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Papers by Saeid Maghsoudi
Chemical Biology & Drug Design
Application of materials capable of energy harvesting to increase the efficiency and environmenta... more Application of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer‐aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development of unprecedented drugs. The expensive and time‐consuming process of traditional drug discovery is no longer feasible, for nowadays the identification of potential drug candidates is much easier for therapeutic targets through elaborate in silico approaches, allowing the prediction of the toxicity of drugs, such as drug repositioning (DR) and chemical genomics (chemogenomics). Coronaviruses (CoVs) are cross‐species viruses that are able to spread expeditiously from the into new host species, which in turn cause epidemic diseases. In this sense, this revi...
Critical Reviews in Food Science and Nutrition, 2021
The therapeutic effects of carotenoids as dietary supplements to control or even treat some speci... more The therapeutic effects of carotenoids as dietary supplements to control or even treat some specific diseases including diabetic retinopathy, cardiovascular diseases, bacterial infections, as well as breast, prostate, and skin cancer are discussed in this review and also thoughts on future research for their widespread use are emphasized. From the stability standpoint, carotenoids have low bioavailability and bioaccessibility owing to their poor water solubility, deterioration in the presence of environmental stresses such as oxygen, light, and high heat as well as rapid degradation during digestion. Nanoencapsulation technologies as wall or encapsulation materials have been increasingly used for improving food product functionality. Nanoencapsulation is a versatile process employed for the protection, entrapment, and the delivery of food bioactive products including carotenoids from diverse environmental conditions for extended shelf lives and for providing controlled release. Therefore, we present here, recent (mostly during the last five years) nanoencapsulation methods of carotenoids with various nanocarriers. To us, this review can be considered as the first highlighting not only the potential therapeutic effects of carotenoids on various diseases but also their most effective nanodelivery systems. Highlights Bioactive compounds are of deep interest to improve food properties. Carotenoids (such as β-carotene and xanthophylls) play indispensable roles in maintaining human health and well-being. A substantial research effort has been carried out on developing beneficial nanodelivery systems for various carotenoids. Nanoencapsulation of carotenoids can enhance their functional properties. Stable nanoencapsulated carotenoids could be utilized in food products.
International Journal of Nanomedicine, 2020
With continual rapid developments in the biomedical field and understanding of the important mech... more With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.
Coordination Chemistry Reviews, 2020
Since the emergence of mechanical bonds, considerable research efforts have been devoted to the c... more Since the emergence of mechanical bonds, considerable research efforts have been devoted to the construction of mechanically interlocked molecules (MIMs), including rotaxanes, catenanes, and molecular knots, due to their mechanically bonded components that can undergo molecular motions and create distinguishing features. They have demonstrated valuable functions in many areas of science such as polymer and materials science, nanotechnology and medicine. Furthermore, since MIMs are magnificently suited for constructing artificial molecular machines (AMMs), immense attention has currently been attracted to this area. Recent elaborate synthetic strategies accompanied by novel analytical characterization techniques have led to a number of elegant catenanes and rotaxanes for various applications. The challenge now is to make more and more sophisticated compounds and novel architectures in higher yields. Here, we provide a ''state-of-the-art" overview of research involving advances in MIMs synthesis, the newest architectures and their applications since the announcement of the 2016 Nobel Prize in Chemistry and the increasing interest in research into this field. The present review is designed to cover most of the recent studies in the synthesis of catenanes and rotaxanes depicting novel synthetic procedures to generate unprecedented MIMs with diverse properties that have not been mentioned en bloc in any reviews before.
Biomedical Applications of Microfluidic Devices, 2021
Abstract In the timeline of the 21st century, developing a new area of science is an urgent need ... more Abstract In the timeline of the 21st century, developing a new area of science is an urgent need which should be considered for addressing some insurmountable dilemmas. A judicious choice could be an innovative technology that can embrace such important issues in the life sciences. But, which technology can break these barriers? In this chapter, we focused on different aspects of microfluidic devices, from their concept towards their biomedical applications, and discussed in-depth.
Chemical Biology & Drug Design
Application of materials capable of energy harvesting to increase the efficiency and environmenta... more Application of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer‐aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development of unprecedented drugs. The expensive and time‐consuming process of traditional drug discovery is no longer feasible, for nowadays the identification of potential drug candidates is much easier for therapeutic targets through elaborate in silico approaches, allowing the prediction of the toxicity of drugs, such as drug repositioning (DR) and chemical genomics (chemogenomics). Coronaviruses (CoVs) are cross‐species viruses that are able to spread expeditiously from the into new host species, which in turn cause epidemic diseases. In this sense, this revi...
Critical Reviews in Food Science and Nutrition, 2021
The therapeutic effects of carotenoids as dietary supplements to control or even treat some speci... more The therapeutic effects of carotenoids as dietary supplements to control or even treat some specific diseases including diabetic retinopathy, cardiovascular diseases, bacterial infections, as well as breast, prostate, and skin cancer are discussed in this review and also thoughts on future research for their widespread use are emphasized. From the stability standpoint, carotenoids have low bioavailability and bioaccessibility owing to their poor water solubility, deterioration in the presence of environmental stresses such as oxygen, light, and high heat as well as rapid degradation during digestion. Nanoencapsulation technologies as wall or encapsulation materials have been increasingly used for improving food product functionality. Nanoencapsulation is a versatile process employed for the protection, entrapment, and the delivery of food bioactive products including carotenoids from diverse environmental conditions for extended shelf lives and for providing controlled release. Therefore, we present here, recent (mostly during the last five years) nanoencapsulation methods of carotenoids with various nanocarriers. To us, this review can be considered as the first highlighting not only the potential therapeutic effects of carotenoids on various diseases but also their most effective nanodelivery systems. Highlights Bioactive compounds are of deep interest to improve food properties. Carotenoids (such as β-carotene and xanthophylls) play indispensable roles in maintaining human health and well-being. A substantial research effort has been carried out on developing beneficial nanodelivery systems for various carotenoids. Nanoencapsulation of carotenoids can enhance their functional properties. Stable nanoencapsulated carotenoids could be utilized in food products.
International Journal of Nanomedicine, 2020
With continual rapid developments in the biomedical field and understanding of the important mech... more With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.
Coordination Chemistry Reviews, 2020
Since the emergence of mechanical bonds, considerable research efforts have been devoted to the c... more Since the emergence of mechanical bonds, considerable research efforts have been devoted to the construction of mechanically interlocked molecules (MIMs), including rotaxanes, catenanes, and molecular knots, due to their mechanically bonded components that can undergo molecular motions and create distinguishing features. They have demonstrated valuable functions in many areas of science such as polymer and materials science, nanotechnology and medicine. Furthermore, since MIMs are magnificently suited for constructing artificial molecular machines (AMMs), immense attention has currently been attracted to this area. Recent elaborate synthetic strategies accompanied by novel analytical characterization techniques have led to a number of elegant catenanes and rotaxanes for various applications. The challenge now is to make more and more sophisticated compounds and novel architectures in higher yields. Here, we provide a ''state-of-the-art" overview of research involving advances in MIMs synthesis, the newest architectures and their applications since the announcement of the 2016 Nobel Prize in Chemistry and the increasing interest in research into this field. The present review is designed to cover most of the recent studies in the synthesis of catenanes and rotaxanes depicting novel synthetic procedures to generate unprecedented MIMs with diverse properties that have not been mentioned en bloc in any reviews before.
Biomedical Applications of Microfluidic Devices, 2021
Abstract In the timeline of the 21st century, developing a new area of science is an urgent need ... more Abstract In the timeline of the 21st century, developing a new area of science is an urgent need which should be considered for addressing some insurmountable dilemmas. A judicious choice could be an innovative technology that can embrace such important issues in the life sciences. But, which technology can break these barriers? In this chapter, we focused on different aspects of microfluidic devices, from their concept towards their biomedical applications, and discussed in-depth.