Sadik Mohammed - Academia.edu (original) (raw)
Papers by Sadik Mohammed
Journal of anaesthesiology, clinical pharmacology
Physiological changes of pregnancy imposes higher risk of acute respiratory failure (ARF) with ev... more Physiological changes of pregnancy imposes higher risk of acute respiratory failure (ARF) with even a slight insult and remains an important cause of maternal and fetal morbidity and mortality. Although pregnant women have different respiratory physiology and different causes of ARF, guidelines specific to ventilatory settings, goals of oxygenation and weaning process could not be framed due to lack of large-scale randomized controlled trials. During the 2009 H1N1 pandemic, pregnant women had higher morbidity and mortality compared to nonpregnant women. During this period, alternative strategies of ventilation such as high-frequency oscillatory ventilation, inhalational of nitric oxide, prone positioning, and extra corporeal membrane oxygenation were increasingly used as a desperate measure to rescue pregnant patients with severe hypoxemia who were not improving with conventional mechanical ventilation. This article highlights the causes of ARF and recent advances in invasive, nonin...
Indian Journal of Anaesthesia, 2016
Dexamethasone has a powerful anti-inflammatory action with significant analgesic benefits. The ai... more Dexamethasone has a powerful anti-inflammatory action with significant analgesic benefits. The aim of this study was to compare the efficacy of dexamethasone administered through intravenous (IV) and caudal route on post-operative analgesia in paediatric inguinal herniotomy patients. One hundred and five paediatric patients undergoing inguinal herniotomy were included and divided into three groups. Each patient received a single caudal dose of ropivacaine 0.15%, 1.5 mL/kg combined with either corresponding volume of normal saline (Group 1) or caudal dexamethasone 0.1 mg/kg (Group 2) or IV dexamethasone 0.5 mg/kg (Group 3). Baseline, intra- and post-operative haemodynamic parameters, pain scores, time to rescue analgesia, total analgesic consumption and adverse effects were evaluated for 24 h after surgery. Unpaired Student's t-test and analysis of variance were applied for quantitative data and Chi-square test for qualitative data. Time to first analgesic administration was analysed by Kaplan-Meier survival analysis and log-rank test. Duration of analgesia was significantly longer (P < 0.001), and total consumption of analgesics was significantly lower (P < 0.001) in Group II and III compared to Group I. The incidence of nausea and vomiting was higher in Group I (31.4%) compared to Group II and III (8.6%). Addition of dexamethasone both caudally or intravenously as an adjuvant to caudal 0.15% ropivacaine significantly reduced the intensity of post-operative pain and prolonged the duration of post-operative analgesia with the significant advantage of caudal over IV route.
Journal of Anaesthesiology Clinical Pharmacology, 2015
Journal of anaesthesiology, clinical pharmacology
Physiological changes of pregnancy imposes higher risk of acute respiratory failure (ARF) with ev... more Physiological changes of pregnancy imposes higher risk of acute respiratory failure (ARF) with even a slight insult and remains an important cause of maternal and fetal morbidity and mortality. Although pregnant women have different respiratory physiology and different causes of ARF, guidelines specific to ventilatory settings, goals of oxygenation and weaning process could not be framed due to lack of large-scale randomized controlled trials. During the 2009 H1N1 pandemic, pregnant women had higher morbidity and mortality compared to nonpregnant women. During this period, alternative strategies of ventilation such as high-frequency oscillatory ventilation, inhalational of nitric oxide, prone positioning, and extra corporeal membrane oxygenation were increasingly used as a desperate measure to rescue pregnant patients with severe hypoxemia who were not improving with conventional mechanical ventilation. This article highlights the causes of ARF and recent advances in invasive, nonin...
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2016
Indian Journal of Anaesthesia, 2016
The American Journal of Emergency Medicine, 2016
Indian Journal of Anaesthesia, 2016
Dexamethasone has a powerful anti-inflammatory action with significant analgesic benefits. The ai... more Dexamethasone has a powerful anti-inflammatory action with significant analgesic benefits. The aim of this study was to compare the efficacy of dexamethasone administered through intravenous (IV) and caudal route on post-operative analgesia in paediatric inguinal herniotomy patients. One hundred and five paediatric patients undergoing inguinal herniotomy were included and divided into three groups. Each patient received a single caudal dose of ropivacaine 0.15%, 1.5 mL/kg combined with either corresponding volume of normal saline (Group 1) or caudal dexamethasone 0.1 mg/kg (Group 2) or IV dexamethasone 0.5 mg/kg (Group 3). Baseline, intra- and post-operative haemodynamic parameters, pain scores, time to rescue analgesia, total analgesic consumption and adverse effects were evaluated for 24 h after surgery. Unpaired Student's t-test and analysis of variance were applied for quantitative data and Chi-square test for qualitative data. Time to first analgesic administration was analysed by Kaplan-Meier survival analysis and log-rank test. Duration of analgesia was significantly longer (P < 0.001), and total consumption of analgesics was significantly lower (P < 0.001) in Group II and III compared to Group I. The incidence of nausea and vomiting was higher in Group I (31.4%) compared to Group II and III (8.6%). Addition of dexamethasone both caudally or intravenously as an adjuvant to caudal 0.15% ropivacaine significantly reduced the intensity of post-operative pain and prolonged the duration of post-operative analgesia with the significant advantage of caudal over IV route.
Accelerated hypertension following therapeutic arterial embolization is a rare phenomenon. A pati... more Accelerated hypertension following therapeutic arterial embolization is a rare phenomenon. A patient of left upper limb chronic lymphedema was posted for shoulder disarticulation under general anaesthesia. Coil embolization of the left subclavian artery was done prior to surgery. Following the intervention, patient's blood pressure increased by more than 30% of the base line value and was managed with antihypertensives for the next 3 hours to get the blood pressure optimised prior to taking the patient for surgery.
The Indian Anaesthetists Forum, 2016
The Indian Anaesthetists Forum, Jun 21, 2013
Saudi Journal of Anaesthesia, 2016
Caudal analgesia is a reliable and an easy method to provide intraoperative and postoperative ana... more Caudal analgesia is a reliable and an easy method to provide intraoperative and postoperative analgesia for infraumbilical surgeries in pediatric population but with the disadvantage of short duration of action after single injection. Many additives were used in combination with local anesthetics in the caudal block to prolong the postoperative analgesia. We compared the analgesic effects and side effects of dexmedetomidine added to ropivacaine in pediatric patients undergoing lower abdominal surgeries. Double-blinded randomized controlled trial. Sixty patients (2-10 years) were evenly and randomly assigned into two groups in a double-blinded manner. After sevoflurane in oxygen anesthesia, each patient received a single caudal dose of ropivacaine 0.25% (1 ml/kg) combined with either dexmedetomidine 2 μg/kg in normal saline 0.5 ml, or corresponding volume of normal saline according to group assignment. Hemodynamic variables, end-tidal sevoflurane, and emergence time were monitored. Postoperative analgesia, requirement of additional analgesic, sedation, and side effects were assessed during the first 24 h. The duration of postoperative analgesia was significantly longer (P = 0.001) and total consumption of rescue analgesic was significantly lower in Group RD compared with Group R (P < 0.05). Group RD have better quality of sleep and prolonged duration of sedation (P = 0.001). No significant difference was observed in the incidence of hemodynamic changes or side effects. Addition of dexmedetomidine to caudal ropivacaine significantly prolongs analgesia in children undergoing lower abdominal surgeries without an increase in the incidence of side effects.
The Indian Anaesthetists Forum, May 24, 2014
Journal of Anaesthesiology Clinical Pharmacology, 2015
Indian Journal of Anaesthesia, 2015
Indian Journal of Clinical Anaesthesia, 2015
Various adjuvants like opioids, alpha-2 agonists, steroids and many more drugs have been mixed wi... more Various adjuvants like opioids, alpha-2 agonists, steroids and many more drugs have been mixed with local anaesthetic (LA) solutions for Intravenous Regional Anaesthesia (IVRA). These drugs are added with the aim of hastening the onset of action and prolonging the duration of analgesia. They may also allow for a reduction in the total dose of LA used and related side effects. In this article, we have reviewed clinical trials using nitroglycerine (NTG) as an adjuvant to LA in IVRA and have summarized the advantages, disadvantages and current role of this drug. To the best of our knowledge, no meta-analysis, or review article has analysed the role of NTG as an adjuvant to Bier’s block.
Background: The LMA CTrach TM system is a new device for airway management and endotracheal intub... more Background: The LMA CTrach TM system is a new device for airway management and endotracheal intubation under direct vision in both anticipated and unexpected difficult intubation situations. This randomized controlled study was undertaken to compare the hemodynamic effects, ease of intubation, time taken for intubation, upper airway morbidity following tracheal intubation through LMA CTrach TM with that of conventional Macintosh laryngoscope. Material and Method: Eighty adult patients of age 16-72 years and ASA I and ASA II grade scheduled to undergo elective surgery under GA were randomly allocated to one of the group i.e. Group A: LMA CTrach TM (Laryngeal Mask Airway CTrach TM) and Group B: DLS (Direct Laryngoscopy). The patients were intubated orally using either equipment after induction of general anaesthesia. Results: In both the groups, there was a significant increase in heart rate and blood pressure from base line values after tracheal intubation. The rise in heart rate and...
Central venous cannulation is routinely carried out by anaesthesiologist in ICU as well as OR set... more Central venous cannulation is routinely carried out by anaesthesiologist in ICU as well as OR setup. Definitely it requires expertise for proper placement of a CVC, but malposition of a CVC inserted by blind technique is not rare.
Gestational Trophoblastic Disease (GTD) is a spectrum of tumours with a wide range of biologic be... more Gestational Trophoblastic Disease (GTD) is a spectrum of tumours with a wide range of biologic behaviour and potential for metastases, which were often fatal in the past. However, with better understanding of patho-physiology in the last few years, most women can now be cured. A Hydatidiform Mole (or Molar Pregnancy) is a benign Gestational Trophoblastic Disease that originates from the placenta. Treatment consists of vacuum evacuation but rarely hysterectomy may be required. Anaesthetic management is often complicated by the associated systemic derangements.
Egyptian Journal of Anaesthesia, 2014
Laryngo-tracheal injuries resulting from blunt trauma neck are fortunately rare, but may have dir... more Laryngo-tracheal injuries resulting from blunt trauma neck are fortunately rare, but may have dire consequences. A high index of suspicion is required to make the diagnosis. Here we report a case of airway management of a patient with blunt trauma neck with tracheal tear posted for tracheal tear repair under GA. Tracheostomy, FOB guided intubation and direct laryngoscopy are the standard methods used to secure the airway in these patients, but sometimes they may aggravate the underlying injury. Technique of choice depends upon patient's condition, urgency, and experience of anesthesiologist and surgeon.
Journal of anaesthesiology, clinical pharmacology
Physiological changes of pregnancy imposes higher risk of acute respiratory failure (ARF) with ev... more Physiological changes of pregnancy imposes higher risk of acute respiratory failure (ARF) with even a slight insult and remains an important cause of maternal and fetal morbidity and mortality. Although pregnant women have different respiratory physiology and different causes of ARF, guidelines specific to ventilatory settings, goals of oxygenation and weaning process could not be framed due to lack of large-scale randomized controlled trials. During the 2009 H1N1 pandemic, pregnant women had higher morbidity and mortality compared to nonpregnant women. During this period, alternative strategies of ventilation such as high-frequency oscillatory ventilation, inhalational of nitric oxide, prone positioning, and extra corporeal membrane oxygenation were increasingly used as a desperate measure to rescue pregnant patients with severe hypoxemia who were not improving with conventional mechanical ventilation. This article highlights the causes of ARF and recent advances in invasive, nonin...
Indian Journal of Anaesthesia, 2016
Dexamethasone has a powerful anti-inflammatory action with significant analgesic benefits. The ai... more Dexamethasone has a powerful anti-inflammatory action with significant analgesic benefits. The aim of this study was to compare the efficacy of dexamethasone administered through intravenous (IV) and caudal route on post-operative analgesia in paediatric inguinal herniotomy patients. One hundred and five paediatric patients undergoing inguinal herniotomy were included and divided into three groups. Each patient received a single caudal dose of ropivacaine 0.15%, 1.5 mL/kg combined with either corresponding volume of normal saline (Group 1) or caudal dexamethasone 0.1 mg/kg (Group 2) or IV dexamethasone 0.5 mg/kg (Group 3). Baseline, intra- and post-operative haemodynamic parameters, pain scores, time to rescue analgesia, total analgesic consumption and adverse effects were evaluated for 24 h after surgery. Unpaired Student's t-test and analysis of variance were applied for quantitative data and Chi-square test for qualitative data. Time to first analgesic administration was analysed by Kaplan-Meier survival analysis and log-rank test. Duration of analgesia was significantly longer (P < 0.001), and total consumption of analgesics was significantly lower (P < 0.001) in Group II and III compared to Group I. The incidence of nausea and vomiting was higher in Group I (31.4%) compared to Group II and III (8.6%). Addition of dexamethasone both caudally or intravenously as an adjuvant to caudal 0.15% ropivacaine significantly reduced the intensity of post-operative pain and prolonged the duration of post-operative analgesia with the significant advantage of caudal over IV route.
Journal of Anaesthesiology Clinical Pharmacology, 2015
Journal of anaesthesiology, clinical pharmacology
Physiological changes of pregnancy imposes higher risk of acute respiratory failure (ARF) with ev... more Physiological changes of pregnancy imposes higher risk of acute respiratory failure (ARF) with even a slight insult and remains an important cause of maternal and fetal morbidity and mortality. Although pregnant women have different respiratory physiology and different causes of ARF, guidelines specific to ventilatory settings, goals of oxygenation and weaning process could not be framed due to lack of large-scale randomized controlled trials. During the 2009 H1N1 pandemic, pregnant women had higher morbidity and mortality compared to nonpregnant women. During this period, alternative strategies of ventilation such as high-frequency oscillatory ventilation, inhalational of nitric oxide, prone positioning, and extra corporeal membrane oxygenation were increasingly used as a desperate measure to rescue pregnant patients with severe hypoxemia who were not improving with conventional mechanical ventilation. This article highlights the causes of ARF and recent advances in invasive, nonin...
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2016
Indian Journal of Anaesthesia, 2016
The American Journal of Emergency Medicine, 2016
Indian Journal of Anaesthesia, 2016
Dexamethasone has a powerful anti-inflammatory action with significant analgesic benefits. The ai... more Dexamethasone has a powerful anti-inflammatory action with significant analgesic benefits. The aim of this study was to compare the efficacy of dexamethasone administered through intravenous (IV) and caudal route on post-operative analgesia in paediatric inguinal herniotomy patients. One hundred and five paediatric patients undergoing inguinal herniotomy were included and divided into three groups. Each patient received a single caudal dose of ropivacaine 0.15%, 1.5 mL/kg combined with either corresponding volume of normal saline (Group 1) or caudal dexamethasone 0.1 mg/kg (Group 2) or IV dexamethasone 0.5 mg/kg (Group 3). Baseline, intra- and post-operative haemodynamic parameters, pain scores, time to rescue analgesia, total analgesic consumption and adverse effects were evaluated for 24 h after surgery. Unpaired Student's t-test and analysis of variance were applied for quantitative data and Chi-square test for qualitative data. Time to first analgesic administration was analysed by Kaplan-Meier survival analysis and log-rank test. Duration of analgesia was significantly longer (P < 0.001), and total consumption of analgesics was significantly lower (P < 0.001) in Group II and III compared to Group I. The incidence of nausea and vomiting was higher in Group I (31.4%) compared to Group II and III (8.6%). Addition of dexamethasone both caudally or intravenously as an adjuvant to caudal 0.15% ropivacaine significantly reduced the intensity of post-operative pain and prolonged the duration of post-operative analgesia with the significant advantage of caudal over IV route.
Accelerated hypertension following therapeutic arterial embolization is a rare phenomenon. A pati... more Accelerated hypertension following therapeutic arterial embolization is a rare phenomenon. A patient of left upper limb chronic lymphedema was posted for shoulder disarticulation under general anaesthesia. Coil embolization of the left subclavian artery was done prior to surgery. Following the intervention, patient's blood pressure increased by more than 30% of the base line value and was managed with antihypertensives for the next 3 hours to get the blood pressure optimised prior to taking the patient for surgery.
The Indian Anaesthetists Forum, 2016
The Indian Anaesthetists Forum, Jun 21, 2013
Saudi Journal of Anaesthesia, 2016
Caudal analgesia is a reliable and an easy method to provide intraoperative and postoperative ana... more Caudal analgesia is a reliable and an easy method to provide intraoperative and postoperative analgesia for infraumbilical surgeries in pediatric population but with the disadvantage of short duration of action after single injection. Many additives were used in combination with local anesthetics in the caudal block to prolong the postoperative analgesia. We compared the analgesic effects and side effects of dexmedetomidine added to ropivacaine in pediatric patients undergoing lower abdominal surgeries. Double-blinded randomized controlled trial. Sixty patients (2-10 years) were evenly and randomly assigned into two groups in a double-blinded manner. After sevoflurane in oxygen anesthesia, each patient received a single caudal dose of ropivacaine 0.25% (1 ml/kg) combined with either dexmedetomidine 2 μg/kg in normal saline 0.5 ml, or corresponding volume of normal saline according to group assignment. Hemodynamic variables, end-tidal sevoflurane, and emergence time were monitored. Postoperative analgesia, requirement of additional analgesic, sedation, and side effects were assessed during the first 24 h. The duration of postoperative analgesia was significantly longer (P = 0.001) and total consumption of rescue analgesic was significantly lower in Group RD compared with Group R (P < 0.05). Group RD have better quality of sleep and prolonged duration of sedation (P = 0.001). No significant difference was observed in the incidence of hemodynamic changes or side effects. Addition of dexmedetomidine to caudal ropivacaine significantly prolongs analgesia in children undergoing lower abdominal surgeries without an increase in the incidence of side effects.
The Indian Anaesthetists Forum, May 24, 2014
Journal of Anaesthesiology Clinical Pharmacology, 2015
Indian Journal of Anaesthesia, 2015
Indian Journal of Clinical Anaesthesia, 2015
Various adjuvants like opioids, alpha-2 agonists, steroids and many more drugs have been mixed wi... more Various adjuvants like opioids, alpha-2 agonists, steroids and many more drugs have been mixed with local anaesthetic (LA) solutions for Intravenous Regional Anaesthesia (IVRA). These drugs are added with the aim of hastening the onset of action and prolonging the duration of analgesia. They may also allow for a reduction in the total dose of LA used and related side effects. In this article, we have reviewed clinical trials using nitroglycerine (NTG) as an adjuvant to LA in IVRA and have summarized the advantages, disadvantages and current role of this drug. To the best of our knowledge, no meta-analysis, or review article has analysed the role of NTG as an adjuvant to Bier’s block.
Background: The LMA CTrach TM system is a new device for airway management and endotracheal intub... more Background: The LMA CTrach TM system is a new device for airway management and endotracheal intubation under direct vision in both anticipated and unexpected difficult intubation situations. This randomized controlled study was undertaken to compare the hemodynamic effects, ease of intubation, time taken for intubation, upper airway morbidity following tracheal intubation through LMA CTrach TM with that of conventional Macintosh laryngoscope. Material and Method: Eighty adult patients of age 16-72 years and ASA I and ASA II grade scheduled to undergo elective surgery under GA were randomly allocated to one of the group i.e. Group A: LMA CTrach TM (Laryngeal Mask Airway CTrach TM) and Group B: DLS (Direct Laryngoscopy). The patients were intubated orally using either equipment after induction of general anaesthesia. Results: In both the groups, there was a significant increase in heart rate and blood pressure from base line values after tracheal intubation. The rise in heart rate and...
Central venous cannulation is routinely carried out by anaesthesiologist in ICU as well as OR set... more Central venous cannulation is routinely carried out by anaesthesiologist in ICU as well as OR setup. Definitely it requires expertise for proper placement of a CVC, but malposition of a CVC inserted by blind technique is not rare.
Gestational Trophoblastic Disease (GTD) is a spectrum of tumours with a wide range of biologic be... more Gestational Trophoblastic Disease (GTD) is a spectrum of tumours with a wide range of biologic behaviour and potential for metastases, which were often fatal in the past. However, with better understanding of patho-physiology in the last few years, most women can now be cured. A Hydatidiform Mole (or Molar Pregnancy) is a benign Gestational Trophoblastic Disease that originates from the placenta. Treatment consists of vacuum evacuation but rarely hysterectomy may be required. Anaesthetic management is often complicated by the associated systemic derangements.
Egyptian Journal of Anaesthesia, 2014
Laryngo-tracheal injuries resulting from blunt trauma neck are fortunately rare, but may have dir... more Laryngo-tracheal injuries resulting from blunt trauma neck are fortunately rare, but may have dire consequences. A high index of suspicion is required to make the diagnosis. Here we report a case of airway management of a patient with blunt trauma neck with tracheal tear posted for tracheal tear repair under GA. Tracheostomy, FOB guided intubation and direct laryngoscopy are the standard methods used to secure the airway in these patients, but sometimes they may aggravate the underlying injury. Technique of choice depends upon patient's condition, urgency, and experience of anesthesiologist and surgeon.