Ala Salhab - Academia.edu (original) (raw)
Papers by Ala Salhab
ABSTRACT In collaboration with Tucson Electric Power we studied the performance of twenty differe... more ABSTRACT In collaboration with Tucson Electric Power we studied the performance of twenty different grid-tied photovoltaic systems, consisting of over 600 PV modules in all. We added data acquisition hardware to monitor DC power from the modules, AC power from the inverters, PV module temperatures, and meteorological data such as the irradiance incident on the PV systems. We report measurements of PV system yields and efficiencies over periods of minutes, days, and years. We also report temperature and irradiance coefficients of efficiency and measurements of long-term degradation. We also use our data to validate models that predict the output from PV systems.
Food and Cosmetics Toxicology, 1975
ABSTRACT Aflatoxin B1 hydroxylation to aflatoxin Q1 and aflatoxin M1 is catalysed by hepatic micr... more ABSTRACT Aflatoxin B1 hydroxylation to aflatoxin Q1 and aflatoxin M1 is catalysed by hepatic microsomal mixed-function oxidases from the rhesus monkey and is accompanied by the formation of three unidentified organosoluble metabolites. The enzyme systems involved require NADPH and molecular oxygen for maximum catalytic activity and both are inhibited by carbon monoxide and by SKF 525-A. The optimum pH for aflatoxin Q1 formation is 7·4 and that for aflatoxin M1 is 8·4. The apparent Km and V for aflatoxin Q1 production are 0·166 mM and 7·7 nmol/mg microsomal protein/min, respectively, and for aflatoxin M1 production 0·012 mM and 0·44 nmol/mg microsomal protein/min. The results are discussed in relation to the hepatocarcinogenic potency of aflatoxin B1 in the rhesus monkey and man.
International Journal of Pharmaceutics, 1999
The bioequivalence of Folifer-Z ® tablets, a new sustained-release iron and zinc formulation was ... more The bioequivalence of Folifer-Z ® tablets, a new sustained-release iron and zinc formulation was evaluated and compared to that of Fefol-Z ® capsules in 30 healthy male subjects. Each subject received a single oral dose of either product according to a randomized two-way crossover design. A washout period of 1 week was allowed after each treatment. Blood samples were obtained over a 24-h period, and iron and zinc concentrations were measured. The pharmacokinetic parameters of Folifer-Z ® were C max (1039 46.2 mg/dl), T max (5.9392.94 h) and AUC 0-24 h (19379 706 mg/dl per h), whereas the corresponding Fefol-Z ® values were C max (1099 41.5 mg/dl), T max (6.6492.54) and AUC 0-24 h (1865 9699 mg/h per dl). Analysis of variance on log-transformed data for C max and AUC 0-24 h revealed lack of significant differences among the two formulations. The mean relative bioavailability of AUC test / AUC reference was 1.07 (90% confidence interval range: 99-115%) and for C max test /C max reference was 0.96 (90% confidence interval range: 88-105%). Regarding the zinc results, the pharmacokinetic parameters of Folifer-Z ® values were C max (1019 20.7 mg/dl), T max (4.869 1.53 h) and AUC 0-24 h (19449202 mg/h per dl), while the corresponding Fefol-Z ® values were C max (102920.7), T max (4.939 1.51) and AUC 0-24 h (19539200). Analysis of variance on log-transformed zinc data for C max , T max and AUC 0-24 h revealed lack of significant difference among the two formulations. The mean relative bioavailability of AUC test /AUC reference was 0.98 (90% confidence interval range; 95-101%) and for C max test /C max reference was 0.92 (90% confidence interval range: 89-96%). The results also indicate a possible inhibition of zinc absorption by iron content of both formulations. It is concluded that Folifer-Z ® product is bioequivalent to Fefol-Z ® product.
Toxicology Letters, 1984
Cellular uptake and cytotoxicity of chenodeoxycholic acid, delivered free or encapsulated in lipo... more Cellular uptake and cytotoxicity of chenodeoxycholic acid, delivered free or encapsulated in liposomes, were compared in isolated rat hepatocytes. As quantified by leakage of cytoplasmic and lysosomal enzymes into the medium, cells exposed to free chenodeoxycholic acid displayed a dose-dependent cytotoxic response. Cellular uptake of the drug was either similar or less for free than for entrapped chenodeoxycholic acid at 100 to 400 microM. However, the cytolytic changes were prevented when the cells were exposed to liposome-encapsulated drug. The prevention of cytotoxicity by delivering the drug entrapped in liposomes indicates that the free drug has the capacity to injure cell membranes directly, and suggests that drug-membrane interactions play a role in the hepatotoxic potential of chenodeoxycholic acid.
Pharmacology, 1980
Chang liver cells and isolated rat hepatocytes were exposed to medium containing different concen... more Chang liver cells and isolated rat hepatocytes were exposed to medium containing different concentrations of erythromycin estolate or erythromycin base for 1-5 h. Hepatotoxicity was quantitated by measuring leakage of enzymes from cells into surrounding medium and the damage to the plasma cell membrane seen under surface scanning electron microscopy. Only the cells exposed to erythromycin estolate showed significantly greater enzyme leakage than controls and appeared severely affected by cytopathic changes when observed under scanning electron microscopy.
Pharmacology, 1986
Isolated rat hepatocytes were used to determine the relationship between magnitude of uptake by c... more Isolated rat hepatocytes were used to determine the relationship between magnitude of uptake by cells and cytotoxic effects of chlorpromazine (CPZ) and promazine (PZ). Cell injury was evaluated by the extent of leakage of cytoplasmic and lysosomal enzymes from cells to surrounding medium and by cytopathic changes seen under surface scanning electron microscopy, after drug exposure. The drug uptake was time- and dose-dependent; cell preparations exposed to equal concentrations of either drug in the medium contained a twice greater concentration of CPZ than of PZ. Cytoplasmic and lysosomal enzyme leakage from cells exposed to 200 and 500 microM of CPZ showed significantly greater toxicity than control cells or those exposed to PZ at the same concentration. Surface activity of drugs was determined to calculate their surface excess. The surface pressure of CPZ is about twice that of PZ at equimolar concentration and correlated with extent of drug uptake and toxicity, suggesting that the surfactibility could play a role in bioavailability and toxicity of these drugs to liver cell membranes. Cytotoxicity was decreased by entrapment of CPZ inside liposomes; up to 40% for lactate dehydrogenase leakage and 47% of beta-glucuronidase, presenting further evidence for the potential use of liposomes.
Pharmaceutical Biology, 1990
ABSTRACT Abstract The effect of the volatile oil of Teucrium polium was investigated in vitro usi... more ABSTRACT Abstract The effect of the volatile oil of Teucrium polium was investigated in vitro using isolated segments of rabbit intestine. The volatile oil was found to inhibit the spontaneous movements of the intestine and the contractions of the intestine induced by depolarization with high potassium (K+) solution. Also, the volatile oil was found to inhibit 45Ca influx in the intestine in a dose dependent manner. Our results suggest that the volatile oil inhibits Ca2+ influx through the potential dependent Ca2+ channels.
PEDIATRICS, 2004
To determine the potential contribution of initial hypoglycemia to the development of neonatal br... more To determine the potential contribution of initial hypoglycemia to the development of neonatal brain injury in term infants with severe fetal acidemia. A retrospective chart review was conducted of 185 term infants who were admitted to the neonatal intensive care unit between January 1993 and December 2002 with an umbilical arterial pH <7.00. Short-term neurologic outcome measures include death as a consequence of severe encephalopathy and evidence of moderate to severe encephalopathy with or without seizures. Hypoglycemia was defined as an initial blood glucose < or =40 mg/dL. Forty-one (22%) infants developed an abnormal neurologic outcome, including 14 (34%) with severe hypoxic ischemic encephalopathy who died, 24 (59%) with moderate to severe hypoxic ischemic encephalopathy, and 3 (7%) with seizures. Twenty-seven (14.5%) of the 185 infants had an initial blood sugar < or =40 mg/dL. Fifteen (56%) of 27 infants with a blood sugar < or =40 mg/dL versus 26 (16%) of 158 infants with a blood sugar >40 mg/dL had an abnormal neurologic outcome (odds ratio [OR]: 6.3; 95% confidence interval [CI]: 2.6-15.3). Infants with abnormal outcomes and a blood sugar < or =40 mg/dL versus >40 mg/dL had a higher pH (6.86 +/- 0.07 vs 6.75 +/- 0.09), a lesser base deficit (-19 +/- 4 vs -23.8 +/- 4 mEq/L), and lower mean arterial blood pressure (34 +/- 10 vs 45 +/- 14 mm Hg), respectively. There was no difference between groups in the proportion of infants who required cardiopulmonary resuscitation (7 [46%] vs 15 [57%]) and those with a 5-minute Apgar score <5 (11 [73%] vs 22 [85%]). By multivariate logistic analysis, 4 variables were significantly associated with abnormal outcome: initial blood glucose < or =40 mg/dL versus >40 mg/dL (OR: 18.5; 95% CI: 3.1-111.9), cord arterial pH < or =6.90 versus >6.90 (OR: 9.8; 95% CI: 2.1-44.7), a 5-minute Apgar score < or =5 versus >5 (OR: 6.4; 95% CI: 1.7-24.5), and the requirement for intubation with or without cardiopulmonary resuscitation versus neither (OR: 4.7; 95% CI: 1.2-17.9). Initial hypoglycemia is an important risk factor for perinatal brain injury, particularly in depressed term infants who require resuscitation and have severe fetal acidemia. It remains unclear, however, whether earlier detection of hypoglycemia, such as in the delivery room, in this population could modify subsequent neurologic outcome.
Journal of Hepatology, 2014
Bulletin of the American …, 2011
... 8:30 AM–9:30 AM, Saturday, October 22, 2011. UA Student Union Room: Santa Cruz Chair: Koen Vi... more ... 8:30 AM–9:30 AM, Saturday, October 22, 2011. UA Student Union Room: Santa Cruz Chair: Koen Visscher, University ... Sean Orsburn Adria Brooks Daniel Cormode James Greenberg Garrett Hardesty Vincent Lonij Anas Salhab Tyler St. Germaine Gabe Torres Alexander Cronin. ...
Journal of Ethnopharmacology, 1991
Journal of perinatology : official journal of the California Perinatal Association, 2003
To assess the outcome of extremely low birth weight (ELBW) infants < or =1000 g as it relates ... more To assess the outcome of extremely low birth weight (ELBW) infants < or =1000 g as it relates to antenatal steroids (ANS) therapy.
Journal of perinatology : official journal of the California Perinatal Association, 2004
To determine patterns of survival for very low birth weight (VLBW, birth weight 501 to 1500 g) ne... more To determine patterns of survival for very low birth weight (VLBW, birth weight 501 to 1500 g) neonates over 23 years.
Journal of perinatology : official journal of the California Perinatal Association, 2004
To determine the growth and neurodevelopmental outcome, as well as predictors of the latter in ex... more To determine the growth and neurodevelopmental outcome, as well as predictors of the latter in extremely low-birth-weight (ELBW) infants with definitive necrotizing enterocolitis (NEC).
Pediatric neurology, 2005
The contribution of intrapartum hypoxia-ischemia to neonatal encephalopathy in the larger preterm... more The contribution of intrapartum hypoxia-ischemia to neonatal encephalopathy in the larger preterm infant remains poorly defined. Such infants could become potential candidates for neuroprotective strategies. The objective of this study was to determine in preterm infants of gestation 31 to 36 weeks, with severe fetal acidemia (i.e., cord arterial pH < 7.00) the incidence of moderate to severe neonatal encephalopathy as well as the perinatal characteristics that may facilitate early identification. The data of 61 preterm infants of mean birth weight 1998 gm and mean gestation of 33.6 weeks were retrieved. Short-term abnormal neurologic outcome measures included evidence of encephalopathy with or without seizures or neuroimaging abnormalities. Eight (13%) of 61 infants developed an abnormal neonatal neurologic outcome. More infants with abnormal vs normal outcome had 1-minute Apgar of 0, i.e., 4/8 vs 3/53, 5-minute Apgar score </=5 (7/8 vs 17/53), required chest compressions (5/...
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2011
Variation in nicotine metabolism may be due to genetic alterations in CYP 2A6, environmental fact... more Variation in nicotine metabolism may be due to genetic alterations in CYP 2A6, environmental factors, and diet. The purpose of this research was to evaluate mint drink effect on nicotine metabolism as judged by nicotine/cotinine ratio in urine of Jordanian smokers.
Contraception, 2003
Meloxicam, a selective cyclooxygenase-2 inhibitor, was administered orally or intravaginally, to ... more Meloxicam, a selective cyclooxygenase-2 inhibitor, was administered orally or intravaginally, to sperm-positive female rabbits to assess its effect on ovulation. A single oral dose (20 mg/kg), administered 5 h postcoitus resulted in 100% contraceptive rate. On the other hand, for females receiving meloxicam suppositories (14.9 mg/kg), 5 h postcoitus, the contraceptive rate was 62.5% compared to placebo. The decrease in the contraceptive effect of meloxicam suppository may be due to the rejection of the dose by some females. Corpora lutea, maternal plasma progesterone, ovary fresh weight and maternal body weight gain were not affected by meloxicam treatment compared to placebo. Histopathologically, the surface of the ovary of meloxicam-treated females appears irregular and dilated due to the presence of different-sized cysts. Some of the cystic follicles were retained ova. Further, immunohistochemical stains for estrogen and progesterone receptors showed positive staining in granulosa cells and the wall of the unruptured follicle. It is concluded that contraceptive effect of meloxicam in female rabbits resulted in a failure of follicular rupturing.
Contraception, 2001
The nonsteroidal antiinflammatory, selective cyclo-oxygenase-2 (COX-2) inhibitor, meloxicam, was ... more The nonsteroidal antiinflammatory, selective cyclo-oxygenase-2 (COX-2) inhibitor, meloxicam, was tested to assess its effect on rabbit ovulation. Meloxicam in different doses was administered intraperitoneally (ip) to adult female Californian rabbits at 2, 5, 8, and 24 h postcoitus with sperm-positive rabbits. Rabbits were killed on Day 10 of gestation. Meloxicam produced significant inhibition of ovulation in rabbits. This inhibition of ovulation by meloxicam was dose- and time-dependent. Ovulation in rabbits was completely inhibited by a single ip administration of meloxicam (20 mg/kg) when the drug was administered at 2 and 5 h postcoitus, whereas neither ovulation nor implantation were inhibited (pregnancy rate 75%) by the same dose administered 24 h postcoitus (approximately 14 h post ovulation). Further, ovulation was completely inhibited by 10 mg/kg of meloxicam when the drug was administered at 5 or 8 h postcoitus, but there was less inhibition of ovulation when 10 mg/kg of the drug was administered at 2 or 24 h postcoitus (pregnancy rate 25 and 80%, respectively). Corpora lutea, maternal plasma progesterone, ovary fresh weight, and maternal body weight gain were affected by meloxicam treatment. Histopathological findings observed in the ovaries of treated rabbits included microscopic dilatation of graffian follicles, particularly mature follicles. Some of the follicles were cystically dilated in addition to severe hemorrhage within the follicles which lost ova. These results show that ovulation can be inhibited in rabbits by meloxicam. Further studies are needed to assess the value of selective COX-2 inhibitors as potential nonhormonal contraceptive agents.
ABSTRACT In collaboration with Tucson Electric Power we studied the performance of twenty differe... more ABSTRACT In collaboration with Tucson Electric Power we studied the performance of twenty different grid-tied photovoltaic systems, consisting of over 600 PV modules in all. We added data acquisition hardware to monitor DC power from the modules, AC power from the inverters, PV module temperatures, and meteorological data such as the irradiance incident on the PV systems. We report measurements of PV system yields and efficiencies over periods of minutes, days, and years. We also report temperature and irradiance coefficients of efficiency and measurements of long-term degradation. We also use our data to validate models that predict the output from PV systems.
Food and Cosmetics Toxicology, 1975
ABSTRACT Aflatoxin B1 hydroxylation to aflatoxin Q1 and aflatoxin M1 is catalysed by hepatic micr... more ABSTRACT Aflatoxin B1 hydroxylation to aflatoxin Q1 and aflatoxin M1 is catalysed by hepatic microsomal mixed-function oxidases from the rhesus monkey and is accompanied by the formation of three unidentified organosoluble metabolites. The enzyme systems involved require NADPH and molecular oxygen for maximum catalytic activity and both are inhibited by carbon monoxide and by SKF 525-A. The optimum pH for aflatoxin Q1 formation is 7·4 and that for aflatoxin M1 is 8·4. The apparent Km and V for aflatoxin Q1 production are 0·166 mM and 7·7 nmol/mg microsomal protein/min, respectively, and for aflatoxin M1 production 0·012 mM and 0·44 nmol/mg microsomal protein/min. The results are discussed in relation to the hepatocarcinogenic potency of aflatoxin B1 in the rhesus monkey and man.
International Journal of Pharmaceutics, 1999
The bioequivalence of Folifer-Z ® tablets, a new sustained-release iron and zinc formulation was ... more The bioequivalence of Folifer-Z ® tablets, a new sustained-release iron and zinc formulation was evaluated and compared to that of Fefol-Z ® capsules in 30 healthy male subjects. Each subject received a single oral dose of either product according to a randomized two-way crossover design. A washout period of 1 week was allowed after each treatment. Blood samples were obtained over a 24-h period, and iron and zinc concentrations were measured. The pharmacokinetic parameters of Folifer-Z ® were C max (1039 46.2 mg/dl), T max (5.9392.94 h) and AUC 0-24 h (19379 706 mg/dl per h), whereas the corresponding Fefol-Z ® values were C max (1099 41.5 mg/dl), T max (6.6492.54) and AUC 0-24 h (1865 9699 mg/h per dl). Analysis of variance on log-transformed data for C max and AUC 0-24 h revealed lack of significant differences among the two formulations. The mean relative bioavailability of AUC test / AUC reference was 1.07 (90% confidence interval range: 99-115%) and for C max test /C max reference was 0.96 (90% confidence interval range: 88-105%). Regarding the zinc results, the pharmacokinetic parameters of Folifer-Z ® values were C max (1019 20.7 mg/dl), T max (4.869 1.53 h) and AUC 0-24 h (19449202 mg/h per dl), while the corresponding Fefol-Z ® values were C max (102920.7), T max (4.939 1.51) and AUC 0-24 h (19539200). Analysis of variance on log-transformed zinc data for C max , T max and AUC 0-24 h revealed lack of significant difference among the two formulations. The mean relative bioavailability of AUC test /AUC reference was 0.98 (90% confidence interval range; 95-101%) and for C max test /C max reference was 0.92 (90% confidence interval range: 89-96%). The results also indicate a possible inhibition of zinc absorption by iron content of both formulations. It is concluded that Folifer-Z ® product is bioequivalent to Fefol-Z ® product.
Toxicology Letters, 1984
Cellular uptake and cytotoxicity of chenodeoxycholic acid, delivered free or encapsulated in lipo... more Cellular uptake and cytotoxicity of chenodeoxycholic acid, delivered free or encapsulated in liposomes, were compared in isolated rat hepatocytes. As quantified by leakage of cytoplasmic and lysosomal enzymes into the medium, cells exposed to free chenodeoxycholic acid displayed a dose-dependent cytotoxic response. Cellular uptake of the drug was either similar or less for free than for entrapped chenodeoxycholic acid at 100 to 400 microM. However, the cytolytic changes were prevented when the cells were exposed to liposome-encapsulated drug. The prevention of cytotoxicity by delivering the drug entrapped in liposomes indicates that the free drug has the capacity to injure cell membranes directly, and suggests that drug-membrane interactions play a role in the hepatotoxic potential of chenodeoxycholic acid.
Pharmacology, 1980
Chang liver cells and isolated rat hepatocytes were exposed to medium containing different concen... more Chang liver cells and isolated rat hepatocytes were exposed to medium containing different concentrations of erythromycin estolate or erythromycin base for 1-5 h. Hepatotoxicity was quantitated by measuring leakage of enzymes from cells into surrounding medium and the damage to the plasma cell membrane seen under surface scanning electron microscopy. Only the cells exposed to erythromycin estolate showed significantly greater enzyme leakage than controls and appeared severely affected by cytopathic changes when observed under scanning electron microscopy.
Pharmacology, 1986
Isolated rat hepatocytes were used to determine the relationship between magnitude of uptake by c... more Isolated rat hepatocytes were used to determine the relationship between magnitude of uptake by cells and cytotoxic effects of chlorpromazine (CPZ) and promazine (PZ). Cell injury was evaluated by the extent of leakage of cytoplasmic and lysosomal enzymes from cells to surrounding medium and by cytopathic changes seen under surface scanning electron microscopy, after drug exposure. The drug uptake was time- and dose-dependent; cell preparations exposed to equal concentrations of either drug in the medium contained a twice greater concentration of CPZ than of PZ. Cytoplasmic and lysosomal enzyme leakage from cells exposed to 200 and 500 microM of CPZ showed significantly greater toxicity than control cells or those exposed to PZ at the same concentration. Surface activity of drugs was determined to calculate their surface excess. The surface pressure of CPZ is about twice that of PZ at equimolar concentration and correlated with extent of drug uptake and toxicity, suggesting that the surfactibility could play a role in bioavailability and toxicity of these drugs to liver cell membranes. Cytotoxicity was decreased by entrapment of CPZ inside liposomes; up to 40% for lactate dehydrogenase leakage and 47% of beta-glucuronidase, presenting further evidence for the potential use of liposomes.
Pharmaceutical Biology, 1990
ABSTRACT Abstract The effect of the volatile oil of Teucrium polium was investigated in vitro usi... more ABSTRACT Abstract The effect of the volatile oil of Teucrium polium was investigated in vitro using isolated segments of rabbit intestine. The volatile oil was found to inhibit the spontaneous movements of the intestine and the contractions of the intestine induced by depolarization with high potassium (K+) solution. Also, the volatile oil was found to inhibit 45Ca influx in the intestine in a dose dependent manner. Our results suggest that the volatile oil inhibits Ca2+ influx through the potential dependent Ca2+ channels.
PEDIATRICS, 2004
To determine the potential contribution of initial hypoglycemia to the development of neonatal br... more To determine the potential contribution of initial hypoglycemia to the development of neonatal brain injury in term infants with severe fetal acidemia. A retrospective chart review was conducted of 185 term infants who were admitted to the neonatal intensive care unit between January 1993 and December 2002 with an umbilical arterial pH &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;7.00. Short-term neurologic outcome measures include death as a consequence of severe encephalopathy and evidence of moderate to severe encephalopathy with or without seizures. Hypoglycemia was defined as an initial blood glucose &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; or =40 mg/dL. Forty-one (22%) infants developed an abnormal neurologic outcome, including 14 (34%) with severe hypoxic ischemic encephalopathy who died, 24 (59%) with moderate to severe hypoxic ischemic encephalopathy, and 3 (7%) with seizures. Twenty-seven (14.5%) of the 185 infants had an initial blood sugar &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; or =40 mg/dL. Fifteen (56%) of 27 infants with a blood sugar &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; or =40 mg/dL versus 26 (16%) of 158 infants with a blood sugar &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;40 mg/dL had an abnormal neurologic outcome (odds ratio [OR]: 6.3; 95% confidence interval [CI]: 2.6-15.3). Infants with abnormal outcomes and a blood sugar &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; or =40 mg/dL versus &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;40 mg/dL had a higher pH (6.86 +/- 0.07 vs 6.75 +/- 0.09), a lesser base deficit (-19 +/- 4 vs -23.8 +/- 4 mEq/L), and lower mean arterial blood pressure (34 +/- 10 vs 45 +/- 14 mm Hg), respectively. There was no difference between groups in the proportion of infants who required cardiopulmonary resuscitation (7 [46%] vs 15 [57%]) and those with a 5-minute Apgar score &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;5 (11 [73%] vs 22 [85%]). By multivariate logistic analysis, 4 variables were significantly associated with abnormal outcome: initial blood glucose &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; or =40 mg/dL versus &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;40 mg/dL (OR: 18.5; 95% CI: 3.1-111.9), cord arterial pH &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; or =6.90 versus &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;6.90 (OR: 9.8; 95% CI: 2.1-44.7), a 5-minute Apgar score &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; or =5 versus &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;5 (OR: 6.4; 95% CI: 1.7-24.5), and the requirement for intubation with or without cardiopulmonary resuscitation versus neither (OR: 4.7; 95% CI: 1.2-17.9). Initial hypoglycemia is an important risk factor for perinatal brain injury, particularly in depressed term infants who require resuscitation and have severe fetal acidemia. It remains unclear, however, whether earlier detection of hypoglycemia, such as in the delivery room, in this population could modify subsequent neurologic outcome.
Journal of Hepatology, 2014
Bulletin of the American …, 2011
... 8:30 AM–9:30 AM, Saturday, October 22, 2011. UA Student Union Room: Santa Cruz Chair: Koen Vi... more ... 8:30 AM–9:30 AM, Saturday, October 22, 2011. UA Student Union Room: Santa Cruz Chair: Koen Visscher, University ... Sean Orsburn Adria Brooks Daniel Cormode James Greenberg Garrett Hardesty Vincent Lonij Anas Salhab Tyler St. Germaine Gabe Torres Alexander Cronin. ...
Journal of Ethnopharmacology, 1991
Journal of perinatology : official journal of the California Perinatal Association, 2003
To assess the outcome of extremely low birth weight (ELBW) infants < or =1000 g as it relates ... more To assess the outcome of extremely low birth weight (ELBW) infants < or =1000 g as it relates to antenatal steroids (ANS) therapy.
Journal of perinatology : official journal of the California Perinatal Association, 2004
To determine patterns of survival for very low birth weight (VLBW, birth weight 501 to 1500 g) ne... more To determine patterns of survival for very low birth weight (VLBW, birth weight 501 to 1500 g) neonates over 23 years.
Journal of perinatology : official journal of the California Perinatal Association, 2004
To determine the growth and neurodevelopmental outcome, as well as predictors of the latter in ex... more To determine the growth and neurodevelopmental outcome, as well as predictors of the latter in extremely low-birth-weight (ELBW) infants with definitive necrotizing enterocolitis (NEC).
Pediatric neurology, 2005
The contribution of intrapartum hypoxia-ischemia to neonatal encephalopathy in the larger preterm... more The contribution of intrapartum hypoxia-ischemia to neonatal encephalopathy in the larger preterm infant remains poorly defined. Such infants could become potential candidates for neuroprotective strategies. The objective of this study was to determine in preterm infants of gestation 31 to 36 weeks, with severe fetal acidemia (i.e., cord arterial pH < 7.00) the incidence of moderate to severe neonatal encephalopathy as well as the perinatal characteristics that may facilitate early identification. The data of 61 preterm infants of mean birth weight 1998 gm and mean gestation of 33.6 weeks were retrieved. Short-term abnormal neurologic outcome measures included evidence of encephalopathy with or without seizures or neuroimaging abnormalities. Eight (13%) of 61 infants developed an abnormal neonatal neurologic outcome. More infants with abnormal vs normal outcome had 1-minute Apgar of 0, i.e., 4/8 vs 3/53, 5-minute Apgar score </=5 (7/8 vs 17/53), required chest compressions (5/...
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2011
Variation in nicotine metabolism may be due to genetic alterations in CYP 2A6, environmental fact... more Variation in nicotine metabolism may be due to genetic alterations in CYP 2A6, environmental factors, and diet. The purpose of this research was to evaluate mint drink effect on nicotine metabolism as judged by nicotine/cotinine ratio in urine of Jordanian smokers.
Contraception, 2003
Meloxicam, a selective cyclooxygenase-2 inhibitor, was administered orally or intravaginally, to ... more Meloxicam, a selective cyclooxygenase-2 inhibitor, was administered orally or intravaginally, to sperm-positive female rabbits to assess its effect on ovulation. A single oral dose (20 mg/kg), administered 5 h postcoitus resulted in 100% contraceptive rate. On the other hand, for females receiving meloxicam suppositories (14.9 mg/kg), 5 h postcoitus, the contraceptive rate was 62.5% compared to placebo. The decrease in the contraceptive effect of meloxicam suppository may be due to the rejection of the dose by some females. Corpora lutea, maternal plasma progesterone, ovary fresh weight and maternal body weight gain were not affected by meloxicam treatment compared to placebo. Histopathologically, the surface of the ovary of meloxicam-treated females appears irregular and dilated due to the presence of different-sized cysts. Some of the cystic follicles were retained ova. Further, immunohistochemical stains for estrogen and progesterone receptors showed positive staining in granulosa cells and the wall of the unruptured follicle. It is concluded that contraceptive effect of meloxicam in female rabbits resulted in a failure of follicular rupturing.
Contraception, 2001
The nonsteroidal antiinflammatory, selective cyclo-oxygenase-2 (COX-2) inhibitor, meloxicam, was ... more The nonsteroidal antiinflammatory, selective cyclo-oxygenase-2 (COX-2) inhibitor, meloxicam, was tested to assess its effect on rabbit ovulation. Meloxicam in different doses was administered intraperitoneally (ip) to adult female Californian rabbits at 2, 5, 8, and 24 h postcoitus with sperm-positive rabbits. Rabbits were killed on Day 10 of gestation. Meloxicam produced significant inhibition of ovulation in rabbits. This inhibition of ovulation by meloxicam was dose- and time-dependent. Ovulation in rabbits was completely inhibited by a single ip administration of meloxicam (20 mg/kg) when the drug was administered at 2 and 5 h postcoitus, whereas neither ovulation nor implantation were inhibited (pregnancy rate 75%) by the same dose administered 24 h postcoitus (approximately 14 h post ovulation). Further, ovulation was completely inhibited by 10 mg/kg of meloxicam when the drug was administered at 5 or 8 h postcoitus, but there was less inhibition of ovulation when 10 mg/kg of the drug was administered at 2 or 24 h postcoitus (pregnancy rate 25 and 80%, respectively). Corpora lutea, maternal plasma progesterone, ovary fresh weight, and maternal body weight gain were affected by meloxicam treatment. Histopathological findings observed in the ovaries of treated rabbits included microscopic dilatation of graffian follicles, particularly mature follicles. Some of the follicles were cystically dilated in addition to severe hemorrhage within the follicles which lost ova. These results show that ovulation can be inhibited in rabbits by meloxicam. Further studies are needed to assess the value of selective COX-2 inhibitors as potential nonhormonal contraceptive agents.