Sami Arap - Academia.edu (original) (raw)

Papers by Sami Arap

Research paper thumbnail of A prospective study evaluating the long term efficacyand safety of the adjustable continence therapy (ProACT⊥M) for post radical prostatectomy urinary incontinence

European Urology Supplements, 2005

Research paper thumbnail of Assessment of sexual function in patients undergoing vasectomy using the international index of erectile function

International braz j urol : official journal of the Brazilian Society of Urology

The present study aims to prospectively compare the sexual function in males before and after vas... more The present study aims to prospectively compare the sexual function in males before and after vasectomy surgery using the international index of erectile function (IIEF). From October to December 2002, sixty-four patients who were candidates for male sterilization in the vasectomy program of the Urology Section at the General Hospital of the University of São Paulo were included. The same investigator applied the IIEF before and 90 days after the surgery. The mean scores obtained on pre and postoperative visits for all domains of sexual function were analyzed and compared with the Wilcoxon test. The mean patient age was 35 years (range from 25 to 48 years) and the mean number of children per man was 3. The total mean score of the IIEF was 64.06 before surgery and 65.64 after the procedure, with this difference considered statistically significant (p < 0.001). Sixty-seven per cent of the patients improved their scores, versus 17% and 16% who showed worsening or no change at all in...

Research paper thumbnail of Prosthetic repair of incisional hernia in kidney transplant patients. A technique with onlay polypropylene mesh

Hernia : the journal of hernias and abdominal wall surgery, 2001

The employment of synthetic mesh for incisional hernia repair in kidney-transplanted patients is ... more The employment of synthetic mesh for incisional hernia repair in kidney-transplanted patients is rarely reported in the present literature. Many authors believe that mesh employment in such conditions is not safe due to fear of mesh related complications. From 1965 through 1999, a total of 1685 kidney transplants were performed at our Kidney Transplant Unit and 19 patients developed eventrations in the kidney transplant incision, an incidence of 1.1%. From September 1996 eight of these patients had prosthetic repair of the abdominal wall with onlay polypropylene mesh. All patients were under immunosuppressive therapy with prednisone, ciclosporine and azathioprine. Mean age was 48.8 years, mean body mass index was 22.5 and mean number of previous abdominal operations was 2.5. A large polypropylene mesh (Marlex mesh) was fixed over the aponeurosis after primary closure of the aponeurotic borders, as an onlay graft. There was neither morbidity nor mortality associated to the surgical p...

Research paper thumbnail of artigo original Eficácia e Segurança da Prótese Peniana Inflável no Tratamento de Disfunção Erétil em Pacientes Diabéticos

Many factors lead to erectile dysfunction in the diabetic patient. Neuropathy and microangiopathy... more Many factors lead to erectile dysfunction in the diabetic patient. Neuropathy and microangiopathy are involved in loss of potency in this group of patients. Diabetic patients with erectile dysfunction who have failed clinical treatment are candidates to intracavernos al injections or penile prosthesis. In these cases the risk of infection relat- ed to poor immunity cause concerns related to prosthesis

Research paper thumbnail of Effects of medical therapy, alcohol, smoking, and endocrine disruptors on male infertility

Revista do Hospital das Clínicas, 2004

Infertility affects up to 15% of the sexually active population, and in 50% of cases, a male fact... more Infertility affects up to 15% of the sexually active population, and in 50% of cases, a male factor is involved, either as a primary problem or in combination with a problem in the female partner. Because many commonly encountered drugs and medications can have a detrimental effect on male fertility, the medical evaluation should include a discussion regarding the use of recreational and illicit drugs, medications, and other substances that may impair fertility. With the knowledge of which drugs and medications may be detrimental to fertility, it may be possible to modify medication regimens or convince a patient to modify habits to decrease adverse effects on fertility and improve the chances of achieving a successful pregnancy. Concern is growing that male sexual development and reproduction have changed for the worse over the past 30 to 50 years. Although some reports find no changes, others suggest that sperm counts appear to be decreasing and that the incidence of developmental abnormalities such as hypospadias and cryptorchidism appears to be increasing, as is the incidence of testicular cancer. These concerns center around the possibility that our environment is contaminated with chemicals--both natural and synthetic--that can interact with the endocrine system.

Research paper thumbnail of A cost-effective technique for pure laparoscopic live donor nephrectomy

International braz j urol, 2006

Objective: Compare two different techniques for laparoscopic live donor nephrectomy (LDN), relate... more Objective: Compare two different techniques for laparoscopic live donor nephrectomy (LDN), related to the operative costs and learning curve. Materials and Methods: Between April/2000 and October/2003, 61 patients were submitted to LDN in 2 different reference centers in kidney transplantation. At center A (CA), 11 patients were operated by a pure transperitoneal approach, using Hem-O-Lok ® clips for the renal pedicle control and the specimens were retrieved manually, without using endobags. At center B (CB), 50 patients were also operated by a pure transperitoneal approach, but the renal pedicles were controlled with endo-GIA appliers and the specimens were retrieved using endobags. Results: Operative time (231 ± 39 min vs. 179 ± 30 min; p < 0.000), warm ischemia time (5.85 ± 2.85 min vs. 3.84 ± 3.84 min; p = 0.002) and blood loss (214 ± 98 mL vs. 141 ± 82 mL; p = 0.02) were statistically better in CB, when compared to CA. Discharge time was similar in both centers. One major complication was observed in both centers, leading to an open conversion in CA (9.1%). One donor death occurred in CB (2%). Regarding the recipients, no statistical difference was observed in all parameters analyzed. There was an economy of US$1.440 in each procedure performed in CA, when compared to CB. Conclusions: Despite the learning curve, the technique adopted by CA, showed no deleterious results to the donors and recipients when compared with the CB. On the other hand, this technique was cheaper than the technique performed in the CB, representing an attractive alternative for LDN, mainly in developing centers.

Research paper thumbnail of Percutaneous prostate cryoablation as treatment for high-risk prostate cancer

Clinics, 2007

To evaluate percutaneous cryotherapy as a primary treatment option for high-risk prostate cancer ... more To evaluate percutaneous cryotherapy as a primary treatment option for high-risk prostate cancer patients. From October 2000 to February 2005, 21 high-risk (Gleason e.8 and/or PSA &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 10 and/or stage &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; T2a) prostate cancer patients underwent 24 percutaneous prostate cryoablation procedures. Patients&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; median age was 70.9, and the average pretreatment PSA was 19.5 ng/dL. The follow-up period ranged from 6 to 60 months (median, 41 months). The PSA failure rate was 39%, 52.9%, and 42.8% at 12, 24, and 60 months of follow-up, respectively. Overall complication rates were low, with 8% of urinary incontinence and no cases of rectal injury; however, 96% of erectile dysfunction occurred. The cryoablation procedure failed in 12 patients (57.2%); 7 (58.3%) of these were local failures (positive prostate biopsies). Percutaneous cryoablation of the prostate is a safe minimally invasive treatment, but it has poor PSA-free survival outcomes in high-risk prostate cancer patients.

Research paper thumbnail of Comparison of the fluorescent polarization (TDx) and the enzymatic competitive (EMIT 2000) immune assays for the measurement of cyclosporin A blood concentration

Revista do Hospital das Clínicas, 2000

Evaluation of Cyclosporin A (CyA) blood concentration is imperative in solid organ transplantatio... more Evaluation of Cyclosporin A (CyA) blood concentration is imperative in solid organ transplantation in order to achieve maximal immunosuppression with the least side effects. We compared the results of whole blood concentrations of CyA in 50 blood samples simultaneously evaluated by the fluorescent polarization immune assay (TDx) and the enzymatic competitive immune assay (EMIT 2000). There was a strong correlation between both kits for any range of CyA blood concentration (R=0.99, p&amp;amp;amp;amp;amp;amp;lt;0.001). The within-run and between-days coefficient of variation were less than 4% for both assays. The cost for each CyA measurement was 50% lower for the EMIT assay when compared to the TDx assay. We concluded that the EMIT is as accurate as the TDx in measuring CyA blood concentration and has the advantage of a lower cost, as well as the possibility of widespread access to the EMIT methodology in contrast to the TDx equipment, allowing the laboratory to perform several routines within a working day.

Research paper thumbnail of Augmentation cystoplasty in renal transplantation: a good and safe option--experience with 25 cases

Urology, 2002

To assess the surgical and long-term results of renal transplantation in 25 patients with bladder... more To assess the surgical and long-term results of renal transplantation in 25 patients with bladder dysfunction and augmentation cystoplasty. We retrospectively reviewed the evolution and surgical outcome of 25 renal transplants in 24 recipients with augmentation cystoplasty. The mean patient age at transplantation was 27.6 years. The etiology of bladder dysfunction was neurogenic bladder with detrusor hyperreflexia (11 patients), tuberculosis (5 patients), vesicoureteral reflux (4 patients), posterior urethral valves (3 patients), and interstitial cystitis (1 patient). Seventeen transplants were from living donors. Augmentation cystoplasty was performed before transplantation in 21 patients. The bowel segments used in the augmentation cystoplasty included ileum in 16, ileocecal segments in 2, and sigmoid in 5 patients. The donor ureter was anastomosed to the native bladder in 16 patients, to the bowel segment in 6, and to the native ureter in 3. Twenty kidneys (80%) were functioning ...

Research paper thumbnail of Laparoscopic nephrectomy in live donor

International braz j urol, 2004

To present the initial experience of videolaparoscopic nephrectomy in live renal donor. In the pe... more To present the initial experience of videolaparoscopic nephrectomy in live renal donor. In the period from April 2000 to August 2003, 50 left nephrectomies in live donor were performed by videolaparoscopy for transplantation. Twenty-eight patients were male (56%) and 22 female (44%). Mean age was 37.2 years, and the mean body mass index (BMI) was 27.1 kg/m2. Mean surgical time was 179.5 minutes, and warm ischemia time of the graft was 3.79 minutes. The mean estimated bleeding was 141 mL. There was no need of blood transfusion or conversion to open surgery. In 42 cases (84%), the vascular portion of the graft was considered good by the recipient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s surgical team and in all cases, the ureter was considered of proper size, though in one of them (2%) its vascularization was considered improper. The transplanted kidneys produced urine still in the surgical room in 46 of the 50 transplantations considered. In only 2 cases opioid was required for analgesia. In average, 3.1 doses of dipyrone were used for each patient during hospital stay, and hospital discharge occurred, in average, after 3.2 days post-operatively. Two patients required re-operations and one of them evolved to death. The laparoscopic nephrectomy in live donor for renal transplantation is an alternative to conventional open surgery. In relation to the graft, no alteration, either anatomic or functional, was detected. Though there is already a large documentation in the international literature regarding this procedure, in our setting a prospective randomized study with the usual surgical study is still necessary in order to prove the advantages and disadvantages of the method.

Research paper thumbnail of Voiding dysfunction and urodynamic abnormalities in elderly patients

GOMES CM et al. Voiding dysfunction and urodynamic abnormalities in elderly patients. Rev. Hosp. ... more GOMES CM et al. Voiding dysfunction and urodynamic abnormalities in elderly patients. Rev. Hosp. Clín. Fac. Med. S. Paulo 59(4):206-215, 2004.

Research paper thumbnail of Evaluation and treatment of the overactive bladder

RHCFAP/3067 ROVNER ES et al. -Evaluation and treatment of the overactive bladder. Rev. Hosp. Clín... more RHCFAP/3067 ROVNER ES et al. -Evaluation and treatment of the overactive bladder. Rev. Hosp. Clín. Fac. Med. S. Paulo 57(1):39-48, 2002.

Research paper thumbnail of Surgical complications after renal transplantation in grafts with multiple arteries

International braz j urol, 2005

Introduction: Renal transplantation with multiple arteries appears, in literature, associated to ... more Introduction: Renal transplantation with multiple arteries appears, in literature, associated to a major index of surgical complications. This study compared the surgical complications and shortterm outcome renal transplants with multiple arteries and single artery grafts.

Research paper thumbnail of SHOULD WE TREAT A SEVERE ACUTE CELLULAR REJECTION WITH NO CLINICAL SIGNS?

Transplantation, 1991

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maint... more Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home &gt; June ...

Research paper thumbnail of Comparative and prospective analysis of three different approaches for live-donor nephrectomy

Clinics, 2009

Mitre AI, Dénes FT, Nahas WC, Simões FA, Colombo Jr JR, Piovesan AC, Chambô JL, Arap S, Srougi M.... more Mitre AI, Dénes FT, Nahas WC, Simões FA, Colombo Jr JR, Piovesan AC, Chambô JL, Arap S, Srougi M. Comparative and prospective analysis of three different approaches for live-donor nephrectomy. Clinics. 2009;64(1):23-8.

Research paper thumbnail of Laparoscopic treatment of retroperitoneal fibrosis: report of two cases and review of the literature

Revista do Hospital das Clínicas, 2000

We present the results of treatment by laparoscopy of two patients with retroperitoneal fibrosis ... more We present the results of treatment by laparoscopy of two patients with retroperitoneal fibrosis and review the literature since 1992, when the first case of this disease that was treated using laparoscopy was published. We also discuss the contemporary alternatives of clinical treatment with corticosteroids and tamoxifen. Two female patients, one with idiopathic retroperitoneal fibrosis, and other with retroperitoneal fibrosis associated with Riedel&#39;s thyroiditis, were treated using laparoscopic surgery. Both cases had bilateral pelvic ureteral obstruction and were treated using the same technique: transperitoneal laparoscopy, medial mobilization of both colons, liberation of both ureters from the fibrosis, and intraperitonealisation of the ureters. Double-J catheters were inserted before the operations and removed 3 weeks after the procedures. The first patient underwent intraperitonealisation of both ureters in a single procedure. The other had 2 different surgical procedures because of technical difficulties during the first operation. Both patients were followed for more than 1 year and recovered completely from the renal insufficiency. One of them still has occasional vague lumbar pain. There were no abnormalities in the intravenous pyelography in either case. Surgical correction of retroperitoneal fibrosis, when indicated, should be attempted using laparoscopy. If possible, bilateral ureterolysis and intraperitonealisation of both ureters should be performed in the same operation.

Research paper thumbnail of Pheochromocytoma treated by laparoscopic surgery

Revista do Hospital das Clínicas, 2000

To evaluate the results of the laparoscopic technique in the treatment of adrenal pheochromocytom... more To evaluate the results of the laparoscopic technique in the treatment of adrenal pheochromocytoma. Ten patients, 7 men and 3 women, between 10 and 67 years of age (mean 48) with pheochromocytoma underwent transperitoneal laparoscopic adrenalectomy and were evaluated retrospectively, based on clinical, laboratory, and pathological diagnosis. In all cases there was a solid unilateral adrenal tumor, 5 on the left side and 5 on the right side, whose greater diameter varied from 7 to 80 mm (mean 32). Nine of the 10 patients were chronically hypertensive or had already had hypertensive crises. One patient was normotensive, but presented metabolic alterations suggestive of adrenergic hyperfunction. No deaths occurred in this series. There were two (20%) conversions to open surgery, one due to venous bleeding and one due to the difficulty of dissection behind the vena cava in a patient presenting a partially retro-caval tumor. Surgical time in the 8 non-converted cases ranged from 70 to 215 minutes (mean 136). One patient (10%) received blood transfusion, and another (10%) presented two complications - acute renal failure and a subcutaneous infection. Both had been converted to open surgery. None of the non-converted cases was transfused or presented complications. Hospital discharge occurred between the 2nd and 11th post-operative day (mean 3). The pathological exam of the surgical specimens confirmed the diagnoses of pheochromocytoma in all 10 cases, one of them associated with an aldosterone-producing cortical tumor. Laparoscopic adrenalectomy for selected patients presenting pheochromocytoma is feasible and provides good results.

Research paper thumbnail of Splenic rupture and abscess after extracorporeal shock wave lithotripsy

Urology, 1998

Extracorporeal shock wave lithotripsy (ESWL) is the first choice for the treatment of most urinar... more Extracorporeal shock wave lithotripsy (ESWL) is the first choice for the treatment of most urinary stones. Complications of ESWL can be separated into two groups: those related to the administration of the shock waves and those related to fragmentation and elimination of the stone&#39;s particles. We report a rare case of splenic trauma followed by abscess after ESWL.

Research paper thumbnail of How to deal with children with end-stage renal disease and severe bladder dysfunction

Transplantation Proceedings, 2003

Research paper thumbnail of The original extravesical antireflux Plasty: Does it need improvement?

Current Urology Reports, 2006

Research paper thumbnail of A prospective study evaluating the long term efficacyand safety of the adjustable continence therapy (ProACT⊥M) for post radical prostatectomy urinary incontinence

European Urology Supplements, 2005

Research paper thumbnail of Assessment of sexual function in patients undergoing vasectomy using the international index of erectile function

International braz j urol : official journal of the Brazilian Society of Urology

The present study aims to prospectively compare the sexual function in males before and after vas... more The present study aims to prospectively compare the sexual function in males before and after vasectomy surgery using the international index of erectile function (IIEF). From October to December 2002, sixty-four patients who were candidates for male sterilization in the vasectomy program of the Urology Section at the General Hospital of the University of São Paulo were included. The same investigator applied the IIEF before and 90 days after the surgery. The mean scores obtained on pre and postoperative visits for all domains of sexual function were analyzed and compared with the Wilcoxon test. The mean patient age was 35 years (range from 25 to 48 years) and the mean number of children per man was 3. The total mean score of the IIEF was 64.06 before surgery and 65.64 after the procedure, with this difference considered statistically significant (p < 0.001). Sixty-seven per cent of the patients improved their scores, versus 17% and 16% who showed worsening or no change at all in...

Research paper thumbnail of Prosthetic repair of incisional hernia in kidney transplant patients. A technique with onlay polypropylene mesh

Hernia : the journal of hernias and abdominal wall surgery, 2001

The employment of synthetic mesh for incisional hernia repair in kidney-transplanted patients is ... more The employment of synthetic mesh for incisional hernia repair in kidney-transplanted patients is rarely reported in the present literature. Many authors believe that mesh employment in such conditions is not safe due to fear of mesh related complications. From 1965 through 1999, a total of 1685 kidney transplants were performed at our Kidney Transplant Unit and 19 patients developed eventrations in the kidney transplant incision, an incidence of 1.1%. From September 1996 eight of these patients had prosthetic repair of the abdominal wall with onlay polypropylene mesh. All patients were under immunosuppressive therapy with prednisone, ciclosporine and azathioprine. Mean age was 48.8 years, mean body mass index was 22.5 and mean number of previous abdominal operations was 2.5. A large polypropylene mesh (Marlex mesh) was fixed over the aponeurosis after primary closure of the aponeurotic borders, as an onlay graft. There was neither morbidity nor mortality associated to the surgical p...

Research paper thumbnail of artigo original Eficácia e Segurança da Prótese Peniana Inflável no Tratamento de Disfunção Erétil em Pacientes Diabéticos

Many factors lead to erectile dysfunction in the diabetic patient. Neuropathy and microangiopathy... more Many factors lead to erectile dysfunction in the diabetic patient. Neuropathy and microangiopathy are involved in loss of potency in this group of patients. Diabetic patients with erectile dysfunction who have failed clinical treatment are candidates to intracavernos al injections or penile prosthesis. In these cases the risk of infection relat- ed to poor immunity cause concerns related to prosthesis

Research paper thumbnail of Effects of medical therapy, alcohol, smoking, and endocrine disruptors on male infertility

Revista do Hospital das Clínicas, 2004

Infertility affects up to 15% of the sexually active population, and in 50% of cases, a male fact... more Infertility affects up to 15% of the sexually active population, and in 50% of cases, a male factor is involved, either as a primary problem or in combination with a problem in the female partner. Because many commonly encountered drugs and medications can have a detrimental effect on male fertility, the medical evaluation should include a discussion regarding the use of recreational and illicit drugs, medications, and other substances that may impair fertility. With the knowledge of which drugs and medications may be detrimental to fertility, it may be possible to modify medication regimens or convince a patient to modify habits to decrease adverse effects on fertility and improve the chances of achieving a successful pregnancy. Concern is growing that male sexual development and reproduction have changed for the worse over the past 30 to 50 years. Although some reports find no changes, others suggest that sperm counts appear to be decreasing and that the incidence of developmental abnormalities such as hypospadias and cryptorchidism appears to be increasing, as is the incidence of testicular cancer. These concerns center around the possibility that our environment is contaminated with chemicals--both natural and synthetic--that can interact with the endocrine system.

Research paper thumbnail of A cost-effective technique for pure laparoscopic live donor nephrectomy

International braz j urol, 2006

Objective: Compare two different techniques for laparoscopic live donor nephrectomy (LDN), relate... more Objective: Compare two different techniques for laparoscopic live donor nephrectomy (LDN), related to the operative costs and learning curve. Materials and Methods: Between April/2000 and October/2003, 61 patients were submitted to LDN in 2 different reference centers in kidney transplantation. At center A (CA), 11 patients were operated by a pure transperitoneal approach, using Hem-O-Lok ® clips for the renal pedicle control and the specimens were retrieved manually, without using endobags. At center B (CB), 50 patients were also operated by a pure transperitoneal approach, but the renal pedicles were controlled with endo-GIA appliers and the specimens were retrieved using endobags. Results: Operative time (231 ± 39 min vs. 179 ± 30 min; p < 0.000), warm ischemia time (5.85 ± 2.85 min vs. 3.84 ± 3.84 min; p = 0.002) and blood loss (214 ± 98 mL vs. 141 ± 82 mL; p = 0.02) were statistically better in CB, when compared to CA. Discharge time was similar in both centers. One major complication was observed in both centers, leading to an open conversion in CA (9.1%). One donor death occurred in CB (2%). Regarding the recipients, no statistical difference was observed in all parameters analyzed. There was an economy of US$1.440 in each procedure performed in CA, when compared to CB. Conclusions: Despite the learning curve, the technique adopted by CA, showed no deleterious results to the donors and recipients when compared with the CB. On the other hand, this technique was cheaper than the technique performed in the CB, representing an attractive alternative for LDN, mainly in developing centers.

Research paper thumbnail of Percutaneous prostate cryoablation as treatment for high-risk prostate cancer

Clinics, 2007

To evaluate percutaneous cryotherapy as a primary treatment option for high-risk prostate cancer ... more To evaluate percutaneous cryotherapy as a primary treatment option for high-risk prostate cancer patients. From October 2000 to February 2005, 21 high-risk (Gleason e.8 and/or PSA &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 10 and/or stage &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; T2a) prostate cancer patients underwent 24 percutaneous prostate cryoablation procedures. Patients&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; median age was 70.9, and the average pretreatment PSA was 19.5 ng/dL. The follow-up period ranged from 6 to 60 months (median, 41 months). The PSA failure rate was 39%, 52.9%, and 42.8% at 12, 24, and 60 months of follow-up, respectively. Overall complication rates were low, with 8% of urinary incontinence and no cases of rectal injury; however, 96% of erectile dysfunction occurred. The cryoablation procedure failed in 12 patients (57.2%); 7 (58.3%) of these were local failures (positive prostate biopsies). Percutaneous cryoablation of the prostate is a safe minimally invasive treatment, but it has poor PSA-free survival outcomes in high-risk prostate cancer patients.

Research paper thumbnail of Comparison of the fluorescent polarization (TDx) and the enzymatic competitive (EMIT 2000) immune assays for the measurement of cyclosporin A blood concentration

Revista do Hospital das Clínicas, 2000

Evaluation of Cyclosporin A (CyA) blood concentration is imperative in solid organ transplantatio... more Evaluation of Cyclosporin A (CyA) blood concentration is imperative in solid organ transplantation in order to achieve maximal immunosuppression with the least side effects. We compared the results of whole blood concentrations of CyA in 50 blood samples simultaneously evaluated by the fluorescent polarization immune assay (TDx) and the enzymatic competitive immune assay (EMIT 2000). There was a strong correlation between both kits for any range of CyA blood concentration (R=0.99, p&amp;amp;amp;amp;amp;amp;lt;0.001). The within-run and between-days coefficient of variation were less than 4% for both assays. The cost for each CyA measurement was 50% lower for the EMIT assay when compared to the TDx assay. We concluded that the EMIT is as accurate as the TDx in measuring CyA blood concentration and has the advantage of a lower cost, as well as the possibility of widespread access to the EMIT methodology in contrast to the TDx equipment, allowing the laboratory to perform several routines within a working day.

Research paper thumbnail of Augmentation cystoplasty in renal transplantation: a good and safe option--experience with 25 cases

Urology, 2002

To assess the surgical and long-term results of renal transplantation in 25 patients with bladder... more To assess the surgical and long-term results of renal transplantation in 25 patients with bladder dysfunction and augmentation cystoplasty. We retrospectively reviewed the evolution and surgical outcome of 25 renal transplants in 24 recipients with augmentation cystoplasty. The mean patient age at transplantation was 27.6 years. The etiology of bladder dysfunction was neurogenic bladder with detrusor hyperreflexia (11 patients), tuberculosis (5 patients), vesicoureteral reflux (4 patients), posterior urethral valves (3 patients), and interstitial cystitis (1 patient). Seventeen transplants were from living donors. Augmentation cystoplasty was performed before transplantation in 21 patients. The bowel segments used in the augmentation cystoplasty included ileum in 16, ileocecal segments in 2, and sigmoid in 5 patients. The donor ureter was anastomosed to the native bladder in 16 patients, to the bowel segment in 6, and to the native ureter in 3. Twenty kidneys (80%) were functioning ...

Research paper thumbnail of Laparoscopic nephrectomy in live donor

International braz j urol, 2004

To present the initial experience of videolaparoscopic nephrectomy in live renal donor. In the pe... more To present the initial experience of videolaparoscopic nephrectomy in live renal donor. In the period from April 2000 to August 2003, 50 left nephrectomies in live donor were performed by videolaparoscopy for transplantation. Twenty-eight patients were male (56%) and 22 female (44%). Mean age was 37.2 years, and the mean body mass index (BMI) was 27.1 kg/m2. Mean surgical time was 179.5 minutes, and warm ischemia time of the graft was 3.79 minutes. The mean estimated bleeding was 141 mL. There was no need of blood transfusion or conversion to open surgery. In 42 cases (84%), the vascular portion of the graft was considered good by the recipient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s surgical team and in all cases, the ureter was considered of proper size, though in one of them (2%) its vascularization was considered improper. The transplanted kidneys produced urine still in the surgical room in 46 of the 50 transplantations considered. In only 2 cases opioid was required for analgesia. In average, 3.1 doses of dipyrone were used for each patient during hospital stay, and hospital discharge occurred, in average, after 3.2 days post-operatively. Two patients required re-operations and one of them evolved to death. The laparoscopic nephrectomy in live donor for renal transplantation is an alternative to conventional open surgery. In relation to the graft, no alteration, either anatomic or functional, was detected. Though there is already a large documentation in the international literature regarding this procedure, in our setting a prospective randomized study with the usual surgical study is still necessary in order to prove the advantages and disadvantages of the method.

Research paper thumbnail of Voiding dysfunction and urodynamic abnormalities in elderly patients

GOMES CM et al. Voiding dysfunction and urodynamic abnormalities in elderly patients. Rev. Hosp. ... more GOMES CM et al. Voiding dysfunction and urodynamic abnormalities in elderly patients. Rev. Hosp. Clín. Fac. Med. S. Paulo 59(4):206-215, 2004.

Research paper thumbnail of Evaluation and treatment of the overactive bladder

RHCFAP/3067 ROVNER ES et al. -Evaluation and treatment of the overactive bladder. Rev. Hosp. Clín... more RHCFAP/3067 ROVNER ES et al. -Evaluation and treatment of the overactive bladder. Rev. Hosp. Clín. Fac. Med. S. Paulo 57(1):39-48, 2002.

Research paper thumbnail of Surgical complications after renal transplantation in grafts with multiple arteries

International braz j urol, 2005

Introduction: Renal transplantation with multiple arteries appears, in literature, associated to ... more Introduction: Renal transplantation with multiple arteries appears, in literature, associated to a major index of surgical complications. This study compared the surgical complications and shortterm outcome renal transplants with multiple arteries and single artery grafts.

Research paper thumbnail of SHOULD WE TREAT A SEVERE ACUTE CELLULAR REJECTION WITH NO CLINICAL SIGNS?

Transplantation, 1991

Wolters Kluwer Health may email you for journal alerts and information, but is committed to maint... more Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home &gt; June ...

Research paper thumbnail of Comparative and prospective analysis of three different approaches for live-donor nephrectomy

Clinics, 2009

Mitre AI, Dénes FT, Nahas WC, Simões FA, Colombo Jr JR, Piovesan AC, Chambô JL, Arap S, Srougi M.... more Mitre AI, Dénes FT, Nahas WC, Simões FA, Colombo Jr JR, Piovesan AC, Chambô JL, Arap S, Srougi M. Comparative and prospective analysis of three different approaches for live-donor nephrectomy. Clinics. 2009;64(1):23-8.

Research paper thumbnail of Laparoscopic treatment of retroperitoneal fibrosis: report of two cases and review of the literature

Revista do Hospital das Clínicas, 2000

We present the results of treatment by laparoscopy of two patients with retroperitoneal fibrosis ... more We present the results of treatment by laparoscopy of two patients with retroperitoneal fibrosis and review the literature since 1992, when the first case of this disease that was treated using laparoscopy was published. We also discuss the contemporary alternatives of clinical treatment with corticosteroids and tamoxifen. Two female patients, one with idiopathic retroperitoneal fibrosis, and other with retroperitoneal fibrosis associated with Riedel&#39;s thyroiditis, were treated using laparoscopic surgery. Both cases had bilateral pelvic ureteral obstruction and were treated using the same technique: transperitoneal laparoscopy, medial mobilization of both colons, liberation of both ureters from the fibrosis, and intraperitonealisation of the ureters. Double-J catheters were inserted before the operations and removed 3 weeks after the procedures. The first patient underwent intraperitonealisation of both ureters in a single procedure. The other had 2 different surgical procedures because of technical difficulties during the first operation. Both patients were followed for more than 1 year and recovered completely from the renal insufficiency. One of them still has occasional vague lumbar pain. There were no abnormalities in the intravenous pyelography in either case. Surgical correction of retroperitoneal fibrosis, when indicated, should be attempted using laparoscopy. If possible, bilateral ureterolysis and intraperitonealisation of both ureters should be performed in the same operation.

Research paper thumbnail of Pheochromocytoma treated by laparoscopic surgery

Revista do Hospital das Clínicas, 2000

To evaluate the results of the laparoscopic technique in the treatment of adrenal pheochromocytom... more To evaluate the results of the laparoscopic technique in the treatment of adrenal pheochromocytoma. Ten patients, 7 men and 3 women, between 10 and 67 years of age (mean 48) with pheochromocytoma underwent transperitoneal laparoscopic adrenalectomy and were evaluated retrospectively, based on clinical, laboratory, and pathological diagnosis. In all cases there was a solid unilateral adrenal tumor, 5 on the left side and 5 on the right side, whose greater diameter varied from 7 to 80 mm (mean 32). Nine of the 10 patients were chronically hypertensive or had already had hypertensive crises. One patient was normotensive, but presented metabolic alterations suggestive of adrenergic hyperfunction. No deaths occurred in this series. There were two (20%) conversions to open surgery, one due to venous bleeding and one due to the difficulty of dissection behind the vena cava in a patient presenting a partially retro-caval tumor. Surgical time in the 8 non-converted cases ranged from 70 to 215 minutes (mean 136). One patient (10%) received blood transfusion, and another (10%) presented two complications - acute renal failure and a subcutaneous infection. Both had been converted to open surgery. None of the non-converted cases was transfused or presented complications. Hospital discharge occurred between the 2nd and 11th post-operative day (mean 3). The pathological exam of the surgical specimens confirmed the diagnoses of pheochromocytoma in all 10 cases, one of them associated with an aldosterone-producing cortical tumor. Laparoscopic adrenalectomy for selected patients presenting pheochromocytoma is feasible and provides good results.

Research paper thumbnail of Splenic rupture and abscess after extracorporeal shock wave lithotripsy

Urology, 1998

Extracorporeal shock wave lithotripsy (ESWL) is the first choice for the treatment of most urinar... more Extracorporeal shock wave lithotripsy (ESWL) is the first choice for the treatment of most urinary stones. Complications of ESWL can be separated into two groups: those related to the administration of the shock waves and those related to fragmentation and elimination of the stone&#39;s particles. We report a rare case of splenic trauma followed by abscess after ESWL.

Research paper thumbnail of How to deal with children with end-stage renal disease and severe bladder dysfunction

Transplantation Proceedings, 2003

Research paper thumbnail of The original extravesical antireflux Plasty: Does it need improvement?

Current Urology Reports, 2006