SUBH NAMAN - Academia.edu (original) (raw)
Papers by SUBH NAMAN
Authorea (Authorea), Jul 6, 2023
Journal of Drug Delivery Science and Technology
Indian Journal of Pharmaceutical Education and Research, Jan 9, 2023
Background: Atovaquone are important drugs that are used in the treatment of malaria and in combi... more Background: Atovaquone are important drugs that are used in the treatment of malaria and in combination with mefloquine hydrochloride increases the efficacy and potency. Present study covers the development of UV-spectrophotometry based analytical techniques for the simultaneous estimation of mefloquine HCl and atovaquone employing the Quality by Design (QbD) methods. Materials and Methods: C-N-X method were employed for risk assessment study and Ishikawa fishbone diagram was plotted for understanding of various factors that affect method development. Central Composite Design (CCD) was utilized for selected significant factors optimization. Scanning speed and scanning interval were considered as independent variables and absorption at 222 nm and 251 nm were considered as responses. Response surface plots and design space were developed for mathematical modelling-based prediction of responses obtained within specified ranges and optimization. Developed simultaneous analytical method was further validated as per the ICH Q2 guidelines. Results: The method showed good linearity with R 2 > 0.9 and good recovery with % RSD less than 2. The LOD and LOQ of UV developed method was found to be satisfactory and well between the acceptable range. Conclusion: The developed method for simultaneous estimation of atovaquone and mefloquine hydrochloride may act as a quick, precise, accurate, and economical quality control method for regular and simultaneous estimation of atovaquone and mefloquine HCl in bulk and mixed dosage forms at industrial level.
Acs Symposium Series, Dec 28, 2022
Acs Symposium Series, Dec 28, 2022
Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases, 2023
Drug Delivery Systems for Metabolic Disorders, 2022
Journal of Drug Delivery and Therapeutics, Jul 15, 2019
Indian Journal of Natural Products, 2021
Background: Capsaicin, the main active constituent of oleoresin capsicum present in capsicum frui... more Background: Capsaicin, the main active constituent of oleoresin capsicum present in capsicum fruits, is responsible for their pungency and color. Capsaicinoids is an important phytoconstituents and hence exported for various benefits. Hypothesis of work: The process of extraction of oleoresin capsicum by reflux method was to be optimized using in terms of their percentage yield. Further ICH complicent analytical method for quantitative analysis of caipsaicin using HPLC was developed and validated in present study. Methods: Critical extraction parameters like extraction time, temperature and solvent were optimized to develop an efficient method for extraction of oleoresin from capsicum fruits. A simple, rapid and stable HPLC method of capsaicin was developed using C 18 (2) HPLC column, 250x4.5 (mm), particle size 5 μm and validated using various parameters viz., linearity, accuracy, precision and LOD and LOQ using methanol and HPLC grade water (65:35v/v) as mobile phase. The elution was performed at 280 nm with run time of 10 min and flow rate of 1 mL/min. Results: The optimized conditions for oleoresin extraction were found to be 40°C (temperature), 5 hr (extraction time) and acetone as a solvent with highest percentage yield of (3.7% w/w). Furthermore, the developed HPLC method showed linear response over a concentration range of 1-9 μg/mL with standard regression equation (y=4614.9x+5344.1.9) with a coefficient of correlation value, of R 2 0.9974. The validation parameter evaluated using this method showed effective and satisfactory results as per ICH Q2 (R 1) guidelines and percentage recovery ranged from (98%-99.71%) indicated good accuracy. The inter and intraday precision with relative standard deviations of capsaicin < 1%, while the LOD and LOQ 1.04 to 3.03 μg/mL respectively. The oleoresin capsicum extract was analyzed for the content of capsaicin using HPLC showing the same retention time with highly pungency value. The percentage of capsaicin in the extract was 7.30%. Conclusion: The developed extraction and analytical method for capsaicin and oleoresin capsicum was accurate, precise, stable and may be useful for routine analysis of capsaicin content in capsicum fruits as well as various pharmaceutical and food preparations.
Letters in Drug Design & Discovery, 2020
Background: Over the last decade, there has been a sudden rise in the demand of herbal as well as... more Background: Over the last decade, there has been a sudden rise in the demand of herbal as well as Information and Technology (IT) industry around the world. Identification of plant species has become useful and relevant to all the members of the society including farmers, traders and hikers etc. Conventional authentication techniques such as morphological characterization, histological methods, and optical microscopy require multiple skills which are tedious, time-consuming and difficult to learn for non-experts. This creates hurdle for individuals interested in acquiring knowledge of species. Relying on rapid, economical and computerized approaches to identify and authenticate medicinal plants has become a recent development. Objective: The purpose of this review is to summarize artificial intelligence-based technologies for wider dissemination of common plant-based knowledge such as identification and authentication to common people earlier limited to only experts. Methods: A robu...
Journal of Drug Delivery Science and Technology
Authorea (Authorea), Jul 6, 2023
Journal of Drug Delivery Science and Technology
Indian Journal of Pharmaceutical Education and Research, Jan 9, 2023
Background: Atovaquone are important drugs that are used in the treatment of malaria and in combi... more Background: Atovaquone are important drugs that are used in the treatment of malaria and in combination with mefloquine hydrochloride increases the efficacy and potency. Present study covers the development of UV-spectrophotometry based analytical techniques for the simultaneous estimation of mefloquine HCl and atovaquone employing the Quality by Design (QbD) methods. Materials and Methods: C-N-X method were employed for risk assessment study and Ishikawa fishbone diagram was plotted for understanding of various factors that affect method development. Central Composite Design (CCD) was utilized for selected significant factors optimization. Scanning speed and scanning interval were considered as independent variables and absorption at 222 nm and 251 nm were considered as responses. Response surface plots and design space were developed for mathematical modelling-based prediction of responses obtained within specified ranges and optimization. Developed simultaneous analytical method was further validated as per the ICH Q2 guidelines. Results: The method showed good linearity with R 2 > 0.9 and good recovery with % RSD less than 2. The LOD and LOQ of UV developed method was found to be satisfactory and well between the acceptable range. Conclusion: The developed method for simultaneous estimation of atovaquone and mefloquine hydrochloride may act as a quick, precise, accurate, and economical quality control method for regular and simultaneous estimation of atovaquone and mefloquine HCl in bulk and mixed dosage forms at industrial level.
Acs Symposium Series, Dec 28, 2022
Acs Symposium Series, Dec 28, 2022
Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases, 2023
Drug Delivery Systems for Metabolic Disorders, 2022
Journal of Drug Delivery and Therapeutics, Jul 15, 2019
Indian Journal of Natural Products, 2021
Background: Capsaicin, the main active constituent of oleoresin capsicum present in capsicum frui... more Background: Capsaicin, the main active constituent of oleoresin capsicum present in capsicum fruits, is responsible for their pungency and color. Capsaicinoids is an important phytoconstituents and hence exported for various benefits. Hypothesis of work: The process of extraction of oleoresin capsicum by reflux method was to be optimized using in terms of their percentage yield. Further ICH complicent analytical method for quantitative analysis of caipsaicin using HPLC was developed and validated in present study. Methods: Critical extraction parameters like extraction time, temperature and solvent were optimized to develop an efficient method for extraction of oleoresin from capsicum fruits. A simple, rapid and stable HPLC method of capsaicin was developed using C 18 (2) HPLC column, 250x4.5 (mm), particle size 5 μm and validated using various parameters viz., linearity, accuracy, precision and LOD and LOQ using methanol and HPLC grade water (65:35v/v) as mobile phase. The elution was performed at 280 nm with run time of 10 min and flow rate of 1 mL/min. Results: The optimized conditions for oleoresin extraction were found to be 40°C (temperature), 5 hr (extraction time) and acetone as a solvent with highest percentage yield of (3.7% w/w). Furthermore, the developed HPLC method showed linear response over a concentration range of 1-9 μg/mL with standard regression equation (y=4614.9x+5344.1.9) with a coefficient of correlation value, of R 2 0.9974. The validation parameter evaluated using this method showed effective and satisfactory results as per ICH Q2 (R 1) guidelines and percentage recovery ranged from (98%-99.71%) indicated good accuracy. The inter and intraday precision with relative standard deviations of capsaicin < 1%, while the LOD and LOQ 1.04 to 3.03 μg/mL respectively. The oleoresin capsicum extract was analyzed for the content of capsaicin using HPLC showing the same retention time with highly pungency value. The percentage of capsaicin in the extract was 7.30%. Conclusion: The developed extraction and analytical method for capsaicin and oleoresin capsicum was accurate, precise, stable and may be useful for routine analysis of capsaicin content in capsicum fruits as well as various pharmaceutical and food preparations.
Letters in Drug Design & Discovery, 2020
Background: Over the last decade, there has been a sudden rise in the demand of herbal as well as... more Background: Over the last decade, there has been a sudden rise in the demand of herbal as well as Information and Technology (IT) industry around the world. Identification of plant species has become useful and relevant to all the members of the society including farmers, traders and hikers etc. Conventional authentication techniques such as morphological characterization, histological methods, and optical microscopy require multiple skills which are tedious, time-consuming and difficult to learn for non-experts. This creates hurdle for individuals interested in acquiring knowledge of species. Relying on rapid, economical and computerized approaches to identify and authenticate medicinal plants has become a recent development. Objective: The purpose of this review is to summarize artificial intelligence-based technologies for wider dissemination of common plant-based knowledge such as identification and authentication to common people earlier limited to only experts. Methods: A robu...
Journal of Drug Delivery Science and Technology