S. Beath - Academia.edu (original) (raw)

Papers by S. Beath

Journal of the Canadian Association of Gastroenterology, 2018

Transplantation Proceedings, 1994

British Medical Journal, 1992

Transplantation Proceedings, 1997

There is no single complete enteral feed which is suitable for children immediately after small b... more There is no single complete enteral feed which is suitable for children immediately after small bowel transplantation owing to the changing physiological environment of the newly engrafted bowel. The function of a small bowel allograft immediately after transplantation is compromised by a period of perioperative ischaemia and hypomotility. Within a week of transplantation these conditions have usually resolved, but impaired

Proceedings of the Nutrition Society, 2010

There has been a rising demand for home parenteral nutrition (HPN) services for children over the... more There has been a rising demand for home parenteral nutrition (HPN) services for children over the past 20 years. In order to help plan a strategy for delivery of care at the regional level, our aim was to carry out a national point prevalence survey of HPN during February 2010.

Pediatric Transplantation, 2003

Journal of Pediatric Gastroenterology and Nutrition, 1991

Journal of Pediatric Gastroenterology and Nutrition, 2004

Journal of Medical Virology, 1994

Mutations of the precore region of hepatitis B virus (HBV) genome have been associated with fulmi... more Mutations of the precore region of hepatitis B virus (HBV) genome have been associated with fulminant and severe chronic hepatitis. However uncertainty remains about the clinical significance and transmissibility of these mutant strains. A point mutation assay (PMA) was developed to identify qualitatively and quantitatively mutations affecting precore amino acids 1 and 28. We have analysed serum samples from six mother-infant pairs where perinatal transmission of HBV has occurred and where the mothers were HBV carriers without detectable serum HBeAg. In three cases fulminant hepatitis developed in the infant, in two cases acute hepatitis resolved, and in one case the infant was immunised and did not become infected. We also examined serum from a healthcare worker, an anti-HBe-seropositive HBV carrier, believed to have transmitted HBV infection to a patient.

Clinical Nutrition, 2011

Background & aims: The demand for home parenteral nutrition (HPN) services for children has risen... more Background & aims: The demand for home parenteral nutrition (HPN) services for children has risen over the past 20 years. To plan a strategy for delivery of care at regional level, we carried out a national point prevalence survey of HPN during February 2010. Methods: Paediatric gastroenterologists in 33 hospitals known to have provided HPN services were identified from their membership of the British Society of Paediatric Gastroenterology, Hepatology and Nutrition and participation in the British Intestinal Failure Survey (BIFS). Anonymised data were collated by the BIFS administrator and results compared with a similar study performed by the British Paediatric Surveillance Unit in 1993. Trends in underlying diagnosis were explored using the BIFS database for 2006e2009. Results: 139 children on HPN were reported; a fourfold increase since 1993; six of these were older than 16 years. The regional point prevalence of HPN varied from 1.76 to 41.4 per million, with a mean of 13.7 patients per million. Short bowel syndrome had increased from 27% to 63% of cases. Conclusions: The large overall increase in numbers of HPN patients suggests that a national strategy needs to be developed for the management of chronic IF.

Archives of Disease in Childhood, 2001

Background-Early and accurate diagnosis of Crigler-Najjar syndrome, which causes prolonged unconj... more Background-Early and accurate diagnosis of Crigler-Najjar syndrome, which causes prolonged unconjugated hyperbilirubinaemia in infancy, is important, as orthotopic liver transplantation is the definitive treatment. Aim-To determine whether bilirubin pigment analysis of bile in infants with prolonged unconjugated hyperbilirubinaemia provides useful diagnostic information in the first 3 months of life. Methods-Retrospective review of patients with prolonged unconjugated hyperbilirubinaemia referred to the liver unit, Birmingham Children's Hospital, for the diagnosis of Crigler-Najjar syndrome. Bile bilirubin pigment composition was determined by high performance liquid chromatography. Initial diagnoses were made based on the result of bile bilirubin pigment composition. Final diagnoses were made after reviewing the clinical course, response to phenobarbitone, repeat bile bilirubin pigment composition analysis, and genetic studies. Results-Between 1992 and 1999, nine infants aged less than 3 months of age with prolonged hyperbilirubinaemia underwent bile bilirubin pigment analyses. Based on these, two children were diagnosed with Crigler-Najjar syndrome (CNS) type 1, six with CNS type 2, and one with Gilbert's syndrome. Five children whose initial diagnosis was CNS type 2 had resolution of jaundice and normalisation of serum bilirubin after discontinuing phenobarbitone, and these cases were thought to be normal or to have Gilbert's syndrome. One of the initial cases of CNS type 1 responded to phenobarbitone with an 80% reduction in serum bilirubin consistent with CNS type 2. In all, the diagnoses of six cases needed to be reviewed. Conclusions-Early bile pigment analysis, performed during the first 3 months of life, often shows high levels of unconjugated bilirubin or bilirubin monoconjugates, leading to the incorrect diagnosis of both type 1 and type 2 Crigler-Najjar syndrome. (Arch Dis Child 2001;85:38-42)

Archives of Disease in Childhood, 1994

Clinical Nutrition ESPEN, 2015

Transplantation proceedings, 1994

Transplantation proceedings

The terminal ileum (TI) is important for the active reabsorption of bile salts and is the site of... more The terminal ileum (TI) is important for the active reabsorption of bile salts and is the site of allograft rejection; disruption of enterohepatic circulation (EHC) may give insights to inflammatory and other physiologic processes at the TI. Four children aged 5 to 12 years who had received small bowel transplantation (SBTx), 3 recovering from post-transplant lymphoproliferative disease (PTLD) and 1 with acute rejection, were studied. Two of the 4 had stoma reversal. Another child (15 years) with progressive familial intrahepatic cholestasis (PFIC) and pruritus, despite liver transplantation and biliary diversion, was studied. Selenium homocholic acid taurocholate scanning ((75)SeHCAT) capsule was given orally (n = 3) or via introducer during endoscopy (n = 2); a baseline whole-body gamma camera scan was done 4 hours later and on days 1 to 5. The normal 3-day bile salt retention is 30% to 70% of baseline and normal adult biological half-life, t½ is 62 ± 17 hours. The results in chil...

Transplantation Proceedings, 2002