Sahar Razmjou - Academia.edu (original) (raw)

Papers by Sahar Razmjou

Research paper thumbnail of Menopause Transition and Postmenopausal Period: Relationship with Inflammatory Markers, Physical Activity Energy Expenditure and Bone Mineral Density in Healthy Women

Menopause transition is usually associated with changes in body composition and a decrease in phy... more Menopause transition is usually associated with changes in body composition and a decrease in physical activity energy expenditure. Adipose tissue, especially visceral fat, is an important source of inflammatory markers, which contributes to the development of a pro-inflammatory state. Conversely, high levels of physical activity and exercise have an anti-inflammatory effect. One-hundred and two healthy premenopausal women participated in a 5-year longitudinal observational study (MONET: Montreal Ottawa New Emerging Team). The present secondary analyses were performed on 58 participants between the ages of 47 and 54 years with a full set of data.The aim of study was to investigate the impact of menopause transition and physical activity on inflammatory makers. The major finding of the first of 3 studies was that menopausal transition is accompanied by an increase in inflammatory markers, namely ferritin, IL-8, and sTNFR 1 and 2. The increase in IL-8 and sTNFR2 with menopause could b...

Research paper thumbnail of Effect of Physical Activity and Menopause Transition on Inflammatory Markers

Medicine & Science in Sports & Exercise, 2014

Use of embrocation oil significantly improved time to exhaustion. The average heart rate differen... more Use of embrocation oil significantly improved time to exhaustion. The average heart rate difference between the oil and non-oil groups was negligible, suggesting the physiological mechanism may be unrelated to the cardiovascular system. The physiological mechanisms for improvement by use of embrocation oil warrant further investigation.

Research paper thumbnail of Body composition, cardiometabolic risk factors, physical activity, and inflammatory markers in premenopausal women after a 10-year follow-up: a MONET study

Menopause, 2017

Objective: Menopausal transition and postmenopause are usually associated with changes in body co... more Objective: Menopausal transition and postmenopause are usually associated with changes in body composition and a decrease in physical activity energy expenditure (PAEE). This study investigated body composition, cardiometabolic risk factors, PAEE, and inflammatory markers in premenopausal women after a 10-year follow-up. Methods: In all, 102 premenopausal women participated in the 5-year observational longitudinal Montreal Ottawa New Emerging Team (MONET) study. This present substudy included 48 participants (age: 60.0 AE 1.7 years; body mass index: 23.2 AE 2.2 kg/m 2) 6.0 AE 0.3 years after completion of the initial MONET study. Measures included body composition, waist circumference (WC), fasting glucose and insulin levels, insulin sensitivity (QUICKI model), plasma lipid levels, PAEE, and inflammatory markers. Results: Compared with baseline measures of the MONET study, analyses revealed no significant increase in body weight, although there were significant increases in WC, fat mass (FM), % FM, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, haptoglobin, apolipoprotein B, ferritin, adiponectin, and soluble cluster of differentiation 14 (all P < 0.001) after the 10-year follow-up. However, significant decreases were observed for fat-free mass, PAEE, fasting glucose levels, interleukin-8 levels, and soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2) levels (all P < 0.05). To determine the effect of postmenopausal years, data were restructured based on final menstrual period (FMP), and one-way analyses of variance were performed. Waist circumference, % FM, total cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, ferritin, adiponectin, and soluble cluster of differentiation 14 were higher in early and late postmenopausal periods in these women. sTNFR-1 and sTNFR-2 levels were higher at the FMP and early postmenopausal years as compared with the late postmenopausal periods. Finally, interleukin-8 levels were lower in years after FMP. Conclusion: The number of years elapsed since the FMP can affect body composition, cardiometabolic risk factors, and inflammatory markers in healthy premenopausal women going through menopausal transition and postmenopausal periods.

Research paper thumbnail of Influence of cardiorespiratory fitness and physical activity levels on cardiometabolic risk factors during menopause transition: A MONET study

Preventive Medicine Reports, 2016

To determine the influence of cardiorespiratory fitness (hereafter "fitness") and physical activi... more To determine the influence of cardiorespiratory fitness (hereafter "fitness") and physical activity levels on cardiometabolic risk factors in premenopausal women going through the menopause transition. An ancillary study including 66 premenopausal women who participated to a 5-year observational, longitudinal study (2004 to 2009 in Ottawa) on the effects of menopause transition on body composition and cardiometabolic risk factors. Women underwent a graded exercise test on treadmill to measure peak oxygen uptake (VO 2 peak) at year 1 and 5 and physical activity levels were measured using accelerometers. Cardiometabolic risk factors included: waist circumference, fasting plasma lipids, glucose and insulin levels, HOMA-IR score, c-reactive protein, apolipoprotein B (apoB) and resting systolic and diastolic blood pressure. Change in fitness was not associated with changes in cardiometabolic risk factors. The changes in total physical activity levels on the other hand showed a significant negative association with apoB levels. Three-way linear mixed model repeated measures, showed lower values of waist circumference, fasting triglycerides, insulin levels, HOMA-IR score, apoB and diastolic blood pressure in women with a fitness ≥30.0 mlO 2 kg −1 min −1 compared to women with a fitness b30.0 mlO 2 kg −1 min −1 (P b 0.05). However, only fasting triglycerides was lower in women with physical activity levels ≥ 770.0 Kcal/day (P b 0.05). Between fitness and physical activity levels, fitness was associated with more favorable values of cardiometabolic risk factors in women followed for 5 years during the menopause transition.

Research paper thumbnail of Effect of the menopausal transition and physical activity energy expenditure on inflammatory markers: a MONET group study

Menopause, 2016

Objective: Menopausal transition is usually associated with changes in body composition and a dec... more Objective: Menopausal transition is usually associated with changes in body composition and a decrease in physical activity energy expenditure. Adipose tissue, especially visceral fat, is an important source of inflammatory markers, which contributes to the development of a proinflammatory state. Conversely, high levels of physical activity and exercise have an anti-inflammatory effect. This study aimed to investigate the impact of menopausal transition and physical activity on inflammatory makers. Methods: One hundred two healthy premenopausal women participated in a 5-year longitudinal study. The present secondary analyses were performed on 58 participants with a full set of data (age: 49.6 AE 1.7 y; body mass index: 23.3 AE 2.4 kg/m 2). Measures included body composition, waist circumference, fasting glucose and insulin levels, insulin sensitivity, plasma lipid levels, cardiorespiratory fitness, physical activity energy expenditure, and inflammatory markers. Results: Repeated measure analyses revealed, after the 5-year follow-up, significant increases in ferritin, interleukin-8 (IL-8), and soluble tumor necrosis factor-a receptor 1 and 2 (sTNFR1 and sTNFR2) (P < 0.001), and a significant decrease in serum high-sensitive C-reactive protein (P < 0.05). Positive correlations were observed between change (year 5 to baseline) in waist circumference and changes in high-sensitive C-reactive protein, orosomucoid (ORM), haptoglobin, and apolipoprotein B (ApoB) levels (0.26 r 0.34; P < 0.05), and between change in peripheral fat and changes in ORM, ApoB, sTNFR2 (0.28 r 0.39; P < 0.05). On the contrary, negative correlations were found between change in physical activity energy expenditure and changes in ORM as well as ApoB (r ¼ À0.35 and r ¼ À0.36, respectively; P < 0.05). No significant correlations were found between change in cardiorespiratory fitness, glucose, insulin, insulin sensitivity and changes in inflammatory markers. Multiple regression analyses showed that changes in physical activity energy expenditure and waist circumference together explained 23% of the individual variance of change in ORM (P < 0.05). Also, change in physical activity energy expenditure explained 15% (P < 0.05) of the variance of change in ApoB. Fat mass change explained 15% (P < 0.05) of the variance of change in IL-8, and finally change in peripheral fat explained 15% of variance of change in sTNFR2 (P < 0.05). Conclusions: The present study indicates that the menopausal transition is accompanied by an increase in inflammatory markers, namely ferritin, IL-8, sTNFR1, and sTNFR2. The increase in IL-8 and sTNFR2 with menopause could be explained, in part, by changes in fat mass and peripheral fat, respectively.

Research paper thumbnail of Reproducibility of a food menu to measure energy and macronutrient intakes in a laboratory and under real-life conditions

British Journal of Nutrition, 2012

Given the limitations associated with the measurement of food intake, we aimed to determine the r... more Given the limitations associated with the measurement of food intake, we aimed to determine the reliability of a food menu to measure energy intake (EI) and macronutrient intake within the laboratory and under free-living conditions. A total of eight men and eight women (age 25·74 (sd5·9) years, BMI 23·7 (sd2·7) kg/m2) completed three identical in-laboratory sessions (ILS) and three out-of-laboratory sessions (OLS). During the ILS, participants hadad libitumaccess to a variety of foods, which they chose from a menu every hour, for 5 h. For the OLS, the foods were chosen from the menu at the start of the day and packed into containers to bring home. There were no significant differences in total EI (6118·6 (sd2691·2), 6678·8 (sd2371·3), 6489·5 (sd2742·9) kJ; NS) between the three ILS and three OLS (6816·0 (sd2713·2), 6553·5 (sd2364·5), 6456·4 (sd3066·8) kJ; NS). Significant intraclass correlations (ICC) for total energy (r0·77,P < 0·0001), carbohydrate (r0·81,P < 0·0001), dieta...

Research paper thumbnail of Validation of a food menu to measure energy and macronutrient intake in the laboratory and under real-life conditions: Preliminary data

Canadian Journal of Diabetes, 2011

Research paper thumbnail of Pre-Exposure Prophylaxis Among Gay, Bisexual, and Other Men Who Have Sex With Men in Ottawa: A Real World View With Benefits Beyond HIV Risk Reduction

International Journal of Sexual Health, 2021

Abstract The number of gay, bisexual, and other men who have sex with men taking pre-exposure pro... more Abstract The number of gay, bisexual, and other men who have sex with men taking pre-exposure prophylaxis (PrEP) has grown since its approval in Canada. While there are sound clinical data on PrEP efficacy, there is less research describing outcomes in routine clinical practice. We conducted a cross-sectional study with 113 men attending our PrEP clinic. Participants completed a one-time survey and chart reviews were conducted. We found that men in our clinic were educated and affluent. While PrEP did not lead to more reported sexual partners, condom use declined, as did sexual anxiety. These results reinforce that PrEP benefits extend beyond HIV prevention.

Research paper thumbnail of Determinants of Inflammatory Markers in Premenopausal Women: A MONET Group Study

Canadian Journal of Diabetes, 2013

Purpose: The purpose of this study was to investigate the associations between adiposity and meta... more Purpose: The purpose of this study was to investigate the associations between adiposity and metabolic indices, cardiorespiratory fitness (CRF), total daily physical activity energy expenditure (PAEE) and inflammatory markers (IM: C-reactive protein, orosomucoid, haptoglobin and apolipoprotein B) in premenopausal women. Methods: Statistical analyses were performed using baseline data of 102 premenopausal women (age, 49.9AE1.9 years; BMI, 23.3AE2.2 kg/m 2 ) who participated to a 5-year MONET (Montreal, Ottawa, New Emerging Team) study on the effect of menopause transition on cardiovascular risk factors. Results: Positive correlations (0.22!r 0.39; p<0.05) were observed between adiposity indices and triglycerides levels and IM. On the other hand, negative correlations (e0.20!r e0.30; p<0.05) were observed between CRF and IM. PAEE was negatively correlated only with haptoglobin (r¼e0.33; p<0.05). Participants with a VO 2peak !30 mL O 2 /kg/min had significant lower C-reactive protein, haptoglobin and apolipoprotein B levels (all p<0.05). Also, participants reporting PAEE !1000 kcal/day had a significantly lower haptoglobin (p<0.05). The multiple regression analysis to document the determinants of IM individual variation showed that: 1) visceral fat and LDL-Chol explained 18% of Creactive proteins, 2) visceral fat explained 20% of orosomucoid, 3) PAEE, fasting glucose and % body fat explained 32% of haptoglobin and 4) LDL-Chol and % body fat explained 41% of apolipoprotein B levels. Conclusion: Higher adiposity indices, especially high visceral fat and low CRF and PAEE are associated with higher inflammatory markers levels in premenopausal women.

Research paper thumbnail of Reproducibility of a food menu to measure energy and macronutrient intakes in a laboratory and under real-life conditions

British Journal of Nutrition, 2012

Given the limitations associated with the measurement of food intake, we aimed to determine the r... more Given the limitations associated with the measurement of food intake, we aimed to determine the reliability of a food menu to measure energy intake (EI) and macronutrient intake within the laboratory and under free-living conditions. A total of eight men and eight women (age 25·74 (SD 5·9) years, BMI 23·7 (SD 2·7) kg/m 2 ) completed three identical in-laboratory sessions (ILS) and three out-of-laboratory sessions (OLS). During the ILS, participants had ad libitum access to a variety of foods, which they chose from a menu every hour, for 5 h. For the OLS, the foods were chosen from the menu at the start of the day and packed into containers to bring home. There were no significant differences in total EI (6118·6 (SD 2691·2), 6678·8 (SD 2371·3), 6489·5 (SD 2742·9) kJ; NS) between the three ILS and three OLS (6816·0 (SD 2713·2), 6553·5 (SD 2364·5), 6456·4 (SD 3066·8) kJ; NS). Significant intraclass correlations (ICC) for total energy (r 0·77, P, 0·0001), carbohydrate (r 0·81, P,0·0001), dietary fat (r 0·54, P,0·0001) and protein (r 0·81, P,0·0001) intakes for the ILS and significant ICC for total energy (r 0·85, P, 0·0001), carbohydrate (0·85, P, 0·0001), dietary fat (0·72 P, 0·0001) and protein (0·80, P, 0·0001) intakes for the OLS were noted. The average within-subject CV for total EI was 18·3 (SD 10·0) and 16·1 (SD 10·3) % for the ILS and OLS, respectively, with a pleasantness rating for foods consumed of 124 (SD 14) mm out of 150 mm (83 %). Overall, the food menu produces a relatively reliable measure of EI inside and outside the laboratory. The results also underscore the difficulties in capturing a representative image of food intake given the relatively high day-to-day variation in the amount and composition of foods consumed.

Research paper thumbnail of Reproducibility of a food menu to measure energy and macronutrient intakes in a laboratory and under real-life conditions

British Journal of Nutrition, 2012

Given the limitations associated with the measurement of food intake, we aimed to determine the r... more Given the limitations associated with the measurement of food intake, we aimed to determine the reliability of a food menu to measure energy intake (EI) and macronutrient intake within the laboratory and under free-living conditions. A total of eight men and eight women (age 25·74 (SD 5·9) years, BMI 23·7 (SD 2·7) kg/m 2 ) completed three identical in-laboratory sessions (ILS) and three out-of-laboratory sessions (OLS). During the ILS, participants had ad libitum access to a variety of foods, which they chose from a menu every hour, for 5 h. For the OLS, the foods were chosen from the menu at the start of the day and packed into containers to bring home. There were no significant differences in total EI (6118·6 (SD 2691·2), 6678·8 (SD 2371·3), 6489·5 (SD 2742·9) kJ; NS) between the three ILS and three OLS (6816·0 (SD 2713·2), 6553·5 (SD 2364·5), 6456·4 (SD 3066·8) kJ; NS). Significant intraclass correlations (ICC) for total energy (r 0·77, P, 0·0001), carbohydrate (r 0·81, P,0·0001), dietary fat (r 0·54, P,0·0001) and protein (r 0·81, P,0·0001) intakes for the ILS and significant ICC for total energy (r 0·85, P, 0·0001), carbohydrate (0·85, P, 0·0001), dietary fat (0·72 P, 0·0001) and protein (0·80, P, 0·0001) intakes for the OLS were noted. The average within-subject CV for total EI was 18·3 (SD 10·0) and 16·1 (SD 10·3) % for the ILS and OLS, respectively, with a pleasantness rating for foods consumed of 124 (SD 14) mm out of 150 mm (83 %). Overall, the food menu produces a relatively reliable measure of EI inside and outside the laboratory. The results also underscore the difficulties in capturing a representative image of food intake given the relatively high day-to-day variation in the amount and composition of foods consumed.

Research paper thumbnail of Menopause Transition and Postmenopausal Period: Relationship with Inflammatory Markers, Physical Activity Energy Expenditure and Bone Mineral Density in Healthy Women

Menopause transition is usually associated with changes in body composition and a decrease in phy... more Menopause transition is usually associated with changes in body composition and a decrease in physical activity energy expenditure. Adipose tissue, especially visceral fat, is an important source of inflammatory markers, which contributes to the development of a pro-inflammatory state. Conversely, high levels of physical activity and exercise have an anti-inflammatory effect. One-hundred and two healthy premenopausal women participated in a 5-year longitudinal observational study (MONET: Montreal Ottawa New Emerging Team). The present secondary analyses were performed on 58 participants between the ages of 47 and 54 years with a full set of data.The aim of study was to investigate the impact of menopause transition and physical activity on inflammatory makers. The major finding of the first of 3 studies was that menopausal transition is accompanied by an increase in inflammatory markers, namely ferritin, IL-8, and sTNFR 1 and 2. The increase in IL-8 and sTNFR2 with menopause could b...

Research paper thumbnail of Effect of Physical Activity and Menopause Transition on Inflammatory Markers

Medicine & Science in Sports & Exercise, 2014

Use of embrocation oil significantly improved time to exhaustion. The average heart rate differen... more Use of embrocation oil significantly improved time to exhaustion. The average heart rate difference between the oil and non-oil groups was negligible, suggesting the physiological mechanism may be unrelated to the cardiovascular system. The physiological mechanisms for improvement by use of embrocation oil warrant further investigation.

Research paper thumbnail of Body composition, cardiometabolic risk factors, physical activity, and inflammatory markers in premenopausal women after a 10-year follow-up: a MONET study

Menopause, 2017

Objective: Menopausal transition and postmenopause are usually associated with changes in body co... more Objective: Menopausal transition and postmenopause are usually associated with changes in body composition and a decrease in physical activity energy expenditure (PAEE). This study investigated body composition, cardiometabolic risk factors, PAEE, and inflammatory markers in premenopausal women after a 10-year follow-up. Methods: In all, 102 premenopausal women participated in the 5-year observational longitudinal Montreal Ottawa New Emerging Team (MONET) study. This present substudy included 48 participants (age: 60.0 AE 1.7 years; body mass index: 23.2 AE 2.2 kg/m 2) 6.0 AE 0.3 years after completion of the initial MONET study. Measures included body composition, waist circumference (WC), fasting glucose and insulin levels, insulin sensitivity (QUICKI model), plasma lipid levels, PAEE, and inflammatory markers. Results: Compared with baseline measures of the MONET study, analyses revealed no significant increase in body weight, although there were significant increases in WC, fat mass (FM), % FM, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, haptoglobin, apolipoprotein B, ferritin, adiponectin, and soluble cluster of differentiation 14 (all P < 0.001) after the 10-year follow-up. However, significant decreases were observed for fat-free mass, PAEE, fasting glucose levels, interleukin-8 levels, and soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2) levels (all P < 0.05). To determine the effect of postmenopausal years, data were restructured based on final menstrual period (FMP), and one-way analyses of variance were performed. Waist circumference, % FM, total cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, ferritin, adiponectin, and soluble cluster of differentiation 14 were higher in early and late postmenopausal periods in these women. sTNFR-1 and sTNFR-2 levels were higher at the FMP and early postmenopausal years as compared with the late postmenopausal periods. Finally, interleukin-8 levels were lower in years after FMP. Conclusion: The number of years elapsed since the FMP can affect body composition, cardiometabolic risk factors, and inflammatory markers in healthy premenopausal women going through menopausal transition and postmenopausal periods.

Research paper thumbnail of Influence of cardiorespiratory fitness and physical activity levels on cardiometabolic risk factors during menopause transition: A MONET study

Preventive Medicine Reports, 2016

To determine the influence of cardiorespiratory fitness (hereafter "fitness") and physical activi... more To determine the influence of cardiorespiratory fitness (hereafter "fitness") and physical activity levels on cardiometabolic risk factors in premenopausal women going through the menopause transition. An ancillary study including 66 premenopausal women who participated to a 5-year observational, longitudinal study (2004 to 2009 in Ottawa) on the effects of menopause transition on body composition and cardiometabolic risk factors. Women underwent a graded exercise test on treadmill to measure peak oxygen uptake (VO 2 peak) at year 1 and 5 and physical activity levels were measured using accelerometers. Cardiometabolic risk factors included: waist circumference, fasting plasma lipids, glucose and insulin levels, HOMA-IR score, c-reactive protein, apolipoprotein B (apoB) and resting systolic and diastolic blood pressure. Change in fitness was not associated with changes in cardiometabolic risk factors. The changes in total physical activity levels on the other hand showed a significant negative association with apoB levels. Three-way linear mixed model repeated measures, showed lower values of waist circumference, fasting triglycerides, insulin levels, HOMA-IR score, apoB and diastolic blood pressure in women with a fitness ≥30.0 mlO 2 kg −1 min −1 compared to women with a fitness b30.0 mlO 2 kg −1 min −1 (P b 0.05). However, only fasting triglycerides was lower in women with physical activity levels ≥ 770.0 Kcal/day (P b 0.05). Between fitness and physical activity levels, fitness was associated with more favorable values of cardiometabolic risk factors in women followed for 5 years during the menopause transition.

Research paper thumbnail of Effect of the menopausal transition and physical activity energy expenditure on inflammatory markers: a MONET group study

Menopause, 2016

Objective: Menopausal transition is usually associated with changes in body composition and a dec... more Objective: Menopausal transition is usually associated with changes in body composition and a decrease in physical activity energy expenditure. Adipose tissue, especially visceral fat, is an important source of inflammatory markers, which contributes to the development of a proinflammatory state. Conversely, high levels of physical activity and exercise have an anti-inflammatory effect. This study aimed to investigate the impact of menopausal transition and physical activity on inflammatory makers. Methods: One hundred two healthy premenopausal women participated in a 5-year longitudinal study. The present secondary analyses were performed on 58 participants with a full set of data (age: 49.6 AE 1.7 y; body mass index: 23.3 AE 2.4 kg/m 2). Measures included body composition, waist circumference, fasting glucose and insulin levels, insulin sensitivity, plasma lipid levels, cardiorespiratory fitness, physical activity energy expenditure, and inflammatory markers. Results: Repeated measure analyses revealed, after the 5-year follow-up, significant increases in ferritin, interleukin-8 (IL-8), and soluble tumor necrosis factor-a receptor 1 and 2 (sTNFR1 and sTNFR2) (P < 0.001), and a significant decrease in serum high-sensitive C-reactive protein (P < 0.05). Positive correlations were observed between change (year 5 to baseline) in waist circumference and changes in high-sensitive C-reactive protein, orosomucoid (ORM), haptoglobin, and apolipoprotein B (ApoB) levels (0.26 r 0.34; P < 0.05), and between change in peripheral fat and changes in ORM, ApoB, sTNFR2 (0.28 r 0.39; P < 0.05). On the contrary, negative correlations were found between change in physical activity energy expenditure and changes in ORM as well as ApoB (r ¼ À0.35 and r ¼ À0.36, respectively; P < 0.05). No significant correlations were found between change in cardiorespiratory fitness, glucose, insulin, insulin sensitivity and changes in inflammatory markers. Multiple regression analyses showed that changes in physical activity energy expenditure and waist circumference together explained 23% of the individual variance of change in ORM (P < 0.05). Also, change in physical activity energy expenditure explained 15% (P < 0.05) of the variance of change in ApoB. Fat mass change explained 15% (P < 0.05) of the variance of change in IL-8, and finally change in peripheral fat explained 15% of variance of change in sTNFR2 (P < 0.05). Conclusions: The present study indicates that the menopausal transition is accompanied by an increase in inflammatory markers, namely ferritin, IL-8, sTNFR1, and sTNFR2. The increase in IL-8 and sTNFR2 with menopause could be explained, in part, by changes in fat mass and peripheral fat, respectively.

Research paper thumbnail of Reproducibility of a food menu to measure energy and macronutrient intakes in a laboratory and under real-life conditions

British Journal of Nutrition, 2012

Given the limitations associated with the measurement of food intake, we aimed to determine the r... more Given the limitations associated with the measurement of food intake, we aimed to determine the reliability of a food menu to measure energy intake (EI) and macronutrient intake within the laboratory and under free-living conditions. A total of eight men and eight women (age 25·74 (sd5·9) years, BMI 23·7 (sd2·7) kg/m2) completed three identical in-laboratory sessions (ILS) and three out-of-laboratory sessions (OLS). During the ILS, participants hadad libitumaccess to a variety of foods, which they chose from a menu every hour, for 5 h. For the OLS, the foods were chosen from the menu at the start of the day and packed into containers to bring home. There were no significant differences in total EI (6118·6 (sd2691·2), 6678·8 (sd2371·3), 6489·5 (sd2742·9) kJ; NS) between the three ILS and three OLS (6816·0 (sd2713·2), 6553·5 (sd2364·5), 6456·4 (sd3066·8) kJ; NS). Significant intraclass correlations (ICC) for total energy (r0·77,P < 0·0001), carbohydrate (r0·81,P < 0·0001), dieta...

Research paper thumbnail of Validation of a food menu to measure energy and macronutrient intake in the laboratory and under real-life conditions: Preliminary data

Canadian Journal of Diabetes, 2011

Research paper thumbnail of Pre-Exposure Prophylaxis Among Gay, Bisexual, and Other Men Who Have Sex With Men in Ottawa: A Real World View With Benefits Beyond HIV Risk Reduction

International Journal of Sexual Health, 2021

Abstract The number of gay, bisexual, and other men who have sex with men taking pre-exposure pro... more Abstract The number of gay, bisexual, and other men who have sex with men taking pre-exposure prophylaxis (PrEP) has grown since its approval in Canada. While there are sound clinical data on PrEP efficacy, there is less research describing outcomes in routine clinical practice. We conducted a cross-sectional study with 113 men attending our PrEP clinic. Participants completed a one-time survey and chart reviews were conducted. We found that men in our clinic were educated and affluent. While PrEP did not lead to more reported sexual partners, condom use declined, as did sexual anxiety. These results reinforce that PrEP benefits extend beyond HIV prevention.

Research paper thumbnail of Determinants of Inflammatory Markers in Premenopausal Women: A MONET Group Study

Canadian Journal of Diabetes, 2013

Purpose: The purpose of this study was to investigate the associations between adiposity and meta... more Purpose: The purpose of this study was to investigate the associations between adiposity and metabolic indices, cardiorespiratory fitness (CRF), total daily physical activity energy expenditure (PAEE) and inflammatory markers (IM: C-reactive protein, orosomucoid, haptoglobin and apolipoprotein B) in premenopausal women. Methods: Statistical analyses were performed using baseline data of 102 premenopausal women (age, 49.9AE1.9 years; BMI, 23.3AE2.2 kg/m 2 ) who participated to a 5-year MONET (Montreal, Ottawa, New Emerging Team) study on the effect of menopause transition on cardiovascular risk factors. Results: Positive correlations (0.22!r 0.39; p<0.05) were observed between adiposity indices and triglycerides levels and IM. On the other hand, negative correlations (e0.20!r e0.30; p<0.05) were observed between CRF and IM. PAEE was negatively correlated only with haptoglobin (r¼e0.33; p<0.05). Participants with a VO 2peak !30 mL O 2 /kg/min had significant lower C-reactive protein, haptoglobin and apolipoprotein B levels (all p<0.05). Also, participants reporting PAEE !1000 kcal/day had a significantly lower haptoglobin (p<0.05). The multiple regression analysis to document the determinants of IM individual variation showed that: 1) visceral fat and LDL-Chol explained 18% of Creactive proteins, 2) visceral fat explained 20% of orosomucoid, 3) PAEE, fasting glucose and % body fat explained 32% of haptoglobin and 4) LDL-Chol and % body fat explained 41% of apolipoprotein B levels. Conclusion: Higher adiposity indices, especially high visceral fat and low CRF and PAEE are associated with higher inflammatory markers levels in premenopausal women.

Research paper thumbnail of Reproducibility of a food menu to measure energy and macronutrient intakes in a laboratory and under real-life conditions

British Journal of Nutrition, 2012

Given the limitations associated with the measurement of food intake, we aimed to determine the r... more Given the limitations associated with the measurement of food intake, we aimed to determine the reliability of a food menu to measure energy intake (EI) and macronutrient intake within the laboratory and under free-living conditions. A total of eight men and eight women (age 25·74 (SD 5·9) years, BMI 23·7 (SD 2·7) kg/m 2 ) completed three identical in-laboratory sessions (ILS) and three out-of-laboratory sessions (OLS). During the ILS, participants had ad libitum access to a variety of foods, which they chose from a menu every hour, for 5 h. For the OLS, the foods were chosen from the menu at the start of the day and packed into containers to bring home. There were no significant differences in total EI (6118·6 (SD 2691·2), 6678·8 (SD 2371·3), 6489·5 (SD 2742·9) kJ; NS) between the three ILS and three OLS (6816·0 (SD 2713·2), 6553·5 (SD 2364·5), 6456·4 (SD 3066·8) kJ; NS). Significant intraclass correlations (ICC) for total energy (r 0·77, P, 0·0001), carbohydrate (r 0·81, P,0·0001), dietary fat (r 0·54, P,0·0001) and protein (r 0·81, P,0·0001) intakes for the ILS and significant ICC for total energy (r 0·85, P, 0·0001), carbohydrate (0·85, P, 0·0001), dietary fat (0·72 P, 0·0001) and protein (0·80, P, 0·0001) intakes for the OLS were noted. The average within-subject CV for total EI was 18·3 (SD 10·0) and 16·1 (SD 10·3) % for the ILS and OLS, respectively, with a pleasantness rating for foods consumed of 124 (SD 14) mm out of 150 mm (83 %). Overall, the food menu produces a relatively reliable measure of EI inside and outside the laboratory. The results also underscore the difficulties in capturing a representative image of food intake given the relatively high day-to-day variation in the amount and composition of foods consumed.

Research paper thumbnail of Reproducibility of a food menu to measure energy and macronutrient intakes in a laboratory and under real-life conditions

British Journal of Nutrition, 2012

Given the limitations associated with the measurement of food intake, we aimed to determine the r... more Given the limitations associated with the measurement of food intake, we aimed to determine the reliability of a food menu to measure energy intake (EI) and macronutrient intake within the laboratory and under free-living conditions. A total of eight men and eight women (age 25·74 (SD 5·9) years, BMI 23·7 (SD 2·7) kg/m 2 ) completed three identical in-laboratory sessions (ILS) and three out-of-laboratory sessions (OLS). During the ILS, participants had ad libitum access to a variety of foods, which they chose from a menu every hour, for 5 h. For the OLS, the foods were chosen from the menu at the start of the day and packed into containers to bring home. There were no significant differences in total EI (6118·6 (SD 2691·2), 6678·8 (SD 2371·3), 6489·5 (SD 2742·9) kJ; NS) between the three ILS and three OLS (6816·0 (SD 2713·2), 6553·5 (SD 2364·5), 6456·4 (SD 3066·8) kJ; NS). Significant intraclass correlations (ICC) for total energy (r 0·77, P, 0·0001), carbohydrate (r 0·81, P,0·0001), dietary fat (r 0·54, P,0·0001) and protein (r 0·81, P,0·0001) intakes for the ILS and significant ICC for total energy (r 0·85, P, 0·0001), carbohydrate (0·85, P, 0·0001), dietary fat (0·72 P, 0·0001) and protein (0·80, P, 0·0001) intakes for the OLS were noted. The average within-subject CV for total EI was 18·3 (SD 10·0) and 16·1 (SD 10·3) % for the ILS and OLS, respectively, with a pleasantness rating for foods consumed of 124 (SD 14) mm out of 150 mm (83 %). Overall, the food menu produces a relatively reliable measure of EI inside and outside the laboratory. The results also underscore the difficulties in capturing a representative image of food intake given the relatively high day-to-day variation in the amount and composition of foods consumed.