S. B. BHAWAR - Academia.edu (original) (raw)

Papers by S. B. BHAWAR

International Journal of Applied Pharmaceutics

Objective: The rationale of the current work is to design, develop and optimize of mouth dissolvi... more Objective: The rationale of the current work is to design, develop and optimize of mouth dissolving tablet of ambrisentan to treat hypertension. Methods: Sodium starch glycolate and crospovidone were used as the super disintegrants in the direct compression method to create nine ambrisentan mouth-dissolving tablet formulations. Wetting time, drug content, in vitro disintegration time, dispersion time, and dissolution time were all assessed for the produced formulations. Results: Based on the results obtained, formulation F6 containing 30 mg of crospovidone exhibited good wetting time, dispersion time, disintegration time and drug release. The hardness of formulations AS1 to AS9 was found to be in the range of 2.5 to 3.11 Kg/cm2. The friability of formulations AS1 to AS9 was found to be less than 1%. A water absorption ratio was performed for ensuring the moisture sorption and water uptake properties of super disintegrants. The in vitro drug release of formulation AS6 containing a co...

Research Journal of Pharmacology and Pharmacodynamics

Kounis syndrome is characterised by a group of symptoms that manifests as unstable vasospastic or... more Kounis syndrome is characterised by a group of symptoms that manifests as unstable vasospastic or non-vasospastic angina secondary to a hypersensitivity reaction. It was first described by Kounis and Zavras in 1991 as the concurrence of an allergic response with an anaphylactic or anaphylactoid reaction and coronary artery spasm or even myocardial infarction. Since then, this condition has evolved to include a number of mast cell activation disorders associated with acute coronary syndrome. There are many triggering factors, including reactions to multiple medications, exposure to radiological contrast media, poison ivy, bee stings, shellfish, and coronary stents. In addition to coronary arterial involvement, Kounis syndrome comprises other arterial systems with similar physiologies, such as mesenteric and cerebral circulation resulting in ischemia / infraction of the vital organs. The Incidence of this condition is difficult to establish owing to the number of potential instigating...

Research Journal of Pharmacology and Pharmacodynamics

Biosimilars are biological products that are the replicas of their innovator biopharmaceuticals. ... more Biosimilars are biological products that are the replicas of their innovator biopharmaceuticals. The term “biosimilar” is in common use in the European Union, while the term “follow on biologics” is more popular in the American context. These are developed after patent expiration of innovator biopharmaceuticals and are submitted for separate marketing approval. In view of the structural and manufacturing complexities of biopharmaceuticals, biosimilars should not be considered as “biological generics”. These are rather unique molecules with limited data at time of approval, so there are concerns about the safety and efficacy of biosimilars. The Indian biotechnology industry is also gaining momentum, with revenues of over U.S. $ 2.0 billion in 2006, 70% of which is biopharmaceuticals. These are projected to reach up to $580 million in 2012.This article will address the differences between biosimilars and chemical generics, issues of concern with the use of biosimilars and need of appr...

Research Journal of Pharmacognosy and Phytochemistry, 2009

Achyranthes aspera is common weed found in India and has great medicinal importance. The plant is... more Achyranthes aspera is common weed found in India and has great medicinal importance. The plant is beneficial in various ailments including stomachache, piles, boils, skin eruption and in asthma. It is also used as anti-inflammatory and as immunomodulator drug. It may act on reactive oxygen species which are one of the factor in the pathogenesis of these diseases. Various extracts of A. aspera, viz., petroleum ether extract, chloroform extract, ethyl acetate extract, ethanol extract and aqueous extract were screened for the antioxidant activity of the plant by using DPPH assay, ABTS assay and FRAP assay. Among all these extracts petroleum ether extract was found to be active as it shows lowest IC50 value in DPPH assay and highest trolox equivalent antioxidant concentration (TEAC) in ABTS assay and FRAP assay. Phytochemical screening revealed that as flavonoids, tannins and phenolic compound are absent in the plant, nonpolar compounds like steroids may be responsible for the antioxida...

The objective of the current study was to develop a simple, accurate, precise and rapid RP-HPLC m... more The objective of the current study was to develop a simple, accurate, precise and rapid RP-HPLC method with subsequently validate as per ICH guidelines for the determination of Entecavirby using mobile phase [mixture of Buffer solution ph 5.0 and Acetonitrile in the ratio 80:20v/v respectively.]. The proposed method involves the measurement of Retention time at selected analytical wavelength. 254.0 nm was selected as the analytical wavelength. The retention time of Entecavir was found to be 6.8 min. respectively. The Linearity was evaluated in the range of 50% to 150% of the working concentration level. As the working concentration level of Entecavir is about 50 ppm for Entecavir oral solution 1mg. The Linearity of response was determined by preparing different concentrations of standard stock solution ranging from 50% of 50ppm to 150% of 50 ppm. The method was statistically validated for its linearity, accuracy and precision.

INDIAN DRUGS, 2012

A significantly rising interest in the design of metal compounds as drugs and diagnostic agents i... more A significantly rising interest in the design of metal compounds as drugs and diagnostic agents is currently observed in the area of scientific inquiry, appropriately termed medicinal inorganic chemistry. Investigations in this area focus mostly on the speciation of metal species in biological media based on possible interactions of these metal ions with diverse biomolecules, in an effort to contribute to future development of new therapeutics or diagnostic agents. Metallopharmaceuticals used as anticancer agents, metal-mediated antibiotics, antibacterials, antivirals, antiparasitics, antiarthritics, antidiabetics and radio-sensitizing agents appear in therapeutic medicinal inorganic chemistry. The medicinal uses and applications of metals and metal complexes are of increasing clinical and commercial importance.

Journal of Ethnopharmacology, 2012

Ethnopharmacological relevance: Berries of the plant Solanum nigrum Linn (Solanaceae) are used fo... more Ethnopharmacological relevance: Berries of the plant Solanum nigrum Linn (Solanaceae) are used for the treatment of asthma in folk medicine and ancient books. Aim of study: To evaluate potential of the plant berries in the treatment of asthma. Materials and methods: Petroleum ether, ethanol and aqueous extracts of S. nigrum berries (50, 100 and 200 mg/kg, i.p.) were screened for the treatment of asthma by the various methods viz. effect on clonidine and haloperidol induced catalepsy, milk-induced leucocytosis and eosinophilia, mast cell stabilizing activity in mice and studies on smooth muscle preparation of guinea pig ileum (in vitro). Active petroleum ether extract was standardized by HPTLC. Results: The petroleum ether extract of S. nigrum berries inhibited clonidine-induced catalepsy significantly but not haloperidol-induced catalepsy. Petroleum ether extract significantly inhibited increased leukocyte and eosinophil count due to milk allergen and showed maximum protection against mast cell degranulation by clonidine. Petroleum ether extract resisted contraction induced by histamine better than other extracts. All the results are dose dependant. Active petroleum ether extract showed presence of antiasthmatic compound, b-sitosterol. Conclusion: The petroleum ether extract of S. nigrum berries can inhibits parameters linked to the asthma disease.

Pharmacologyonline

Various extracts of the aerial parts of the Achyranthes aspera were evaluated for antiallergic ac... more Various extracts of the aerial parts of the Achyranthes aspera were evaluated for antiallergic activity. Plant may show antiallergic activity as the plant shows potent antiasthmatic activity where allergy is one of the pathological condition observed. Petroleum ether extract (200 mg/kg, i.p.) of the plant shows significant antiallergic activity in both milk induced leukocytosis and milk induced eosinophilia in mice. Thus the antiallergic activity of A. aspera may be due to nonpolar constituents. The phytochemical screening of petroleum ether extract shows the presence of steroids. Literature shows the presence of steroids like β-sitosterol, ecdysone and ecdysterone. Thus these steroids present in the plant may be responsible for the antiallergic activity.

International Journal of Applied Pharmaceutics, Jul 7, 2023

Objective: The rationale of the current work is to design, develop and optimize of mouth dissolvi... more Objective: The rationale of the current work is to design, develop and optimize of mouth dissolving tablet of ambrisentan to treat hypertension. Methods: Sodium starch glycolate and crospovidone were used as the super disintegrants in the direct compression method to create nine ambrisentan mouth-dissolving tablet formulations. Wetting time, drug content, in vitro disintegration time, dispersion time, and dissolution time were all assessed for the produced formulations. Results: Based on the results obtained, formulation F6 containing 30 mg of crospovidone exhibited good wetting time, dispersion time, disintegration time and drug release. The hardness of formulations AS1 to AS9 was found to be in the range of 2.5 to 3.11 Kg/cm 2. The friability of formulations AS1 to AS9 was found to be less than 1%. A water absorption ratio was performed for ensuring the moisture sorption and water uptake properties of super disintegrants. The in vitro drug release of formulation AS6 containing a concentration of Crospovidone 30 mg, shows 91.30% drug release respectively at the end of 12 min. Conclusion: The mouth-dissolving tablets of ambrisentan were successfully designed, developed, and fabricated. It can be reasonably concluded that the AS6 batch of mouth-dissolving tablets of ambrisentan with 30 mg of crospovidone exhibited maximum cumulative drug release in 12 min.

International Journal of Applied Pharmaceutics

Objective: The rationale of the current work is to design, develop and optimize of mouth dissolvi... more Objective: The rationale of the current work is to design, develop and optimize of mouth dissolving tablet of ambrisentan to treat hypertension. Methods: Sodium starch glycolate and crospovidone were used as the super disintegrants in the direct compression method to create nine ambrisentan mouth-dissolving tablet formulations. Wetting time, drug content, in vitro disintegration time, dispersion time, and dissolution time were all assessed for the produced formulations. Results: Based on the results obtained, formulation F6 containing 30 mg of crospovidone exhibited good wetting time, dispersion time, disintegration time and drug release. The hardness of formulations AS1 to AS9 was found to be in the range of 2.5 to 3.11 Kg/cm2. The friability of formulations AS1 to AS9 was found to be less than 1%. A water absorption ratio was performed for ensuring the moisture sorption and water uptake properties of super disintegrants. The in vitro drug release of formulation AS6 containing a co...

Research Journal of Pharmacology and Pharmacodynamics

Kounis syndrome is characterised by a group of symptoms that manifests as unstable vasospastic or... more Kounis syndrome is characterised by a group of symptoms that manifests as unstable vasospastic or non-vasospastic angina secondary to a hypersensitivity reaction. It was first described by Kounis and Zavras in 1991 as the concurrence of an allergic response with an anaphylactic or anaphylactoid reaction and coronary artery spasm or even myocardial infarction. Since then, this condition has evolved to include a number of mast cell activation disorders associated with acute coronary syndrome. There are many triggering factors, including reactions to multiple medications, exposure to radiological contrast media, poison ivy, bee stings, shellfish, and coronary stents. In addition to coronary arterial involvement, Kounis syndrome comprises other arterial systems with similar physiologies, such as mesenteric and cerebral circulation resulting in ischemia / infraction of the vital organs. The Incidence of this condition is difficult to establish owing to the number of potential instigating...

Research Journal of Pharmacology and Pharmacodynamics

Biosimilars are biological products that are the replicas of their innovator biopharmaceuticals. ... more Biosimilars are biological products that are the replicas of their innovator biopharmaceuticals. The term “biosimilar” is in common use in the European Union, while the term “follow on biologics” is more popular in the American context. These are developed after patent expiration of innovator biopharmaceuticals and are submitted for separate marketing approval. In view of the structural and manufacturing complexities of biopharmaceuticals, biosimilars should not be considered as “biological generics”. These are rather unique molecules with limited data at time of approval, so there are concerns about the safety and efficacy of biosimilars. The Indian biotechnology industry is also gaining momentum, with revenues of over U.S. $ 2.0 billion in 2006, 70% of which is biopharmaceuticals. These are projected to reach up to $580 million in 2012.This article will address the differences between biosimilars and chemical generics, issues of concern with the use of biosimilars and need of appr...

Research Journal of Pharmacognosy and Phytochemistry, 2009

Achyranthes aspera is common weed found in India and has great medicinal importance. The plant is... more Achyranthes aspera is common weed found in India and has great medicinal importance. The plant is beneficial in various ailments including stomachache, piles, boils, skin eruption and in asthma. It is also used as anti-inflammatory and as immunomodulator drug. It may act on reactive oxygen species which are one of the factor in the pathogenesis of these diseases. Various extracts of A. aspera, viz., petroleum ether extract, chloroform extract, ethyl acetate extract, ethanol extract and aqueous extract were screened for the antioxidant activity of the plant by using DPPH assay, ABTS assay and FRAP assay. Among all these extracts petroleum ether extract was found to be active as it shows lowest IC50 value in DPPH assay and highest trolox equivalent antioxidant concentration (TEAC) in ABTS assay and FRAP assay. Phytochemical screening revealed that as flavonoids, tannins and phenolic compound are absent in the plant, nonpolar compounds like steroids may be responsible for the antioxida...

The objective of the current study was to develop a simple, accurate, precise and rapid RP-HPLC m... more The objective of the current study was to develop a simple, accurate, precise and rapid RP-HPLC method with subsequently validate as per ICH guidelines for the determination of Entecavirby using mobile phase [mixture of Buffer solution ph 5.0 and Acetonitrile in the ratio 80:20v/v respectively.]. The proposed method involves the measurement of Retention time at selected analytical wavelength. 254.0 nm was selected as the analytical wavelength. The retention time of Entecavir was found to be 6.8 min. respectively. The Linearity was evaluated in the range of 50% to 150% of the working concentration level. As the working concentration level of Entecavir is about 50 ppm for Entecavir oral solution 1mg. The Linearity of response was determined by preparing different concentrations of standard stock solution ranging from 50% of 50ppm to 150% of 50 ppm. The method was statistically validated for its linearity, accuracy and precision.

INDIAN DRUGS, 2012

A significantly rising interest in the design of metal compounds as drugs and diagnostic agents i... more A significantly rising interest in the design of metal compounds as drugs and diagnostic agents is currently observed in the area of scientific inquiry, appropriately termed medicinal inorganic chemistry. Investigations in this area focus mostly on the speciation of metal species in biological media based on possible interactions of these metal ions with diverse biomolecules, in an effort to contribute to future development of new therapeutics or diagnostic agents. Metallopharmaceuticals used as anticancer agents, metal-mediated antibiotics, antibacterials, antivirals, antiparasitics, antiarthritics, antidiabetics and radio-sensitizing agents appear in therapeutic medicinal inorganic chemistry. The medicinal uses and applications of metals and metal complexes are of increasing clinical and commercial importance.

Journal of Ethnopharmacology, 2012

Ethnopharmacological relevance: Berries of the plant Solanum nigrum Linn (Solanaceae) are used fo... more Ethnopharmacological relevance: Berries of the plant Solanum nigrum Linn (Solanaceae) are used for the treatment of asthma in folk medicine and ancient books. Aim of study: To evaluate potential of the plant berries in the treatment of asthma. Materials and methods: Petroleum ether, ethanol and aqueous extracts of S. nigrum berries (50, 100 and 200 mg/kg, i.p.) were screened for the treatment of asthma by the various methods viz. effect on clonidine and haloperidol induced catalepsy, milk-induced leucocytosis and eosinophilia, mast cell stabilizing activity in mice and studies on smooth muscle preparation of guinea pig ileum (in vitro). Active petroleum ether extract was standardized by HPTLC. Results: The petroleum ether extract of S. nigrum berries inhibited clonidine-induced catalepsy significantly but not haloperidol-induced catalepsy. Petroleum ether extract significantly inhibited increased leukocyte and eosinophil count due to milk allergen and showed maximum protection against mast cell degranulation by clonidine. Petroleum ether extract resisted contraction induced by histamine better than other extracts. All the results are dose dependant. Active petroleum ether extract showed presence of antiasthmatic compound, b-sitosterol. Conclusion: The petroleum ether extract of S. nigrum berries can inhibits parameters linked to the asthma disease.

Pharmacologyonline

Various extracts of the aerial parts of the Achyranthes aspera were evaluated for antiallergic ac... more Various extracts of the aerial parts of the Achyranthes aspera were evaluated for antiallergic activity. Plant may show antiallergic activity as the plant shows potent antiasthmatic activity where allergy is one of the pathological condition observed. Petroleum ether extract (200 mg/kg, i.p.) of the plant shows significant antiallergic activity in both milk induced leukocytosis and milk induced eosinophilia in mice. Thus the antiallergic activity of A. aspera may be due to nonpolar constituents. The phytochemical screening of petroleum ether extract shows the presence of steroids. Literature shows the presence of steroids like β-sitosterol, ecdysone and ecdysterone. Thus these steroids present in the plant may be responsible for the antiallergic activity.

International Journal of Applied Pharmaceutics, Jul 7, 2023

Objective: The rationale of the current work is to design, develop and optimize of mouth dissolvi... more Objective: The rationale of the current work is to design, develop and optimize of mouth dissolving tablet of ambrisentan to treat hypertension. Methods: Sodium starch glycolate and crospovidone were used as the super disintegrants in the direct compression method to create nine ambrisentan mouth-dissolving tablet formulations. Wetting time, drug content, in vitro disintegration time, dispersion time, and dissolution time were all assessed for the produced formulations. Results: Based on the results obtained, formulation F6 containing 30 mg of crospovidone exhibited good wetting time, dispersion time, disintegration time and drug release. The hardness of formulations AS1 to AS9 was found to be in the range of 2.5 to 3.11 Kg/cm 2. The friability of formulations AS1 to AS9 was found to be less than 1%. A water absorption ratio was performed for ensuring the moisture sorption and water uptake properties of super disintegrants. The in vitro drug release of formulation AS6 containing a concentration of Crospovidone 30 mg, shows 91.30% drug release respectively at the end of 12 min. Conclusion: The mouth-dissolving tablets of ambrisentan were successfully designed, developed, and fabricated. It can be reasonably concluded that the AS6 batch of mouth-dissolving tablets of ambrisentan with 30 mg of crospovidone exhibited maximum cumulative drug release in 12 min.