San Land Young - Academia.edu (original) (raw)

Papers by San Land Young

Frontiers in Nutrition

In humans, aging is characterized by the progressive decline in biological, physiological, and ps... more In humans, aging is characterized by the progressive decline in biological, physiological, and psychological functions, and is a major risk factor in the development of chronic diseases. Therefore, the development of strategies aimed at attenuating aging-related disorders and promoting healthy aging is critical. In a previous study, we have demonstrated that Lactobacillus plantarum TWK10 (TWK10), a probiotic strain isolated from Taiwanese pickled cabbage, improved muscle strength, exercise endurance, and overall body composition in healthy humans. In this study, the effect of TWK10 on the progression of age-related impairments was investigated in mice. We found that TWK10 not only enhanced muscle strength in young mice, but also prevented the aging-related loss of muscle strength in aged mice, which was accompanied by elevated muscle glycogen levels. Furthermore, TWK10 attenuated the aging-associated decline in learning and memory abilities, as well as bone mass. Further analyses of...

Nutrients

Probiotics have been rapidly developed for health promotion, but clinical validation of the effec... more Probiotics have been rapidly developed for health promotion, but clinical validation of the effects on exercise physiology has been limited. In a previous study, Lactobacillus plantarum TWK10 (TWK10), isolated from Taiwanese pickled cabbage as a probiotic, was demonstrated to improve exercise performance in an animal model. Thus, in the current study, we attempted to further validate the physiological function and benefits through clinical trials for the purpose of translational research. The study was designed as a double-blind placebo-controlled experiment. A total of 54 healthy participants (27 men and 27 women) aged 20–30 years without professional athletic training were enrolled and randomly allocated to the placebo, low (3 × 1010 colony forming units (CFU)), and high dose (9 × 1010 CFU) TWK10 administration groups (n = 18 per group, with equal sexes). The functional and physiological assessments were conducted by exhaustive treadmill exercise measurements (85% VO2max), and rel...

Journal of The Science of Food and Agriculture, 1994

The potentiometric behavior of xanthan solutions was analyzed as a function of ionic strength, po... more The potentiometric behavior of xanthan solutions was analyzed as a function of ionic strength, polymer concentration and temperature. For a given value of the polymer dissociation constant, α, pKa was linearly correlated with Cs1/3 (salt concentration). At polymer concentrations below 7.5 g liter-1, pKa was a function of polymer concentration. However, when the polymer concentration was higher than this value, pKa was independent of polymer concentration. Potentiometric titration confirmed the significance of the hydrogen bond and the carboxylate group on the secondary structure of xanthan which suggested that the ordered xanthan conformation is stabilized mainly by hydrogen bonds. These can be disrupted by increasing the electrostatic potential of the molecule or by increasing the solution temperature. Neither the ionic strength nor the polymer concentration affected the secondary structure of xanthan at 25°C. However, ionic strength should reduce the repulsive force between charged groups in xanthan; this would explain the salt stabilization of the secondary structure observed at the higher test temperatures (35–70°C).

Food Hydrocolloids, 1990

ABSTRACT

Journal of Applied Polymer Science, 1991

A rotational rheometer with cone and plate fixtures was used to measure the intrinsic viscosities... more A rotational rheometer with cone and plate fixtures was used to measure the intrinsic viscosities of aqueous suspensions of xanthan gum and carboxymethyl cellulose (CMC). The reduced viscosities or hydrodynamic volumes of CMC suspensions increased with dilution. However, the reduced viscosities of xanthan gum suspensions decreased with dilution within the concentration range of 0.1–0.06% and increased with dilution within the concentration range of 0.04–0.01%. When the gums were suspended and diluted with 0.06 M sodium acetate, the reduced viscosities of all the xanthan gum and CMC suspensions decreased upon dilution. The intrinsic viscosities of xanthan gum and CMC suspensions decreased with increasing the shear rate, showing a dependence of hydrodynamic volume on shear rate.

Frontiers in Nutrition

In humans, aging is characterized by the progressive decline in biological, physiological, and ps... more In humans, aging is characterized by the progressive decline in biological, physiological, and psychological functions, and is a major risk factor in the development of chronic diseases. Therefore, the development of strategies aimed at attenuating aging-related disorders and promoting healthy aging is critical. In a previous study, we have demonstrated that Lactobacillus plantarum TWK10 (TWK10), a probiotic strain isolated from Taiwanese pickled cabbage, improved muscle strength, exercise endurance, and overall body composition in healthy humans. In this study, the effect of TWK10 on the progression of age-related impairments was investigated in mice. We found that TWK10 not only enhanced muscle strength in young mice, but also prevented the aging-related loss of muscle strength in aged mice, which was accompanied by elevated muscle glycogen levels. Furthermore, TWK10 attenuated the aging-associated decline in learning and memory abilities, as well as bone mass. Further analyses of...

Nutrients

Probiotics have been rapidly developed for health promotion, but clinical validation of the effec... more Probiotics have been rapidly developed for health promotion, but clinical validation of the effects on exercise physiology has been limited. In a previous study, Lactobacillus plantarum TWK10 (TWK10), isolated from Taiwanese pickled cabbage as a probiotic, was demonstrated to improve exercise performance in an animal model. Thus, in the current study, we attempted to further validate the physiological function and benefits through clinical trials for the purpose of translational research. The study was designed as a double-blind placebo-controlled experiment. A total of 54 healthy participants (27 men and 27 women) aged 20–30 years without professional athletic training were enrolled and randomly allocated to the placebo, low (3 × 1010 colony forming units (CFU)), and high dose (9 × 1010 CFU) TWK10 administration groups (n = 18 per group, with equal sexes). The functional and physiological assessments were conducted by exhaustive treadmill exercise measurements (85% VO2max), and rel...

Journal of The Science of Food and Agriculture, 1994

The potentiometric behavior of xanthan solutions was analyzed as a function of ionic strength, po... more The potentiometric behavior of xanthan solutions was analyzed as a function of ionic strength, polymer concentration and temperature. For a given value of the polymer dissociation constant, α, pKa was linearly correlated with Cs1/3 (salt concentration). At polymer concentrations below 7.5 g liter-1, pKa was a function of polymer concentration. However, when the polymer concentration was higher than this value, pKa was independent of polymer concentration. Potentiometric titration confirmed the significance of the hydrogen bond and the carboxylate group on the secondary structure of xanthan which suggested that the ordered xanthan conformation is stabilized mainly by hydrogen bonds. These can be disrupted by increasing the electrostatic potential of the molecule or by increasing the solution temperature. Neither the ionic strength nor the polymer concentration affected the secondary structure of xanthan at 25°C. However, ionic strength should reduce the repulsive force between charged groups in xanthan; this would explain the salt stabilization of the secondary structure observed at the higher test temperatures (35–70°C).

Food Hydrocolloids, 1990

ABSTRACT

Journal of Applied Polymer Science, 1991

A rotational rheometer with cone and plate fixtures was used to measure the intrinsic viscosities... more A rotational rheometer with cone and plate fixtures was used to measure the intrinsic viscosities of aqueous suspensions of xanthan gum and carboxymethyl cellulose (CMC). The reduced viscosities or hydrodynamic volumes of CMC suspensions increased with dilution. However, the reduced viscosities of xanthan gum suspensions decreased with dilution within the concentration range of 0.1–0.06% and increased with dilution within the concentration range of 0.04–0.01%. When the gums were suspended and diluted with 0.06 M sodium acetate, the reduced viscosities of all the xanthan gum and CMC suspensions decreased upon dilution. The intrinsic viscosities of xanthan gum and CMC suspensions decreased with increasing the shear rate, showing a dependence of hydrodynamic volume on shear rate.