Sahin Oğreden - Academia.edu (original) (raw)

Papers by Sahin Oğreden

DergiPark (Istanbul University), Jul 19, 2014

ölner ve Wulstein, 1952'de timpanoplastinin bafllama-s›ndan beri s›ras›yla greft materyali ve yer... more ölner ve Wulstein, 1952'de timpanoplastinin bafllama-s›ndan beri s›ras›yla greft materyali ve yerlefltirme yöntemi timpanik membrandaki perforasyonlar› kapatmak amac›yla tan›mlam›fllard›r [1,2]. Günümüzde greft materyali olarak en yayg›n temporal fasya, perikondrium veya perikondriumlu tragal k›k›rdak çok yayg›n olarak kullan›lmaktad›r [3]. Timpanoplasti, orta kulaktaki infeksiyonun eradikasyonu yan›nda iflitmenin rekonstrüksiyonu amac›yla yap›lan bir ameliyatt›r. Mastoidektomi ile birlikte yap›labildi¤i gibi uygun olgularda mastoidektomisizde yap›labilir. Genellikle kolesteatomsuz kronik otitis media, atelektazik

KBB-Forum: Elektronik Kulak Burun Boğaz ve Baş Boyun Cerrahisi Dergisi, Jun 17, 2019

Aims: To investigate histopathological effects of local and systemic ozone application in experim... more Aims: To investigate histopathological effects of local and systemic ozone application in experimental tympanic membrane perforations. Methods: Traumatic perforation was created by using a 21 gauge syringe needle under the microscope and then animals were then divided into 4 equal groups. The first group was the control group and it healed spontaneously. 0.5 mL local ozone oil was dropped to external ear in second group; 1.0 mL (1 µg / mL) ozone gas was given by rectal way in third group; 0.5 mL local ozone oil and 1.0 mL (1 µg / mL) rectal ozone gas was given in fourth group for 10 days. On day 11th, the tympanic membranes of the rats were excised and examined for inflammation, fibroblast proliferation, vascular density, collagenization and epithelization. Results: It was observed that fibroblast proliferation, collagenization and epithelization scores of local, local+rectal, rectal ozone treatment groups were more significant compared to the control group (p<0.05). Conclusion: This study showed the contribitions of local and systemic ozone treatment to wound healing by increasing inflammation, fibroblast proliferation, collagenization, vascular density and epithelization in experimental tympanic membrane perforations of rats.

Indian Journal of Otolaryngology and Head & Neck Surgery, Jul 9, 2020

During the past decade, several inflammationbased periferic prognostic systems have been reported... more During the past decade, several inflammationbased periferic prognostic systems have been reported in the field of chronic rhinosinusitis with nasal polyps (CRSwNP). Recently, C-reactive protein (CRP) and albümin ratio (CAR) showed its impact on a large variety of diseases conditions that cause chronic inflammation. We aimed to compare the inflammatory markers in patients with recurrent and non-recurrent nasal polyps and if a significant inflammatory profile is associated with multiple recurrences. The study concerned 144 patients who underwent FESS for CRSwNP from 2012 to 2017 and had a postoperative follow-up longer than 12 months and 120 healthy individuals. We evaluated the impact of the CAR, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, eosinophil-to-lymphocyte ratio (ELR) between patients with and without polyp recurrences and control groups. There was a statistically significant difference in CRP, CAR and ELR values between multiple recurrence group and no-recurrence group (p = 0.02; 0.004; 0.019 respectively), mean eosinophil and CRP values, CAR, NLR and ELR was significantly higher in NP patients than control group (p \ 0.001). The receiver operating curve analysis showed CAR and ELR as a potential marker of recurrence of NP (AUC = 0.713 and 0.613, respectively p \ 0.001). The cutoff values for were 1.03 for CAR and 0.22 for ELR. The mean CRP, CAR and ELR were significantly higher in patients with CRSwNP whose disease recurred after surgery. CAR may be a potential marker to predict the recurrence before endoscopic sinus surgery as well as ELR in CRSwNP disease.

Goztepe Tip Dergisi, 2014

Amac : Endoskopik sinus cerrahisi (ESC) sonrasi sinus boslugunda uzun sureli topikal steroid uygu... more Amac : Endoskopik sinus cerrahisi (ESC) sonrasi sinus boslugunda uzun sureli topikal steroid uygulamasinin etkilerini arttirmayi hedefledik. Ayrica sinus bosluguna tekrarli topikal steroid uygulamasinin dogrudan yara iyilesmesine ve erken postoperative komplikasyonlarin onlenmesine olan etkisini degerlendirdik. Yontem : Calismaya bilateral endoskopik sinus cerrahisi uygulanan otuz bes hasta dahil edildi. Cerrahi mudahalenin tamamlanmasi sonrasi orta meatusun bir tarafina nazal steroid iceren NasoPore (budesonide 0.5µg/2ml) ve antibiyotik krem diger tarafina sadece antibiyotik krem yerlestirildi. Butun hastalar 1.,2.,4.,8., ve 12. haftalarda mudahale sonuclarinin gozlemlenmesi amaciyla muayene edildi. Bulgular : Operasyon sonrasi ilk uc ayda steroid uygulanan grupta ortalama sinesi, mukozal odem ve doku granulasyonu skorlari uygulanmayan gruba gore daha dusuktur. Fakat iki grup arasinda istatistiksel olarak anlamli bir fark gozlemlenememistir. Ortalama odem skoru steroid grubunda d...

Aerospace Medicine and Human Performance, 2021

OBJECTIVE: This study aimed to evaluate the effects of repeated pressure alterations on cochlear ... more OBJECTIVE: This study aimed to evaluate the effects of repeated pressure alterations on cochlear structures in rats in an attempt to understand indirectly the inner ear status of flight crew who are repeatedly exposed to pressure alterations.METHODS: There were 12 adult Wistar albino rats equally divided into 2 groups: Group 1 (controls) and Group 2 (study group). The animals in Group 2 were exposed to repeated pressure changes in a pressure cabin which is regulated by manometers. The animals in Group 1 were placed in the cabin without being exposed to pressure changes. Auditory brainstem response (ABR) testing was performed in all animals at the beginning and at the end of the study. After 12 wk the animals were sacrificed and their cochleas were investigated using scanning electron microscopy (SEM).RESULTS: In the study group, hearing decreases at 2 kHz, 4 kHz, 6 dB at 8 kHz, and 32 kHz were encountered at the end of 3 mo. On SEM evaluation of the control group, the outer hair cel...

The Journal of International Advanced Otology, 2019

To evaluate the effects of size of temporal fascia graft on healing of the mastoid cavity in pati... more To evaluate the effects of size of temporal fascia graft on healing of the mastoid cavity in patients undergoing canal wall down (CWD) procedures. MATERIALS AND METHODS: The study included 32 patients (ages from 10 to 69 years) who were performed CWD tympanomastoidectomy from 2016 to 2018. Patients were divided into 2 different groups randomly based on size of fascia used in the operations. Group 1 consisted of 19 patients with temporal muscle fascia large enough to extend up to antrum by passing through over the facial ridge. Group 2 consisted of 13 patients with fascia of a size hardly enough to create a middle ear space, which were quite smaller than those the first group. It was also observed that whether or not the type of pathology (cholesteatoma, granulation tissue or both) had an effect to the epithelialization time of the cavity. RESULTS: Thirty-two patients met inclusion criteria. Nineteen patients were randomized to study (large fascia) group and 13 patients were to control (small fascia) group. The mean duration for epithelialization of cavities with study group-large grafts was 34.10 days and that was 39.76 days in control group-small grafts. According to type of pathology; in cases with cholesteatoma, with granulation, and cases of coexisting granulation with cholestatoma; the mean epithelialization times were 38.73, 31.33 and 34.42 days, with respectively. CONCLUSION: Placement of larger fascia graft to line the mastoidectomy cavity facilitate rapid epithelialization and healing in patients undergoing CWD tympanomastoidectomy. Further studies with larger groups would be beneficial to confirm this result in the aspect of statistical significance.

Bagcilar Medical Bulletin, 2019

The hypertrophic adenoid tissue can cause to eustachian tube dysfunction by mechanical or inflamm... more The hypertrophic adenoid tissue can cause to eustachian tube dysfunction by mechanical or inflammatory effect both of which block the nasopharyngeal ostium of the eustachian tube. Adenoidectomy, with or without tonsillectomy, is the most common surgical procedure in children. In this study, we aimed to investigate whether nasopharyngeal irrigation for hemorrhage control in adenoidectomy patients has an effect on eustachian tube functions. Method: Patients who underwent adenoidectomy for adenoid hypertrophy evaluated on both the preoperatively and on the postoperative first day by otomicroscopic examination and with tympanometry for eustachian tube functions. Patients were divided into two groups according to nasopharyngeal irrigation type after surgery. Group 1 was the transnasal pressure irrigation group; group 2 was transoral passive irrigation group. Tympanometry was used to measure pressure, volumetric, and compliance values to compare pre-and postoperative values. Results: 40 patients were included in the study. There was no significant difference between the age and sex distributions of the patients. Volume and compliance values between the groups were similar before and after the surgery. The mean pressure values of the tympanometry parameters were highly significantly different for the right ear and moderately different for the left ear in group 1; were significantly different for the right ear and highly significantly different for the left ear in group 2. Postoperative

Journal of Craniofacial Surgery, 2019

Introduction: Glass ionomer bone cement is frequently applied with cartilage grafts in otology, e... more Introduction: Glass ionomer bone cement is frequently applied with cartilage grafts in otology, even as a single unit. Objective: This experimental study was performed to investigate the histopathological effects of bone cement on cartilage tissue. Methods: The study was conducted between January 2018 and April 2018 and used 12 New Zealand White rabbits. The right ears of the rabbits constituted the study group, while the left ears were the controls. Ketac Cem Radiopaque (3 M Germany) was used as glass ionomer cement. Tissue samples from the rabbits were subjected to histopathological analysis to compare acute and chronic inflammation, foreign body reaction, angiogenesis, collagenesis, fibrosis, necrosis, cartilage fracture, osseous metaplasia, and loss of chondrocyte nuclei between the groups. Results: The rates of cartilage fracture (P ¼ 0.044), foreign body reaction (P < 0.001), acute inflammation (P ¼ 0.009), chronic inflammation (P ¼ 0.002), and angiogenesis (P ¼ 0.003) were significantly higher in the study group compared with the controls. The study group showed some degree of necrosis; no necrosis was observed in the control group, but the difference was not statistically significant (P ¼ 0.101). There were no significant differences in fibrosis, collagenesis, osseous metaplasia, or loss of chondrocyte nuclei between the groups. Conclusions: This study showed that application of bone cement can cause acute and chronic inflammation, foreign body reactions, angiogenesis, and cartilage fractures. Further studies are needed to determine the long-term effects of bone cement on cartilage.

Ear, Nose & Throat Journal, 2013

We conducted a prospective study to evaluate the vertebrobasilar system in adults with and withou... more We conducted a prospective study to evaluate the vertebrobasilar system in adults with and without obstructive sleep apnea (OSA). Our study population was made up of 48 patients with OSA and 21 healthy volunteers who served as controls; the OSA patients were subdivided into one group with mild or moderate OSA (n = 22) and another with severe OSA (n = 26). Each participant underwent Doppler ultrasonography three times to measure the diameter of the vertebral artery, the peak systolic velocity (PSV), the resistive index (RI), and the vertebral artery flow volume; the mean of the three measurements was calculated for each patient, for the OSA and control groups, and for various subgroups. No significant differences in vessel diameter, PSV, or RI were seen among any of the subgroups. Overall, the vertebral artery flow volume was slightly, but not significantly, higher in all patients with OSA (206 ml/min) than in the control group (177 ml/min); this difference might reflect the body's daytime response to the chronic apneic events experienced during sleep. The only statistically significant difference we found was in vertebral artery flow volume between the controls and the subgroup with mild or moderate OSA (p = 0.026); no difference was seen between the controls and the patients with severe OSA (p = 0.318). Likewise, no significant difference in any of the four parameters was seen when patients were subclassified by body mass index and arterial oxygen saturation level.

Istanbul Medical Journal, 2018

Brazilian Journal of Otorhinolaryngology, 2017

Introduction: Lateral osteotomy is mainly performed either endonasally or percutaneously in rhino... more Introduction: Lateral osteotomy is mainly performed either endonasally or percutaneously in rhinoplasty which is a frequently performed operation for the correction of nasal deformities. Both techniques have both advantages and disadvantages relative to each other. Objective: The aim of this study was to compare the histopathological effects of endonasal and percutaneous osteotomy techniques performed in rhinoplasty on bone healing and nasal stability in an experimental animal model. Methods: Eight one year-old New Zealand white rabbits were included. Xylazine hydrocloride and intramuscular ketamine anesthesia were administered to the rabbits. Endonasal osteotomy (8 bones) was performed in Group 1 (n = 4), and percutaneous osteotomy (8 bones) in Group 2 (n = 4). One month later the rabbits were sacrificed. Bone healing of the rabbits was staged according to the bone healing score of Huddleston et al. In both groups, nasal bone integrity was assessed subjectively. Results: In the percutaneous osteotomy group, Grade 1 bone healing was observed in two samples (25%), Grade 2 bone healing in two samples (25%), Grade 3 bone healing in four samples (50%). In the endonasal osteotomy group, Grade 1 bone healing was observed in 6 samples (75%) and Grade 2 bone healing was observed in 2 samples (25%). In the percutaneous group, fibrous tissue was observed in 2, predominantly fibrous tissue and a lesser amount of cartilage was

Cerrahpasa Tıp Dergisi, 2007

Revue de Stomatologie et de Chirurgie Maxillo-faciale, 2006

Revue de presse Supériorité de la décompression orbitaire des trois parois sur la décompression d... more Revue de presse Supériorité de la décompression orbitaire des trois parois sur la décompression de deux parois dans l'ophtalmopathie basedowienne Three-wall orbital decompression superiority to 2-wall orbital decompression in thyroid-associated ophthalmopathy

Medical Mycology, 2006

We report a histologically and mycologically proven sinonasal mucormycosis case causing palatal n... more We report a histologically and mycologically proven sinonasal mucormycosis case causing palatal necrosis in a nondiabetic patient with renal failure. Mycological examination of Giemsa stained imprinted tissue preparations revealed abundant yeast-like cells besides the typical mucoraceous hyphae. The fungus was isolated from surgical specimens and identified as Rhizopus oryzae by phenotypic and genotypic tests. Laboratory studies were performed to investigate the association of the yeast-like cells observed in tissue specimens and the fungus recovered in culture. In vitro induced yeast-like cell development of the case isolate was found under certain growth conditions and documented by photomicrographs.

Allergy, 2007

Objective: Currently, the diagnosis of chronic rhinosinusitis (CRS) is a symptom‐based definitio... more Objective: Currently, the diagnosis of chronic rhinosinusitis (CRS) is a symptom‐based definition. This study aims to study, verify and evaluate the predictive value of the symptom‐based definition of CRS and compare this with objective tests.Methods: Seven hundred and sixty‐eight adults, who were referred from primary care centers as patients who met the definition of CRS, were enrolled in the study. The patients were divided into two groups according to their allergic status. The patients were subjected to nasal endoscopy and computed tomography (CT) on the same day.Results: The results showed 73.15% of the nonallergic patients with symptom‐based diagnosed CRS and 65.34% of the allergic patients with symptom‐based diagnosed CRS had no CT and endoscopic pathology (Endoscopic score 0 + CT score 0). Nasal discharge was the most common major symptom in all patients from both groups who had pathologic endoscopic and/or CT scan scores.Conclusions: It is well established that symptom...