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Papers by Sana Khedher
La Tunisie medicale, 2017
La Tunisie medicale, 2017
Médecine Intensive Réanimation, 2019
Le syndrome de Budd-Chiari (SBC) est une maladie vasculaire du foie faisant suite souvent à une t... more Le syndrome de Budd-Chiari (SBC) est une maladie vasculaire du foie faisant suite souvent à une thrombose veineuse sus-hépatique. L’hémoglobinurie paroxystique nocturne (HPN), affection clonale acquise rare, réalise une des conditions prothrombotiques bien connues prédisposant au SBC primitif. L’association SBC–HPN est souvent rapportée sous forme de cas cliniques isolés ou de petites séries présentant des spécificités pronostiques et thérapeutiques. Nous rapportons le cas d’une fille de 27 ans ayant une HPN révélée dans le cadre du bilan étiologique d’un SBC, associé à des thromboses veineuses portale, mésentérique et à une embolie pulmonaire.
Gastroenterology Research and Practice, 2018
Background. Bacterial infection (BI) represents the main cause of decompensation and death in cir... more Background. Bacterial infection (BI) represents the main cause of decompensation and death in cirrhotic patients. Procalcitonin (PCT) and C-reactive protein (CRP) are two widely used biomarkers that may be helpful for early detection of BI especially in the presence of inflammation. Their accuracy for the diagnosis of BI in patients with chronic liver disease has been a subject of debate. In this study, we aimed to learn whether PCT and CRP would be helpful as early markers of BI in patients with cirrhosis and to evaluate their prognostic value in terms of mortality. Subjects and Methods. We retrospectively included 92 adult patients with decompensated cirrhosis. PCT and CRP plasma levels were obtained within the first 24 hours of admission. Their diagnostic and prognostic values were compared using the appropriate statistical analysis. Results. Ninety-two patients were included. BI was diagnosed in 60 patients (65%). Mean white blood cell (WBC) count (p=0.005) and PCT and CRP serum...
La Tunisie medicale, 2017
Atherosclerosis, 2016
Objectives: Hyponatremia is a commun complication of advanced cirrrhosis caused by impairement in... more Objectives: Hyponatremia is a commun complication of advanced cirrrhosis caused by impairement in the renal capacity for eliminating solutefree water. The aim was to evaluate the prevalence of hyponatremia in patients with cirrhosis and to detect the prognostic value of hyponatremia and its impact on mortality. Methods: During a 12-month period, we studied all adult subjects admitted in the gastroenterology department of the academic hospital Charles Nicolle of Tunis. Data were recorded on etiology of liver cirrhosis, reason for hospitalization, routine biochemistry including the item of the Abstracts / Atherosclerosis 252 (2016) e1ee196 e86
Annals of Intensive Care, 2016
La Revue de Médecine Interne, 2014
La Tunisie medicale, 2016
Hepatic hydrothorax is a less common complication of cirrhosis with an estimated prevalence of 10... more Hepatic hydrothorax is a less common complication of cirrhosis with an estimated prevalence of 10- 15%. In the vast majority of cases, ascites are also present but significant pleural effusion may develop in patients without ascites. Hepatic hydrothorax is associated with cirrhosis whatever its etiology. The prognosis of hepatic hydrothorax remains unclear and is closely related to available therapeutic options. The aim of our study is to determine the prevalence of hydrothorax in cirrhotic patients, detail its clinical and therapeutic characteristics, and study the evolutive profile of cirrhotic patients with hydrothorax by comparing it to those without hydrothorax. We also search predictive factors of development of this complication in cirrhotic patients. We conduct a retrospective and case-control study including 63 cirrhotic patients with hepatic hydrothorax hospitalized in gastroenterology department of Charles Nicolle hospital of Tunis, during a period of fiveteen years, from...
La Tunisie medicale, 2017
La Tunisie medicale, 2017
Médecine Intensive Réanimation, 2019
Le syndrome de Budd-Chiari (SBC) est une maladie vasculaire du foie faisant suite souvent à une t... more Le syndrome de Budd-Chiari (SBC) est une maladie vasculaire du foie faisant suite souvent à une thrombose veineuse sus-hépatique. L’hémoglobinurie paroxystique nocturne (HPN), affection clonale acquise rare, réalise une des conditions prothrombotiques bien connues prédisposant au SBC primitif. L’association SBC–HPN est souvent rapportée sous forme de cas cliniques isolés ou de petites séries présentant des spécificités pronostiques et thérapeutiques. Nous rapportons le cas d’une fille de 27 ans ayant une HPN révélée dans le cadre du bilan étiologique d’un SBC, associé à des thromboses veineuses portale, mésentérique et à une embolie pulmonaire.
Gastroenterology Research and Practice, 2018
Background. Bacterial infection (BI) represents the main cause of decompensation and death in cir... more Background. Bacterial infection (BI) represents the main cause of decompensation and death in cirrhotic patients. Procalcitonin (PCT) and C-reactive protein (CRP) are two widely used biomarkers that may be helpful for early detection of BI especially in the presence of inflammation. Their accuracy for the diagnosis of BI in patients with chronic liver disease has been a subject of debate. In this study, we aimed to learn whether PCT and CRP would be helpful as early markers of BI in patients with cirrhosis and to evaluate their prognostic value in terms of mortality. Subjects and Methods. We retrospectively included 92 adult patients with decompensated cirrhosis. PCT and CRP plasma levels were obtained within the first 24 hours of admission. Their diagnostic and prognostic values were compared using the appropriate statistical analysis. Results. Ninety-two patients were included. BI was diagnosed in 60 patients (65%). Mean white blood cell (WBC) count (p=0.005) and PCT and CRP serum...
La Tunisie medicale, 2017
Atherosclerosis, 2016
Objectives: Hyponatremia is a commun complication of advanced cirrrhosis caused by impairement in... more Objectives: Hyponatremia is a commun complication of advanced cirrrhosis caused by impairement in the renal capacity for eliminating solutefree water. The aim was to evaluate the prevalence of hyponatremia in patients with cirrhosis and to detect the prognostic value of hyponatremia and its impact on mortality. Methods: During a 12-month period, we studied all adult subjects admitted in the gastroenterology department of the academic hospital Charles Nicolle of Tunis. Data were recorded on etiology of liver cirrhosis, reason for hospitalization, routine biochemistry including the item of the Abstracts / Atherosclerosis 252 (2016) e1ee196 e86
Annals of Intensive Care, 2016
La Revue de Médecine Interne, 2014
La Tunisie medicale, 2016
Hepatic hydrothorax is a less common complication of cirrhosis with an estimated prevalence of 10... more Hepatic hydrothorax is a less common complication of cirrhosis with an estimated prevalence of 10- 15%. In the vast majority of cases, ascites are also present but significant pleural effusion may develop in patients without ascites. Hepatic hydrothorax is associated with cirrhosis whatever its etiology. The prognosis of hepatic hydrothorax remains unclear and is closely related to available therapeutic options. The aim of our study is to determine the prevalence of hydrothorax in cirrhotic patients, detail its clinical and therapeutic characteristics, and study the evolutive profile of cirrhotic patients with hydrothorax by comparing it to those without hydrothorax. We also search predictive factors of development of this complication in cirrhotic patients. We conduct a retrospective and case-control study including 63 cirrhotic patients with hepatic hydrothorax hospitalized in gastroenterology department of Charles Nicolle hospital of Tunis, during a period of fiveteen years, from...