux symptom score and LPR disease index do not seem reliable to diagnose LPR and GER in children with asthma. The frequency of LPR and GER are independent of asthma control, atopy and long acting beta agonist usage.
Journal of Experimental and Clinical Medicine, 2012