Said Ettair - Academia.edu (original) (raw)

Papers by Said Ettair

The Lancet Gastroenterology & Hepatology, 2022

Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency;... more Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's one of the rare genetic diseases for which therapy is now available. The purpose of this work is to study the epidemiological features of the disease and to highlight the diagnostic difficulties. We performed an 11-year retrospective study of 11 patients with GD followed-up in the department of paediatric hepatology gastroenterology and nutrition of Rabat children's Hospital. We observed 11 patients with GD: 6 males and 5 females. Age at onset ranged from 3 months to 10 years with an average of 3.41 years. Mean age at diagnosis was 4 years (range 3months-14years).Parental consanguinity was noted in 85 % cases. According to the clinical presentation, we classified our patients into: 9 cases of type 1 (81%) and two cases of type 2 (19%), none of the patients presented GD type 3. GD type 1: The age at diagnosis ranged from 2 years to 14 year with an average of 6 years. Main ...

Ecological Engineering & Environmental Technology, May 1, 2023

Ecological Engineering & Environmental Technology

The symbiotic have been shown to be effective in prophylaxis and treatment of various diseases. I... more The symbiotic have been shown to be effective in prophylaxis and treatment of various diseases. Indeed, one of the main functions of probiotics is to improve microbial homeostasis in the body and to decrease the invasion of pathogens and their colonization. The objective of our study is to assess and then compare the rate of sales and the use of symbiotics by the Moroccan population in order to describe the status of sale of this type of Medicine. The collection of belly data was carried out using a questionnaire which contains information on all Moroccan market products and this study includes fifteen of the most widespread symbiotics products (probiotics and prebiotics). The study suggests that the sale of symbiotic products increased in some strains such as bacterial strain Bifidobacterium infantis which reached 96,300 units and Bifidobacterium lactis with a sale which reached 35,000 units and also there was also a decrease in sales of other symbiotic products such as Lactobacillus casei in 2019 compared to the sale in 2018 and according to the student test there is no significant difference between the average sales during the two successive years of 2018 and 2019 (p = 0.496). The results show that the consumption and use of symbiotic in Morocco has undergone significant fluctuations trending towards a regression.

BMC Pediatrics, 2018

Background: Allgrove syndrome is a rare autosomal recessive disorder characterized by the triad o... more Background: Allgrove syndrome is a rare autosomal recessive disorder characterized by the triad of achalasia, alacrimia and adrenal insufficiency. It is caused by the mutations of the AAAS gene located on chromosome 12q13. The c.1331 + 1G > A mutation is one of the most common described in North Africa including Tunisia, Algeria and Libya. We report here the clinical and genetic profile of a Moroccan family with Allgrove syndrome. Case presentation: A Moroccan sister and brother born to consanguineous parents were found, at the ages of twelve and fifteen months old respectively, to have alacrimia and isolated glucocorticoid deficiency. Later, they developed achalasia whereupon Allgrove syndrome was diagnosed clinically and confirmed by DNA sequencing which revealed a c.1331 + 1G > A mutation in the AAAS gene. Conclusion: This finding reinforces previous studies in demonstrating the geographic expansion of the ancestral mutation c.1331 + 1G > A in North African patients and thus enabling targeted genetic counseling. To the best of our knowledge, this is the first report of the AAAS gene mutation in Moroccan patients.

Digestive and Liver Disease, 2014

Celiac disease (CD) has a heterogeneous clinical expression. This report describes an uncommon CD... more Celiac disease (CD) has a heterogeneous clinical expression. This report describes an uncommon CD diagnosis in a 21 year old girl, affected by thalassemia major and followed at our Hematology Unit. Her ferritin levels used to range between 700 and 1000 g/L when she was on deferoxamine (40 mg/kg/day s.c.), therefore replaced with deferosilax (30-40 mg/kg/day per os) with stabilization of values around 400 g/L. After EBV infection, recurrent abdominal pains and diarrhea appeared. Few months later, ferritin levels decreased stepwise to 120 g/L albeit the same daily iron intake (blood transfusions) and the same drug dose, leading hematologists to reduce deferosilax up to 13 mg/kg/day. Her values increased up to 300 g/L. Thereafter, she was sent at our Gastroenterology and Hepatology Unit because of persisting gastrointestinal symptoms. Screening for CD showed anti-transglutaminase IgA > 100 UA/mL (<16) and positive antiendomysial antibodies. A reduction in number and height of folds was found in bulb and duodenum at upper gastrointestinal endoscopy and histological examination confirmed CD diagnosis (Marsh-Oberhuber 3a-3b). Once on gluten-free diet (GFD) ferritin levels rose to 568 g/L, thus requiring to increase deferosilax dose. This report suggests to consider undiagnosed CD in thalassemic patients when ferritin levels unexpectedly decrease demanding a lower iron chelator dose, perhaps due to un underlying malabsorption. Although the GFD leads to increased ferritin levels, it remains essential in order to prevent the risk of CD complication in organs such as liver, pancreas, thyroid, bone and heart, already potentially damaged by hematological condition.

Digestive and Liver Disease, 2014

21st National Conference of the Societa-Italiana-di-Gastroenterologia-Epatologia-e-Nutrizione-Ped... more 21st National Conference of the Societa-Italiana-di-Gastroenterologia-Epatologia-e-Nutrizione-Pediatrica (SIGENAP) -- OCT 02-04, 2014 -- Sorrento, ITALYWOS: 000209827300121Soc Italiana Gastroenterologia Epatologia & Nutrizione Pediatric

Case Reports in Pediatrics

Background and Aims. There is growing evidence that the 2019 coronavirus disease (COVID-19) is em... more Background and Aims. There is growing evidence that the 2019 coronavirus disease (COVID-19) is emerging as a potential trigger virus for the development of diabetes mellitus in children. This can occur even in patients without factors predisposing to impaired glucose metabolism. Here, we report two rare cases of diabetic ketoacidosis revealing new-onset diabetes and precipitated by COVID-19. These cases are reported in view of their rarity and originality. The relationship between type 1 diabetes mellitus and COVID-19 is discussed. Results. Two children developed symptoms suggestive of diabetic ketoacidosis preceded by polyuria, polydipsia, and asbestos. There is a documented COVID-19 infection in the parents of the 2 children. An asymptomatic infection was detected in the 2 patients on the basis of a reverse transcription polymerase chain reaction (RT-PCR) test. Thoracic imaging and inflammatory workup were negative in both cases. Both patients responded well to treatment, includin...

Batna journal of medical sciences, Dec 30, 2019

Malignant Infantile Osteopetrosis (MIOP) is a rare genetic disorder due to osteoclast abnormal ac... more Malignant Infantile Osteopetrosis (MIOP) is a rare genetic disorder due to osteoclast abnormal activity.We report a thirteen month-old male patient, diagnosed as MIOP while investigating the cause of hepatosplenomegaly associated with hydrocephalus. His medical history revealed non consanguineous parents and one brother's death at the same age of unknown etiology (similar symptoms).Systemic examination showed hepatosplenomegaly, growth failure, developmental milestones delay, and rickets features. Ophthalmic exam yielded bilateral optic atrophy. Skeleton radiographs detected generalized dense bone and rickets. Cerebral CT scan revealed hydrocephalus. Histological examination showed hypoplastic bone marrow and extra-medullary hematopoeisis. Diagnosis was confirmed by genetic testing that showed two heterozygote mutations within the TCIRG1 gene. The patient received supportive treatment. He died from an acute respiratory distress.MIOP should be kept in mind as a rare cause of hep...

The Pan African Medical Journal, 2021

Introduction nul ne peut nier les résultats protecteurs satisfaisants de la vaccination contre pl... more Introduction nul ne peut nier les résultats protecteurs satisfaisants de la vaccination contre plusieurs maladies graves dans le monde et particulièrement au Maroc. L´extension de la pandémie COVID-19 dans notre pays a entrainé une baisse importante de la vaccination des enfants, ce qui pourrait causer des flambées épidémiques dans le futur. D´où l´intervention du ministère de la santé pour pallier à cette situation. L´objectif était de montrer l´ampleur du relâchement de la vaccination en temps COVID-19 et sortir avec des recommandations visant à rétablir ce changement. Méthodes il s´agit d´une étude transversale sur l´impact de cette pandémie sur le suivi vaccinal des enfants. Nous avons mené une enquête nationale auprès des pédiatres sous forme d´un questionnaire électronique via Google Forms. Nous avons procédé à la collecte, l´analyse et l´interprétation des résultats. Résultats cent trois pédiatres marocains ont répondu au questionnaire. Plus de 2 tiers des pédiatres exercent ...

Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contrai... more Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. This report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning. Case report: A 5-year-old girl was presented with acute blindness following closantel poisoning. She was given mistakenly a dose of 500 mg/day (25mg/kg/day) for 8 days. Clinical examination revealed a well-appearing child with bilateral mydriasis, loss of pupillary light reflex and absence of blinking to threat. Fundoscopic exam revealed bilateral pre-atrophic papilledema. Electroretinogram showed a highly significant decrease in retinal activity. Laboratory examinations revealed 52% increase in prothrombin time, prolongation of activated partial thromboplastin time to 1.3 times the normal and rise of aspartate aminotransferase to 120 IU/L. In addition, creatine kinase peaked at 904 IU/L. Moreover, normocytic normochromic anemia with hemoglobin at 1...

World Journal of GASTROENTEROLOGY, HEPATOLOGY AND ENDOSCOPY, 2021

The term bezoar refers to foreign bodies found in the digestive tract. It results in a stagnation... more The term bezoar refers to foreign bodies found in the digestive tract. It results in a stagnation of ingested non-digestible substances. We report a case of an esophageal bezoar collected in the pediatric gastroenterology department of the children's hospital in Rabat-MO-ROCCO. This observation of an esophageal bezoar, the first in our institution, to our knowledge, confirms the rarity of the pathology. 7-year-old child, taken by his parents to the children's hospital of the university hospital in Rabat for total aphagia. His history shows: psychomotor retardation, followed for 2 years for peptic esophagitis complicated by peptic stenosis. The course was marked by total aphagia, early postprandial vomiting, and weight loss of 6 kg in 3 months. This symptomatology has been evolving for 2 months. Esophagogastroduodenal fibroscopy, using an 8.5mm pediatric fiberscope, revealed an esophageal bezoar made of tissues, fibers, hair, sponge, plastics and ropes. A multistage endoscopic extraction was performed, which extracted a 430g bezoar. After a complete cleansing of the esophagus, the esophagogastroduodenal exploration showed ascension of the gastric folds on retrovision, a gaping cardia, a hernial pouch, an esophageal caliber disparity of 25 cm to 20 cm of the dental arches with presence of mucous ulcerations and false membranes. After extraction, the child resumed his normal diet with no vomiting. a proton pump inhibitor and antibiotic therapy were prescribed. PATIENT AND OBSERVATION 7-year-old child, taken by his parents to the children's hospital of the university hospital in Rabat for total aphagia. His history shows: psychomotor retardation, followed for 2 years for peptic esophagitis complicated by peptic stenosis. The course was marked by total aphagia, early postprandial vomiting, and weight loss of 6 kg in 3 months. This symptomatology has been evolving for 2 months. The admission exam noted: a pale patient. A weight of 12kg (-3 DS), a height of 114cm (-2DS).

Archives de Pédiatrie, 1999

Primary hyperoxaluria type 1 (PH1) is a metabolic disorder that mainly affects the kidneys. It re... more Primary hyperoxaluria type 1 (PH1) is a metabolic disorder that mainly affects the kidneys. It results from build-up of a substance called oxalate, which normally is filtered through the kidneys and excreted in the urine. In people with PH1, the accumulated oxalate is deposited in the kidneys and urinary tract. We report a series of 4 cases of different ages, grouping various clinical forms and presentations. Hydro-electrolyte disorders and renal insufficiency were present in all cases, genetic diagnosis was made in 2 cases. All patients were placed on supportive therapies and peritoneal dialysis. Additionally, a review of the literature for presentations, diagnosis, complications, and treatment of this rare genetic metabolic disease were included.

Journal of Academic Research in Medicine, 2015

The Pan African medical journal, 2017

This study aimed to evaluate the daily consumption of milk products in a population of Moroccan c... more This study aimed to evaluate the daily consumption of milk products in a population of Moroccan children and to determine the factors influencing this consumption. We conducted a prospective study from 1 October 2013 to 31 April 2014. Children aged between 2 and 16 years were included in the study. The participants were recruited in the city of Fez. Data were collected using a frequency questionnaire. Enrolled parents and children were interviewed on their consumption of milk products and on sociodemographic factors. Children underwent anthropometric examination. The association between variables in milk products consumption was analyzed using univariate and multivariate analysis with logistic regression model. Food survey involved 286 children: 151 girls (52.8%) and 131 boys (45.8%). Children aged 2 to 3 years accounted for 26.4%, those aged 4 to 7 years accounted for 28.9%, those aged 7 to 9 years accounted for 18.3% and adolescents aged 10 to 16 years accounted for 26.4%. Childre...

Pan African Medical Journal, 2015

Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's... more Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's one of the rare genetic diseases for which therapy is now available. The purpose of this work is to study the epidemiological features of the disease and to highlight the diagnostic difficulties. We performed an 11-year retrospective study of 11 patients with GD followed-up in the department of paediatric hepatology gastroenterology and nutrition of Rabat children's Hospital. We observed 11 patients with GD: 6 males and 5 females. Age at onset ranged from 3 months to 10 years with an average of 3.41 years. Mean age at diagnosis was 4 years (range 3months-14years).Parental consanguinity was noted in 85% cases. According to the clinical presentation, we classified our patients into: 9 cases of type 1 (81%) and two cases of type 2 (19%), none of the patients presented GD type 3. GD type 1: The age at diagnosis ranged from 2 years to 14 year with an average of 6 years. Main symptoms were: splenomegaly, hepatomegaly , pallor, haemorrhagic appearance (40%), bone pain (40%). The diagnosis was based on histology showing the Gaucher's cells in various tissues (100%). Enzymatic activity dosage confirmed the diagnosis of GD for 4 patients (44.5%). The treatment was always symptomatic (analgesics, transfusion). A splenectomy was performed in one case presenting with multiple splenic abscesses and high transfusion requirements. None of the patients received a specific treatment (substitutive enzymotherapy). The follow-up period ranged from 3 months to 6 years with an average follow-up of 4 years. We noticed stability in 4 cases, 2 worsening cases with bone and spleen complications. Three patients were lost to follow-up. GD type 2: we observed two cases of GD type 2 diagnosed at 3 and 18 months. The visceral symptoms were serious and the neurological features included seizures, hypertony, squint, physical developmental milestones delay. Both of them died. Gaucher's disease is not exceptional in Morocco. Type 1 is the most common type. We noted through this study some diagnostic difficulties as the diagnosis was delayed and the enzymatic dosage was performed in only 42% of the cases as well as therapeutic difficulty with no prescription of the specific treatment given the high cost of the enzyme.

Archives of medical research, 2011

We undertook this study to assess the prevalence of obesity and overweight in children enrolled i... more We undertook this study to assess the prevalence of obesity and overweight in children enrolled in government primary schools in the city of Rabat, Morocco. Twenty three schools were randomly selected. A cross-sectional study was conducted between April 2010 and June 2010. The survey was conducted on the basis of two questionnaires for both parents and children. The references used are those of the WHO (2007). Our study involved a sample of 1570 children with an average age of 9.7 ± 0.95 years. The prevalence of overweight and obesity was 8.7%. Overweight affected 5.1% and obesity affected 3.6%. The majority of our population consisted of children of low socioeconomic status where 59% of fathers are laborers and 85% of mothers are unemployed. Overweight and obesity do not spare the most underprivileged social strata of our country. Therefore, prevention strategies and programs to raise awareness of risks and threats involved must be a public health priority.

Pan African Medical Journal

The Lancet Gastroenterology & Hepatology, 2022

Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency;... more Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's one of the rare genetic diseases for which therapy is now available. The purpose of this work is to study the epidemiological features of the disease and to highlight the diagnostic difficulties. We performed an 11-year retrospective study of 11 patients with GD followed-up in the department of paediatric hepatology gastroenterology and nutrition of Rabat children's Hospital. We observed 11 patients with GD: 6 males and 5 females. Age at onset ranged from 3 months to 10 years with an average of 3.41 years. Mean age at diagnosis was 4 years (range 3months-14years).Parental consanguinity was noted in 85 % cases. According to the clinical presentation, we classified our patients into: 9 cases of type 1 (81%) and two cases of type 2 (19%), none of the patients presented GD type 3. GD type 1: The age at diagnosis ranged from 2 years to 14 year with an average of 6 years. Main ...

Ecological Engineering & Environmental Technology, May 1, 2023

Ecological Engineering & Environmental Technology

The symbiotic have been shown to be effective in prophylaxis and treatment of various diseases. I... more The symbiotic have been shown to be effective in prophylaxis and treatment of various diseases. Indeed, one of the main functions of probiotics is to improve microbial homeostasis in the body and to decrease the invasion of pathogens and their colonization. The objective of our study is to assess and then compare the rate of sales and the use of symbiotics by the Moroccan population in order to describe the status of sale of this type of Medicine. The collection of belly data was carried out using a questionnaire which contains information on all Moroccan market products and this study includes fifteen of the most widespread symbiotics products (probiotics and prebiotics). The study suggests that the sale of symbiotic products increased in some strains such as bacterial strain Bifidobacterium infantis which reached 96,300 units and Bifidobacterium lactis with a sale which reached 35,000 units and also there was also a decrease in sales of other symbiotic products such as Lactobacillus casei in 2019 compared to the sale in 2018 and according to the student test there is no significant difference between the average sales during the two successive years of 2018 and 2019 (p = 0.496). The results show that the consumption and use of symbiotic in Morocco has undergone significant fluctuations trending towards a regression.

BMC Pediatrics, 2018

Background: Allgrove syndrome is a rare autosomal recessive disorder characterized by the triad o... more Background: Allgrove syndrome is a rare autosomal recessive disorder characterized by the triad of achalasia, alacrimia and adrenal insufficiency. It is caused by the mutations of the AAAS gene located on chromosome 12q13. The c.1331 + 1G > A mutation is one of the most common described in North Africa including Tunisia, Algeria and Libya. We report here the clinical and genetic profile of a Moroccan family with Allgrove syndrome. Case presentation: A Moroccan sister and brother born to consanguineous parents were found, at the ages of twelve and fifteen months old respectively, to have alacrimia and isolated glucocorticoid deficiency. Later, they developed achalasia whereupon Allgrove syndrome was diagnosed clinically and confirmed by DNA sequencing which revealed a c.1331 + 1G > A mutation in the AAAS gene. Conclusion: This finding reinforces previous studies in demonstrating the geographic expansion of the ancestral mutation c.1331 + 1G > A in North African patients and thus enabling targeted genetic counseling. To the best of our knowledge, this is the first report of the AAAS gene mutation in Moroccan patients.

Digestive and Liver Disease, 2014

Celiac disease (CD) has a heterogeneous clinical expression. This report describes an uncommon CD... more Celiac disease (CD) has a heterogeneous clinical expression. This report describes an uncommon CD diagnosis in a 21 year old girl, affected by thalassemia major and followed at our Hematology Unit. Her ferritin levels used to range between 700 and 1000 g/L when she was on deferoxamine (40 mg/kg/day s.c.), therefore replaced with deferosilax (30-40 mg/kg/day per os) with stabilization of values around 400 g/L. After EBV infection, recurrent abdominal pains and diarrhea appeared. Few months later, ferritin levels decreased stepwise to 120 g/L albeit the same daily iron intake (blood transfusions) and the same drug dose, leading hematologists to reduce deferosilax up to 13 mg/kg/day. Her values increased up to 300 g/L. Thereafter, she was sent at our Gastroenterology and Hepatology Unit because of persisting gastrointestinal symptoms. Screening for CD showed anti-transglutaminase IgA > 100 UA/mL (<16) and positive antiendomysial antibodies. A reduction in number and height of folds was found in bulb and duodenum at upper gastrointestinal endoscopy and histological examination confirmed CD diagnosis (Marsh-Oberhuber 3a-3b). Once on gluten-free diet (GFD) ferritin levels rose to 568 g/L, thus requiring to increase deferosilax dose. This report suggests to consider undiagnosed CD in thalassemic patients when ferritin levels unexpectedly decrease demanding a lower iron chelator dose, perhaps due to un underlying malabsorption. Although the GFD leads to increased ferritin levels, it remains essential in order to prevent the risk of CD complication in organs such as liver, pancreas, thyroid, bone and heart, already potentially damaged by hematological condition.

Digestive and Liver Disease, 2014

21st National Conference of the Societa-Italiana-di-Gastroenterologia-Epatologia-e-Nutrizione-Ped... more 21st National Conference of the Societa-Italiana-di-Gastroenterologia-Epatologia-e-Nutrizione-Pediatrica (SIGENAP) -- OCT 02-04, 2014 -- Sorrento, ITALYWOS: 000209827300121Soc Italiana Gastroenterologia Epatologia & Nutrizione Pediatric

Case Reports in Pediatrics

Background and Aims. There is growing evidence that the 2019 coronavirus disease (COVID-19) is em... more Background and Aims. There is growing evidence that the 2019 coronavirus disease (COVID-19) is emerging as a potential trigger virus for the development of diabetes mellitus in children. This can occur even in patients without factors predisposing to impaired glucose metabolism. Here, we report two rare cases of diabetic ketoacidosis revealing new-onset diabetes and precipitated by COVID-19. These cases are reported in view of their rarity and originality. The relationship between type 1 diabetes mellitus and COVID-19 is discussed. Results. Two children developed symptoms suggestive of diabetic ketoacidosis preceded by polyuria, polydipsia, and asbestos. There is a documented COVID-19 infection in the parents of the 2 children. An asymptomatic infection was detected in the 2 patients on the basis of a reverse transcription polymerase chain reaction (RT-PCR) test. Thoracic imaging and inflammatory workup were negative in both cases. Both patients responded well to treatment, includin...

Batna journal of medical sciences, Dec 30, 2019

Malignant Infantile Osteopetrosis (MIOP) is a rare genetic disorder due to osteoclast abnormal ac... more Malignant Infantile Osteopetrosis (MIOP) is a rare genetic disorder due to osteoclast abnormal activity.We report a thirteen month-old male patient, diagnosed as MIOP while investigating the cause of hepatosplenomegaly associated with hydrocephalus. His medical history revealed non consanguineous parents and one brother's death at the same age of unknown etiology (similar symptoms).Systemic examination showed hepatosplenomegaly, growth failure, developmental milestones delay, and rickets features. Ophthalmic exam yielded bilateral optic atrophy. Skeleton radiographs detected generalized dense bone and rickets. Cerebral CT scan revealed hydrocephalus. Histological examination showed hypoplastic bone marrow and extra-medullary hematopoeisis. Diagnosis was confirmed by genetic testing that showed two heterozygote mutations within the TCIRG1 gene. The patient received supportive treatment. He died from an acute respiratory distress.MIOP should be kept in mind as a rare cause of hep...

The Pan African Medical Journal, 2021

Introduction nul ne peut nier les résultats protecteurs satisfaisants de la vaccination contre pl... more Introduction nul ne peut nier les résultats protecteurs satisfaisants de la vaccination contre plusieurs maladies graves dans le monde et particulièrement au Maroc. L´extension de la pandémie COVID-19 dans notre pays a entrainé une baisse importante de la vaccination des enfants, ce qui pourrait causer des flambées épidémiques dans le futur. D´où l´intervention du ministère de la santé pour pallier à cette situation. L´objectif était de montrer l´ampleur du relâchement de la vaccination en temps COVID-19 et sortir avec des recommandations visant à rétablir ce changement. Méthodes il s´agit d´une étude transversale sur l´impact de cette pandémie sur le suivi vaccinal des enfants. Nous avons mené une enquête nationale auprès des pédiatres sous forme d´un questionnaire électronique via Google Forms. Nous avons procédé à la collecte, l´analyse et l´interprétation des résultats. Résultats cent trois pédiatres marocains ont répondu au questionnaire. Plus de 2 tiers des pédiatres exercent ...

Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contrai... more Background: Closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. This report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning. Case report: A 5-year-old girl was presented with acute blindness following closantel poisoning. She was given mistakenly a dose of 500 mg/day (25mg/kg/day) for 8 days. Clinical examination revealed a well-appearing child with bilateral mydriasis, loss of pupillary light reflex and absence of blinking to threat. Fundoscopic exam revealed bilateral pre-atrophic papilledema. Electroretinogram showed a highly significant decrease in retinal activity. Laboratory examinations revealed 52% increase in prothrombin time, prolongation of activated partial thromboplastin time to 1.3 times the normal and rise of aspartate aminotransferase to 120 IU/L. In addition, creatine kinase peaked at 904 IU/L. Moreover, normocytic normochromic anemia with hemoglobin at 1...

World Journal of GASTROENTEROLOGY, HEPATOLOGY AND ENDOSCOPY, 2021

The term bezoar refers to foreign bodies found in the digestive tract. It results in a stagnation... more The term bezoar refers to foreign bodies found in the digestive tract. It results in a stagnation of ingested non-digestible substances. We report a case of an esophageal bezoar collected in the pediatric gastroenterology department of the children's hospital in Rabat-MO-ROCCO. This observation of an esophageal bezoar, the first in our institution, to our knowledge, confirms the rarity of the pathology. 7-year-old child, taken by his parents to the children's hospital of the university hospital in Rabat for total aphagia. His history shows: psychomotor retardation, followed for 2 years for peptic esophagitis complicated by peptic stenosis. The course was marked by total aphagia, early postprandial vomiting, and weight loss of 6 kg in 3 months. This symptomatology has been evolving for 2 months. Esophagogastroduodenal fibroscopy, using an 8.5mm pediatric fiberscope, revealed an esophageal bezoar made of tissues, fibers, hair, sponge, plastics and ropes. A multistage endoscopic extraction was performed, which extracted a 430g bezoar. After a complete cleansing of the esophagus, the esophagogastroduodenal exploration showed ascension of the gastric folds on retrovision, a gaping cardia, a hernial pouch, an esophageal caliber disparity of 25 cm to 20 cm of the dental arches with presence of mucous ulcerations and false membranes. After extraction, the child resumed his normal diet with no vomiting. a proton pump inhibitor and antibiotic therapy were prescribed. PATIENT AND OBSERVATION 7-year-old child, taken by his parents to the children's hospital of the university hospital in Rabat for total aphagia. His history shows: psychomotor retardation, followed for 2 years for peptic esophagitis complicated by peptic stenosis. The course was marked by total aphagia, early postprandial vomiting, and weight loss of 6 kg in 3 months. This symptomatology has been evolving for 2 months. The admission exam noted: a pale patient. A weight of 12kg (-3 DS), a height of 114cm (-2DS).

Archives de Pédiatrie, 1999

Primary hyperoxaluria type 1 (PH1) is a metabolic disorder that mainly affects the kidneys. It re... more Primary hyperoxaluria type 1 (PH1) is a metabolic disorder that mainly affects the kidneys. It results from build-up of a substance called oxalate, which normally is filtered through the kidneys and excreted in the urine. In people with PH1, the accumulated oxalate is deposited in the kidneys and urinary tract. We report a series of 4 cases of different ages, grouping various clinical forms and presentations. Hydro-electrolyte disorders and renal insufficiency were present in all cases, genetic diagnosis was made in 2 cases. All patients were placed on supportive therapies and peritoneal dialysis. Additionally, a review of the literature for presentations, diagnosis, complications, and treatment of this rare genetic metabolic disease were included.

Journal of Academic Research in Medicine, 2015

The Pan African medical journal, 2017

This study aimed to evaluate the daily consumption of milk products in a population of Moroccan c... more This study aimed to evaluate the daily consumption of milk products in a population of Moroccan children and to determine the factors influencing this consumption. We conducted a prospective study from 1 October 2013 to 31 April 2014. Children aged between 2 and 16 years were included in the study. The participants were recruited in the city of Fez. Data were collected using a frequency questionnaire. Enrolled parents and children were interviewed on their consumption of milk products and on sociodemographic factors. Children underwent anthropometric examination. The association between variables in milk products consumption was analyzed using univariate and multivariate analysis with logistic regression model. Food survey involved 286 children: 151 girls (52.8%) and 131 boys (45.8%). Children aged 2 to 3 years accounted for 26.4%, those aged 4 to 7 years accounted for 28.9%, those aged 7 to 9 years accounted for 18.3% and adolescents aged 10 to 16 years accounted for 26.4%. Childre...

Pan African Medical Journal, 2015

Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's... more Gaucher's disease (GD) is a lysosomal storage disorder due to glucocerebrosidase deficiency; it's one of the rare genetic diseases for which therapy is now available. The purpose of this work is to study the epidemiological features of the disease and to highlight the diagnostic difficulties. We performed an 11-year retrospective study of 11 patients with GD followed-up in the department of paediatric hepatology gastroenterology and nutrition of Rabat children's Hospital. We observed 11 patients with GD: 6 males and 5 females. Age at onset ranged from 3 months to 10 years with an average of 3.41 years. Mean age at diagnosis was 4 years (range 3months-14years).Parental consanguinity was noted in 85% cases. According to the clinical presentation, we classified our patients into: 9 cases of type 1 (81%) and two cases of type 2 (19%), none of the patients presented GD type 3. GD type 1: The age at diagnosis ranged from 2 years to 14 year with an average of 6 years. Main symptoms were: splenomegaly, hepatomegaly , pallor, haemorrhagic appearance (40%), bone pain (40%). The diagnosis was based on histology showing the Gaucher's cells in various tissues (100%). Enzymatic activity dosage confirmed the diagnosis of GD for 4 patients (44.5%). The treatment was always symptomatic (analgesics, transfusion). A splenectomy was performed in one case presenting with multiple splenic abscesses and high transfusion requirements. None of the patients received a specific treatment (substitutive enzymotherapy). The follow-up period ranged from 3 months to 6 years with an average follow-up of 4 years. We noticed stability in 4 cases, 2 worsening cases with bone and spleen complications. Three patients were lost to follow-up. GD type 2: we observed two cases of GD type 2 diagnosed at 3 and 18 months. The visceral symptoms were serious and the neurological features included seizures, hypertony, squint, physical developmental milestones delay. Both of them died. Gaucher's disease is not exceptional in Morocco. Type 1 is the most common type. We noted through this study some diagnostic difficulties as the diagnosis was delayed and the enzymatic dosage was performed in only 42% of the cases as well as therapeutic difficulty with no prescription of the specific treatment given the high cost of the enzyme.

Archives of medical research, 2011

We undertook this study to assess the prevalence of obesity and overweight in children enrolled i... more We undertook this study to assess the prevalence of obesity and overweight in children enrolled in government primary schools in the city of Rabat, Morocco. Twenty three schools were randomly selected. A cross-sectional study was conducted between April 2010 and June 2010. The survey was conducted on the basis of two questionnaires for both parents and children. The references used are those of the WHO (2007). Our study involved a sample of 1570 children with an average age of 9.7 ± 0.95 years. The prevalence of overweight and obesity was 8.7%. Overweight affected 5.1% and obesity affected 3.6%. The majority of our population consisted of children of low socioeconomic status where 59% of fathers are laborers and 85% of mothers are unemployed. Overweight and obesity do not spare the most underprivileged social strata of our country. Therefore, prevention strategies and programs to raise awareness of risks and threats involved must be a public health priority.

Pan African Medical Journal