SUNIL MISHRA - Academia.edu (original) (raw)

Papers by SUNIL MISHRA

Beni-Suef University Journal of Basic and Applied Sciences, 2022

Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxi... more Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, neuroprotective and enhancing bioavailability and fertility-related activities. Piperine has the ability to alter gastrointestinal disorders, drug-metabolizing enzymes, and bioavailability of several drugs. The present review explores the available clinical and preclinical data, nanoformulations, extraction process, structure–activity relationships, molecular docking, bioavailability enhancement of phytochemicals and drugs, and brain penetration properties of piperine in the prevention, management, and treatment of various diseases and disorders. Main body Piperine provides therapeutic benefits in patients suffering from diabetes, obesity, arthritis, oral cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Parkinson's disease, Alzheimer’s disease, cerebral stroke, cardiovascular diseases, ...

A phenomenological model for the lattice dynamics of gold metal is developed. The total interacti... more A phenomenological model for the lattice dynamics of gold metal is developed. The total interaction inside the metal is composed of mainly the interactions between the ions and the interaction between the ions and electrons. A many parameter potential corresponding to two-body and three-body interactions is introduced to describe the forces between ions. The contribution to the potential energy from ion-electron interaction is considered by a screened Coulomb potential. The theoretical model developed is employed to obtain the phonon dispersion curves of gold. Computed phonon frequencies are used to explain the Debye characteristic temperatures at different temperatures. The computed results for phonon dispersion curves and Debye characteristic temperatures compare satisfactorily with the experimental results.

Dental and Medical Problems, 2021

Background. Polyetheretherketone (PEEK) is a new material that was introduced for the fabrication... more Background. Polyetheretherketone (PEEK) is a new material that was introduced for the fabrication of implants and their superstructure along with other available materials. It is not yet known whether the carbon fiber-reinforced polyetheretherketone (CFR-PEEK) material can be used as an implant and its superstructure in place of titanium (Ti). Objectives. The study evaluated stress distribution around CFR-PEEK implants and Ti implants with 5 different prosthetic crowns. Material and methods. A three-dimensional (3D) model of a bone block was created to represent the right maxillary premolar area with a bone-level implant system with 100% osseointegration, using the Ansys Workbench software, v. 15.0. In total, 10 3D finite element analysis (FEA) models were created. The models were divided into 2 groups according to the type of implant: the CFR-PEEK group (n = 5); and the Ti group (n = 5). Each group was subdivided to imitate 5 different restorative crown materials (PEEK, zirconia, porcelain fused to metal (PFM), metal, and acrylic resin). Each implant model was loaded vertically (200 N) and obliquely (100 N). Stress distribution in the implants, the abutments, the cement layers, and the crowns was evaluated using the von Mises stress analysis. Maximum and minimum principal stress analyses were used to determine the stress generated in the bone. Results. The CFR-PEEK implants bore more stress in vertical and oblique loading as compared to the Ti implants. The stress generated in the bone with the CFR-PEEK implants was similar to that generated with the Ti implants under vertical loading. Under oblique loading, less stress was transferred to the bone with the CFR-PEEK implants as compared to the Ti implants, showing better adaptation of the CFR-PEEK implants to lateral stress. Conclusions. In this FEA study, the amount of stress generated within the bone in the case of the CFR-PEEK implants with different restorative crowns was smaller in comparison with the Ti implants in oblique loading. This could help reduce lateral stress on implants as well as crestal bone loss.

Notulae Scientia Biologicae, 2013

Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen... more Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gamma-aminobutyric acid, dopamine and their receptor subtypes. The present study investigated the ability of 100, 200 and 400 mg/kg of ethanolic extract of Capparis zeylanica root (EECZ) circumvent aggression. Foot shock induced aggression, isolation-induced aggression, resident-intruder aggression and water competition test were utilized as models for screening of antiaggressive activity. Extract was given orally at three different dose levels (100, 200 and 400 mg/kg) once daily for three consecutive days, while Diazepam (2.5 mg/kg), was administered as positive control. EECZ significantly (p<0.05) minimized aggression dose dependently in the entire dose (100, 200, 400 mg/kg). Results suggested that EECZ showed significant antiagressive activity in aforementioned validated models of aggre...

Scientific Journal of October 6 University, 2014

Petroleum ether and acetone extracts of Citrus aurantifolia Swingle seeds were tested against Tox... more Petroleum ether and acetone extracts of Citrus aurantifolia Swingle seeds were tested against Toxocara vitulorum (Ascaris), and Fasciola gicantica {larvae and Eggs), Trihconstronylus colubriformis (adult worms , larvae and Eggs), larvae of Trichinella spiralis , in addition to Eimeria oocyst The results revealed variation in the lethal effect with different organisms. Petroleum ether (40-60) extract tested at 100% concentration showed 100% mortality effect against all parasites except T. colubriformis. larvae (39.6% mortality) .The larvicidal effect of acetone extract vary from T. colubriformis (adult worms) , F. gicantica (mature fluks) and T.spiralis larvae (LC 50 = 415,522,630 ppm) respectively, but no effect was observed against ascaris (adult worms) or T. colubriformis (larvae). Acetone extract was effective against the eggs of T.vitulorum, F. gicantica and T. colubriformis (LC 50 275, 155, 309 ppm) respectively. An oocidal effect was observed against Eimeria (LC 50 = 631 ppm) Phytochemical study of the bioactive extracts lead to identification of limonin and limonexic acid beside nine coumarins from acetone extract, the isolated compounds were identified by chemical and spectral analysis. The petroleum ether extract was saponified and analyzed by GC/Mass.

Diabetes care, Aug 12, 2018

Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent ... more Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent models. Data regarding the effect of SGLT-2 inhibitors on human liver fat are scarce. This study examined the effect of empagliflozin (an SGLT-2 inhibitor) on liver fat in patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) by using MRI-derived proton density fat fraction (MRI-PDFF). Fifty patients with type 2 diabetes and NAFLD were randomly assigned to either the empagliflozin group (standard treatment for type 2 diabetes plus empagliflozin 10 mg daily) or the control group (standard treatment without empagliflozin) for 20 weeks. Change in liver fat was measured by MRI-PDFF. Secondary outcome measures were change in alanine transaminase (ALT), aspartate transaminase (AST), and γ-glutamyl transferase (GGT) levels. When included in the standard treatment for type 2 diabetes, empagliflozin was significantly better at reducing liver fat (mean MRI-PDFF difference betw...

AI Magazine, 2010

In the winter, 2004 issue of AI Magazine, we reported Vulcan Inc.'s first step toward creatin... more In the winter, 2004 issue of AI Magazine, we reported Vulcan Inc.'s first step toward creating a question-answering system called "Digital Aristotle." The goal of that first step was to assess the state of the art in applied Knowledge Representation and Reasoning (KRR) by asking AI experts to represent 70 pages from the advanced placement (AP) chemistry syllabus and to deliver knowledge-based systems capable of answering questions from that syllabus. This paper reports the next step toward realizing a Digital Aristotle: we present the design and evaluation results for a system called AURA, which enables domain experts in physics, chemistry, and biology to author a knowledge base and that then allows a different set of users to ask novel questions against that knowledge base. These results represent a substantial advance over what we reported in 2004, both in the breadth of covered subjects and in the provision of sophisticated technologies in knowledge representation a...

Journal of clinical and experimental dentistry, 2017

The key to success of any root canal therapy is adequate obturation of the prepared root canal sp... more The key to success of any root canal therapy is adequate obturation of the prepared root canal space. Root canal sealers are not dimensionally stable and might dissolve partially over a period of time. The objective of this in vitro study is to evaluate the push-out bond strength to intraradicular dentin of two endodontic obturation materials. Forty extracted single rooted permanent teeth were used. Canals orifice was explored, teeth were instrumented. The samples were divided into two groups each containing twenty specimens obturated with different obturation material (Group1 Epiphany/Resilon and Group 2 Gutta Percha/AH Plus).The obturation systems used in this study was Element Obturation unit (Sybron Endo). Each tooth root was horizontally sectioned in approximately 2-mm thick slices from the coronal 1/3rd, middle 1/3rd and apical 1/3rd. The push-out bond strength of each specimen was calculated using Universal Testing Machine. The statistical analysis was done using two way anal...

Journal of Prosthodontics, 2016

Purpose: Replacement of lost teeth has significant functional and psychosocial effects. The capab... more Purpose: Replacement of lost teeth has significant functional and psychosocial effects. The capability of osseointegrated dental implants to transmit a certain amount of sensibility is still unclear. The phenomenon of developing a certain amount of tactile sensibility through osseointegrated dental implants is called osseoperception. The aim of this article is to evaluate the available literature to find osseoperception associated with dental implants. Materials and Methods: To identify suitable literature, an electronic search was performed using Medline and PubMed database. Articles published in English and articles whose abstract is available in English were included. The articles included in the review were based on osseoperception, tactile sensation, and neurophysiological mechanoreceptors in relation to dental implants. Articles on peri-implantitis and infection-related sensitivity were not included. Review articles without the original data were excluded, although references to potentially pertinent articles were noted for further follow-up. The phenomenon of osseoperception remains a matter of debate, so the search strategy mainly focused on articles on osseoperception and tactile sensibility of dental implants. This review presents the histological, neurophysiological, and psychophysical evidence of osseoperception and also the role of mechanoreceptors in osseoperception. Results: The literature on osseoperception in dental implants is very scarce. The initial literature search resulted in 90 articles, of which 81 articles that fulfilled the inclusion criteria were included in this systematic review. Conclusion: Patients restored with implant-supported prostheses reported improved tactile and motor function when compared with patients wearing complete dentures.

This is to certify that the work in the report entitled "Synthesis of CNTs by Pyrolysis and fabri... more This is to certify that the work in the report entitled "Synthesis of CNTs by Pyrolysis and fabrication and study of the electrical transport characteristics of FET configured CNT device" " by Subhasmita Mishra, in partial fulfilment of Master of Science degree in PHYSICS at the National Institute of Technology, Rourkela, is an authentic work carried out by her under my supervision and guidance. The work is satisfactory to the best of my knowledge.

The Journal of Indian Prosthodontic Society, 2008

Denture repair involves joining two parts of fractured denture with a denture repair material. Th... more Denture repair involves joining two parts of fractured denture with a denture repair material. The success of denture repair relies on the phenomenon of adhesion. Polymer surface can be etched by appropriate chemical, which changes the morphology and chemical properties of surface and promotes better adhesion. Taking into account the importance of adhesion in denture repair, the study was designed to evaluate and compare the transverse strength of repaired conventional, high-impact and glass fi ber-reinforced heat cure denture base resins with and without surface chemical treatment with ethyl acetate and methylene chloride. METHODOLOGY: The study was conducted by surface treatment of different denture base resins (conventional, high impact, and glass fi ber) with different chemicals (ethyl acetate and methylene chloride), with control group formed without surface chemical treatment. Specimens were repaired with autopolymerizing acrylic resin using 'sprinkle on' technique. The testing of the transverse strength of the repaired specimen was carried out on universal testing machine. PRINCIPAL CONCLUSION: The study revealed that surface chemical treatment with methylene chloride and ethyl acetate improved the transverse strength of repaired heat cure denture base when compared with control group. The glass fi ber subgroup with methylene chloride surface treatment is recommended as the combination possessing the most superior transverse strength among the various combinations.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015

Background: In patients with extensive tooth loss, restoration of masticatory function and aesthe... more Background: In patients with extensive tooth loss, restoration of masticatory function and aesthetics is main concern for a prosthodontist. Aim of Study: This study aimed to evaluate and compare differences in masticatory efficiency of patients treated with complete dentures made with either high impact or flexible resins. Setting and design: The sample size consisted of 10 study sub jects. Two sets of dentures first conventional followed by flexible dentures were fabricated for each subject and both the sets of dentures were accessed for masticatory performance and efficiency. Materials and Methods: This study compared the masticatory performance and efficiency of dentures by means of standardized mesh sieves. Masticatory efficiency was calculated by recording the total number of chewing cycles and time required to completely swallow a standardized food item. A patient satisfaction questionnaire was given and evaluated. Statistical Analysis used: The statistical analyses were performed using Z-test of Proportion and Paired t-test. results: The masticatory performance ratio was found to be more for hard food in conventional dentures. The values of masticatory performance ratios for soft food, time and number of masticatory strokes were indicating better masticatory efficiency of conventional dentures. conclusion: Though masticatory efficiency and performance were found to be better for patient's dentures made with Polymethyl methacrylate (PMMA), a statistically significant number of patients reported that the flexible dentures were more satisfying than the conventional dentures.

New Journal of Physics, 2014

We study a quantum Otto engine operating on the basis of a helical spin-1 2

Physical Review A, 2014

Within the framework of a general three-level problem, the dynamics of the nitrogen-vacancy (NV) ... more Within the framework of a general three-level problem, the dynamics of the nitrogen-vacancy (NV) spin is studied for the case of a special type of external driving consisting of a set of continuous fields with decreasing intensities. Such a set has been proposed for minimizing coherence losses. Each new driving field with smaller intensity is designed to protect against the fluctuations induced by the driving field at the preceding step with larger intensity. We show that indeed this particular type of external driving minimizes the loss of coherence, using purity and entropy as quantifiers for this purpose. As an illustration, we study the coherence loss of an NV spin due to a surrounding spin bath of 13 C nuclei.

AI Magazine, 2010

In the winter, 2004 issue of AI Magazine, we reported Vulcan Inc.'s first step toward creatin... more In the winter, 2004 issue of AI Magazine, we reported Vulcan Inc.'s first step toward creating a question-answering system called "Digital Aristotle." The goal of that first step was to assess the state of the art in applied Knowledge Representation and Reasoning (KRR) by asking AI experts to represent 70 pages from the advanced placement (AP) chemistry syllabus and to deliver knowledge-based systems capable of answering questions from that syllabus. This paper reports the next step toward realizing a Digital Aristotle: we present the design and evaluation results for a system called AURA, which enables domain experts in physics, chemistry, and biology to author a knowledge base and that then allows a different set of users to ask novel questions against that knowledge base. These results represent a substantial advance over what we reported in 2004, both in the breadth of covered subjects and in the provision of sophisticated technologies in knowledge representation a...

International Journal of Modern Physics B, 2011

The finite size and surface roughness effects on the magnetization of NiO nanoparticles is invest... more The finite size and surface roughness effects on the magnetization of NiO nanoparticles is investigated. A large magnetic moment arises for an antiferromagnetic nanoparticle due to these effects. The magnetic moment without the surface roughness has a nonmonotonic and oscillatory dependence on R, the size of the particles, with the amplitude of the fluctuations varying linearly with R. The geometry of the particle also matters a lot in the calculation of the net magnetic moment. An oblate spheroid shape particle shows an increase in net magnetic moment by increasing oblateness of the particle. However, the magnetic moment values thus calculated are very small compared to the experimental values for various sizes, indicating that the bulk antiferromagnetic structure may not hold near the surface. We incorporate the surface roughness in two different ways; an ordered surface with surface spins inside a surface roughness shell aligned due to an internal field, and a disordered surface ...

New Journal of Physics, 2014

We study a quantum Otto engine operating on the basis of a helical spin-1 2

The Journal of Indian Prosthodontic Society, 2014

Statementof problem: Osseointegration is the more stable situation and results in a high success ... more Statementof problem: Osseointegration is the more stable situation and results in a high success rate of dental implants. Heat generation during rotary cutting is one of the important factors influencing the development of osseointegration. Purpose: To assess the various factors related to implant drills responsible for heat generation during osteotomy. Materials and Methods: To identify suitable literature, an electronic search was performed using Medline and Pubmed database. Articles published in between 1960 to February 2013 were searched. The search is focused on heat generated by dental implant drills during osteotomy. Various factors related to implant drill such effect of number of blades; drill design, drill fatigue, drill speed and force applied during osteotomies which were responsible for heat generation were reviewed. Titles and abstracts were screened, and literature that fulfilled the inclusion criteria was selected for a full-text reading. Results: The initial literature search resulted in 299 articles out of which only 70 articles fulfils the inclusion criteria and were included in this systematic review. Many factors related to implant drill responsible for heat generation were found. Successful preparation of an implant cavity with minimal damage to the surrounding bone depends on the avoidance of excessive temperature generation during surgical drilling. Conclusion: The relationship between heat generated and implant drilling osteotomy is multifactorial in nature and its complexity has not been fully studied. Lack of scientific knowledge regarding this issue still exists. Further studies should be conducted to determine the various factors which generate less heat while osteotomy such as ideal ratio of force and speed in vivo, exact time to replace a drill, ideal drill design, irrigation system, drill-bone contact area.

Physical Review A, 2014

Within the framework of a general three-level problem, the dynamics of the nitrogen-vacancy (NV) ... more Within the framework of a general three-level problem, the dynamics of the nitrogen-vacancy (NV) spin is studied for the case of a special type of external driving consisting of a set of continuous fields with decreasing intensities. Such a set has been proposed for minimizing coherence losses. Each new driving field with smaller intensity is designed to protect against the fluctuations induced by the driving field at the preceding step with larger intensity. We show that indeed this particular type of external driving minimizes the loss of coherence, using purity and entropy as quantifiers for this purpose. As an illustration, we study the coherence loss of an NV spin due to a surrounding spin bath of 13 C nuclei.

Physical Review A, 2015

We present a solvable model of iterating cluster state protocols that lead to entanglement produc... more We present a solvable model of iterating cluster state protocols that lead to entanglement production, between contiguous blocks, of 1 ebit per iteration. This continues till the blocks are maximally entangled at which stage an unravelling begins at the same rate till the blocks are unentangled. The model is a variant of the transverse field Ising model and can be implemented with CNOT and single qubit gates. The inter qubit entanglement as measured by the concurrence is shown to be zero for periodic chain realizations while for open boundaries there are very specific instances at which these can develop. Thus we introduce a class of simply produced states with very large multipartite entanglement content of potential use in measurement based quantum computing.

Beni-Suef University Journal of Basic and Applied Sciences, 2022

Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxi... more Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, neuroprotective and enhancing bioavailability and fertility-related activities. Piperine has the ability to alter gastrointestinal disorders, drug-metabolizing enzymes, and bioavailability of several drugs. The present review explores the available clinical and preclinical data, nanoformulations, extraction process, structure–activity relationships, molecular docking, bioavailability enhancement of phytochemicals and drugs, and brain penetration properties of piperine in the prevention, management, and treatment of various diseases and disorders. Main body Piperine provides therapeutic benefits in patients suffering from diabetes, obesity, arthritis, oral cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Parkinson's disease, Alzheimer’s disease, cerebral stroke, cardiovascular diseases, ...

A phenomenological model for the lattice dynamics of gold metal is developed. The total interacti... more A phenomenological model for the lattice dynamics of gold metal is developed. The total interaction inside the metal is composed of mainly the interactions between the ions and the interaction between the ions and electrons. A many parameter potential corresponding to two-body and three-body interactions is introduced to describe the forces between ions. The contribution to the potential energy from ion-electron interaction is considered by a screened Coulomb potential. The theoretical model developed is employed to obtain the phonon dispersion curves of gold. Computed phonon frequencies are used to explain the Debye characteristic temperatures at different temperatures. The computed results for phonon dispersion curves and Debye characteristic temperatures compare satisfactorily with the experimental results.

Dental and Medical Problems, 2021

Background. Polyetheretherketone (PEEK) is a new material that was introduced for the fabrication... more Background. Polyetheretherketone (PEEK) is a new material that was introduced for the fabrication of implants and their superstructure along with other available materials. It is not yet known whether the carbon fiber-reinforced polyetheretherketone (CFR-PEEK) material can be used as an implant and its superstructure in place of titanium (Ti). Objectives. The study evaluated stress distribution around CFR-PEEK implants and Ti implants with 5 different prosthetic crowns. Material and methods. A three-dimensional (3D) model of a bone block was created to represent the right maxillary premolar area with a bone-level implant system with 100% osseointegration, using the Ansys Workbench software, v. 15.0. In total, 10 3D finite element analysis (FEA) models were created. The models were divided into 2 groups according to the type of implant: the CFR-PEEK group (n = 5); and the Ti group (n = 5). Each group was subdivided to imitate 5 different restorative crown materials (PEEK, zirconia, porcelain fused to metal (PFM), metal, and acrylic resin). Each implant model was loaded vertically (200 N) and obliquely (100 N). Stress distribution in the implants, the abutments, the cement layers, and the crowns was evaluated using the von Mises stress analysis. Maximum and minimum principal stress analyses were used to determine the stress generated in the bone. Results. The CFR-PEEK implants bore more stress in vertical and oblique loading as compared to the Ti implants. The stress generated in the bone with the CFR-PEEK implants was similar to that generated with the Ti implants under vertical loading. Under oblique loading, less stress was transferred to the bone with the CFR-PEEK implants as compared to the Ti implants, showing better adaptation of the CFR-PEEK implants to lateral stress. Conclusions. In this FEA study, the amount of stress generated within the bone in the case of the CFR-PEEK implants with different restorative crowns was smaller in comparison with the Ti implants in oblique loading. This could help reduce lateral stress on implants as well as crestal bone loss.

Notulae Scientia Biologicae, 2013

Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen... more Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gamma-aminobutyric acid, dopamine and their receptor subtypes. The present study investigated the ability of 100, 200 and 400 mg/kg of ethanolic extract of Capparis zeylanica root (EECZ) circumvent aggression. Foot shock induced aggression, isolation-induced aggression, resident-intruder aggression and water competition test were utilized as models for screening of antiaggressive activity. Extract was given orally at three different dose levels (100, 200 and 400 mg/kg) once daily for three consecutive days, while Diazepam (2.5 mg/kg), was administered as positive control. EECZ significantly (p<0.05) minimized aggression dose dependently in the entire dose (100, 200, 400 mg/kg). Results suggested that EECZ showed significant antiagressive activity in aforementioned validated models of aggre...

Scientific Journal of October 6 University, 2014

Petroleum ether and acetone extracts of Citrus aurantifolia Swingle seeds were tested against Tox... more Petroleum ether and acetone extracts of Citrus aurantifolia Swingle seeds were tested against Toxocara vitulorum (Ascaris), and Fasciola gicantica {larvae and Eggs), Trihconstronylus colubriformis (adult worms , larvae and Eggs), larvae of Trichinella spiralis , in addition to Eimeria oocyst The results revealed variation in the lethal effect with different organisms. Petroleum ether (40-60) extract tested at 100% concentration showed 100% mortality effect against all parasites except T. colubriformis. larvae (39.6% mortality) .The larvicidal effect of acetone extract vary from T. colubriformis (adult worms) , F. gicantica (mature fluks) and T.spiralis larvae (LC 50 = 415,522,630 ppm) respectively, but no effect was observed against ascaris (adult worms) or T. colubriformis (larvae). Acetone extract was effective against the eggs of T.vitulorum, F. gicantica and T. colubriformis (LC 50 275, 155, 309 ppm) respectively. An oocidal effect was observed against Eimeria (LC 50 = 631 ppm) Phytochemical study of the bioactive extracts lead to identification of limonin and limonexic acid beside nine coumarins from acetone extract, the isolated compounds were identified by chemical and spectral analysis. The petroleum ether extract was saponified and analyzed by GC/Mass.

Diabetes care, Aug 12, 2018

Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent ... more Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent models. Data regarding the effect of SGLT-2 inhibitors on human liver fat are scarce. This study examined the effect of empagliflozin (an SGLT-2 inhibitor) on liver fat in patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) by using MRI-derived proton density fat fraction (MRI-PDFF). Fifty patients with type 2 diabetes and NAFLD were randomly assigned to either the empagliflozin group (standard treatment for type 2 diabetes plus empagliflozin 10 mg daily) or the control group (standard treatment without empagliflozin) for 20 weeks. Change in liver fat was measured by MRI-PDFF. Secondary outcome measures were change in alanine transaminase (ALT), aspartate transaminase (AST), and γ-glutamyl transferase (GGT) levels. When included in the standard treatment for type 2 diabetes, empagliflozin was significantly better at reducing liver fat (mean MRI-PDFF difference betw...

AI Magazine, 2010

In the winter, 2004 issue of AI Magazine, we reported Vulcan Inc.'s first step toward creatin... more In the winter, 2004 issue of AI Magazine, we reported Vulcan Inc.'s first step toward creating a question-answering system called "Digital Aristotle." The goal of that first step was to assess the state of the art in applied Knowledge Representation and Reasoning (KRR) by asking AI experts to represent 70 pages from the advanced placement (AP) chemistry syllabus and to deliver knowledge-based systems capable of answering questions from that syllabus. This paper reports the next step toward realizing a Digital Aristotle: we present the design and evaluation results for a system called AURA, which enables domain experts in physics, chemistry, and biology to author a knowledge base and that then allows a different set of users to ask novel questions against that knowledge base. These results represent a substantial advance over what we reported in 2004, both in the breadth of covered subjects and in the provision of sophisticated technologies in knowledge representation a...

Journal of clinical and experimental dentistry, 2017

The key to success of any root canal therapy is adequate obturation of the prepared root canal sp... more The key to success of any root canal therapy is adequate obturation of the prepared root canal space. Root canal sealers are not dimensionally stable and might dissolve partially over a period of time. The objective of this in vitro study is to evaluate the push-out bond strength to intraradicular dentin of two endodontic obturation materials. Forty extracted single rooted permanent teeth were used. Canals orifice was explored, teeth were instrumented. The samples were divided into two groups each containing twenty specimens obturated with different obturation material (Group1 Epiphany/Resilon and Group 2 Gutta Percha/AH Plus).The obturation systems used in this study was Element Obturation unit (Sybron Endo). Each tooth root was horizontally sectioned in approximately 2-mm thick slices from the coronal 1/3rd, middle 1/3rd and apical 1/3rd. The push-out bond strength of each specimen was calculated using Universal Testing Machine. The statistical analysis was done using two way anal...

Journal of Prosthodontics, 2016

Purpose: Replacement of lost teeth has significant functional and psychosocial effects. The capab... more Purpose: Replacement of lost teeth has significant functional and psychosocial effects. The capability of osseointegrated dental implants to transmit a certain amount of sensibility is still unclear. The phenomenon of developing a certain amount of tactile sensibility through osseointegrated dental implants is called osseoperception. The aim of this article is to evaluate the available literature to find osseoperception associated with dental implants. Materials and Methods: To identify suitable literature, an electronic search was performed using Medline and PubMed database. Articles published in English and articles whose abstract is available in English were included. The articles included in the review were based on osseoperception, tactile sensation, and neurophysiological mechanoreceptors in relation to dental implants. Articles on peri-implantitis and infection-related sensitivity were not included. Review articles without the original data were excluded, although references to potentially pertinent articles were noted for further follow-up. The phenomenon of osseoperception remains a matter of debate, so the search strategy mainly focused on articles on osseoperception and tactile sensibility of dental implants. This review presents the histological, neurophysiological, and psychophysical evidence of osseoperception and also the role of mechanoreceptors in osseoperception. Results: The literature on osseoperception in dental implants is very scarce. The initial literature search resulted in 90 articles, of which 81 articles that fulfilled the inclusion criteria were included in this systematic review. Conclusion: Patients restored with implant-supported prostheses reported improved tactile and motor function when compared with patients wearing complete dentures.

This is to certify that the work in the report entitled "Synthesis of CNTs by Pyrolysis and fabri... more This is to certify that the work in the report entitled "Synthesis of CNTs by Pyrolysis and fabrication and study of the electrical transport characteristics of FET configured CNT device" " by Subhasmita Mishra, in partial fulfilment of Master of Science degree in PHYSICS at the National Institute of Technology, Rourkela, is an authentic work carried out by her under my supervision and guidance. The work is satisfactory to the best of my knowledge.

The Journal of Indian Prosthodontic Society, 2008

Denture repair involves joining two parts of fractured denture with a denture repair material. Th... more Denture repair involves joining two parts of fractured denture with a denture repair material. The success of denture repair relies on the phenomenon of adhesion. Polymer surface can be etched by appropriate chemical, which changes the morphology and chemical properties of surface and promotes better adhesion. Taking into account the importance of adhesion in denture repair, the study was designed to evaluate and compare the transverse strength of repaired conventional, high-impact and glass fi ber-reinforced heat cure denture base resins with and without surface chemical treatment with ethyl acetate and methylene chloride. METHODOLOGY: The study was conducted by surface treatment of different denture base resins (conventional, high impact, and glass fi ber) with different chemicals (ethyl acetate and methylene chloride), with control group formed without surface chemical treatment. Specimens were repaired with autopolymerizing acrylic resin using 'sprinkle on' technique. The testing of the transverse strength of the repaired specimen was carried out on universal testing machine. PRINCIPAL CONCLUSION: The study revealed that surface chemical treatment with methylene chloride and ethyl acetate improved the transverse strength of repaired heat cure denture base when compared with control group. The glass fi ber subgroup with methylene chloride surface treatment is recommended as the combination possessing the most superior transverse strength among the various combinations.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2015

Background: In patients with extensive tooth loss, restoration of masticatory function and aesthe... more Background: In patients with extensive tooth loss, restoration of masticatory function and aesthetics is main concern for a prosthodontist. Aim of Study: This study aimed to evaluate and compare differences in masticatory efficiency of patients treated with complete dentures made with either high impact or flexible resins. Setting and design: The sample size consisted of 10 study sub jects. Two sets of dentures first conventional followed by flexible dentures were fabricated for each subject and both the sets of dentures were accessed for masticatory performance and efficiency. Materials and Methods: This study compared the masticatory performance and efficiency of dentures by means of standardized mesh sieves. Masticatory efficiency was calculated by recording the total number of chewing cycles and time required to completely swallow a standardized food item. A patient satisfaction questionnaire was given and evaluated. Statistical Analysis used: The statistical analyses were performed using Z-test of Proportion and Paired t-test. results: The masticatory performance ratio was found to be more for hard food in conventional dentures. The values of masticatory performance ratios for soft food, time and number of masticatory strokes were indicating better masticatory efficiency of conventional dentures. conclusion: Though masticatory efficiency and performance were found to be better for patient's dentures made with Polymethyl methacrylate (PMMA), a statistically significant number of patients reported that the flexible dentures were more satisfying than the conventional dentures.

New Journal of Physics, 2014

We study a quantum Otto engine operating on the basis of a helical spin-1 2

Physical Review A, 2014

Within the framework of a general three-level problem, the dynamics of the nitrogen-vacancy (NV) ... more Within the framework of a general three-level problem, the dynamics of the nitrogen-vacancy (NV) spin is studied for the case of a special type of external driving consisting of a set of continuous fields with decreasing intensities. Such a set has been proposed for minimizing coherence losses. Each new driving field with smaller intensity is designed to protect against the fluctuations induced by the driving field at the preceding step with larger intensity. We show that indeed this particular type of external driving minimizes the loss of coherence, using purity and entropy as quantifiers for this purpose. As an illustration, we study the coherence loss of an NV spin due to a surrounding spin bath of 13 C nuclei.

AI Magazine, 2010

In the winter, 2004 issue of AI Magazine, we reported Vulcan Inc.'s first step toward creatin... more In the winter, 2004 issue of AI Magazine, we reported Vulcan Inc.'s first step toward creating a question-answering system called "Digital Aristotle." The goal of that first step was to assess the state of the art in applied Knowledge Representation and Reasoning (KRR) by asking AI experts to represent 70 pages from the advanced placement (AP) chemistry syllabus and to deliver knowledge-based systems capable of answering questions from that syllabus. This paper reports the next step toward realizing a Digital Aristotle: we present the design and evaluation results for a system called AURA, which enables domain experts in physics, chemistry, and biology to author a knowledge base and that then allows a different set of users to ask novel questions against that knowledge base. These results represent a substantial advance over what we reported in 2004, both in the breadth of covered subjects and in the provision of sophisticated technologies in knowledge representation a...

International Journal of Modern Physics B, 2011

The finite size and surface roughness effects on the magnetization of NiO nanoparticles is invest... more The finite size and surface roughness effects on the magnetization of NiO nanoparticles is investigated. A large magnetic moment arises for an antiferromagnetic nanoparticle due to these effects. The magnetic moment without the surface roughness has a nonmonotonic and oscillatory dependence on R, the size of the particles, with the amplitude of the fluctuations varying linearly with R. The geometry of the particle also matters a lot in the calculation of the net magnetic moment. An oblate spheroid shape particle shows an increase in net magnetic moment by increasing oblateness of the particle. However, the magnetic moment values thus calculated are very small compared to the experimental values for various sizes, indicating that the bulk antiferromagnetic structure may not hold near the surface. We incorporate the surface roughness in two different ways; an ordered surface with surface spins inside a surface roughness shell aligned due to an internal field, and a disordered surface ...

New Journal of Physics, 2014

We study a quantum Otto engine operating on the basis of a helical spin-1 2

The Journal of Indian Prosthodontic Society, 2014

Statementof problem: Osseointegration is the more stable situation and results in a high success ... more Statementof problem: Osseointegration is the more stable situation and results in a high success rate of dental implants. Heat generation during rotary cutting is one of the important factors influencing the development of osseointegration. Purpose: To assess the various factors related to implant drills responsible for heat generation during osteotomy. Materials and Methods: To identify suitable literature, an electronic search was performed using Medline and Pubmed database. Articles published in between 1960 to February 2013 were searched. The search is focused on heat generated by dental implant drills during osteotomy. Various factors related to implant drill such effect of number of blades; drill design, drill fatigue, drill speed and force applied during osteotomies which were responsible for heat generation were reviewed. Titles and abstracts were screened, and literature that fulfilled the inclusion criteria was selected for a full-text reading. Results: The initial literature search resulted in 299 articles out of which only 70 articles fulfils the inclusion criteria and were included in this systematic review. Many factors related to implant drill responsible for heat generation were found. Successful preparation of an implant cavity with minimal damage to the surrounding bone depends on the avoidance of excessive temperature generation during surgical drilling. Conclusion: The relationship between heat generated and implant drilling osteotomy is multifactorial in nature and its complexity has not been fully studied. Lack of scientific knowledge regarding this issue still exists. Further studies should be conducted to determine the various factors which generate less heat while osteotomy such as ideal ratio of force and speed in vivo, exact time to replace a drill, ideal drill design, irrigation system, drill-bone contact area.

Physical Review A, 2014

Within the framework of a general three-level problem, the dynamics of the nitrogen-vacancy (NV) ... more Within the framework of a general three-level problem, the dynamics of the nitrogen-vacancy (NV) spin is studied for the case of a special type of external driving consisting of a set of continuous fields with decreasing intensities. Such a set has been proposed for minimizing coherence losses. Each new driving field with smaller intensity is designed to protect against the fluctuations induced by the driving field at the preceding step with larger intensity. We show that indeed this particular type of external driving minimizes the loss of coherence, using purity and entropy as quantifiers for this purpose. As an illustration, we study the coherence loss of an NV spin due to a surrounding spin bath of 13 C nuclei.

Physical Review A, 2015

We present a solvable model of iterating cluster state protocols that lead to entanglement produc... more We present a solvable model of iterating cluster state protocols that lead to entanglement production, between contiguous blocks, of 1 ebit per iteration. This continues till the blocks are maximally entangled at which stage an unravelling begins at the same rate till the blocks are unentangled. The model is a variant of the transverse field Ising model and can be implemented with CNOT and single qubit gates. The inter qubit entanglement as measured by the concurrence is shown to be zero for periodic chain realizations while for open boundaries there are very specific instances at which these can develop. Thus we introduce a class of simply produced states with very large multipartite entanglement content of potential use in measurement based quantum computing.