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Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 1993
Auditory and visual event-related brain potentials (ERPs) were used to complement neuropsychologi... more Auditory and visual event-related brain potentials (ERPs) were used to complement neuropsychological and medical assessment in neurologically healthy subjects with asymptomatic and symptomatic human immunodeficiency virus type 1 (HIV-1) infection. Auditory and visual ERPs, recorded using standard oddball paradigms, disclosed delays in late waves (N2 and P3) in symptomatic subjects (CDC stage IV) when compared with matched controls. Abnormally delayed P3 waves in at least one modality were recorded in 41% of symptomatics and this was associated with deficits in neuropsychological performance, particularly psychomotor slowing. However, no differences in late wave latencies between asymptomatic and control subjects were found, though asymptomatics showed delays in auditory N1 and P2 latencies. The number of morphological abnormalities, such as indiscernible late waves as well as topographical variability of the P3 wave, was increased in both HIV seropositive groups and possibly indicates a distinct mechanism of impairment, different from latency delay. Whilst P3 delay in symptomatics was not associated with changes in immune function (T4 cells) there was, however, a link with anaemia and subclinical hepatic dysfunction.
Journal of Clinical Pathology, 1990
AIDS Care, 1995
The object of this paper is to explore the health beliefs associated with taking AZT in asymptoma... more The object of this paper is to explore the health beliefs associated with taking AZT in asymptomatic HIV seropositive individuals. Twenty-eight asymptomatic gay men receiving out-patient care completed self-report questionnaires. Information was gathered on demography, general state of health, health locus of control and health beliefs about AZT therapy. Analyses revealed that 'acceptors' and 'decliners' of early (controversial) medical intervention in HIV disease hold distinctly different beliefs regarding their own health and its relation to treatment. An awareness of the fact that a patient's view of themselves is likely to accord with any action or treatment decision they may have taken, could help to promote a better understanding of why treatment behaviours may or may not appear to be in harmony with the doctors own views and any current medical advice being offered.
Journal of The Electrochemical Society, 1994
Current voltage curves for reduction of iron ferricyanide at room temperature using thin Pt films... more Current voltage curves for reduction of iron ferricyanide at room temperature using thin Pt films on n-Si (100)/25 A SiO 2 /Pt electrodes are explained by the action of hot electrons and interface states. The exchange current for electron transfer was determined as a function of Pt film thickness in 0.3M each potassium Fe(CN) 6 -3/-4 pH 6.0. The current density-thickness plots had maxima at 160 to 180 A at η=0 to 0.5 V overpotential. The energy loss, δ, defined as the difference between qV cb and the energy level of the electron at the metal/electrolyte interface surface varied from 0.05 at 25 A to 0.84 eV at t≥250 A and remained constant to 400 A signifying fully cooled electrons for such thicker films
Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 1993
Auditory and visual event-related brain potentials (ERPs) were used to complement neuropsychologi... more Auditory and visual event-related brain potentials (ERPs) were used to complement neuropsychological and medical assessment in neurologically healthy subjects with asymptomatic and symptomatic human immunodeficiency virus type 1 (HIV-1) infection. Auditory and visual ERPs, recorded using standard oddball paradigms, disclosed delays in late waves (N2 and P3) in symptomatic subjects (CDC stage IV) when compared with matched controls. Abnormally delayed P3 waves in at least one modality were recorded in 41% of symptomatics and this was associated with deficits in neuropsychological performance, particularly psychomotor slowing. However, no differences in late wave latencies between asymptomatic and control subjects were found, though asymptomatics showed delays in auditory N1 and P2 latencies. The number of morphological abnormalities, such as indiscernible late waves as well as topographical variability of the P3 wave, was increased in both HIV seropositive groups and possibly indicates a distinct mechanism of impairment, different from latency delay. Whilst P3 delay in symptomatics was not associated with changes in immune function (T4 cells) there was, however, a link with anaemia and subclinical hepatic dysfunction.
Journal of Clinical Pathology, 1990
AIDS Care, 1995
The object of this paper is to explore the health beliefs associated with taking AZT in asymptoma... more The object of this paper is to explore the health beliefs associated with taking AZT in asymptomatic HIV seropositive individuals. Twenty-eight asymptomatic gay men receiving out-patient care completed self-report questionnaires. Information was gathered on demography, general state of health, health locus of control and health beliefs about AZT therapy. Analyses revealed that 'acceptors' and 'decliners' of early (controversial) medical intervention in HIV disease hold distinctly different beliefs regarding their own health and its relation to treatment. An awareness of the fact that a patient's view of themselves is likely to accord with any action or treatment decision they may have taken, could help to promote a better understanding of why treatment behaviours may or may not appear to be in harmony with the doctors own views and any current medical advice being offered.
Journal of The Electrochemical Society, 1994
Current voltage curves for reduction of iron ferricyanide at room temperature using thin Pt films... more Current voltage curves for reduction of iron ferricyanide at room temperature using thin Pt films on n-Si (100)/25 A SiO 2 /Pt electrodes are explained by the action of hot electrons and interface states. The exchange current for electron transfer was determined as a function of Pt film thickness in 0.3M each potassium Fe(CN) 6 -3/-4 pH 6.0. The current density-thickness plots had maxima at 160 to 180 A at η=0 to 0.5 V overpotential. The energy loss, δ, defined as the difference between qV cb and the energy level of the electron at the metal/electrolyte interface surface varied from 0.05 at 25 A to 0.84 eV at t≥250 A and remained constant to 400 A signifying fully cooled electrons for such thicker films