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Papers by Sara Bianchetti

Annals of Oncology, Sep 1, 2016

$Research paper thumbnail of Erratum: Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo$

The Prostate, Jul 16, 2009

Annals of Oncology, May 1, 2020

The 5-years RFS (a) and DFS (b) related to treatment.</p

Patient Characteristics (N = 834).</p

BO: bowel obstruction; S: Symptoms; M: male; F: female; AC: adjuvant chemotherapy, ns: n... more BO: bowel obstruction; S: Symptoms; M: male; F: female; AC: adjuvant chemotherapy, ns: not statistical significant;yr:year.</p

The 5-years RFS and DFS related to treatment in low risk group (a,b) and in high risk gr... more The 5-years RFS and DFS related to treatment in low risk group (a,b) and in high risk group (c,d).</p

BO: bowel obstruction; S: Symptoms; M: male; F: female; AC: adjuvant chemotherapy; LN: l... more BO: bowel obstruction; S: Symptoms; M: male; F: female; AC: adjuvant chemotherapy; LN: lymph nodes; yr: year.</p

AKT A protein-serine-threonine kinase that is activated by phosphorylation in response to growth ... more AKT A protein-serine-threonine kinase that is activated by phosphorylation in response to growth factors or insulin CD117 Antigen specific for the proto-oncogene c-kit CD56 Antigen expressed by all lymphocytes CD99 Cluster of differentiation CDX-2 Transcription factor expressed specifically in gut epithelium CEACAM1 Cell adhesion molecule

Journal of Clinical Oncology

e18065 Background: PEM plus platinum–based regimen is a standard of care in chemonaïve advanced n... more e18065 Background: PEM plus platinum–based regimen is a standard of care in chemonaïve advanced non-squamous NSCLC pts. This retrospective multicenter analysis was performed to evaluate the predictive value of clinical variables for PFS in an unselected population. Methods: Data were obtained by reviewing the clinical data of pts affected with advanced NSCLC treated from 2009 to 2011. 193 pts were retrieved. Main characteristics were: median age: 63 years (range 33-79); male/female (M/F): 67%/33%; ECOG PS 0-1: 97%; weight loss >5%: 34%; current smoker 31%. Stage IV disease: 81% ; ≥ 1 site of metastasis: 79%. Brain metastasis: 28% of pts at diagnosis. Results: All 193 pts are evaluable for analysis. 158 pts (82%) received the cisplatin- and 35 pts (18%) the carboplatin-based regimen. Most pts received at least 2 cycles of therapy and 21% received PEM maintenance treatment. The overall disease control rate observed was 69%. (CR+PR = 44%, SD 25%). At a median follow-up of 6.7 months...

International Journal of Endocrine Oncology, 2016

$Research paper thumbnail of Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo$

Supportive Care in Cancer, 2013

Anti-epidermal growth factor receptor (EGFR) target therapies like erlotinib for metastatic lung ... more Anti-epidermal growth factor receptor (EGFR) target therapies like erlotinib for metastatic lung cancer and cetuximab or panitumumab for metastatic colorectal cancer (mCRC) cause skin reaction that seems to be related to treatment efficacy. Skin toxicity evaluation protocol with panitumumab study has shown that preemptive treatment reduces the incidence of ≥Grade 2 (G2) skin toxicity in mCRC treated with panitumumab. Aim of this study is to evaluate if preemptive skin toxicity treatment with different drugs has good efficacy in patients receiving anti-EGFR therapies, such as cetuximab, panitumumab, and erlotinib, for mCRC and metastatic lung cancer. Treatment included skin moisturizers with sunscreen and lymecycline 300 mg/daily. Primary objective is to reduce the incidence of ≥G2 skin toxicity during the first 3 months of therapy. Toxicities are reported with confidence interval at 95%. Quality of life was assessed with Dermatology Life Quality Index every 2 weeks and evaluated with repeated measure ANOVA. Fifty-one patients with mCRC (60.8%) and metastatic lung cancer (39.2%) were enrolled. Anticancer drugs were erlotinib/cetuximab/panitumumab 20:30:1. At 3-month evaluation, 27.4% patients had =G2 skin toxicity. Skin toxicity was not related with age (p = 0.67), sex (p = 0.65), previous chemotherapy regimens (p = 0.41), and current anti-EGFR treatment (p = 0.22). No gastrointestinal or hematological toxicities related to lymecycline were observed. Only six patients required further drugs. Quality of life analysis did not show a significant difference from the beginning and the end of treatment. Data show efficacy of preemptive treatment with a well-tolerated profile. A reduction of severe skin toxicities is shown with an increase of grade 1 toxicities, not leading to anti-EGFR dose reduction and with better quality of life for patients.

PLoS ONE, 2013

Adjuvant chemotherapy (AC) in Stage II Colon Cancer (CC) is still under debate. Choice should be ... more Adjuvant chemotherapy (AC) in Stage II Colon Cancer (CC) is still under debate. Choice should be based on patients and disease characteristics. According to guidelines AC should be considered in high-risk T3N0 patients. No data are available for better option in low-risk patients. The aim of the study is to retrospectively evaluate relapse-free survival (RFS) and disease-free survival (DFS) according to treatment received in T3N0 CC. RFS and DFS are evaluated with Kaplan-Meier method. Multivariate Cox proportional hazard model was developed using stepwise regression, enter limit and remove limit were p = 0.10 and p = 0.15, respectively. 834 patients with T3N0 CC were recruited. Median age was 69 (29-93), M/F 463/371, 335 low-risk patients (40.2%), 387 high-risk (46.4%), 112 unknown (13.4%); 127 (15.2%) patients showed symptoms at diagnosis. Median sampled lymph nodes were 15 (1-76); 353 (42.3%) patients were treated with AC. Median follow up was 5 years (range 3-24). The 5-years RFS was 78.4% and the 5-years DFS was 76.7%. At multivariate analysis symptoms, lymph nodes, and adjuvant chemotherapy were prognostic factors for RFS. AC is prognostic factor for all endpoints. In low-risk group 5-years RFS was 87.3% in treated patients and 74.7% in non-treated patients (p 0.03); in high-risk group was respectively 82.7% and 71.4% (p 0.005). Data confirmed the role of known prognostic factors and suggest the relevance of adjuvant chemotherapy also in low-risk stage II T3N0 CC patients. However, the highest risk in low-risk subgroup should be identified to be submitted to AC.

Endocrine, 2014

Thyroid disease and diabetes mellitus, the most common disorders in endocrine practice, are not i... more Thyroid disease and diabetes mellitus, the most common disorders in endocrine practice, are not infrequently associated in the same subject. An altered thyroid function may affect glucose tolerance and worsen metabolic control in patients with diabetes. Thyrotoxicosis increases the risk of hyperglycemic emergencies, while a clinically relevant hypothyroidism may have a detrimental effect on glycemic control in diabetic patients. The association of alterations in thyroid function with diabetes mellitus may adversely affect the risk of cardiovascular and microvascular complications resulting from diabetes. Moreover, the treatments used for both diabetes and thyroid disease, respectively, can impact one other. Finally, multinodular goiter, but not thyroid carcinoma, was shown to be more prevalent in type 2 diabetes mellitus. Aim of the present Position Statement is to focus on the evidence concerning the association of thyroid disease and diabetes mellitus and to provide some practical suggestions for an updated clinical management.