Stefan Koppi - Academia.edu (original) (raw)
Papers by Stefan Koppi
Aktuelle Neurologie, 2009
Neuroepidemiology, 2015
Objectives: To assess the epidemiology of ALS in Austria and to evaluate the long-term effect of ... more Objectives: To assess the epidemiology of ALS in Austria and to evaluate the long-term effect of riluzole treatment on survival. Methods: Hospital discharge and riluzole prescription databases were used to identify ALS cases from January 2008 to June 2012. Using the capture-recapture method we evaluated the incidence and prevalence of ALS and patients' survival in dependence of age, gender and riluzole treatment. Results: The corrected incidence and prevalence of ALS were 3.13/100,000 person-years (95% CI, 2.77 to 3.50) and 9.14/100,000 persons (95% CI, 8.53 to 9.79), respectively. Median survival from diagnosis was 676 days (95% CI, 591 to 761). A younger age at diagnosis was associated with a longer survival. Gender did not appear to affect survival time. Riluzole therapy was associated with a survival advantage only for the initial treatment period. The adjusted hazard ratio of mortality for using riluzole increased continually over time resulting in an apparent reversal of its beneficial effect after 6 months of therapy. Conclusions: We report incidence and prevalence estimates that are on the upper end of the wide range discussed in literature. Riluzole seems to exert a beneficial effect only in the first 6 months of therapy.
Wiener medizinische Wochenschrift (1946), Jan 15, 1988
Adequate help for the apoplectic patient according to recent standards can be given only by simul... more Adequate help for the apoplectic patient according to recent standards can be given only by simultaneous and equivalent orientation towards both acute therapy and rehabilitation, which should merge smoothly into each other. This can be achieved only by specialised hospitalisation. The idea of totally domestic treatment, as advocated in times past, has to be abandoned for good. In the foreground of acute therapy are treatment of edema, cardiac output and blood pressure, rheological factors: blood viscosity, thrombocyte aggregation, erythrocyte elasticity. In the foreground of rehabilitation efforts we place the principle of "totality and permanence" regardless of prognostic selectivity. The principle of permanence refers to rehabilitative efforts from the very beginning to long-term rehabilitation for months and years with the help of our special rehabilitation service and systematic training of relatives. At least, it has to be stressed that the rehabilitation patient is n...
The World Journal of Biological Psychiatry, 2009
Our aim was to observe the frequency of combination therapy using antiepileptic drugs (AEDs) and ... more Our aim was to observe the frequency of combination therapy using antiepileptic drugs (AEDs) and electroconvulsive therapy (ECT) in Austria and the literature, and to provide rationales and recommendations based on clinical and molecular properties. The responsible ECT leaders of eight Austrian departments were contacted for information about combination therapy. A computerized PubMed database search was performed and supplemented by cross-referencing from papers, review articles and psychiatric manuals. The frequency of combination therapy in Austrian departments ranges between 0 and 85.7%. In 17 studies enrolling a total of 189 patients, 87 (46.0%) patients received combination therapy. Of these 87 patients, nine (10.3%) reported adverse effects. ECT and AEDs show overlapping clinical and molecular properties. Combination therapy is an observed reality and, according to the currently available literature, feasible. A comparison of clinical and molecular properties indicates possible augmentative effects, making combination therapy a promising alternative in treatment-resistant cases. But there is still a clear need for prospective case controlled data concerning side effects, safety profiles and effectiveness until it can be recommended.
Neuropsychobiology, 1987
... goto top of page Abstract. We present a randomized double-blind study on the efficacy of caro... more ... goto top of page Abstract. We present a randomized double-blind study on the efficacy of caroverine in the treatment of alcohol withdrawal symptoms. ... This may be an important factor in the treatment and management of alcohol withdrawal symptoms. ...
Journal of Neurology, Neurosurgery & Psychiatry, 1991
Two generations of a family affected by hereditary motor and sensory neuropathy with pyramidal si... more Two generations of a family affected by hereditary motor and sensory neuropathy with pyramidal signs (HMSN V) were clinically and electrophysiologically examined. Apart from electroneurographic studies, the central motor conduction (CMC) to arm and leg muscles was assessed using magnetic transcranial motor cortex stimulation. Abnormal CMC was confined to the clinically affected members, with the exception of an unaffected subject who had a diminished but normal latency response in a leg. The typical pattern was a significant diminution of the compound muscle action potential from the tibialis anterior and a moderately prolonged cortico-muscular conduction time (CoMCT) to this muscle.
Australian and New Zealand Journal of Psychiatry, 2006
Objective: To review the accumulated literature on the efficacy, safety and predictors of respons... more Objective: To review the accumulated literature on the efficacy, safety and predictors of response for repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression. Methods: A descriptive review of the more than 25 published sham-controlled rTMS studies in depression was undertaken, focusing on reported meta-analyses as well as individual trial reports. Potential determinants of efficacy were examined, including the form of shams employed, stimulation parameters and clinical features. Results: There is now clear evidence for the statistical superiority of left-prefrontal high frequency rTMS compared with sham therapy. However, the clinical benefits are marginal in the majority of reports. There is also still considerable uncertainty concerning the optimal stimulation parameters. Those clinical features which appear to be associated with greater response include younger age, lack of refractoriness to antidepressants and no psychotic features. Conclusions: Curren...
Objectives: To assess the epidemiology of ALS in Austria and to evaluate the long-term effect of ... more Objectives: To assess the epidemiology of ALS in Austria and to evaluate the long-term effect of riluzole treatment on survival. Methods: Hospital discharge and riluzole prescription databases were used to identify ALS cases from January 2008 to June 2012. Using the capture-recapture method we evaluated the incidence and prevalence of ALS and patients' survival in dependence of age, gender and riluzole treatment. Results: The corrected incidence and prevalence of ALS were 3.13/100,000 person-years (95% CI, 2.77 to 3.50) and 9.14/100,000 persons (95% CI, 8.53 to 9.79), respectively. Median survival from diagnosis was 676 days (95% CI, 591 to 761). A younger age at diagnosis was associated with a longer survival. Gender did not appear to affect survival time. Riluzole therapy was associated with a survival advantage only for the initial treatment period. The adjusted hazard ratio of mortality for using riluzole increased continually over time resulting in an apparent reversal of i...
Multiple Sclerosis Journal
Background: The month-of-birth-effect (MoBE) describes the finding that multiple sclerosis (MS) p... more Background: The month-of-birth-effect (MoBE) describes the finding that multiple sclerosis (MS) patients seem to have been born significantly more frequently in spring, with a rise in May, and significantly less often in autumn and winter with the fewest births in November. Objectives: To analyse if the MoBE can also be found in the Austrian MS population, and if so, whether the pattern is similar to the reported pattern in Canada, United Kingdom, and some Scandinavian countries. Methods: The data of 7886 MS patients in Austria were compared to all live births in Austria from 1940 to 2010, that is, 7.256545 data entries of the Austrian birth registry and analysed in detail. Results: Patterns observed in our MS cohort were not different from patterns in the general population, even when stratifying for gender. However, the noticeable and partly significant ups and downs over the examined years did not follow the distinct specific pattern with highest birth rates in spring and lowest ...
Neurology(R) neuroimmunology & neuroinflammation, 2017
Psychiatry and Clinical Neurosciences, Jun 1, 2008
Neuroepidemiology, Jan 7, 2015
Brain : a journal of neurology, Jun 23, 2016
We performed whole exome sequencing on a patient with Charcot-Marie-Tooth disease type 1 and iden... more We performed whole exome sequencing on a patient with Charcot-Marie-Tooth disease type 1 and identified ade novomutation inPMP2, the gene that encodes the myelin P2 protein. This mutation (p.Ile52Thr) was passed from the proband to his one affected son, and segregates with clinical and electrophysiological evidence of demyelinating neuropathy. We then screened a cohort of 136 European probands with uncharacterized genetic cause of Charcot-Marie-Tooth disease and identified another family with Charcot-Marie-Tooth disease type 1 that has a mutation affecting an adjacent amino acid (p.Thr51Pro), which segregates with disease. Our genetic and clinical findings in these kindred demonstrate that dominantPMP2mutations cause Charcot-Marie-Tooth disease type 1.
Histology and Histopathology Cellular and Molecular Biology, 2013
Tubular aggregates (TAs) are aggregates of densely packed tubules in human skeletal muscle fibers... more Tubular aggregates (TAs) are aggregates of densely packed tubules in human skeletal muscle fibers with particular histochemical and ultrastructural features that most probably arise from the sarcoplasmic reticulum. Some studies have shown an additional mitochondrial origin of TAs. We studied the histopathological spectrum and clinical features in a large cohort of patients with TAs in their muscle biopsy (106 biopsies), derived from our muscle biopsy archive (15,412 biopsies in total). In particular, we examined light microscopic, enzyme histochemical, immunohistochemical and ultrastructural features in the muscle biopsies, as well as the patients' clinical data. We found TAs in 0.5% of all muscle biopsies. Based on the size of TAs, we identified two sub-groups: (1) myopathies with large TAs (29 biopsies) in type 2 fibers and sometimes also in type 1 fibers, absence of any other associated disorder, and a familial history in half of the cases, and (2) myopathies with small TAs (77 biopsies), exclusively in type 2 fibers, presence of another associated disease in the majority of patients and mostly no familial history. In the sub-group with large TAs, we observed a high variability of ultrastructural changes. The most frequent clinical symptom in both groups was limb muscle weakness. No significant differences in clinical presentation, age at onset or disease duration at the time of biopsy were found between the two groups. In conclusion, myopathies with TAs can be sub-divided into a group with large TAs, probably corresponding to the so-called primary TA myopathies, and into a group with small TAs as a feature of another underlying condition.
Acta Medica Austriaca
The clinical outcome of 65 patients with malazia alba of the brain was documented by the use of o... more The clinical outcome of 65 patients with malazia alba of the brain was documented by the use of our "Valduna-Disability-Score" examining the patients at defined points of time. Simultaneously several rheological parameters of venous blood gained by punction of the cubital veine were examined before and after hemodilution therapy using dextran 40. The items or progress concerning clinical outcome and changes of the rheological parameters were correlated. There was not found any significance. We conclude, that the changes of rheological parameters in venous blood are not able to predict the clinical outcome after hemodilution therapy. The important role of disability scores--in our case the "Valduna-disability-score"--is to be stressed.
Journal fur Neurologie, Neurochirurgie und Psychiatrie
Eine ambulante neurologische Rehabilitation (ANR) ist in Österreich noch nicht weit verbreitet. I... more Eine ambulante neurologische Rehabilitation (ANR) ist in Österreich noch nicht weit verbreitet. In dieser Form existiert sie derzeit flächendeckend nur in Vorarlberg. Die gesteckten Ziele müssen im Sinne einer Evidence-based Rehabilitation ökonomisch umgesetzt und auf deren Wirksamkeit evaluiert werden. Für die Evaluation ist es wichtig, geeignete Scores, die auch international vergleichbar sind, zu verwenden. Mit dem Ziel, Aktivitäten des täglichen Lebens sowie Bereiche der Lebensqualität in einem einzigen Evaluationsbogen zu erfassen, wurde der Barthel-Index von uns um 6 Parameter erweitert (Barthel-Index-Variante-Vorarlberg bzw. BIVV). Die vorliegende Arbeit ist eine prospektive Kohortenstudie im ambulanten Bereich. Von den 411 Patienten wurden 261 (63,5 %) wegen Folgen einer zerebrovaskulären Erkrankung behandelt und 150 aufgrund von anderen neurologischen Erkrankungen wie Schädel-Hirn-Trauma oder M. Parkinson. Der Barthel-Index bei Aufnahme hatte einen Median von 80 (10. bis 90. Perzentile: 25-100), der BIVV betrug bei Aufnahme im Median 120 (10. bis 90. Perzentile: 50-145). Überlebende zeigten eine Veränderung im Barthel-Index von +6,4 (SD ± 14,9), im BIVV von +10,6 (SD ± 19,6). Subgruppenanalysen zeigten den größten Zugewinn für 75-85jährige Patienten. Je zusätzlicher Therapieeinheit pro Behandlungsmonat stieg der Veränderungsscore um 0,85 Punkte (p = 0,004). Bei blutigen zerebrovaskulären Erkrankungen verbesserte jeder zusätzliche Behandlungsmonat das Ergebnis um 1,4 Punkte (p = 0,0015). Diskussion: Patienten mit unblutigen vaskulären Erkrankungen im Alter zwischen 75 und 85 Jahren profitierten am meisten von der ambulanten Nachsorge. Positiv wirkte sich eine höhere Behandlungsintensität (mehr Therapieeinheiten pro Woche) aus. Patienten mit blutigen vaskulären Erkrankungen profitierten von verlängerter Nachsorgedauer.
Klinische Neuroradiologie, 2001
ABSTRACT Background: The etiology and pathogenesis of transient global amnesia, a clinical syndro... more ABSTRACT Background: The etiology and pathogenesis of transient global amnesia, a clinical syndrome during which new information cannot be retained while consciousness and other higher cognitive functions are still preserved, is still unknown. Imaging studies, including MRI, diffusion weighted MRI, MR spectrocopy and single-photon emission CT (SPECT) have shown inconsistent results but were rarely combined in a single patient. Case Report: We report on a patient in whom those different imaging modalities were performed during a period of transient global amnesia. All imaging modalities demonstrated normal results. Conclusion: The normal results underline that the etiology and pathogenesis of transient global amnesia still remains unclarified and can at least in this case not be attributed to changes in brain perfusion or a focal ischemia as proposed in previous studies. Zusammenfassung Hintergrund: Die tiologie und Pathogenese der transienten globalen Amnesie, bei der trotz erhaltenen Bewusstseins und erhaltener kognitiver Funktionen neue Informationen nicht erinnert werden knne, ist bislang nicht geklrt. Bildgebende Studien, wie z. B. die MRT, Diffusionsbildgebung, MR-Spektroskopie und Single-Photon-Emissions-CT (SPECT), kamen in verschiedenen Studien zu unterschiedlichen und z. T. widersprchlichen Ergebnissen. Nur selten wurden die verschiedenen Modalitten miteinander kombiniert. Kasuistik: Wir berichten ber einen Patienten, der whrend einer transienten globalen Amnesie mit allen oben beschriebenen Methoden untersucht wurde. Von der Norm abweichende Ergebnisse konnten jedoch mit keiner Methode dargestellt werden. Schlussfolgerung: Dieser Normalbefund zeigt, dass die tiologie und Pathogenese der transienten globalen Amnesie weiterhin ungeklrt bleibt. Zumindest in diesem Fall lagen offensichtlich keine Vernderung der Hirnperfusion und keine Ischmie vor, die von anderen Autoren als mgliche Ursachen der transienten globalen Amnesie vermutet wurden.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov, 1998
Comparative analysis was performed of results of the treatment of patients with ischemic stroke, ... more Comparative analysis was performed of results of the treatment of patients with ischemic stroke, including 140 ones treated by means of hemodilution method (control group) and 40 patients treated with cerebrolysin (test group). Barolin's scale of the neurorehabilitation was used for the analysis of the results. Statistically significant results of rehabilitation were better in the test group. Improvement of the parameters characterizing social contacts, working activity and behaviour was more pronounced than an improvement of motor functions. Cerebrolysin had accelerating effect on restoration of damaged functions, by creating more stable basis for rehabilitation.
Aktuelle Neurologie, 2009
Neuroepidemiology, 2015
Objectives: To assess the epidemiology of ALS in Austria and to evaluate the long-term effect of ... more Objectives: To assess the epidemiology of ALS in Austria and to evaluate the long-term effect of riluzole treatment on survival. Methods: Hospital discharge and riluzole prescription databases were used to identify ALS cases from January 2008 to June 2012. Using the capture-recapture method we evaluated the incidence and prevalence of ALS and patients' survival in dependence of age, gender and riluzole treatment. Results: The corrected incidence and prevalence of ALS were 3.13/100,000 person-years (95% CI, 2.77 to 3.50) and 9.14/100,000 persons (95% CI, 8.53 to 9.79), respectively. Median survival from diagnosis was 676 days (95% CI, 591 to 761). A younger age at diagnosis was associated with a longer survival. Gender did not appear to affect survival time. Riluzole therapy was associated with a survival advantage only for the initial treatment period. The adjusted hazard ratio of mortality for using riluzole increased continually over time resulting in an apparent reversal of its beneficial effect after 6 months of therapy. Conclusions: We report incidence and prevalence estimates that are on the upper end of the wide range discussed in literature. Riluzole seems to exert a beneficial effect only in the first 6 months of therapy.
Wiener medizinische Wochenschrift (1946), Jan 15, 1988
Adequate help for the apoplectic patient according to recent standards can be given only by simul... more Adequate help for the apoplectic patient according to recent standards can be given only by simultaneous and equivalent orientation towards both acute therapy and rehabilitation, which should merge smoothly into each other. This can be achieved only by specialised hospitalisation. The idea of totally domestic treatment, as advocated in times past, has to be abandoned for good. In the foreground of acute therapy are treatment of edema, cardiac output and blood pressure, rheological factors: blood viscosity, thrombocyte aggregation, erythrocyte elasticity. In the foreground of rehabilitation efforts we place the principle of "totality and permanence" regardless of prognostic selectivity. The principle of permanence refers to rehabilitative efforts from the very beginning to long-term rehabilitation for months and years with the help of our special rehabilitation service and systematic training of relatives. At least, it has to be stressed that the rehabilitation patient is n...
The World Journal of Biological Psychiatry, 2009
Our aim was to observe the frequency of combination therapy using antiepileptic drugs (AEDs) and ... more Our aim was to observe the frequency of combination therapy using antiepileptic drugs (AEDs) and electroconvulsive therapy (ECT) in Austria and the literature, and to provide rationales and recommendations based on clinical and molecular properties. The responsible ECT leaders of eight Austrian departments were contacted for information about combination therapy. A computerized PubMed database search was performed and supplemented by cross-referencing from papers, review articles and psychiatric manuals. The frequency of combination therapy in Austrian departments ranges between 0 and 85.7%. In 17 studies enrolling a total of 189 patients, 87 (46.0%) patients received combination therapy. Of these 87 patients, nine (10.3%) reported adverse effects. ECT and AEDs show overlapping clinical and molecular properties. Combination therapy is an observed reality and, according to the currently available literature, feasible. A comparison of clinical and molecular properties indicates possible augmentative effects, making combination therapy a promising alternative in treatment-resistant cases. But there is still a clear need for prospective case controlled data concerning side effects, safety profiles and effectiveness until it can be recommended.
Neuropsychobiology, 1987
... goto top of page Abstract. We present a randomized double-blind study on the efficacy of caro... more ... goto top of page Abstract. We present a randomized double-blind study on the efficacy of caroverine in the treatment of alcohol withdrawal symptoms. ... This may be an important factor in the treatment and management of alcohol withdrawal symptoms. ...
Journal of Neurology, Neurosurgery & Psychiatry, 1991
Two generations of a family affected by hereditary motor and sensory neuropathy with pyramidal si... more Two generations of a family affected by hereditary motor and sensory neuropathy with pyramidal signs (HMSN V) were clinically and electrophysiologically examined. Apart from electroneurographic studies, the central motor conduction (CMC) to arm and leg muscles was assessed using magnetic transcranial motor cortex stimulation. Abnormal CMC was confined to the clinically affected members, with the exception of an unaffected subject who had a diminished but normal latency response in a leg. The typical pattern was a significant diminution of the compound muscle action potential from the tibialis anterior and a moderately prolonged cortico-muscular conduction time (CoMCT) to this muscle.
Australian and New Zealand Journal of Psychiatry, 2006
Objective: To review the accumulated literature on the efficacy, safety and predictors of respons... more Objective: To review the accumulated literature on the efficacy, safety and predictors of response for repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression. Methods: A descriptive review of the more than 25 published sham-controlled rTMS studies in depression was undertaken, focusing on reported meta-analyses as well as individual trial reports. Potential determinants of efficacy were examined, including the form of shams employed, stimulation parameters and clinical features. Results: There is now clear evidence for the statistical superiority of left-prefrontal high frequency rTMS compared with sham therapy. However, the clinical benefits are marginal in the majority of reports. There is also still considerable uncertainty concerning the optimal stimulation parameters. Those clinical features which appear to be associated with greater response include younger age, lack of refractoriness to antidepressants and no psychotic features. Conclusions: Curren...
Objectives: To assess the epidemiology of ALS in Austria and to evaluate the long-term effect of ... more Objectives: To assess the epidemiology of ALS in Austria and to evaluate the long-term effect of riluzole treatment on survival. Methods: Hospital discharge and riluzole prescription databases were used to identify ALS cases from January 2008 to June 2012. Using the capture-recapture method we evaluated the incidence and prevalence of ALS and patients' survival in dependence of age, gender and riluzole treatment. Results: The corrected incidence and prevalence of ALS were 3.13/100,000 person-years (95% CI, 2.77 to 3.50) and 9.14/100,000 persons (95% CI, 8.53 to 9.79), respectively. Median survival from diagnosis was 676 days (95% CI, 591 to 761). A younger age at diagnosis was associated with a longer survival. Gender did not appear to affect survival time. Riluzole therapy was associated with a survival advantage only for the initial treatment period. The adjusted hazard ratio of mortality for using riluzole increased continually over time resulting in an apparent reversal of i...
Multiple Sclerosis Journal
Background: The month-of-birth-effect (MoBE) describes the finding that multiple sclerosis (MS) p... more Background: The month-of-birth-effect (MoBE) describes the finding that multiple sclerosis (MS) patients seem to have been born significantly more frequently in spring, with a rise in May, and significantly less often in autumn and winter with the fewest births in November. Objectives: To analyse if the MoBE can also be found in the Austrian MS population, and if so, whether the pattern is similar to the reported pattern in Canada, United Kingdom, and some Scandinavian countries. Methods: The data of 7886 MS patients in Austria were compared to all live births in Austria from 1940 to 2010, that is, 7.256545 data entries of the Austrian birth registry and analysed in detail. Results: Patterns observed in our MS cohort were not different from patterns in the general population, even when stratifying for gender. However, the noticeable and partly significant ups and downs over the examined years did not follow the distinct specific pattern with highest birth rates in spring and lowest ...
Neurology(R) neuroimmunology & neuroinflammation, 2017
Psychiatry and Clinical Neurosciences, Jun 1, 2008
Neuroepidemiology, Jan 7, 2015
Brain : a journal of neurology, Jun 23, 2016
We performed whole exome sequencing on a patient with Charcot-Marie-Tooth disease type 1 and iden... more We performed whole exome sequencing on a patient with Charcot-Marie-Tooth disease type 1 and identified ade novomutation inPMP2, the gene that encodes the myelin P2 protein. This mutation (p.Ile52Thr) was passed from the proband to his one affected son, and segregates with clinical and electrophysiological evidence of demyelinating neuropathy. We then screened a cohort of 136 European probands with uncharacterized genetic cause of Charcot-Marie-Tooth disease and identified another family with Charcot-Marie-Tooth disease type 1 that has a mutation affecting an adjacent amino acid (p.Thr51Pro), which segregates with disease. Our genetic and clinical findings in these kindred demonstrate that dominantPMP2mutations cause Charcot-Marie-Tooth disease type 1.
Histology and Histopathology Cellular and Molecular Biology, 2013
Tubular aggregates (TAs) are aggregates of densely packed tubules in human skeletal muscle fibers... more Tubular aggregates (TAs) are aggregates of densely packed tubules in human skeletal muscle fibers with particular histochemical and ultrastructural features that most probably arise from the sarcoplasmic reticulum. Some studies have shown an additional mitochondrial origin of TAs. We studied the histopathological spectrum and clinical features in a large cohort of patients with TAs in their muscle biopsy (106 biopsies), derived from our muscle biopsy archive (15,412 biopsies in total). In particular, we examined light microscopic, enzyme histochemical, immunohistochemical and ultrastructural features in the muscle biopsies, as well as the patients' clinical data. We found TAs in 0.5% of all muscle biopsies. Based on the size of TAs, we identified two sub-groups: (1) myopathies with large TAs (29 biopsies) in type 2 fibers and sometimes also in type 1 fibers, absence of any other associated disorder, and a familial history in half of the cases, and (2) myopathies with small TAs (77 biopsies), exclusively in type 2 fibers, presence of another associated disease in the majority of patients and mostly no familial history. In the sub-group with large TAs, we observed a high variability of ultrastructural changes. The most frequent clinical symptom in both groups was limb muscle weakness. No significant differences in clinical presentation, age at onset or disease duration at the time of biopsy were found between the two groups. In conclusion, myopathies with TAs can be sub-divided into a group with large TAs, probably corresponding to the so-called primary TA myopathies, and into a group with small TAs as a feature of another underlying condition.
Acta Medica Austriaca
The clinical outcome of 65 patients with malazia alba of the brain was documented by the use of o... more The clinical outcome of 65 patients with malazia alba of the brain was documented by the use of our "Valduna-Disability-Score" examining the patients at defined points of time. Simultaneously several rheological parameters of venous blood gained by punction of the cubital veine were examined before and after hemodilution therapy using dextran 40. The items or progress concerning clinical outcome and changes of the rheological parameters were correlated. There was not found any significance. We conclude, that the changes of rheological parameters in venous blood are not able to predict the clinical outcome after hemodilution therapy. The important role of disability scores--in our case the "Valduna-disability-score"--is to be stressed.
Journal fur Neurologie, Neurochirurgie und Psychiatrie
Eine ambulante neurologische Rehabilitation (ANR) ist in Österreich noch nicht weit verbreitet. I... more Eine ambulante neurologische Rehabilitation (ANR) ist in Österreich noch nicht weit verbreitet. In dieser Form existiert sie derzeit flächendeckend nur in Vorarlberg. Die gesteckten Ziele müssen im Sinne einer Evidence-based Rehabilitation ökonomisch umgesetzt und auf deren Wirksamkeit evaluiert werden. Für die Evaluation ist es wichtig, geeignete Scores, die auch international vergleichbar sind, zu verwenden. Mit dem Ziel, Aktivitäten des täglichen Lebens sowie Bereiche der Lebensqualität in einem einzigen Evaluationsbogen zu erfassen, wurde der Barthel-Index von uns um 6 Parameter erweitert (Barthel-Index-Variante-Vorarlberg bzw. BIVV). Die vorliegende Arbeit ist eine prospektive Kohortenstudie im ambulanten Bereich. Von den 411 Patienten wurden 261 (63,5 %) wegen Folgen einer zerebrovaskulären Erkrankung behandelt und 150 aufgrund von anderen neurologischen Erkrankungen wie Schädel-Hirn-Trauma oder M. Parkinson. Der Barthel-Index bei Aufnahme hatte einen Median von 80 (10. bis 90. Perzentile: 25-100), der BIVV betrug bei Aufnahme im Median 120 (10. bis 90. Perzentile: 50-145). Überlebende zeigten eine Veränderung im Barthel-Index von +6,4 (SD ± 14,9), im BIVV von +10,6 (SD ± 19,6). Subgruppenanalysen zeigten den größten Zugewinn für 75-85jährige Patienten. Je zusätzlicher Therapieeinheit pro Behandlungsmonat stieg der Veränderungsscore um 0,85 Punkte (p = 0,004). Bei blutigen zerebrovaskulären Erkrankungen verbesserte jeder zusätzliche Behandlungsmonat das Ergebnis um 1,4 Punkte (p = 0,0015). Diskussion: Patienten mit unblutigen vaskulären Erkrankungen im Alter zwischen 75 und 85 Jahren profitierten am meisten von der ambulanten Nachsorge. Positiv wirkte sich eine höhere Behandlungsintensität (mehr Therapieeinheiten pro Woche) aus. Patienten mit blutigen vaskulären Erkrankungen profitierten von verlängerter Nachsorgedauer.
Klinische Neuroradiologie, 2001
ABSTRACT Background: The etiology and pathogenesis of transient global amnesia, a clinical syndro... more ABSTRACT Background: The etiology and pathogenesis of transient global amnesia, a clinical syndrome during which new information cannot be retained while consciousness and other higher cognitive functions are still preserved, is still unknown. Imaging studies, including MRI, diffusion weighted MRI, MR spectrocopy and single-photon emission CT (SPECT) have shown inconsistent results but were rarely combined in a single patient. Case Report: We report on a patient in whom those different imaging modalities were performed during a period of transient global amnesia. All imaging modalities demonstrated normal results. Conclusion: The normal results underline that the etiology and pathogenesis of transient global amnesia still remains unclarified and can at least in this case not be attributed to changes in brain perfusion or a focal ischemia as proposed in previous studies. Zusammenfassung Hintergrund: Die tiologie und Pathogenese der transienten globalen Amnesie, bei der trotz erhaltenen Bewusstseins und erhaltener kognitiver Funktionen neue Informationen nicht erinnert werden knne, ist bislang nicht geklrt. Bildgebende Studien, wie z. B. die MRT, Diffusionsbildgebung, MR-Spektroskopie und Single-Photon-Emissions-CT (SPECT), kamen in verschiedenen Studien zu unterschiedlichen und z. T. widersprchlichen Ergebnissen. Nur selten wurden die verschiedenen Modalitten miteinander kombiniert. Kasuistik: Wir berichten ber einen Patienten, der whrend einer transienten globalen Amnesie mit allen oben beschriebenen Methoden untersucht wurde. Von der Norm abweichende Ergebnisse konnten jedoch mit keiner Methode dargestellt werden. Schlussfolgerung: Dieser Normalbefund zeigt, dass die tiologie und Pathogenese der transienten globalen Amnesie weiterhin ungeklrt bleibt. Zumindest in diesem Fall lagen offensichtlich keine Vernderung der Hirnperfusion und keine Ischmie vor, die von anderen Autoren als mgliche Ursachen der transienten globalen Amnesie vermutet wurden.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov, 1998
Comparative analysis was performed of results of the treatment of patients with ischemic stroke, ... more Comparative analysis was performed of results of the treatment of patients with ischemic stroke, including 140 ones treated by means of hemodilution method (control group) and 40 patients treated with cerebrolysin (test group). Barolin's scale of the neurorehabilitation was used for the analysis of the results. Statistically significant results of rehabilitation were better in the test group. Improvement of the parameters characterizing social contacts, working activity and behaviour was more pronounced than an improvement of motor functions. Cerebrolysin had accelerating effect on restoration of damaged functions, by creating more stable basis for rehabilitation.