S. Taleb - Academia.edu (original) (raw)

S. Taleb

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Papers by S. Taleb

Advancing Desalination, 2012

Natural product communications, 2011

Urolithiasis can lead to the loss of renal function in some cases. In this study, we tested the i... more Urolithiasis can lead to the loss of renal function in some cases. In this study, we tested the inhibiting effect of wheat bran (Triticum aestivum L) extract on calcium oxalate crystallization in a turbidimetric model, by FTIR spectroscopy, and polarized microscopy. The results show that this plant extract has a major inhibitory effect on calcium oxalate crystallization.

Asian J …, Jan 1, 2010

The inhibition effect of six medicinal plants used in Algerian Sahara traditional pharmacopoeia o... more The inhibition effect of six medicinal plants used in Algerian Sahara traditional pharmacopoeia on the calcium oxalate crystallization is studied. The inhibiting effect of two concentrations (0.5 and 1 mg/mL) of each extract and compared without extract. The turbidimetric parameters were given such as the time of induction (∆t), turbidimetric slopes of crystalline growth and aggregation, the coefficient of variation CV % and the rate of inhibition I % for each tests. The results showed that the aqueous extract of Cynodon dactylon L presents an inhibiting effect of a rate of 20 % on the crystalline growth and 60 % on the phase of aggregation, whereas the aqueous extract of Quercus prinus has an inhibiting effect of crystalline aggregation with a rate of 40 %. The aqueous extract of Punica granatum L under the concentration 1 mg/mL, exerts an inhibiting effect of crystalline aggregation but does not influence the crystalline growth. The other extracts did not show any effect on calcium oxalate crystallization.

The FASEB Journal, 2005

The molecular mechanisms by which obesity increases the risk of cardiovascular diseases are poorl... more The molecular mechanisms by which obesity increases the risk of cardiovascular diseases are poorly understood. The purpose of this study was to identify candidate biomarkers overexpressed in adipose tissue of obese subjects that could link expanded fat mass to atherosclerosis. We compared gene expression profile in subcutaneous adipose tissue (scWAT) of 28 obese and 11 lean subjects using microarray technology. This analysis identified 240 genes significantly overexpressed in scWAT of obese subjects. The genes were then ranked according to the correlation between gene expression and body mass index (BMI). In this list, the elastolytic cysteine protease cathepsin S was among the highly correlated genes. RT-PCR and Western blotting confirmed the increase in cathepsin S mRNA (P=0.006) and protein (P<0.05) in obese scWAT. The circulating concentrations of cathepsin S were also significantly higher in obese than in nonobese subjects (P<0.0001). Both cathepsin S mRNA in scWAT and circulating levels were positively correlated with BMI, body fat, and plasma triglyceride levels. In addition, we show that the proinflammatory factors, lipopolysaccharide, interleukin-1β, and tumor necrosis factor-α increase cathepsin S secretion in human scWAT explants. This study identifies cathepsin S as a novel marker of adiposity. Since this enzyme has been implicated in the development of atherosclerotic lesions, we propose that cathepsin S represents a molecular link between obesity and atherosclerosis.

The Journal of Clinical Endocrinology & Metabolism, 2006

Context: Human adipose tissue produces several adipokines, including the newly identified protein... more Context: Human adipose tissue produces several adipokines, including the newly identified protein cathepsin S (CTSS), a cysteine protease involved in the pathogenesis of atherosclerosis. Obesity is characterized by high levels of CTSS in the circulation and in sc white adipose tissue (scWAT).

Diabetes, 2005

These cells may contribute to low-grade inflammation and to its metabolic complications. Little i... more These cells may contribute to low-grade inflammation and to its metabolic complications. Little is known about the effect of weight loss on macrophages and genes involved in macrophage attraction. We examined subcutaneous WAT (scWAT) of 7 lean and 17 morbidly obese subjects before and 3 months after bypass surgery. Immunomorphological changes of the number of scWAT-infiltrating macrophages were evaluated, along with concomitant changes in expression of SVF-overexpressed genes. The number of sc-WAT-infiltrating macrophages before surgery was higher in obese than in lean subjects (HAM56؉/CD68؉; 22.6 ؎ 4.3 vs. 1.4 ؎ 0.6%, P < 0.001). Typical "crowns" of macrophages were observed around adipocytes. Drastic weight loss resulted in a significant decrease in macrophage number (؊11.63 ؎ 2.3%, P < 0.001), and remaining macrophages stained positive for the anti-inflammatory protein interleukin 10. Genes involved in macrophage

Energy Procedia, 2012

Polycyclic Aromatic Hydrocarbons are among the most persistent pollutants in various environmenta... more Polycyclic Aromatic Hydrocarbons are among the most persistent pollutants in various environmental matrices including soil. Because of their considerable toxicity even at low concentrations, it is essential to detect them at such very low levels (about ng/Kg) and to quantify them with precision and reliability.