S. Bardet - Academia.edu (original) (raw)

Uploads

Papers by S. Bardet

Research paper thumbnail of O-013 Flow-diverter biological improvement with CD31 biomimetic: preclinical experience

Research paper thumbnail of Optimisation de la biocompatibilité des stents flow-diverters par greffage du P8RI pour le traitement des anévrismes intracrâniens

Journal of Neuroradiology

Research paper thumbnail of The avian lateroseptal organ and the molecular striatopallidal border

Research paper thumbnail of Immunoglobulin genes undergo legitimate repair in human B cells not only after cis- but also frequent trans-class switch recombination

Genes and immunity

Immunoglobulin (Ig) genes specifically recruit activation-induced deaminase (AID) for 'on-tar... more Immunoglobulin (Ig) genes specifically recruit activation-induced deaminase (AID) for 'on-target' DNA deamination, initiating either variable (V) region somatic hypermutation, or double-strand break intermediates of class switch recombination (CSR). Such breaks overwhelmingly undergo legitimate intra-Ig repair rather than rare illegitimate and potentially oncogenic junctions outside of Ig loci. We show that in human B cells, legitimate synapsis and repair efficiently join Ig genes whether physically linked on one chromosome or located apart on both alleles. This indicates mechanisms faithfully recognizing and/or pairing loci with homology in structure and accessibility, thus licensing interchromosomal trans-CSR junctions while usually preventing illegitimate interchromosomal recombination with AID off-target genes. Physical linkage of IgH genes in cis on the same allele just increases the likelihood of legitimate repair by another fourfold. The strongest force driving CSR mi...

Research paper thumbnail of O-013 Flow-diverter biological improvement with CD31 biomimetic: preclinical experience

Research paper thumbnail of Optimisation de la biocompatibilité des stents flow-diverters par greffage du P8RI pour le traitement des anévrismes intracrâniens

Journal of Neuroradiology

Research paper thumbnail of The avian lateroseptal organ and the molecular striatopallidal border

Research paper thumbnail of Immunoglobulin genes undergo legitimate repair in human B cells not only after cis- but also frequent trans-class switch recombination

Genes and immunity

Immunoglobulin (Ig) genes specifically recruit activation-induced deaminase (AID) for 'on-tar... more Immunoglobulin (Ig) genes specifically recruit activation-induced deaminase (AID) for 'on-target' DNA deamination, initiating either variable (V) region somatic hypermutation, or double-strand break intermediates of class switch recombination (CSR). Such breaks overwhelmingly undergo legitimate intra-Ig repair rather than rare illegitimate and potentially oncogenic junctions outside of Ig loci. We show that in human B cells, legitimate synapsis and repair efficiently join Ig genes whether physically linked on one chromosome or located apart on both alleles. This indicates mechanisms faithfully recognizing and/or pairing loci with homology in structure and accessibility, thus licensing interchromosomal trans-CSR junctions while usually preventing illegitimate interchromosomal recombination with AID off-target genes. Physical linkage of IgH genes in cis on the same allele just increases the likelihood of legitimate repair by another fourfold. The strongest force driving CSR mi...

Log In