SERGIO VELASCO - Academia.edu (original) (raw)

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Papers by SERGIO VELASCO

Research paper thumbnail of Gcn4p and the Crabtree effect of yeast: drawing the causal model of the Crabtree effect in Saccharomyces cerevisiae and explaining evolutionary trade-offs of adaptation to galactose through systems biology

FEMS Yeast Research, 2014

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Research paper thumbnail of Dynamic13C-labeling experiments prove important differences in protein turnover rate between twoSaccharomyces cerevisiaestrains

FEMS Yeast Research, 2012

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Research paper thumbnail of Mechanistic Model for the Reclamation of Industrial Wastewaters Using Algal−Bacterial Photobioreactors

Environmental Science & Technology, 2009

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Research paper thumbnail of Symmetries and nonequilibrium thermodynamics

Physical Review E, 2017

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Research paper thumbnail of A metabolic network of a phosphate-accumulating organism provides new insights into enhanced biological phosphorous removal

Water Science & Technology, 2011

Here we present a metabolic network representing the central carbon metabolism as well as the syn... more Here we present a metabolic network representing the central carbon metabolism as well as the synthesis of polyhydroxyalcanohates and the polyphosphate accumulation mechanisms of the bacterium Candidatus Accumulibacter phosphatis, which was previously identified from metagenomic studies in enhanced biological phosphorous removal sludges. The reconstructed metabolic network, together with flux balance analysis can be used to provide new insights into controversial aspects of the metabolism of phosphate-accumulating organisms and is also a tool that can be used in to help enhanced biological phosphorous removal (EBPR) process design and operation.

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Research paper thumbnail of Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism

Scientific reports, 2013

The search for optimization principles in microbial metabolism, such as biomass or ATP yields or ... more The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae and E coli in order to assess if there are relationships between systemic variables that are present in both organisms. Strong correlations between the total flux per unit of substrate and the ATP turnover rate per unit of substrate and between the growth rate divided by the total flux and the total flux per unit of substrate were observed for both organisms. We also observed that the common assumption of biomass yield optimization is not consistent with the experiments.

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Research paper thumbnail of Mathematical models of cell factories: moving towards the core of industrial biotechnology

Microbial Biotechnology, 2011

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Research paper thumbnail of Gcn4p and the Crabtree effect of yeast: drawing the causal model of the Crabtree effect in Saccharomyces cerevisiae and explaining evolutionary trade-offs of adaptation to galactose through systems biology

FEMS Yeast Research, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Dynamic13C-labeling experiments prove important differences in protein turnover rate between twoSaccharomyces cerevisiaestrains

FEMS Yeast Research, 2012

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mechanistic Model for the Reclamation of Industrial Wastewaters Using Algal−Bacterial Photobioreactors

Environmental Science & Technology, 2009

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Symmetries and nonequilibrium thermodynamics

Physical Review E, 2017

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A metabolic network of a phosphate-accumulating organism provides new insights into enhanced biological phosphorous removal

Water Science & Technology, 2011

Here we present a metabolic network representing the central carbon metabolism as well as the syn... more Here we present a metabolic network representing the central carbon metabolism as well as the synthesis of polyhydroxyalcanohates and the polyphosphate accumulation mechanisms of the bacterium Candidatus Accumulibacter phosphatis, which was previously identified from metagenomic studies in enhanced biological phosphorous removal sludges. The reconstructed metabolic network, together with flux balance analysis can be used to provide new insights into controversial aspects of the metabolism of phosphate-accumulating organisms and is also a tool that can be used in to help enhanced biological phosphorous removal (EBPR) process design and operation.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism

Scientific reports, 2013

The search for optimization principles in microbial metabolism, such as biomass or ATP yields or ... more The search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae and E coli in order to assess if there are relationships between systemic variables that are present in both organisms. Strong correlations between the total flux per unit of substrate and the ATP turnover rate per unit of substrate and between the growth rate divided by the total flux and the total flux per unit of substrate were observed for both organisms. We also observed that the common assumption of biomass yield optimization is not consistent with the experiments.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Mathematical models of cell factories: moving towards the core of industrial biotechnology

Microbial Biotechnology, 2011

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