Saba Annigeri - Academia.edu (original) (raw)

Papers by Saba Annigeri

IDCases, 2020

We describe a rare haematological complication of pulmonary thromboembolism in a scrub typhus inf... more We describe a rare haematological complication of pulmonary thromboembolism in a scrub typhus infection. There are very few case reports on scrub typhus infection causing deep venous thrombosis. Vasculitis and perivasculitis with endothelial dysfunction could be considered as the main pathologic mechanism causing this complication.

Journal of Tropical Pediatrics, Apr 1, 2021

Acute disseminated encephalomyelitis (ADEM) is a monophasic demyelinating disorder of central ner... more Acute disseminated encephalomyelitis (ADEM) is a monophasic demyelinating disorder of central nervous system occurring in children with a wide range of clinical manifestations after infection or vaccination. There are few case reports in literature, describing atypical presentations of ADEM with fever of unknown origin, autonomic dysfunction, complex movement disorders such as myoclonus, dystonia and chorea, acute psychosis and myocarditis. Here, we report four cases of ADEM with atypical features like uniocular blindness, myelin oligodendrocyte glycoprotein antibodies negative multiphasic disseminated encephalomyelitis, ADEM mimicking Guillain-Barre syndrome at presentation and isolated spinal ADEM. Treatment with high-dose steroids elicited an excellent neurological outcome in all patients. A high index of clinical suspicion along-with awareness of atypical features, magnetic resonance imaging and cerebrospinal fluid studies are of paramount importance in establishing ADEM diagnosis and initiation of early treatment for better outcome.

Journal of family medicine and primary care, 2022

Indian Journal of Critical Care Medicine

Introduction: The objective was to delineate the clinico-epidemiological characteristics of hospi... more Introduction: The objective was to delineate the clinico-epidemiological characteristics of hospitalized children with RSV-associated acute lower respiratory tract infection (RSV-ALRI) during its recent outbreak and to find out the independent predictors of PICU admission. Methodology: Children aged between 1 month and 12 years who tested positive for respiratory syncytial virus (RSV) were included. Multivariate analysis was performed to identify the independent predictors and predictive scores were developed from the β-coefficients. Receiver operating characteristic curve (ROC) was generated and the area under the curve (AUC) was calculated to assess the overall precision. The performance of sum scores in predicting PICU need, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive and negative likelihood ratios (LR + and LR −) were calculated for each cutoff value. Results: The proportion of RSV positivity was 72.58%. A total of 127 children were included with a median [interquartile range (IQR)] age of 6 (2-12) months, of whom 61.42% were males and 33.07% had underlying comorbidity. Tachypnoea, cough, rhinorrhea, and fever were predominant clinical presentations while hypoxia and extrapulmonary manifestations were present in 30.71% and 14.96% of children, respectively. About 30% required PICU admission, and 24.41% developed complications. Premature birth, age below 1 year, presence of underlying CHD, and hypoxia were independent predictors. The AUC [95% confidence interval (CI)] was 0.869 (0.843−0.935). Sum score below 4 had 97.3% sensitivity and 97.1% NPV whereas sum score above 6 had 98.9% specificity, 89.7% PPV, 81.3% NPV, 46.2 LR + , and 0.83 LR − to predict PICU needs. Conclusion: Awareness of these independent predictors and application of the novel scoring system will be beneficial for busy clinicians in planning the level of care needed, thereby optimizing PICU resource utilization.

Clinical Epidemiology and Global Health

Background: World Health Organization (WHO) declared vaccine-hesitancy (VH) as an emerging threat... more Background: World Health Organization (WHO) declared vaccine-hesitancy (VH) as an emerging threat to global health. There are limited studies from developing countries, especially from Eastern India, addressing parental VH's determinants and its impact on childhood immunization. Current study aims to assess the prevalence of incomplete immunization in children and parental VH, explore the socio-demographic determinants, and delineate their interconnections. Material and methods: In this hospital-based, cross-sectional study vaccination cards or parents' recall method were used to inquire about immunization status and the Likert-vaccine hesitancy scale (VHS) developed by WHO Strategic Advisory Group Experts on Immunization (SAGE) was utilized as an instrument to measure VH. Multivariate analyses were performed to identify the independent predictors. Results: The prevalence of incomplete immunization and VH were 18.9% and 41.6% respectively. Significant predictors of incomplete immunization were maternal education, socioeconomic status, gender, and place of delivery. Most responders believed vaccines are effective (99%), important for child's health (98%) and most vaccines offered by the government are beneficial (95%) but were also concerned about serious adverse effects (41%) and feared about new vaccines carrying more risk than old vaccines (16%). Maternal education and family type were significant determinants of VH. Incomplete immunization was significantly prevalent among children with vaccine-hesitant caregivers, though it was not found to be an independent predictor in multivariate analysis. Conclusions: This study emphasizes the magnitude of the issue of incomplete immunization, VH, and unravels its contributing factors which will help public-health care providers with a roadmap to prioritize resources and focus on preventable measures like health education, ensuring institutional births, and free health-service delivery expansion to increase immunization coverage. Caregivers' VH is a major roadblock to attaining better immunization coverage which can be tackled through proper counselling to improve their health literacy.

Journal of Family Medicine and Primary Care

$Research paper thumbnail of Low-dose steroid-induced bradyarrhythmias and treatment refractory hypokalaemia: a case report$

Cardiology in the Young, 2020

Corticosteroid therapy has become an important modality of treatment for diseases in which rapid ... more Corticosteroid therapy has become an important modality of treatment for diseases in which rapid control of immunoinflammatory processes is required. However, one of the serious, but less known adverse effect of this therapy is cardiac arrhythmias. This includes both tachyarrhythmias and bradyarrhythmias. Corticosteroid use may also be associated with electrolyte imbalances like hypokalaemia by its mineralocorticoid activity. Those side effects are mainly seen with high-dose intravenous methyl-prednisolone or oral pulse dose prednisolone therapy. Here we report our experience in a child with warm idiopathic autoimmune haemolytic anaemia who developed sinus bradyarrhythmias and treatment refractory hypokalaemia during low-dose steroid therapy with reduction in heart rate by 60% of baseline.

Diagnostic dilemma and Management challenges of Neonatal Lupus with Complete Congenital Heart Blo... more Diagnostic dilemma and Management challenges of Neonatal Lupus with Complete Congenital Heart Block in a resource poor set-up – A case report Arindam Ghosh1, Saba Annigeri1, Anupama Nair1 1 Department of Pediatrics, Midnapore Medical College and Hospital, Paschim Mednipur, West Bengal-721101, India *Corresponding Author: Dr. Saba Annigeri, Department of Pediatrics, Midnapore Medical College and Hospital, Paschim Mednipur, West Bengal-721101, India. Email: annigerisaba@gmail.com

ACTA MEDICA IRANICA, 2021

To capture lapses in management, active surveillance of pediatric intensive care unit (PICU) admi... more To capture lapses in management, active surveillance of pediatric intensive care unit (PICU) admissions should consider as an essential tool to bring a better outcome with available resources, while there is a scarcity of data from comparatively newly set up peripheral PICU in developing countries. An observational record-based cross-sectional study was conducted in a peripheral medical college PICU over one year to evaluate morbidity pattern, outcome, and predictors of mortality. Binomial logistic regression (SPSS version-25) was used for analysis. The confidence interval (CI) of Odd’s ratio was used to report the strength of association between dependent and independent variables. Pneumonia was the major cause of admission (27%), followed by septicemia (25.5%), congenital heart diseases (12.2%), bronchiolitis (6.6%), seizure disorders (8.6%), encephalitis (5%), and meningitis (4%). 51.7% were discharged, 14.6 %were referred, 3.2% were left against medical advice, and 30.4% were ex...

Journal of Tropical Pediatrics, 2021