Sameh Zaki - Academia.edu (original) (raw)
Papers by Sameh Zaki
مجلة العمارة والفنون والعلوم الإنسانية
When Islam emerged in the seventh century the Arabs did not have provided anything noteworthy in ... more When Islam emerged in the seventh century the Arabs did not have provided anything noteworthy in the art of Painting But there were modest attempts taken directly from the other arts, The poetry is their first field, However, the Islamic faith has imposed a new reality because of its tremendous spiritual strength, The language of the Koran being strongly present, so Arabic typography has become a hallmark of Islamic art, and a tendency to abstract decorative, As Islam income of many Arab states and other countries have emerged new forms of art, especially with those countries which have an ancient civilization such as the Persians and the Babylonians, Egyptians. Islamic art is no longer the art of the State or specific people, it is art of civilization was formed. painting is one of the aspects of Islamic arts which did not obtain wide acclaim like as architecture or Islamic ornamentation, Although it was the focus of attention of four artistic trends that represented in Arabic, Persian, Turkish and Mughal school. This research will address one of the most prominent symbols of this trend, Al-Wasiti, Islamic painter who belongs to the thirteenth century AD, and he illustrated the Maqamat of al-Ḥariri, The 96 illustrations are of outstanding quality with fine composition, expressive figures. They produced the 13th-century life and are remarkably satisfying as storybook illustrations. and It was the first work in the Arab Paintings known by its creator.
Geosciences Journal, 2018
Halayieb area is located at the southeastern corner on the border between Egypt and Sudan. The ar... more Halayieb area is located at the southeastern corner on the border between Egypt and Sudan. The area has very important strategic aspects to Egypt. Groundwater is the only source of fresh water in the area. The hydrogeochemical characterizations of groundwater in the area were carried out, to assess the quality of groundwater for its suitability for drinking and irrigation purposes. Geologically the Precambrian rocks underlain the Mesozoic sandstone and Tertiary marine sediments. The groundwater of the area is recorded at the Miocene sedimentary succession and the fractured basement aquifers with a maximum water depth of 26.5 m from the ground surface. Groundwater quality is mostly saline caused by the sources of geogenic, anthropogenic, and marine origin of the water bearing formations. The resulting groundwater is characterized by Na + > Ca 2+ > Mg 2+ /Cl − > HCO 3 − > SO 4 2− : Na + > Ca 2+ > K + /SO 4 2− > Cl − > HCO 3 − facies, following the topographical and water flow-path conditions. The hydrochemical facies in this area fall in the field of NaCl type and the hydrogeochemical signatures indicated active hydrolysis and dissolution process of Ca-bearing minerals of the basement rocks and some sodium is lost, most probably through reverse ion exchange. Enrichment of Mn + in some wells is regarded to the mining activity for manganese ores in the area. Groundwater quality is mostly not suitable for drinking purposes. For irrigation, the groundwater is mostly suitable in regard to the residual sodium carbonate and the magnesium hazard. According to the water quality assessment using United States salinity laboratory (USLL) diagram, most water samples located in category C3-S2, C3-S3, C3-S4, C4-S2 highlighting high to very high salinity hazard and medium to very high sodium content class. Most of the groundwater samples that are located away from the shoreline are suitable for livestock and poultry consumption. High salinity contents in the study area create severe problems for using water supplies and for future exploitation.
Sustainable Water Resources Management, 2015
The study area is a part of Wadi Qena, Eastern Desert. It is one of the largest promising areas f... more The study area is a part of Wadi Qena, Eastern Desert. It is one of the largest promising areas for development in Upper Egypt. A new desert road was constructed to join Upper Egypt to the Red Sea, passing through the wadi. This accelerates the forms of development in the middle part of the wadi. The development focused on new cultivation farms established through the drilling of tens of wells to extract groundwater for land reclamation. The present study focused on the assessment of groundwater quality, its origin and suitability for drinking and agricultural purposes. This is made through the chemical analysis of a number of groundwater samples. A comparison of the water quality with the standard of drinking and irrigation water quality revealed that the water was not suitable for drinking purposes and could be used for high salt-tolerant crops. The evaluation of the saturation index (SI) of the water sample indicted that water was oversaturated with respect to iron minerals and undersaturated with carbonate minerals The analysis of the isotope data (d 18 O and d 2 H) of the water samples indicated that water samples of wells more than 500 m deep were mainly of Nubian sources (old water) and could be mixed by recharge from the Quaternary water. The other water samples showed that the origin of water was Quaternary, while the water samples collected from the shallow pits showed that water originated from the relatively fresh water. The study revealed that the old Nubian water was not renewable and should be managed properly to sustain the existing and proposed development.
Clinical laboratory, 2003
The objective of this study was to evaluate the role of osteoclast activating cytokines, interleu... more The objective of this study was to evaluate the role of osteoclast activating cytokines, interleukin-11 (IL-11) and transforming growth factor-beta2 (TGF-beta2) in the assessment of bone turnover in postmenopausal osteoporosis (PO). Eighty postmenopausal osteoporotic women with lumbar spine bone mineral densities (BMD) as measured by DEXA that were more than 2.5 SD below the normal mean of healthy women (controls), participated in this study. Various therapeutic modalities (hormone replacement therapy, HRT, alendronate, calcitonin and 1alpha-hydroxyvitamin D (alfacalcidol) were administered for 12 months to 4 groups of postmenopausal osteoporotic patients. Fasting blood samples and two hour urine samples were collected from control subjects and from patients before and after treatment. Serum samples were assayed for IL-11, TGF-beta2, osteocalcin (OC) and bone alkaline phosphatase (B-ALP), whereas urine samples were assayed for N-telopeptide for type I collagen (NTX) and deoxypyridin...
Journal of Water Resource and Protection, 2014
The area to the southeast of the Western Desert of Egypt has been subjected to considerable devel... more The area to the southeast of the Western Desert of Egypt has been subjected to considerable development activities over the last few years. The development includes the cultivation of about 2260 km 2 of the desert lands "the well-known Toshka Project". The hydrogeological conditions of the area are subjected to detailed investigation based upon the construction of the water table maps, hydrologeologic cross-sections, pumping tests, aquifer geometry, and recharge-discharge relationship. The study revealed that the Quaternary and the Nubia sediments are the main water bearing layers in the area. The Quaternary aquifer is of limited potential and made of mixed sand with clay deposit ranges in thickness between 5 to 10 m. The Nubia aquifer is the oldest sedimentary formation and the main groundwater resources in the area. It is represented by multilayered of sand and silt exists generally under artesian conditions. It is composed of three water bearing horizons partially separated by two confining horizons and extends in thickness ranges between 70 and 230 meters. The thickness increases away from the high dam lake. The analysis of pumping tests of the aquifer indicated that its potentiality is increasing north of the High Dam Lake (HDL) whereas it decreases in the other direction. This is due to high hydraulic conductivity and aquifer thickness in the area northeast of Khor Toshka and at west of Garf Hussein. The hydraulic conductivity of the aquifer ranges between 12.73 and 0.9 m/day. The review of the changes in groundwater levels in the area showed that there is a drop in ranges between 1 and 14 meters in the last few years indicating that the extraction from the groundwater is much more higher that the replacement rate. Also, the analysis of the fluctuation of water levels of the HDL and the groundwater level indicated that the influence of water on groundwater level in the area is observed only at a distance less than 10 km from the lake shore line. Seepage from the HDL is estimated as 238.13 × 10 6 A. A. Abdel Moneim et al. 382 m 3 /year. The geo-environmental impacts of the development on the surface water and groundwater in the area are evaluated.
Journal of the Society for Gynecologic Investigation, 2005
To investigate feto-maternal bone turnover in normal pregnancy and preeclampsia and to test the h... more To investigate feto-maternal bone turnover in normal pregnancy and preeclampsia and to test the hypothesis whether the reported low bone mass at birth in small-for-gestational age infants is associated with decreased bone formation or increased bone resorption. Thirty-two patients with preeclampsia (17 mild and 15 severe) and 20 normotensive women (controls) with singleton gestations in the third trimester participated in this study. Furthermore, 25 nonpregnant healthy women were chosen as nonpregnant controls. Maternal 24-hour urine specimens and venous blood samples were collected. In addition, fetal cord blood and the first voided neonatal urine were also collected. The freshly separated sera were assayed for osteocalcin (OC) and carboxy-terminal propeptide of type 1 collagen (PICP) by radioimmunoassay. Urine samples were assayed for N-telopeptide of type 1 collagen (NTx) by enzyme-linked immunosorbent assay. Maternal and cord serum OC and PICP levels were significantly decreased in severe preeclampsia, whereas maternal and first-voided neonatal urinary NTx level were significantly increased compared to the corresponding levels of controls. In both mother and fetus, the coupling index of markers of bone turnover in normal pregnancy or mild preeclampsia was in favor of bone formation, whereas in severe preeclampsia the markers suggested marked bone resorption. Increased bone resorption and decreased bone formation occur in preeclampsia in both mother and fetus, being more pronounced in the latter. The increased osteoclastic activity in preeclampsia may be attributed to increased RANKL induced by increased interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor beta2 (TGF-beta2) production.
International Journal of Infectious Diseases, 2010
Background: Centre for Health Protection in Hong Kong advocates healthcare workers to wear N95 re... more Background: Centre for Health Protection in Hong Kong advocates healthcare workers to wear N95 respirators during the outbreak of infectious respiratory diseases. Nevertheless, it is evident that the effectiveness of N95 respirator is contingent upon its fitness to the wearer. This study, therefore, aims to explore the undergraduate Chinese nursing students' fitness for N95 respirators in Hong Kong. Methods: A cross-sectional descriptive and prospective design was used in this study. Convenience sampling was adopted to solicit 204 undergraduate nursing students to participate in the study. Two types of N95 respirators, namely 3M 1860s and 3M 1862, were being used to test their fitness for each participant. A quantitative fit testing device, the PortaCount Respirator Fit Tester System which is recommended as the international gold standard in determining the fitness of respirators, was used to measure the users' fitness for those two types of respirator. "Fit factor" was then calculated. A score over 100 was considered as pass, and the respirator was said to be fitted for the participant. Results: 61.3% (n = 125) and 57.4% (n = 117) of the participants were found to be fitted for 3M 1860s and 3M 1862 respirator respectively. 81.4% (n = 166) of the participants passed the fit test in either one of the models. Only 37.3% (n = 76) of the participants were found to be fitted for both models. The use of Chi Square also indicated that there was no association between the fitness for these two models of respirator (X 2 = 1.57, p = 0.134). Conclusion: Only one third of undergraduate Chinese nursing students are fitted for both 3M 1860s and 3M 1862 N95 respirators. Most of the students could only fit for either one model. Therefore, fitness must be ensured via the conduction of fit test to confirm the type of respirators that could offer maximum protection for the students. OL-018 Multi-drug resistance analysis of pathogens of ventilation-assciated pneumonia in ICU
Pathology & Oncology Research, 2008
Fas (CD95-APO-1), a member of tumor necrosis factor receptor super-family, exists in two forms, t... more Fas (CD95-APO-1), a member of tumor necrosis factor receptor super-family, exists in two forms, transmembrane and soluble (sFas). It had been suggested that circulating sFas levels and/or tissue FasL may reflect the severity of invasive breast ductal carcinoma. Few studies showed that neither DNA-index nor ploidy is an independent prognostic indicator, and there is no correlation with clinical outcome. The S-phase fraction (SPF) has been shown to be useful prognostic factor in both node-negative and node-positive tumors. The present work was done to find a correlation between sFas, tissue FasL, ploidy and SPF with prognostic factors and survival of breast ductal carcinoma patients. The present study included two groups; a patients group comprised 30 patients with breast ductal carcinoma and a control group that comprised 15 patients with benign breast swellings. Serum sFas was measured using commercially available ELISA kit and tissue FasL expression was studied using avidin-biotine immunohistochemical staining technique. Cell cycle studies were performed using flow cytometry. Serum sFas was significantly higher in breast ductal carcinoma group than in the benign breast swelling control group. A significant negative correlation between serum sFas and overall survival was found. Tissue FasL expression was directly correlated with distant metastasis and poor overall survival. A significant direct correlation was found between moderate and high SPF with worse pathologic parameters. Serum sFas level, tissue FasL immuno-expression and S-phase fraction are independent prognostic factors in breast ductal carcinoma cases.
Thorax, 1979
An investigation of lung function was carried out in 99 randomly selected patients with classic o... more An investigation of lung function was carried out in 99 randomly selected patients with classic or definite rheumatoid arthritis and in 60 control subjects matched for age, sex, and smoking habits. Mean FEV1 and mean VC were both significantly lower in the rheumatoid patients due to significant differences for women but mean FEV/VC ratio was 730O% in the rheumatoid group and 72%1 % in the control. Steady-state transfer factor was significantly greater in the normal men than in the comparable rheumatoid group, but there was no difference for women. After excluding patients with FEV1 less than 80% predicted normal and patients with low compliance, 72 rheumatoid patients and 45 controls provided series of tracings that could be assessed for a fall in Cdyn of 20% between 20 cycles and 60 cycles a minute. Dynamic compliance was not significantly different in any group at any rate of respiration. Fourteen of 72 rheumatoid patients and three of 45 controls showed frequency dependence (FDC). After the age of 50 the prevalence in the rheumatoid group was 11/38 and in the control group 2/27. This difference was significant (p<0-05). FDC was not consistently related to other abnormalities of lung function or to the duration, severity, or treatment of the rheumatoid arthritis. In various categories of smoking habits, dust exposure, or allergic tendency, the prevalence was always greater in the rheumatoid group. This provides evidence of patchy involvement of small airways, or alveoli and connective tissue, by the rheumatoid process.
مجلة العمارة والفنون والعلوم الإنسانية
When Islam emerged in the seventh century the Arabs did not have provided anything noteworthy in ... more When Islam emerged in the seventh century the Arabs did not have provided anything noteworthy in the art of Painting But there were modest attempts taken directly from the other arts, The poetry is their first field, However, the Islamic faith has imposed a new reality because of its tremendous spiritual strength, The language of the Koran being strongly present, so Arabic typography has become a hallmark of Islamic art, and a tendency to abstract decorative, As Islam income of many Arab states and other countries have emerged new forms of art, especially with those countries which have an ancient civilization such as the Persians and the Babylonians, Egyptians. Islamic art is no longer the art of the State or specific people, it is art of civilization was formed. painting is one of the aspects of Islamic arts which did not obtain wide acclaim like as architecture or Islamic ornamentation, Although it was the focus of attention of four artistic trends that represented in Arabic, Persian, Turkish and Mughal school. This research will address one of the most prominent symbols of this trend, Al-Wasiti, Islamic painter who belongs to the thirteenth century AD, and he illustrated the Maqamat of al-Ḥariri, The 96 illustrations are of outstanding quality with fine composition, expressive figures. They produced the 13th-century life and are remarkably satisfying as storybook illustrations. and It was the first work in the Arab Paintings known by its creator.
Geosciences Journal, 2018
Halayieb area is located at the southeastern corner on the border between Egypt and Sudan. The ar... more Halayieb area is located at the southeastern corner on the border between Egypt and Sudan. The area has very important strategic aspects to Egypt. Groundwater is the only source of fresh water in the area. The hydrogeochemical characterizations of groundwater in the area were carried out, to assess the quality of groundwater for its suitability for drinking and irrigation purposes. Geologically the Precambrian rocks underlain the Mesozoic sandstone and Tertiary marine sediments. The groundwater of the area is recorded at the Miocene sedimentary succession and the fractured basement aquifers with a maximum water depth of 26.5 m from the ground surface. Groundwater quality is mostly saline caused by the sources of geogenic, anthropogenic, and marine origin of the water bearing formations. The resulting groundwater is characterized by Na + > Ca 2+ > Mg 2+ /Cl − > HCO 3 − > SO 4 2− : Na + > Ca 2+ > K + /SO 4 2− > Cl − > HCO 3 − facies, following the topographical and water flow-path conditions. The hydrochemical facies in this area fall in the field of NaCl type and the hydrogeochemical signatures indicated active hydrolysis and dissolution process of Ca-bearing minerals of the basement rocks and some sodium is lost, most probably through reverse ion exchange. Enrichment of Mn + in some wells is regarded to the mining activity for manganese ores in the area. Groundwater quality is mostly not suitable for drinking purposes. For irrigation, the groundwater is mostly suitable in regard to the residual sodium carbonate and the magnesium hazard. According to the water quality assessment using United States salinity laboratory (USLL) diagram, most water samples located in category C3-S2, C3-S3, C3-S4, C4-S2 highlighting high to very high salinity hazard and medium to very high sodium content class. Most of the groundwater samples that are located away from the shoreline are suitable for livestock and poultry consumption. High salinity contents in the study area create severe problems for using water supplies and for future exploitation.
Sustainable Water Resources Management, 2015
The study area is a part of Wadi Qena, Eastern Desert. It is one of the largest promising areas f... more The study area is a part of Wadi Qena, Eastern Desert. It is one of the largest promising areas for development in Upper Egypt. A new desert road was constructed to join Upper Egypt to the Red Sea, passing through the wadi. This accelerates the forms of development in the middle part of the wadi. The development focused on new cultivation farms established through the drilling of tens of wells to extract groundwater for land reclamation. The present study focused on the assessment of groundwater quality, its origin and suitability for drinking and agricultural purposes. This is made through the chemical analysis of a number of groundwater samples. A comparison of the water quality with the standard of drinking and irrigation water quality revealed that the water was not suitable for drinking purposes and could be used for high salt-tolerant crops. The evaluation of the saturation index (SI) of the water sample indicted that water was oversaturated with respect to iron minerals and undersaturated with carbonate minerals The analysis of the isotope data (d 18 O and d 2 H) of the water samples indicated that water samples of wells more than 500 m deep were mainly of Nubian sources (old water) and could be mixed by recharge from the Quaternary water. The other water samples showed that the origin of water was Quaternary, while the water samples collected from the shallow pits showed that water originated from the relatively fresh water. The study revealed that the old Nubian water was not renewable and should be managed properly to sustain the existing and proposed development.
Clinical laboratory, 2003
The objective of this study was to evaluate the role of osteoclast activating cytokines, interleu... more The objective of this study was to evaluate the role of osteoclast activating cytokines, interleukin-11 (IL-11) and transforming growth factor-beta2 (TGF-beta2) in the assessment of bone turnover in postmenopausal osteoporosis (PO). Eighty postmenopausal osteoporotic women with lumbar spine bone mineral densities (BMD) as measured by DEXA that were more than 2.5 SD below the normal mean of healthy women (controls), participated in this study. Various therapeutic modalities (hormone replacement therapy, HRT, alendronate, calcitonin and 1alpha-hydroxyvitamin D (alfacalcidol) were administered for 12 months to 4 groups of postmenopausal osteoporotic patients. Fasting blood samples and two hour urine samples were collected from control subjects and from patients before and after treatment. Serum samples were assayed for IL-11, TGF-beta2, osteocalcin (OC) and bone alkaline phosphatase (B-ALP), whereas urine samples were assayed for N-telopeptide for type I collagen (NTX) and deoxypyridin...
Journal of Water Resource and Protection, 2014
The area to the southeast of the Western Desert of Egypt has been subjected to considerable devel... more The area to the southeast of the Western Desert of Egypt has been subjected to considerable development activities over the last few years. The development includes the cultivation of about 2260 km 2 of the desert lands "the well-known Toshka Project". The hydrogeological conditions of the area are subjected to detailed investigation based upon the construction of the water table maps, hydrologeologic cross-sections, pumping tests, aquifer geometry, and recharge-discharge relationship. The study revealed that the Quaternary and the Nubia sediments are the main water bearing layers in the area. The Quaternary aquifer is of limited potential and made of mixed sand with clay deposit ranges in thickness between 5 to 10 m. The Nubia aquifer is the oldest sedimentary formation and the main groundwater resources in the area. It is represented by multilayered of sand and silt exists generally under artesian conditions. It is composed of three water bearing horizons partially separated by two confining horizons and extends in thickness ranges between 70 and 230 meters. The thickness increases away from the high dam lake. The analysis of pumping tests of the aquifer indicated that its potentiality is increasing north of the High Dam Lake (HDL) whereas it decreases in the other direction. This is due to high hydraulic conductivity and aquifer thickness in the area northeast of Khor Toshka and at west of Garf Hussein. The hydraulic conductivity of the aquifer ranges between 12.73 and 0.9 m/day. The review of the changes in groundwater levels in the area showed that there is a drop in ranges between 1 and 14 meters in the last few years indicating that the extraction from the groundwater is much more higher that the replacement rate. Also, the analysis of the fluctuation of water levels of the HDL and the groundwater level indicated that the influence of water on groundwater level in the area is observed only at a distance less than 10 km from the lake shore line. Seepage from the HDL is estimated as 238.13 × 10 6 A. A. Abdel Moneim et al. 382 m 3 /year. The geo-environmental impacts of the development on the surface water and groundwater in the area are evaluated.
Journal of the Society for Gynecologic Investigation, 2005
To investigate feto-maternal bone turnover in normal pregnancy and preeclampsia and to test the h... more To investigate feto-maternal bone turnover in normal pregnancy and preeclampsia and to test the hypothesis whether the reported low bone mass at birth in small-for-gestational age infants is associated with decreased bone formation or increased bone resorption. Thirty-two patients with preeclampsia (17 mild and 15 severe) and 20 normotensive women (controls) with singleton gestations in the third trimester participated in this study. Furthermore, 25 nonpregnant healthy women were chosen as nonpregnant controls. Maternal 24-hour urine specimens and venous blood samples were collected. In addition, fetal cord blood and the first voided neonatal urine were also collected. The freshly separated sera were assayed for osteocalcin (OC) and carboxy-terminal propeptide of type 1 collagen (PICP) by radioimmunoassay. Urine samples were assayed for N-telopeptide of type 1 collagen (NTx) by enzyme-linked immunosorbent assay. Maternal and cord serum OC and PICP levels were significantly decreased in severe preeclampsia, whereas maternal and first-voided neonatal urinary NTx level were significantly increased compared to the corresponding levels of controls. In both mother and fetus, the coupling index of markers of bone turnover in normal pregnancy or mild preeclampsia was in favor of bone formation, whereas in severe preeclampsia the markers suggested marked bone resorption. Increased bone resorption and decreased bone formation occur in preeclampsia in both mother and fetus, being more pronounced in the latter. The increased osteoclastic activity in preeclampsia may be attributed to increased RANKL induced by increased interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor beta2 (TGF-beta2) production.
International Journal of Infectious Diseases, 2010
Background: Centre for Health Protection in Hong Kong advocates healthcare workers to wear N95 re... more Background: Centre for Health Protection in Hong Kong advocates healthcare workers to wear N95 respirators during the outbreak of infectious respiratory diseases. Nevertheless, it is evident that the effectiveness of N95 respirator is contingent upon its fitness to the wearer. This study, therefore, aims to explore the undergraduate Chinese nursing students' fitness for N95 respirators in Hong Kong. Methods: A cross-sectional descriptive and prospective design was used in this study. Convenience sampling was adopted to solicit 204 undergraduate nursing students to participate in the study. Two types of N95 respirators, namely 3M 1860s and 3M 1862, were being used to test their fitness for each participant. A quantitative fit testing device, the PortaCount Respirator Fit Tester System which is recommended as the international gold standard in determining the fitness of respirators, was used to measure the users' fitness for those two types of respirator. "Fit factor" was then calculated. A score over 100 was considered as pass, and the respirator was said to be fitted for the participant. Results: 61.3% (n = 125) and 57.4% (n = 117) of the participants were found to be fitted for 3M 1860s and 3M 1862 respirator respectively. 81.4% (n = 166) of the participants passed the fit test in either one of the models. Only 37.3% (n = 76) of the participants were found to be fitted for both models. The use of Chi Square also indicated that there was no association between the fitness for these two models of respirator (X 2 = 1.57, p = 0.134). Conclusion: Only one third of undergraduate Chinese nursing students are fitted for both 3M 1860s and 3M 1862 N95 respirators. Most of the students could only fit for either one model. Therefore, fitness must be ensured via the conduction of fit test to confirm the type of respirators that could offer maximum protection for the students. OL-018 Multi-drug resistance analysis of pathogens of ventilation-assciated pneumonia in ICU
Pathology & Oncology Research, 2008
Fas (CD95-APO-1), a member of tumor necrosis factor receptor super-family, exists in two forms, t... more Fas (CD95-APO-1), a member of tumor necrosis factor receptor super-family, exists in two forms, transmembrane and soluble (sFas). It had been suggested that circulating sFas levels and/or tissue FasL may reflect the severity of invasive breast ductal carcinoma. Few studies showed that neither DNA-index nor ploidy is an independent prognostic indicator, and there is no correlation with clinical outcome. The S-phase fraction (SPF) has been shown to be useful prognostic factor in both node-negative and node-positive tumors. The present work was done to find a correlation between sFas, tissue FasL, ploidy and SPF with prognostic factors and survival of breast ductal carcinoma patients. The present study included two groups; a patients group comprised 30 patients with breast ductal carcinoma and a control group that comprised 15 patients with benign breast swellings. Serum sFas was measured using commercially available ELISA kit and tissue FasL expression was studied using avidin-biotine immunohistochemical staining technique. Cell cycle studies were performed using flow cytometry. Serum sFas was significantly higher in breast ductal carcinoma group than in the benign breast swelling control group. A significant negative correlation between serum sFas and overall survival was found. Tissue FasL expression was directly correlated with distant metastasis and poor overall survival. A significant direct correlation was found between moderate and high SPF with worse pathologic parameters. Serum sFas level, tissue FasL immuno-expression and S-phase fraction are independent prognostic factors in breast ductal carcinoma cases.
Thorax, 1979
An investigation of lung function was carried out in 99 randomly selected patients with classic o... more An investigation of lung function was carried out in 99 randomly selected patients with classic or definite rheumatoid arthritis and in 60 control subjects matched for age, sex, and smoking habits. Mean FEV1 and mean VC were both significantly lower in the rheumatoid patients due to significant differences for women but mean FEV/VC ratio was 730O% in the rheumatoid group and 72%1 % in the control. Steady-state transfer factor was significantly greater in the normal men than in the comparable rheumatoid group, but there was no difference for women. After excluding patients with FEV1 less than 80% predicted normal and patients with low compliance, 72 rheumatoid patients and 45 controls provided series of tracings that could be assessed for a fall in Cdyn of 20% between 20 cycles and 60 cycles a minute. Dynamic compliance was not significantly different in any group at any rate of respiration. Fourteen of 72 rheumatoid patients and three of 45 controls showed frequency dependence (FDC). After the age of 50 the prevalence in the rheumatoid group was 11/38 and in the control group 2/27. This difference was significant (p<0-05). FDC was not consistently related to other abnormalities of lung function or to the duration, severity, or treatment of the rheumatoid arthritis. In various categories of smoking habits, dust exposure, or allergic tendency, the prevalence was always greater in the rheumatoid group. This provides evidence of patchy involvement of small airways, or alveoli and connective tissue, by the rheumatoid process.