S. Bansal - Academia.edu (original) (raw)

Papers by S. Bansal

Research paper thumbnail of A Practical “ABCDE” Approach to the Metabolic Syndrome

Mayo Clinic Proceedings, 2008

The metabolic syndrome comprises a cluster of risk factors for cardiovascular disease and type 2 ... more The metabolic syndrome comprises a cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus that are due to abdominal obesity and insulin resistance. This increasingly important proinflammatory condition remains both underrecognized and undertreated. To aid physicians in their approach to the metabolic syndrome, we assessed and synthesized the literature on cardiovascular risk assessment and early intervention for risk reduction. We performed a comprehensive search of MEDLINE and the Cochrane database for peer-reviewed clinical studies mented by consultation with content experts. We used the search terms metabolic syndrome, abdominal obesity, waist circumference, insulin resistance, cardiovascular disease, prediabetes, diabetes, treatment, prevention, aspirin, hypertension, cholesterol, atherogenic dyslipidemia, lifestyle therapy, diet, and exercise. Criteria used for study review were controlled study design, English language, relevance to clinicians, and validity based on experimental design and appropriateness of conclusions. Although growing evidence supports early intervention in patients with the metabolic syndrome, many physicians do not recognize the risk associated with this condition and fail to initiate early treatment. A comprehensive management plan can be assembled through an "ABCDE" approach: "A" for assessment of cardiovascular risk and aspirin therapy, "B" for blood pressure control, "C" for cholesterol management, "D" for diabetes prevention and diet therapy, and "E" for exercise therapy. This ABCDE approach provides a practical and systematic framework for encouraging metabolic syndrome recognition and for implementing a comprehensive, evidence-based management plan for the reduction of cardiovascular risk. Mayo Clin Proc. 2008;83(8):932-943 ACC = American College of Cardiology; ACEI = angiotensin-converting enzyme inhibitor; AHA = American Heart Association; ARB = angiotensin receptor blocker; CI = confidence interval; DREAM = Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication; GL = glycemic load; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; NCEP ATP III = National Cholesterol Education Program Adult Treatment Panel III; PPAR = peroxisome proliferatoractivated receptor; VLDL-C = very low-density lipoprotein cholesterol

Research paper thumbnail of Long-Term Follow-up of the West of Scotland Coronary Prevention Study

New England Journal of Medicine, 2008

A bs t r ac t From the Robertson Centre for Biostatis tics (I.F., H.M.) and the Division of Car d... more A bs t r ac t From the Robertson Centre for Biostatis tics (I.F., H.M.) and the Division of Car diovascular and Medical Sciences (C.

Research paper thumbnail of A Practical “ABCDE” Approach to the Metabolic Syndrome

Mayo Clinic Proceedings, 2008

The metabolic syndrome comprises a cluster of risk factors for cardiovascular disease and type 2 ... more The metabolic syndrome comprises a cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus that are due to abdominal obesity and insulin resistance. This increasingly important proinflammatory condition remains both underrecognized and undertreated. To aid physicians in their approach to the metabolic syndrome, we assessed and synthesized the literature on cardiovascular risk assessment and early intervention for risk reduction. We performed a comprehensive search of MEDLINE and the Cochrane database for peer-reviewed clinical studies mented by consultation with content experts. We used the search terms metabolic syndrome, abdominal obesity, waist circumference, insulin resistance, cardiovascular disease, prediabetes, diabetes, treatment, prevention, aspirin, hypertension, cholesterol, atherogenic dyslipidemia, lifestyle therapy, diet, and exercise. Criteria used for study review were controlled study design, English language, relevance to clinicians, and validity based on experimental design and appropriateness of conclusions. Although growing evidence supports early intervention in patients with the metabolic syndrome, many physicians do not recognize the risk associated with this condition and fail to initiate early treatment. A comprehensive management plan can be assembled through an "ABCDE" approach: "A" for assessment of cardiovascular risk and aspirin therapy, "B" for blood pressure control, "C" for cholesterol management, "D" for diabetes prevention and diet therapy, and "E" for exercise therapy. This ABCDE approach provides a practical and systematic framework for encouraging metabolic syndrome recognition and for implementing a comprehensive, evidence-based management plan for the reduction of cardiovascular risk. Mayo Clin Proc. 2008;83(8):932-943 ACC = American College of Cardiology; ACEI = angiotensin-converting enzyme inhibitor; AHA = American Heart Association; ARB = angiotensin receptor blocker; CI = confidence interval; DREAM = Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication; GL = glycemic load; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; NCEP ATP III = National Cholesterol Education Program Adult Treatment Panel III; PPAR = peroxisome proliferatoractivated receptor; VLDL-C = very low-density lipoprotein cholesterol

Research paper thumbnail of Long-Term Follow-up of the West of Scotland Coronary Prevention Study

New England Journal of Medicine, 2008

A bs t r ac t From the Robertson Centre for Biostatis tics (I.F., H.M.) and the Division of Car d... more A bs t r ac t From the Robertson Centre for Biostatis tics (I.F., H.M.) and the Division of Car diovascular and Medical Sciences (C.