Diane Sabo - Academia.edu (original) (raw)
Papers by Diane Sabo
International journal of clinical & experimental otolaryngology, May 26, 2015
Although IFNs have been successful as potent antivirals, immunomodulators and anticancer agents, ... more Although IFNs have been successful as potent antivirals, immunomodulators and anticancer agents, treatment with IFN carries significant risks [38]. Many side effects have been reported with IFN therapy, including flu-like symptoms, depression, autoimmune reactions [10], and some blood disorders [66]. In addition, there are a considerable number of studies that have reported
International Journal of Audiology, 2006
The validity and accuracy of the application of the auditory steady-state response (ASSR) to elec... more The validity and accuracy of the application of the auditory steady-state response (ASSR) to electric response audiometry (ERA) was tested further in a study permitting subjects to be their own controls for hearing loss. Simulated sensorineural hearing loss (SSHL) of complex configuration and varying degrees was effected using filtered masking noise. Thresholds estimated via ASSR-ERA were compared to those measured via conventional pure-tone audiometry. Further, the slow vertex potential N1-P2 was recorded to permit a comparison with an evoked-response test of common content validity and known accuracy. Results in a homogeneous subject sample demonstrated strong interest correlation and agreement within 10 dB at 1000 to 4000 Hz (on average), but not at 500 Hz. The configurations determined by ASSR-ERA followed behavioral audiometric patterns well, except for the mildest degree of SSHL tested. Consequently, limitations of ERA remain, although ASSR-ERA appears to be quite valid overall and promises (justifiably) broad clinical applicability.
Otolaryngology–Head and Neck Surgery, 2013
Background and Objectives Although serious complications of otitis media (OM) such as brain absce... more Background and Objectives Although serious complications of otitis media (OM) such as brain abscess are rare, sequelae of OM such as tympanic membrane perforation and atelectatic tympanic membrane are quite common. Inner ear sequelae can cause hearing loss and speech and language problems. The objectives of this article are to provide a state-of-the-art review on recent articles on complications and sequelae of OM in different anatomic locations, from the tympanic membrane to intracranial sites, as well as hearing loss and speech and language development. Data Sources Primarily PubMed supplemented by Ovid MEDLINE and the Cochrane Database. Review Methods All types of articles related to OM complications and sequelae published in English between January 2007 and June 2011 were identified. A total of 127 relevant quality articles are summarized and included in this report. Results Key findings are summarized based on the following major anatomic locations and categories: tympanic memb...
Apart from the common cold, otitis media is the most frequently diagnosed illness in a country li... more Apart from the common cold, otitis media is the most frequently diagnosed illness in a country like the United States with treatment by myringotomy and insertion of tympanoplasty tubes being the most frequent operation in children beyond the neonatal period 1,2 . The highest rate of occurrence is in the first two years of life and, in close agreement with several previous studies, a large-scale investigation by Paradise and colleagues 1 revealed that 48% of infants aged 6 months and 79% of infants aged 12 months and 91% of infants aged 24 months presented with at least one episode of otitis media with effusion (OME). This means that nine in every ten children at the age of two years have had at least one episode of OME which can be transient or can persist for several months. These figures may be even higher in a developing country like South Africa with large sections of disadvantaged communities since OME has been associated with poor socioeconomic circumstances. Until recently, g...
NASN School Nurse
The school nurse is the key figure in successful school screening programs. A student with uniden... more The school nurse is the key figure in successful school screening programs. A student with unidentified and unmet health care needs is unlikely to perform at their full potential, both academically and socially. The purpose of the article is to serve as a resource, providing guidance, strategies, and a discussion of available equipment to assist with successful screening programs.
Pediatrics, 2017
Congenital cytomegalovirus (cCMV) infection remains a leading cause of childhood hearing loss. Cu... more Congenital cytomegalovirus (cCMV) infection remains a leading cause of childhood hearing loss. Currently universal CMV screening at birth does not exist in the United States. An alternative approach could be testing infants who do not pass their newborn hearing screening (NHS) for cCMV. This study was undertaken to evaluate whether a targeted approach will identify infants with CMV-related sensorineural hearing loss (SNHL). Infants born at 7 US medical centers received NHS and were also screened for cCMV while in the newborn nursery. Infants who tested positive for CMV received further diagnostic audiologic evaluations to identify or confirm hearing loss. Between 2007 and 2012, 99 945 newborns were screened for both hearing impairment and cCMV. Overall, 7.0% of CMV-positive infants did not pass NHS compared with 0.9% of CMV-negative infants (P < .0001). Among the cCMV infants who failed NHS, diagnostic testing confirmed that 65% had SNHL. In addition, 3.6% of CMV-infected infants...
J Acoust Soc Amer, 2004
Otoacoustic emissions (OAEs) presumably represent active processes within the cochlea fundamental... more Otoacoustic emissions (OAEs) presumably represent active processes within the cochlea fundamental to frequency-selectivity in peripheral auditory function. Maturation of the cochlear amplifier, vis-a-vis frequency encoding or selectivity, has yet to be fully characterized in humans. The purpose of this study was to further investigate the maturation of features of the f2/f1 frequency ratio (Distortion Product OAE amplitude X f2/f1 ratio)
Perspectives on Hearing and Hearing Disorders in Childhood, 2001
Perspectives on Hearing and Hearing Disorders in Childhood, 1998
Perspectives on Hearing and Hearing Disorders in Childhood, 1997
Handbook of Clinical Neurophysiology, 2013
Trends in amplification, 1999
Otolaryngology - Head and Neck Surgery, 1995
The Annals of otology, rhinology & laryngology. Supplement
In an effort to establish the diagnostic value of otoscopy, tympanometry, and the middle ear (ME)... more In an effort to establish the diagnostic value of otoscopy, tympanometry, and the middle ear (ME) muscle reflex in the identification of otitis media with effusion (OME), the diagnostic findings by these three methods were compared with the findings at myringotomy in 333 children (500 ears). The study showed that even experienced clinicians had some difficulty in identifying those ears with effusion (sensitivity) and had even greater difficulty in making a diagnosis of those ears without an effusion (specificity). However, tympanometry, employing patterns that have been validated with myringotomy findings, was found to be more accurate. On the other hand, assessment of the ME muscle reflex as a diagnostic method was unacceptable due to an extremely low specificity (52%). An algorithm derived from the combination of the three methods had highest sensitivity (97%) and specificity (90%).
The New England journal of medicine, Jan 5, 2015
Background The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous... more Background The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 months, but the benefits wane over time. Methods We conducted a randomized, placebo-controlled trial of valganciclovir therapy in neonates with symptomatic congenital CMV disease, comparing 6 months of therapy with 6 weeks of therapy. The primary end point was the change in hearing in the better ear…
JAMA Otolaryngology–Head & Neck Surgery, 2013
To identify and describe the findings of children who passed their newborn hearing screen (NHS) a... more To identify and describe the findings of children who passed their newborn hearing screen (NHS) and were subsequently found to have childhood hearing loss. Setting: Academic tertiary care center. Design: Retrospective medical chart review. Methods: With approval of the institutional review board, hospital records were reviewed for children diagnosed as having hearing loss. We identified 923 children with hearing loss from 2001 to 2011. Patients who passed the NHS with subsequent hearing loss were included. Results: Seventy-eight patients were included in our study. The suspicion of hearing loss in patients who passed the NHS was most often from parental concerns (n=28 [36%]) and failed school hearing screens (n=25 [32%]). Speech and language delay and failed primary care physician screens accounted for 17% and 12%, respectively. Configuration of the audiogram was bilateral symmetric (n=42 [54%]), bilateral asymmetric (n=16 [21%]), and unilateral (n=20 [26%]) loss. Thirty-seven patients (47%) had severe or profound hearing loss. The etiology was unknown in 42 patients (54%); the remaining was attributed to genetics (n=13 [17%]), anatomic abnormality (n=11 [14%]), acquired perinatal (n=9 [12%]), and auditory neuropathy (n=3 [4%]). Conclusions: This is the largest study to characterize children with hearing loss who passed the NHS. In our review, parental concerns and school hearing screens were the most common method to diagnose hearing loss after passing the NHS. Families and primary care physicians may have a false sense of security when patients pass the NHS and overlook symptoms of hearing loss. This study raises the question whether further screens would identify hearing loss in children after passing the NHS.
International journal of clinical & experimental otolaryngology, May 26, 2015
Although IFNs have been successful as potent antivirals, immunomodulators and anticancer agents, ... more Although IFNs have been successful as potent antivirals, immunomodulators and anticancer agents, treatment with IFN carries significant risks [38]. Many side effects have been reported with IFN therapy, including flu-like symptoms, depression, autoimmune reactions [10], and some blood disorders [66]. In addition, there are a considerable number of studies that have reported
International Journal of Audiology, 2006
The validity and accuracy of the application of the auditory steady-state response (ASSR) to elec... more The validity and accuracy of the application of the auditory steady-state response (ASSR) to electric response audiometry (ERA) was tested further in a study permitting subjects to be their own controls for hearing loss. Simulated sensorineural hearing loss (SSHL) of complex configuration and varying degrees was effected using filtered masking noise. Thresholds estimated via ASSR-ERA were compared to those measured via conventional pure-tone audiometry. Further, the slow vertex potential N1-P2 was recorded to permit a comparison with an evoked-response test of common content validity and known accuracy. Results in a homogeneous subject sample demonstrated strong interest correlation and agreement within 10 dB at 1000 to 4000 Hz (on average), but not at 500 Hz. The configurations determined by ASSR-ERA followed behavioral audiometric patterns well, except for the mildest degree of SSHL tested. Consequently, limitations of ERA remain, although ASSR-ERA appears to be quite valid overall and promises (justifiably) broad clinical applicability.
Otolaryngology–Head and Neck Surgery, 2013
Background and Objectives Although serious complications of otitis media (OM) such as brain absce... more Background and Objectives Although serious complications of otitis media (OM) such as brain abscess are rare, sequelae of OM such as tympanic membrane perforation and atelectatic tympanic membrane are quite common. Inner ear sequelae can cause hearing loss and speech and language problems. The objectives of this article are to provide a state-of-the-art review on recent articles on complications and sequelae of OM in different anatomic locations, from the tympanic membrane to intracranial sites, as well as hearing loss and speech and language development. Data Sources Primarily PubMed supplemented by Ovid MEDLINE and the Cochrane Database. Review Methods All types of articles related to OM complications and sequelae published in English between January 2007 and June 2011 were identified. A total of 127 relevant quality articles are summarized and included in this report. Results Key findings are summarized based on the following major anatomic locations and categories: tympanic memb...
Apart from the common cold, otitis media is the most frequently diagnosed illness in a country li... more Apart from the common cold, otitis media is the most frequently diagnosed illness in a country like the United States with treatment by myringotomy and insertion of tympanoplasty tubes being the most frequent operation in children beyond the neonatal period 1,2 . The highest rate of occurrence is in the first two years of life and, in close agreement with several previous studies, a large-scale investigation by Paradise and colleagues 1 revealed that 48% of infants aged 6 months and 79% of infants aged 12 months and 91% of infants aged 24 months presented with at least one episode of otitis media with effusion (OME). This means that nine in every ten children at the age of two years have had at least one episode of OME which can be transient or can persist for several months. These figures may be even higher in a developing country like South Africa with large sections of disadvantaged communities since OME has been associated with poor socioeconomic circumstances. Until recently, g...
NASN School Nurse
The school nurse is the key figure in successful school screening programs. A student with uniden... more The school nurse is the key figure in successful school screening programs. A student with unidentified and unmet health care needs is unlikely to perform at their full potential, both academically and socially. The purpose of the article is to serve as a resource, providing guidance, strategies, and a discussion of available equipment to assist with successful screening programs.
Pediatrics, 2017
Congenital cytomegalovirus (cCMV) infection remains a leading cause of childhood hearing loss. Cu... more Congenital cytomegalovirus (cCMV) infection remains a leading cause of childhood hearing loss. Currently universal CMV screening at birth does not exist in the United States. An alternative approach could be testing infants who do not pass their newborn hearing screening (NHS) for cCMV. This study was undertaken to evaluate whether a targeted approach will identify infants with CMV-related sensorineural hearing loss (SNHL). Infants born at 7 US medical centers received NHS and were also screened for cCMV while in the newborn nursery. Infants who tested positive for CMV received further diagnostic audiologic evaluations to identify or confirm hearing loss. Between 2007 and 2012, 99 945 newborns were screened for both hearing impairment and cCMV. Overall, 7.0% of CMV-positive infants did not pass NHS compared with 0.9% of CMV-negative infants (P < .0001). Among the cCMV infants who failed NHS, diagnostic testing confirmed that 65% had SNHL. In addition, 3.6% of CMV-infected infants...
J Acoust Soc Amer, 2004
Otoacoustic emissions (OAEs) presumably represent active processes within the cochlea fundamental... more Otoacoustic emissions (OAEs) presumably represent active processes within the cochlea fundamental to frequency-selectivity in peripheral auditory function. Maturation of the cochlear amplifier, vis-a-vis frequency encoding or selectivity, has yet to be fully characterized in humans. The purpose of this study was to further investigate the maturation of features of the f2/f1 frequency ratio (Distortion Product OAE amplitude X f2/f1 ratio)
Perspectives on Hearing and Hearing Disorders in Childhood, 2001
Perspectives on Hearing and Hearing Disorders in Childhood, 1998
Perspectives on Hearing and Hearing Disorders in Childhood, 1997
Handbook of Clinical Neurophysiology, 2013
Trends in amplification, 1999
Otolaryngology - Head and Neck Surgery, 1995
The Annals of otology, rhinology & laryngology. Supplement
In an effort to establish the diagnostic value of otoscopy, tympanometry, and the middle ear (ME)... more In an effort to establish the diagnostic value of otoscopy, tympanometry, and the middle ear (ME) muscle reflex in the identification of otitis media with effusion (OME), the diagnostic findings by these three methods were compared with the findings at myringotomy in 333 children (500 ears). The study showed that even experienced clinicians had some difficulty in identifying those ears with effusion (sensitivity) and had even greater difficulty in making a diagnosis of those ears without an effusion (specificity). However, tympanometry, employing patterns that have been validated with myringotomy findings, was found to be more accurate. On the other hand, assessment of the ME muscle reflex as a diagnostic method was unacceptable due to an extremely low specificity (52%). An algorithm derived from the combination of the three methods had highest sensitivity (97%) and specificity (90%).
The New England journal of medicine, Jan 5, 2015
Background The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous... more Background The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 months, but the benefits wane over time. Methods We conducted a randomized, placebo-controlled trial of valganciclovir therapy in neonates with symptomatic congenital CMV disease, comparing 6 months of therapy with 6 weeks of therapy. The primary end point was the change in hearing in the better ear…
JAMA Otolaryngology–Head & Neck Surgery, 2013
To identify and describe the findings of children who passed their newborn hearing screen (NHS) a... more To identify and describe the findings of children who passed their newborn hearing screen (NHS) and were subsequently found to have childhood hearing loss. Setting: Academic tertiary care center. Design: Retrospective medical chart review. Methods: With approval of the institutional review board, hospital records were reviewed for children diagnosed as having hearing loss. We identified 923 children with hearing loss from 2001 to 2011. Patients who passed the NHS with subsequent hearing loss were included. Results: Seventy-eight patients were included in our study. The suspicion of hearing loss in patients who passed the NHS was most often from parental concerns (n=28 [36%]) and failed school hearing screens (n=25 [32%]). Speech and language delay and failed primary care physician screens accounted for 17% and 12%, respectively. Configuration of the audiogram was bilateral symmetric (n=42 [54%]), bilateral asymmetric (n=16 [21%]), and unilateral (n=20 [26%]) loss. Thirty-seven patients (47%) had severe or profound hearing loss. The etiology was unknown in 42 patients (54%); the remaining was attributed to genetics (n=13 [17%]), anatomic abnormality (n=11 [14%]), acquired perinatal (n=9 [12%]), and auditory neuropathy (n=3 [4%]). Conclusions: This is the largest study to characterize children with hearing loss who passed the NHS. In our review, parental concerns and school hearing screens were the most common method to diagnose hearing loss after passing the NHS. Families and primary care physicians may have a false sense of security when patients pass the NHS and overlook symptoms of hearing loss. This study raises the question whether further screens would identify hearing loss in children after passing the NHS.