S. Husain - Academia.edu (original) (raw)

Papers by S. Husain

Research paper thumbnail of Cryptococcosis in liver and kidney transplant recipients receiving anti-thymocyte globulin or alemtuzumab

Transplant Infectious Disease, 2007

Research paper thumbnail of Periumbilical parasitic thumbprint purpura: Strongyloides hyperinfection syndrome acquired from a cadaveric renal transplant

Transplant Infectious Disease, 2011

Research paper thumbnail of Infectious complications at six months in lung transplant recipients undergoing pretranspnat T-cell depletion with alemtuzumab

The Journal of Heart and Lung Transplantation, 2005

Research paper thumbnail of Opioid Receptor-Activation: Retina Protected from Ischemic Injury

Investigative Ophthalmology & Visual Science, 2009

Research paper thumbnail of T cell immunity in lung transplant recipients

Research paper thumbnail of Unrecognized Pretransplant and Donor‐Derived Cryptococcal Disease in Organ Transplant Recipients

Clinical Infectious Diseases, 2010

Research paper thumbnail of Lipid Formulations of Amphotericin B Significantly Improve Outcome in Solid Organ Transplant Recipients with Central Nervous System Cryptococcosis

Clinical Infectious Diseases, 2009

Research paper thumbnail of Opportunistic Infections in 547 Organ Transplant Recipients Receiving Alemtuzumab, a Humanized Monoclonal CD-52 Antibody

Clinical Infectious Diseases, 2007

Alemtuzumab is being increasingly used for the prevention and/or treatment of acute allograft rej... more Alemtuzumab is being increasingly used for the prevention and/or treatment of acute allograft rejection in organ transplant recipients. We assessed the risks of infection in, to our knowledge, the largest cohort and broadest range of organ transplant recipients yet reported to have received alemtuzumab. All patients who received alemtuzumab from September 2002 through March 2004, either as induction therapy at the time of transplantation or for the treatment of rejection, were evaluated for the development of an opportunistic infection (OI) until death or for 12 months after receipt of the last dose of alemtuzumab. A total of 547 recipients were included, 65% of whom received alemtuzumab for induction therapy only. Overall, 56 recipients (10%) developed 62 OIs, including cytomegalovirus disease (n = 16), BK virus infection (n=12), posttransplantation lymphoproliferative disease (n=5), human herpesvirus 6 infection (n=1), parvovirus infection (n=1), esophageal candidiasis (n=12), cryptococcosis (n=2), invasive mold infection (n=4), Nocardia infection (n=4), mycobacterial infection (n=3), Balamuthia mandrillaris infection (n=1), and toxoplasmosis (n=1). Patients who received alemtuzumab for induction therapy were significantly less likely to develop an OI, compared with patients who received alemtuzumab for rejection therapy (4.5% vs. 21%; P<.001). Independent predictors of the development of an OI were administration of alemtuzumab for rejection therapy (odds ratio [OR], 3.5; 95% confidence interval [CI], 1.8-6.8; P<.001), allograft failure (OR, 2.1; 95% CI, 1.1-4.4; P=.04), and receipt of a lung transplant (OR, 3.7; 95% CI, 1.7-8.0; P=.001) or an intestinal transplant (OR, 8.3; 95% CI, 3.5-19.5; P<.001). Patients who received alemtuzumab for the treatment of allograft rejection were significantly more likely to develop an OI, compared with patients who received alemtuzumab for induction therapy only. Such data have implications for new antimicrobial prophylactic strategies.

Research paper thumbnail of Serologic Evidence for Reactivation of Cryptococcosis in Solid-Organ Transplant Recipients

Clinical and Vaccine Immunology, 2007

Research paper thumbnail of Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions

Blood, 2009

Pralatrexate is a novel antifolate, which shows increased antitumor activity in human tumor xenog... more Pralatrexate is a novel antifolate, which shows increased antitumor activity in human tumor xenograft studies in mice compared with methotrexate. We investigated the effects of pralatrexate in a patient with adult T-cell lymphoma/leukemia with significant skin involvement. Atypical lymphocytes in epidermal Pautrier microabscesses were positive for HTLV-1. After the patient presented with leukemic conversion and with worsening of an erythematous generalized papular rash, he received one dose of pralatrexate. Within one week, his skin developed innumerable small erosions limited to the areas of the papular rash, sparing unaffected skin. Here we present in vivo evidence that pralatrexate-induced erosions in skin affected by adult T-cell lymphoma/leukemia are a manifestation of apoptosis of tumor cells infiltrating the epidermis and are not the result of cytotoxicity by pralatrexate on keratinocytes. This distinction is critical and may profoundly influence the clinical decision to continue pralatrexate treatment. Pralatrexate-induced skin erosions may indicate response to treatment.

Research paper thumbnail of Immobilization and stabilization of invertase on Cajanus cajan lectin support

Bioresource Technology, 2001

Research paper thumbnail of Reactivity of Platelia Aspergillus Galactomannan Antigen with Piperacillin-Tazobactam: Clinical Implications Based on Achievable Concentrations in Serum

Antimicrobial Agents and Chemotherapy, 2004

Research paper thumbnail of Recovery of Functional Memory T Cells in Lung Transplant Recipients Following Induction Therapy with Alemtuzumab

American Journal of Transplantation, 2007

Research paper thumbnail of S - 19 Symposium War Trauma & Recovery: The Bosnian Experience Chairperson: Syed Arshad Husain (USA)

War erupted in Bosnia & Herzegovina following it's declaration of independence from Yugoslavi... more War erupted in Bosnia & Herzegovina following it's declaration of independence from Yugoslavia in March 1992. In retaliation, the Bosnian capital - Sarajevo was put under siege by the Yugoslavian army and thousands of shells were dropped on the city on a daily basis by the guns strategically placed in the surrounding hills. Snipers hiding in the highrise apartment buildings specifically targeted children walking on the streets with their families or while standing in lines to collect water By the time the war ended and the Hese lifted three and a half years later, over 1500 children lost their lives and many thousands were injured. The invading army also used rape as a weapon of war. Girls as young as 8 year and women as old as 84, were repeatedly raped in captivity Bosnia did not have a professional army before the independence necessitating the recruitment of ordinary citizens into army t defend the newly formed republic. This symposium presents four research papers that descr...

Research paper thumbnail of Cryptococcosis in liver and kidney transplant recipients receiving anti-thymocyte globulin or alemtuzumab

Transplant Infectious Disease, 2007

Research paper thumbnail of Periumbilical parasitic thumbprint purpura: Strongyloides hyperinfection syndrome acquired from a cadaveric renal transplant

Transplant Infectious Disease, 2011

Research paper thumbnail of Infectious complications at six months in lung transplant recipients undergoing pretranspnat T-cell depletion with alemtuzumab

The Journal of Heart and Lung Transplantation, 2005

Research paper thumbnail of Opioid Receptor-Activation: Retina Protected from Ischemic Injury

Investigative Ophthalmology & Visual Science, 2009

Research paper thumbnail of T cell immunity in lung transplant recipients

Research paper thumbnail of Unrecognized Pretransplant and Donor‐Derived Cryptococcal Disease in Organ Transplant Recipients

Clinical Infectious Diseases, 2010

Research paper thumbnail of Lipid Formulations of Amphotericin B Significantly Improve Outcome in Solid Organ Transplant Recipients with Central Nervous System Cryptococcosis

Clinical Infectious Diseases, 2009

Research paper thumbnail of Opportunistic Infections in 547 Organ Transplant Recipients Receiving Alemtuzumab, a Humanized Monoclonal CD-52 Antibody

Clinical Infectious Diseases, 2007

Alemtuzumab is being increasingly used for the prevention and/or treatment of acute allograft rej... more Alemtuzumab is being increasingly used for the prevention and/or treatment of acute allograft rejection in organ transplant recipients. We assessed the risks of infection in, to our knowledge, the largest cohort and broadest range of organ transplant recipients yet reported to have received alemtuzumab. All patients who received alemtuzumab from September 2002 through March 2004, either as induction therapy at the time of transplantation or for the treatment of rejection, were evaluated for the development of an opportunistic infection (OI) until death or for 12 months after receipt of the last dose of alemtuzumab. A total of 547 recipients were included, 65% of whom received alemtuzumab for induction therapy only. Overall, 56 recipients (10%) developed 62 OIs, including cytomegalovirus disease (n = 16), BK virus infection (n=12), posttransplantation lymphoproliferative disease (n=5), human herpesvirus 6 infection (n=1), parvovirus infection (n=1), esophageal candidiasis (n=12), cryptococcosis (n=2), invasive mold infection (n=4), Nocardia infection (n=4), mycobacterial infection (n=3), Balamuthia mandrillaris infection (n=1), and toxoplasmosis (n=1). Patients who received alemtuzumab for induction therapy were significantly less likely to develop an OI, compared with patients who received alemtuzumab for rejection therapy (4.5% vs. 21%; P<.001). Independent predictors of the development of an OI were administration of alemtuzumab for rejection therapy (odds ratio [OR], 3.5; 95% confidence interval [CI], 1.8-6.8; P<.001), allograft failure (OR, 2.1; 95% CI, 1.1-4.4; P=.04), and receipt of a lung transplant (OR, 3.7; 95% CI, 1.7-8.0; P=.001) or an intestinal transplant (OR, 8.3; 95% CI, 3.5-19.5; P<.001). Patients who received alemtuzumab for the treatment of allograft rejection were significantly more likely to develop an OI, compared with patients who received alemtuzumab for induction therapy only. Such data have implications for new antimicrobial prophylactic strategies.

Research paper thumbnail of Serologic Evidence for Reactivation of Cryptococcosis in Solid-Organ Transplant Recipients

Clinical and Vaccine Immunology, 2007

Research paper thumbnail of Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia causing skin erosions

Blood, 2009

Pralatrexate is a novel antifolate, which shows increased antitumor activity in human tumor xenog... more Pralatrexate is a novel antifolate, which shows increased antitumor activity in human tumor xenograft studies in mice compared with methotrexate. We investigated the effects of pralatrexate in a patient with adult T-cell lymphoma/leukemia with significant skin involvement. Atypical lymphocytes in epidermal Pautrier microabscesses were positive for HTLV-1. After the patient presented with leukemic conversion and with worsening of an erythematous generalized papular rash, he received one dose of pralatrexate. Within one week, his skin developed innumerable small erosions limited to the areas of the papular rash, sparing unaffected skin. Here we present in vivo evidence that pralatrexate-induced erosions in skin affected by adult T-cell lymphoma/leukemia are a manifestation of apoptosis of tumor cells infiltrating the epidermis and are not the result of cytotoxicity by pralatrexate on keratinocytes. This distinction is critical and may profoundly influence the clinical decision to continue pralatrexate treatment. Pralatrexate-induced skin erosions may indicate response to treatment.

Research paper thumbnail of Immobilization and stabilization of invertase on Cajanus cajan lectin support

Bioresource Technology, 2001

Research paper thumbnail of Reactivity of Platelia Aspergillus Galactomannan Antigen with Piperacillin-Tazobactam: Clinical Implications Based on Achievable Concentrations in Serum

Antimicrobial Agents and Chemotherapy, 2004

Research paper thumbnail of Recovery of Functional Memory T Cells in Lung Transplant Recipients Following Induction Therapy with Alemtuzumab

American Journal of Transplantation, 2007

Research paper thumbnail of S - 19 Symposium War Trauma & Recovery: The Bosnian Experience Chairperson: Syed Arshad Husain (USA)

War erupted in Bosnia & Herzegovina following it's declaration of independence from Yugoslavi... more War erupted in Bosnia & Herzegovina following it's declaration of independence from Yugoslavia in March 1992. In retaliation, the Bosnian capital - Sarajevo was put under siege by the Yugoslavian army and thousands of shells were dropped on the city on a daily basis by the guns strategically placed in the surrounding hills. Snipers hiding in the highrise apartment buildings specifically targeted children walking on the streets with their families or while standing in lines to collect water By the time the war ended and the Hese lifted three and a half years later, over 1500 children lost their lives and many thousands were injured. The invading army also used rape as a weapon of war. Girls as young as 8 year and women as old as 84, were repeatedly raped in captivity Bosnia did not have a professional army before the independence necessitating the recruitment of ordinary citizens into army t defend the newly formed republic. This symposium presents four research papers that descr...