Saadain Syed - Academia.edu (original) (raw)

Papers by Saadain Syed

Cancer research, 1999

Allelic losses on the short arm of chromosome 8 (8p) have been reported as frequent events in sev... more Allelic losses on the short arm of chromosome 8 (8p) have been reported as frequent events in several cancers, including lung. However, no comprehensive mapping analysis of chromosome 8p in lung cancer tumors has been performed, and no data are available about the stage at which these abnormalities occur during the multistage development of lung cancer. Using 26 microsatellite markers, we mapped the chromosome 8 regions frequently deleted in lung cancer in 13 small cell carcinoma and 17 non-small cell lung carcinoma cell lines and in 68 microdissected archival primary lung tumors (22 small cell lung carcinomas, 25 squamous cell carcinomas, and 21 adenocarcinomas). We also studied the role of 8p deletions in lung cancer pathogenesis by examining 95 microdissected normal epithelium and preneoplastic samples from 11 surgically resected squamous cell lung carcinomas and from 58 bronchoscopy biopsy samples obtained from 31 current and former smokers. High frequencies of deletions at 8p21-23 regions were detected in lung cancer cell lines and in primary lung tumors. Deletions commenced early during the multistage development of lung cancer at the hyperplasia/metaplasia stage in cancer patients and in smokers without cancer. Allelic deletions persisted for up to 48 years after smoking cessation. There was a progressive increase of the overall 8p21-23 loss of heterozygosity frequency and in the size of the deleted region with increasing severity of histopathological preneoplastic changes. In epithelial samples from resected squamous cell lung carcinomas, we compared the presence of loss of heterozygosity at 8p21-23 with deletions at chromosomes 3p and 9p. Of interest, the pattern of deletions was not random, and 8p21-23 allelic losses always followed 3p deletions and usually followed 9p deletions. We conclude that 8p21-23 deletions are frequent and early events in the pathogenesis of lung carcinomas.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2011

ObjectivesWe studied changes in mean gestational sac diameter (MSD) and embryonic crown–rump leng... more ObjectivesWe studied changes in mean gestational sac diameter (MSD) and embryonic crown–rump length (CRL) in intrauterine pregnancies of uncertain viability (IPUVs). We aimed to establish cut-off values for MSD and CRL growth that could be definitively associated with either viability or miscarriage, and to establish the relationship between growth in MSD and appearance of embryonic structures in the gestational sac.We studied changes in mean gestational sac diameter (MSD) and embryonic crown–rump length (CRL) in intrauterine pregnancies of uncertain viability (IPUVs). We aimed to establish cut-off values for MSD and CRL growth that could be definitively associated with either viability or miscarriage, and to establish the relationship between growth in MSD and appearance of embryonic structures in the gestational sac.MethodsOne thousand and sixty consecutive IPUVs were recruited prospectively from four London University hospitals: 462 with no yolk sac or embryo, 419 with a yolk sac...

European Journal of Neuroscience, 2007

Multisensory neurons in the dorsal cochlear nucleus (DCN) achieve their bimodal response properti... more Multisensory neurons in the dorsal cochlear nucleus (DCN) achieve their bimodal response properties [Shore (2005) Eur. J. Neurosci., 21, 3334–3348] by integrating auditory input via VIIIth nerve fibers with somatosensory input via the axons of cochlear nucleus granule cells [Shore et al. (2000) J. Comp. Neurol., 419, 271–285; Zhou & Shore (2004)J. Neurosci. Res., 78, 901–907]. A unique feature of multisensory neurons is their propensity for receiving cross-modal compensation following sensory deprivation. Thus, we investigated the possibility that reduction of VIIIth nerve input to the cochlear nucleus results in trigeminal system compensation for the loss of auditory inputs. Responses of DCN neurons to trigeminal and bimodal (trigeminal plus acoustic) stimulation were compared in normal and noise-damaged guinea pigs. The guinea pigs with noise-induced hearing loss had significantly lower thresholds, shorter latencies and durations, and increased amplitudes of response to trigeminal...

... Mark Claypool David Finkel Gangadharan Kannan Mikhail Mikhailov Computer Science Department W... more ... Mark Claypool David Finkel Gangadharan Kannan Mikhail Mikhailov Computer Science Department Worcester Polytechnic Institute {mikhail,ganga,claypool,dfinkel}@cs.wpi.edu Saqib Syed Yefim Somin Sujit Kumar BMC Software, Inc. ... NT Server 4.0 64 MB RAM IDE NTFS ...

Proceeding of 15th …, 2009

Developing a vision based, efficient and automatic lane detection system from a moving vehicle is... more Developing a vision based, efficient and automatic lane detection system from a moving vehicle is a challenging task mainly due to poor quality of lane markings, occlusion created by traffic, complex road geometry and nevertheless, the non-existence of unique models. The focus of this paper is to detect line or curve like segments from a video image taken from moving vehicle and merge them to detect road lane marks. In this work, we propose a method of applying weighted regression to fit a curve in place of traditional line grouping and fitting curve separately. The proposed vision based solution is simple but computationally efficient and hence works in real time on the image sequence captured by camera mounted in the vehicle.

ION National Technical Meeting, …, 2004

Salman Syed is an MSc candidate in Geomatics Engineering at the University of Calgary. He complet... more Salman Syed is an MSc candidate in Geomatics Engineering at the University of Calgary. He completed his BTech from the Indian Institute of Technology, Bombay with the specialization in Surveying/GPS. He is currently working on development of Map Matching algorithms ...

BMC Public …, 2007

The interface between research and policymaking in low-income countries is highly complex. The ab... more The interface between research and policymaking in low-income countries is highly complex. The ability of health systems research to influence policy processes in such settings face numerous challenges. Successful analysis of the research-policy interface in these ...

, ita-marrochesi-P-abs2-og15-poster CREAM (Cosmic Ray Energetics And Mass) is a multi-flight ball... more , ita-marrochesi-P-abs2-og15-poster CREAM (Cosmic Ray Energetics And Mass) is a multi-flight balloon mission designed to collect direct data on the elemental composition and individual energy spectra of cosmic rays. Two instrument suites have been built to be flown alternately on a yearly base. The tungsten/Sci-Fi imaging calorimeter for the second flight, scheduled for December 2005, was calibrated with electron and proton beams at CERN. A calibration procedure based on the study of the longitudinal shower profile is described and preliminary results of the beam test are presented.

Schizophrenia Research, 2006

… of Pharmacology and …, 2008

Introduction-695 Discussion-1025 ABBREVIATIONS: ACE, angiotensin converting enxyme; AngII, angiot... more Introduction-695 Discussion-1025 ABBREVIATIONS: ACE, angiotensin converting enxyme; AngII, angiotensin II; APC activated protein C; iNOS, inducible nitro oxide synthase; MIP, macrophage inflammatory protein; PAI-1, plasminogen activator inhibitor-1; PC, protein C; TARC, Thymus and activation-regulated chemokine Section-Inflammation, Immunopharmacology and Asthma This article has not been copyedited and formatted. The final version may differ from this version.

Journal of the …, 2009

Administration of activated protein C (APC) protects from renal dysfunction, but the underlying m... more Administration of activated protein C (APC) protects from renal dysfunction, but the underlying mechanism is unknown. APC exerts both antithrombotic and cytoprotective properties, the latter via modulation of protease-activated receptor-1 (PAR-1) signaling. We generated APC ...

Journal of the …, 2007

Protein C (PC) plays an important role in vascular function, and acquired deficiency during sepsi... more Protein C (PC) plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased mortality in both animal models and in clinical studies. This study explored the consequences of PC suppression on the kidney in a cecal ligation and ...

The Lancet, Jan 4, 2013

BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in t... more BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). METHODS: Of the 291 diseases and injuries in the GBD cause list, 289 cause ...

Unbiased interpretation of noisy single molecular motor recordings remains a challenging task. To... more Unbiased interpretation of noisy single molecular motor recordings remains a challenging task. To address this issue, we have developed robust algorithms based on hidden Markov models (HMMs) of motor proteins. The basic algorithm, called variable-stepsize HMM (VS-HMM), was introduced in the previous article. It improves on currently available Markovmodel based techniques by allowing for arbitrary distributions of step sizes, and shows excellent convergence properties for the characterization of staircase motor timecourses in the presence of large measurement noise. In this article, we extend the VS-HMM framework for better performance with experimental data. The extended algorithm, variable-stepsize integrating-detector HMM (VSI-HMM) better models the data-acquisition process, and accounts for random baseline drifts. Further, as an extension, maximum a posteriori estimation is provided. When used as a blind step detector, the VSI-HMM outperforms conventional step detectors. The fidelity of the VSI-HMM is tested with simulations and is applied to in vitro myosin V data where a small 10 nm population of steps is identified. It is also applied to an in vivo recording of melanosome motion, where strong evidence is found for repeated, bidirectional steps smaller than 8 nm in size, implying that multiple motors simultaneously carry the cargo.