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Shock, 1996
ABSTRACT The effect of methylprednisolone on the myocardial beta-adrenergic receptors after long ... more ABSTRACT The effect of methylprednisolone on the myocardial beta-adrenergic receptors after long term (>;72 h) catecholamine infusion was studied. In 56 patients with pulmonary arterial catheter, 10 mg/kg of methylprednisolone was given as an intravenous bolus. Significant increases could be seen in cardiac output and blood pressure in patients who were simultaneously treated with vasopressors like dopamine and/or dobutamine. In patients who were on dopamine infusion higher than 10 [mu]g/kg/min methylprednisolone there was an increase in the systemic vascular resistance. Patients who were not on vasopressors but received methylprednisolone, had no similar changes in hemodynamic parameters. In an in vitro analysis of tissue from the myocardium in 12/56 patients who succumbed and in four additional patients who expired after multiple trauma, a beta-adrenergic receptor assay was performed. It was found that the long term infusion of catecholamines decreased the receptor number and the methylprednisolone abolished or caused the decrease to be less pronounced. In this study we could not control the selection of the patients; a randomized study needs to be conducted in the future. (C)1996The Shock Society
Health Education Journal, 1988
AS part of the Medical Research Council study on life- style and health, patients from 47 group p... more AS part of the Medical Research Council study on life- style and health, patients from 47 group practices in England and Wales were invited to attend for an interview and a brief physical examination. This report deals with the questions about diet and weight, and the receipt of advice from the general practitioner. Of the 4203 patients who were invited, 2571 attended. Proportionately nearly twice as many women as men expressed concern about their weight. In the 12 months before the interview, 19 per cent of the men had been dieting, compared with 40 per cent of the women. Rather more women (22 per cent) than men (16 per cent) had been advised to lose weight by their GP. Dieting was more frequent among those who had received a GP's advice on weight loss, and there was some evidence that such advice led to greater success. There was no substan tial difference between men and women in their answers on healthy diet. Three-quarters considered their diet to be healthy, and 15 per cent had received advice from their GP. Of these, more than three-quar ters had apparently made an effort to change. Although general practice patients are largely aware of the importance of avoiding overweight, there may be a lack of knowledge, particularly among older patients, of what constitutes a healthy diet. There would appear to be considerable scope for improving patient education in this area.
British Medical Journal, 1988
Shock, 1996
ABSTRACT The effect of methylprednisolone on the myocardial beta-adrenergic receptors after long ... more ABSTRACT The effect of methylprednisolone on the myocardial beta-adrenergic receptors after long term (>;72 h) catecholamine infusion was studied. In 56 patients with pulmonary arterial catheter, 10 mg/kg of methylprednisolone was given as an intravenous bolus. Significant increases could be seen in cardiac output and blood pressure in patients who were simultaneously treated with vasopressors like dopamine and/or dobutamine. In patients who were on dopamine infusion higher than 10 [mu]g/kg/min methylprednisolone there was an increase in the systemic vascular resistance. Patients who were not on vasopressors but received methylprednisolone, had no similar changes in hemodynamic parameters. In an in vitro analysis of tissue from the myocardium in 12/56 patients who succumbed and in four additional patients who expired after multiple trauma, a beta-adrenergic receptor assay was performed. It was found that the long term infusion of catecholamines decreased the receptor number and the methylprednisolone abolished or caused the decrease to be less pronounced. In this study we could not control the selection of the patients; a randomized study needs to be conducted in the future. (C)1996The Shock Society
Health Education Journal, 1988
AS part of the Medical Research Council study on life- style and health, patients from 47 group p... more AS part of the Medical Research Council study on life- style and health, patients from 47 group practices in England and Wales were invited to attend for an interview and a brief physical examination. This report deals with the questions about diet and weight, and the receipt of advice from the general practitioner. Of the 4203 patients who were invited, 2571 attended. Proportionately nearly twice as many women as men expressed concern about their weight. In the 12 months before the interview, 19 per cent of the men had been dieting, compared with 40 per cent of the women. Rather more women (22 per cent) than men (16 per cent) had been advised to lose weight by their GP. Dieting was more frequent among those who had received a GP's advice on weight loss, and there was some evidence that such advice led to greater success. There was no substan tial difference between men and women in their answers on healthy diet. Three-quarters considered their diet to be healthy, and 15 per cent had received advice from their GP. Of these, more than three-quar ters had apparently made an effort to change. Although general practice patients are largely aware of the importance of avoiding overweight, there may be a lack of knowledge, particularly among older patients, of what constitutes a healthy diet. There would appear to be considerable scope for improving patient education in this area.
British Medical Journal, 1988