S Bavdekar - Academia.edu (original) (raw)

Papers by S Bavdekar

International Journal of Pediatric Otorhinolaryngology, 2005

Journal of Postgraduate Medicine, 2010

An 11-year-old girl born of non-consanguineous marriage was brought with a 4-day history of fever... more An 11-year-old girl born of non-consanguineous marriage was brought with a 4-day history of fever, cough, and progressive shortness of breath. The fever was high-grade and continuous, not responding to medications. The cough was associated with scanty whitish expectoration without any hemoptysis. The child had a significant past history of repeated monthly episodes of cold and fever since the age of 5 years, associated with progressive difficulty in walking due to swaying. Her handwriting had also deteriorated over the past 2 years. Her elder sister had similar complaints from the age of 8 years and she was bed-ridden at the age of 14 years. Pulmonary cavitatory lesions and consolidation had been noted on high-resolution computed tomographic scan (HRCT) 6 months back. Considering these lesions and her history of repeated episodes of respiratory infection, she was started on four-drug anti-tuberculosis therapy (ATT) at another institution, which was continued till her present illness. The child, however, had not shown any improvement in her symptomatology, despite the ATT. On examination, the child had stable vitals (normal sensorium, pulse rate of 108/min, blood pressure of 108/58 mm Hg and respiratory rate of 30/min). She was stunted [height 110 cm, below

Journal of Postgraduate Medicine, 2008

India is considered as a preferred site for conducting global clinical trials. Existence of a lar... more India is considered as a preferred site for conducting global clinical trials. Existence of a large treatment-naïve population, availability of English-speaking, skilled doctors, plenty of clinical material, and cost-savings are obvious advantages for carrying out clinical research in India. However, challenges exist at various levels. Lack of formal training in bioethics and research methodology, heavy burden of clinical duties and sub-optimal administrative support restrict investigators. Absence of oversight of functioning of ethics committees (ECs) and lack of mechanisms for ensuring quality of ethics review heighten societal concerns about safety of participants. Conducting research on issues not relevant to local needs and failure to ensure post-trial access further enhance society's cynicism. These issues need to be tackled through capacity building, training of investigators and EC members, strengthening of EC functioning and encouraging greater community participation.

We present a case of disseminated Chromobacterium violaceum sepsis with multiple liver and spleni... more We present a case of disseminated Chromobacterium violaceum sepsis with multiple liver and splenic abscesses presenting with skin lesions and cardiogenic shock, and later diagnosed to have chronic granulomatous disease. The patient was treated with prolonged antimicrobial therapy, after which she recovered and remained asymptomatic on follow-up. Please cite this article in press as: Saboo AR, et al., A rare nonfatal presentation of disseminated Chromobacterium violaceum sepsis, Journal of Microbiology, Immunology and Infection (2012), http://dx.Journal of Microbiology, Immunology and Infection (2012) xx, 1e4 A.R. Saboo et al. + MODEL Please cite this article in press as: Saboo AR, et al., A rare nonfatal presentation of disseminated Chromobacterium violaceum sepsis, Journal of Microbiology, Immunology and Infection (2012), http://dx.

Indian Journal of Medical Sciences, 2009

Annals of Pharmacotherapy, 2004

To report a case of anticonvulsant hypersensitivity syndrome (AHS) precipitated by exposure to ph... more To report a case of anticonvulsant hypersensitivity syndrome (AHS) precipitated by exposure to phenobarbital. An 11-year-old girl receiving phenobarbital developed fever, exfoliative skin rash, mucous membrane lesions, alopecia, and hepatic inflammation. Investigations ruled out an infectious etiology; an adverse event following phenobarbital administration was considered. Applying the Naranjo probability scale for objective causality assessment showed the adverse reaction was probably due to phenobarbital. The diagnosis was confirmed by in vitro lymphocyte toxicity assay, which demonstrated increased cell death following exposure to phenobarbital, as well as other aromatic anticonvulsants and lamotrigine. AHS is a rare, potentially fatal event with multisystem manifestations. It is reported following exposure to aromatic antiepileptics. The mechanism proposed for AHS is accumulation of toxic arene oxide metabolites due to a defect in epoxide hydrolase-mediated detoxification. Despite the difference in chemical structure of lamotrigine, in vitro susceptibility to AHS was demonstrated in our patient. Although AHS is a rare event, it should be suspected in patients who develop unexplained systemic manifestations following exposure to aromatic antiepileptics. The potential of lamotrigine to cause AHS should be remembered when this drug is used in subjects who have developed AHS on exposure to phenobarbital and other first-line antiepileptic agents.

Journal of …, 2003