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Journal of clinical images and medical case reports, Mar 24, 2022
Journal of Clinical Images and Medical Case Reports
Associate Professor, Department of Medicine and Neurology, Jagannath Gupta Institute of Medical S... more Associate Professor, Department of Medicine and Neurology, Jagannath Gupta Institute of Medical Science, Kolkata. India.
Diabetes is characterized by hyperglycemia and metabolic abnormalities due to decreased insulin l... more Diabetes is characterized by hyperglycemia and metabolic abnormalities due to decreased insulin level or action, causing metabolic and physiological changes in various organs. [1] It is also associated with disturbances concerned with protein, carbohydrate and lipid metabolism. [2] The reduced uptake of glucose into muscle and adipose tissue leads to chronic extra cellular hyperglycemia that results in tissue damage and micro as well as macrovascular complications in both type I and II Diabetes Mellitus. [3,4] The development of endothelial dysfunction is considered an important element of diabetic microvascular disease. [5] The adherence of circulating leucocytes to dysfunctional endothelium and their subsequent transmigration into the arterial intima is the subsequent step of the complication. The recruitment of leucocytes into the tissues is dependent on a multiple cascade of events mediated by distinct adhesion molecules. [6-8] The soluble fraction of Association of hsCRP and so...
World Journal of Pharmaceutical Research
Background: Control of plasma glucose could prevent the progression of most of the complications ... more Background: Control of plasma glucose could prevent the progression of most of the complications of diabetes mellitus and glycated hemoglobin is the most important criterion in controlling these complications. But its non-availability in grass root level of health sector and high cost, post-prandial and fasting blood glucose estimation have came into the field particularly in developing countries to assess glycemic control. Aim: To assess the better surrogate parameter fasing or post-prandial blood glucose for glycated haemoglobin that help in detecting the glycemic control status of diabetic patients. Methods: In the study One 120 diabetic patients attending an out-patient medical clinic were selected after simple random method. The study population was divided into three groups based on the HbA1c values i.e. Group 1 (HbA1c<7%-good control), Group 2 (HbA1c 7-9%- fairly controlled), Group 3 (HbA1c >9%-Poorly controlled). Glycated haemoglobin and blood glucose estimations in al...
Journal of Advances in Internal Medicine, 2014
doiBackground and aims: It is known that endothelial dysfunction and low-grade inflammation are i... more doiBackground and aims: It is known that endothelial dysfunction and low-grade inflammation are important element of diabetic complications. The soluble E-selectin is a marker of endothelial dysfunction and C-reactive protein is the most important inflammatory marker. The present study is done to investigate the effect of diabetes on these two markers. Methods: The present hospital based case control study was conducted in the department of Biochemistry with the collaboration of department of Medicine of Burdwan Medical College, Burdwan, west Bengal India. All subjects were selected by simple random sampling between March 2011 and May 2013. Blood level of these soluble E-selectin and high sensitive C-reactive protein were measured in two hundred diabetic and two hundred age, sex and other non-modifiable as well as modifiable risk factors matched non-diabetic healthy controls. Results: Compared with control value of high sensitive C-reactive protein and soluble E-selectin levels wer...
Journal of clinical images and medical case reports, Mar 24, 2022
Journal of Clinical Images and Medical Case Reports
Associate Professor, Department of Medicine and Neurology, Jagannath Gupta Institute of Medical S... more Associate Professor, Department of Medicine and Neurology, Jagannath Gupta Institute of Medical Science, Kolkata. India.
Diabetes is characterized by hyperglycemia and metabolic abnormalities due to decreased insulin l... more Diabetes is characterized by hyperglycemia and metabolic abnormalities due to decreased insulin level or action, causing metabolic and physiological changes in various organs. [1] It is also associated with disturbances concerned with protein, carbohydrate and lipid metabolism. [2] The reduced uptake of glucose into muscle and adipose tissue leads to chronic extra cellular hyperglycemia that results in tissue damage and micro as well as macrovascular complications in both type I and II Diabetes Mellitus. [3,4] The development of endothelial dysfunction is considered an important element of diabetic microvascular disease. [5] The adherence of circulating leucocytes to dysfunctional endothelium and their subsequent transmigration into the arterial intima is the subsequent step of the complication. The recruitment of leucocytes into the tissues is dependent on a multiple cascade of events mediated by distinct adhesion molecules. [6-8] The soluble fraction of Association of hsCRP and so...
World Journal of Pharmaceutical Research
Background: Control of plasma glucose could prevent the progression of most of the complications ... more Background: Control of plasma glucose could prevent the progression of most of the complications of diabetes mellitus and glycated hemoglobin is the most important criterion in controlling these complications. But its non-availability in grass root level of health sector and high cost, post-prandial and fasting blood glucose estimation have came into the field particularly in developing countries to assess glycemic control. Aim: To assess the better surrogate parameter fasing or post-prandial blood glucose for glycated haemoglobin that help in detecting the glycemic control status of diabetic patients. Methods: In the study One 120 diabetic patients attending an out-patient medical clinic were selected after simple random method. The study population was divided into three groups based on the HbA1c values i.e. Group 1 (HbA1c<7%-good control), Group 2 (HbA1c 7-9%- fairly controlled), Group 3 (HbA1c >9%-Poorly controlled). Glycated haemoglobin and blood glucose estimations in al...
Journal of Advances in Internal Medicine, 2014
doiBackground and aims: It is known that endothelial dysfunction and low-grade inflammation are i... more doiBackground and aims: It is known that endothelial dysfunction and low-grade inflammation are important element of diabetic complications. The soluble E-selectin is a marker of endothelial dysfunction and C-reactive protein is the most important inflammatory marker. The present study is done to investigate the effect of diabetes on these two markers. Methods: The present hospital based case control study was conducted in the department of Biochemistry with the collaboration of department of Medicine of Burdwan Medical College, Burdwan, west Bengal India. All subjects were selected by simple random sampling between March 2011 and May 2013. Blood level of these soluble E-selectin and high sensitive C-reactive protein were measured in two hundred diabetic and two hundred age, sex and other non-modifiable as well as modifiable risk factors matched non-diabetic healthy controls. Results: Compared with control value of high sensitive C-reactive protein and soluble E-selectin levels wer...