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Papers by Sai Krishna Tikka
Indian Journal of Psychiatry, 2021
Asia-Pacific Psychiatry, 2021
The study aimed to compare thyroid function between psychosis with postpartum onset (PPO), psycho... more The study aimed to compare thyroid function between psychosis with postpartum onset (PPO), psychosis without postpartum onset (PWPO), and normal postpartum females (HC). Twenty women were recruited in each of the three groups. The PPO group had significantly greater psychopathology and shorter episodes compared to the PWPO group. The PPO group was found to have significantly greater right lobe volume than the other groups. The PPO group also had significantly higher FT4 levels than the HC group. We conclude that isolated increase in FT4 and thyroid lobe volumetric changes could be more specifically associated with psychosis of post‐partum onset.
Indian Journal of Psychological Medicine, 2020
Asia-Pacific Psychiatry, 2019
IntroductionDespite a significant number of patients dependent on “poppy husk” in India, they are... more IntroductionDespite a significant number of patients dependent on “poppy husk” in India, they are poorly characterized. Moreover, scarce data is available with respect to their treatment.MethodsA cohort of 148 patients with “poppy husk” dependence receiving substitution treatment with buprenorphine/naloxone were followed up for 4 years, using a retrospective chart‐based assessment. Baseline demographic and substance‐related characteristics were described. Retention rates (operationally redefined as “6 months of uninterrupted contact anytime during their visits”) over the next 4 years and their predictors were assessed.ResultsMean age of onset of “poppy husk” use was found to be 27.51 years, and mean duration of dependence was 18.25 years. Mean amount of poppy husk consumed per month was 3.7 kg. Commonest reasons for initiating and quitting its use were enhancing work efficiency and lack of availability, respectively. Retention rates were 25%. Significant predictors of retention were...
Tobacco Prevention & Cessation, 2020
Asian Journal of Psychiatry, 2019
Journal of Clinical Psychopharmacology, 2019
Asian Journal of Psychiatry, 2018
Psychiatry research, 2017
Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack clinically eviden... more Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack clinically evident abnormal electrical activity in the brain. We aimed to assess resting gamma spectral power, current source distribution and functional connectivity in adolescents with PNES. Interictal, 32 channels electroencephalographic recording of 15 adolescents with PNES was compared with 10 matched healthy controls. Spectral power, current source distribution and lagged linear coherence were assessed. Statistically significant gamma spectral power, cortical sources and connectivity pattern was found in some brain areas. Region specific aberrant gamma activity and its relationship to psychopathology are discussed.
Asian Journal of Psychiatry, 2017
Neuroscience Letters, 2016
Psychiatry Research, 2016
Toxicology International, 2014
Psychiatry and Clinical Neurosciences, 2015
AimsAn abnormal activity in the electroencephalography (EEG) gamma band (>30 Hz) has been demo... more AimsAn abnormal activity in the electroencephalography (EEG) gamma band (>30 Hz) has been demonstrated in schizophrenia and this has been suggested to be reflecting a deficit in the development and maturation of the basic cognitive functions of attention, working memory and sensory processing. Hypothesizing gamma oscillatory activity as a potential EEG biomarker to antipsychotic response in schizophrenia, the present study aimed at measuring baseline spontaneous gamma activity in schizophrenia patients, and evaluating its response to antipsychotic treatment over 8 weeks.MethodsFifteen drug‐free/naïve patients were recruited, compared at baseline with 15 age‐, sex‐ and education‐matched healthy controls, and were followed up for 8 weeks' treatment on antipsychotics. Resting state EEG waves were recorded using high (192‐channel) resolution EEG at admission, 4 weeks and 8 weeks. Spectral power was calculated using fast Fourier transformation, Hanning window. The power was averag...
Indian Journal of Pharmacology, 2015
Evidence-based Strategies in Herbal Medicine, Psychiatric Disorders and Emergency Medicine, 2015
Indian Journal of Psychological Medicine, 2014
Indian Journal of Psychiatry, 2021
Asia-Pacific Psychiatry, 2021
The study aimed to compare thyroid function between psychosis with postpartum onset (PPO), psycho... more The study aimed to compare thyroid function between psychosis with postpartum onset (PPO), psychosis without postpartum onset (PWPO), and normal postpartum females (HC). Twenty women were recruited in each of the three groups. The PPO group had significantly greater psychopathology and shorter episodes compared to the PWPO group. The PPO group was found to have significantly greater right lobe volume than the other groups. The PPO group also had significantly higher FT4 levels than the HC group. We conclude that isolated increase in FT4 and thyroid lobe volumetric changes could be more specifically associated with psychosis of post‐partum onset.
Indian Journal of Psychological Medicine, 2020
Asia-Pacific Psychiatry, 2019
IntroductionDespite a significant number of patients dependent on “poppy husk” in India, they are... more IntroductionDespite a significant number of patients dependent on “poppy husk” in India, they are poorly characterized. Moreover, scarce data is available with respect to their treatment.MethodsA cohort of 148 patients with “poppy husk” dependence receiving substitution treatment with buprenorphine/naloxone were followed up for 4 years, using a retrospective chart‐based assessment. Baseline demographic and substance‐related characteristics were described. Retention rates (operationally redefined as “6 months of uninterrupted contact anytime during their visits”) over the next 4 years and their predictors were assessed.ResultsMean age of onset of “poppy husk” use was found to be 27.51 years, and mean duration of dependence was 18.25 years. Mean amount of poppy husk consumed per month was 3.7 kg. Commonest reasons for initiating and quitting its use were enhancing work efficiency and lack of availability, respectively. Retention rates were 25%. Significant predictors of retention were...
Tobacco Prevention & Cessation, 2020
Asian Journal of Psychiatry, 2019
Journal of Clinical Psychopharmacology, 2019
Asian Journal of Psychiatry, 2018
Psychiatry research, 2017
Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack clinically eviden... more Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack clinically evident abnormal electrical activity in the brain. We aimed to assess resting gamma spectral power, current source distribution and functional connectivity in adolescents with PNES. Interictal, 32 channels electroencephalographic recording of 15 adolescents with PNES was compared with 10 matched healthy controls. Spectral power, current source distribution and lagged linear coherence were assessed. Statistically significant gamma spectral power, cortical sources and connectivity pattern was found in some brain areas. Region specific aberrant gamma activity and its relationship to psychopathology are discussed.
Asian Journal of Psychiatry, 2017
Neuroscience Letters, 2016
Psychiatry Research, 2016
Toxicology International, 2014
Psychiatry and Clinical Neurosciences, 2015
AimsAn abnormal activity in the electroencephalography (EEG) gamma band (>30 Hz) has been demo... more AimsAn abnormal activity in the electroencephalography (EEG) gamma band (>30 Hz) has been demonstrated in schizophrenia and this has been suggested to be reflecting a deficit in the development and maturation of the basic cognitive functions of attention, working memory and sensory processing. Hypothesizing gamma oscillatory activity as a potential EEG biomarker to antipsychotic response in schizophrenia, the present study aimed at measuring baseline spontaneous gamma activity in schizophrenia patients, and evaluating its response to antipsychotic treatment over 8 weeks.MethodsFifteen drug‐free/naïve patients were recruited, compared at baseline with 15 age‐, sex‐ and education‐matched healthy controls, and were followed up for 8 weeks' treatment on antipsychotics. Resting state EEG waves were recorded using high (192‐channel) resolution EEG at admission, 4 weeks and 8 weeks. Spectral power was calculated using fast Fourier transformation, Hanning window. The power was averag...
Indian Journal of Pharmacology, 2015
Evidence-based Strategies in Herbal Medicine, Psychiatric Disorders and Emergency Medicine, 2015
Indian Journal of Psychological Medicine, 2014