Sanchita Singh - Academia.edu (original) (raw)

Papers by Sanchita Singh

The extreme efforts have been developed to design novel compounds to strains of resistant microor... more The extreme efforts have been developed to design novel compounds to strains of resistant microorganisms. Ongoing search for novel and amazing drug delivery systems is primarily impact of the wellestablished fact that the convectional dosages are not sufficiently effective in conveying the drug compounds to its site of action and this has required the need to search for more efficient drugs. New five metal complexes of Nickel(II), Copper(II), Zinc(II), Cadmium(II) and Tin(II) with Schiff base ligand 4-(Benzylidene-amino)-5pyridin-4-yl-4H-[1,2,4] triazole-3-thiol were synthesized in ethyl alcohol as a solvent. The Synthesized compounds were characterized by different physicochemical techniques such as, elemental analysis C.H.N.S, FT-IR, UVvisible spectrophotometry, 1 H NMR, conductivity and magnetic susceptibility measurements melting point, flame atomic absorption. The Schiff base ligand act as bidentate and coordinated to the metal atoms via the azomethine-N and S atom of thiol group. From the spectral studies, square planar geometry was proposed for the copper complex. The other complexes were proposed to be tetrahedral.

Herbals plants are effective source of traditional and modern medicines, useful for primary healt... more Herbals plants are effective source of traditional and modern medicines, useful for primary health care. Plants are richest source of bioactive organic chemicals on earth. The active metabolites like Phytochemicals from the medicinal plants were under exploration for the development of novel and biodegradable effective drugs as an alternative to the ineffective contemporary medicine. Calotropis gigantea has great medicinal importance to treat fever, indigestion, cold, cough, cardio tonic, asthma, scabies etc. Phytochemical properties of leaf of Calotropis gigantea obtained from methanol and petroleum ether extracts were investigated .The results suggest that the Phytochemical properties of the leaf for using various ailments.

The Zn(II) and Fe(II) Complexes were prepared by the action of equimolar ethanolic solutions with... more The Zn(II) and Fe(II) Complexes were prepared by the action of equimolar ethanolic solutions with the ligands (HL1, HL2 and HL3) with ethanolic metal solutions. Where HL1= 4-N,N-diethylamine-pent-3-ene-2-one, HL2=4-N,N-di npropylamine-pent-3-ene-2-one and HL3=4-N,N-dicyclohexylamine-pent-3-ene-2-one.

Journal of Ultra Chemistry, 2017

Schiff bases are aldehyde-or ketone-like compounds in which the carbonyl group is replaced by an ... more Schiff bases are aldehyde-or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of Antimicrobial Activity. The extreme efforts have been developed to design novel series of Schiff 's bases with triazole ring (8a and 8b) have been synthesized from 4-Amino-5-((4-amino-5-phenyl-4H-1,2,4-Triazol-3ylthio)methyl)-4H-1,2,4-Triazole-3-thiol (7), which is built by multiple consecutive cyclization reactions starting from benzoic acid hydrazide (1). Infrared spectroscopy and melting points were used to characterize the synthesized compounds. The biological activity of compounds (7) and (8a and 8b) were evaluated toward gram negative bacteria (Escherichia coli) and gram positive bacteria (staphylococcus aureus).

International Journal of Technology, 2019

Research Journal of Engineering and Technology, 2019

Asian Journal of Research in Chemistry, 2018

Research Journal of Pharmacy and Technology, 2019

In the present work, an efficient synthesis of some new Amino-Pyrimidine Derivatives has been cre... more In the present work, an efficient synthesis of some new Amino-Pyrimidine Derivatives has been created through response of chalcones of cyclic imides and guanidine nitrate in presence of neutral alumina. The new synthesized amino-pyrimidines showed synergistic significant activities against Candida albicans and Aspergillus nigerfungal strains.

Research Journal of Science and Technology, 2019

Asian Journal of Research in Chemistry, 2017

Advanced Science Letters, 2016

ABSTRACT Aim: The ligands contain O, N, S-Sequence and their metal complexes have their various c... more ABSTRACT Aim: The ligands contain O, N, S-Sequence and their metal complexes have their various chemical and structural characteristics and their wide application in the field of pharmacology. The extreme efforts have been made to design novel drug to strains of resistant micro-organisms. This has required the need to search for more efficient drugs. The Zn (II) metal complexes with a tridentate ligand 2,5-diamino-1,3,4-thiadiazole has been prepared by cyclisation of bithiourea in a 3% hydrogen peroxide medium. 2,5-diamino-1,3, 4-thiadiazole acts as neutral tridentate ligand and coordinates through the sulphur atom and nitrogen of the amines. The complexes are non-electrolyte in DMF. The complexes exhibited octahedral geometry. The antimicrobial activities of ligand and its complexes were screened using sensitivity test, minimum inhibition concentration and minimum bacterial concentration method. Metal chelates showed greater antimicrobial activities as compared to the control and the ligand. The metal chelates and the ligand did not exhibited activity against Aspergillus niger and Penicillin species. Methods: Elemental analyses, IR spectra, magnetic susceptibilities by using Faraday Balance, molar conductance by using Genway 4200 conductivity meter. Metal estimation by using Alpha 4 Atomic Absorption Spectrophotometer. Thin layer chromatography was carried out using TLC plate coated with silica gel. Results: The results of the elemental analyses are in good agreement with those calculated for the suggested formulae, 1:2 (M:L) solid chelates are isolated and found to have the general formulae [(ML2)] X2; M=Zn (II) (X=Cl). The IR spectra revealed that the ligand L is a neutral tridentate ligand. It coordinated to the metal ions via the nitrogen of the amines and sulphur atom. The molar conductance value of the Zn (II) complex was low which indicate the nonelectrolytic nature of the complex. The ligand and metal complexes show antimicrobial effect against the tested organism species except against molds of penicillin and Aspergillius . Niesseria gonorrhoea was probably the most sensitive organism to the 2,5-Diamino-1,3,4-Thiadizole and its metal complexes. Metal complexes showed greater activity against some of the micro-organisms compared to the parent compounds Conclusion: In this paper we conclude from combined results of the chemical and physical analysis that the ligand (2,5-diamino-1,3,4-thiadiazole) coordinated with Zn. The metal complexes possess better physical properties than the parent compound. Metal complex of 2,5-diamino-1,3,4-thiadiazole would be a better therapeutic drug for antibacterial treatment.

International Journal of Chemical and Analytical Science, 2013

ABSTRACT Aim: The extreme efforts have been developed to design novel compounds to strains of res... more ABSTRACT Aim: The extreme efforts have been developed to design novel compounds to strains of resistant micro-organisms. On-going search for novel and amazing drug delivery systems is primarily impact of the well-established fact that the convectional dosages are not sufficiently effective in conveying the drug compounds to its site of action and this has required the need to search for more efficient drugs. The metal complexes of Co (II), Ni (II) and Cu (II) with a tridentate ligand 2, 5-diamino-1, 3, 4-thiadiazole has been prepared by cyclisation of bithiourea in a 3% hydrogen peroxide medium. 2, 5-diamino-1, 3, 4-thiadiazole acts as neutral tridentate ligand and coordinates through the sulphur atom and nitrogen of the amines. The complexes are non-electrolyte in DMF. The complexes exhibited octahedral geometry. The antimicrobial activities of ligand and its complexes were screened using sensitivity test, minimum inhibition concentration and minimum bacterial concentration method. Metal chelates showed greater antimicrobial activities as compared to the control and the ligand. The metal chelates and the ligand did not exhibited activity against Aspergillus niger and Penicillin species. Methods: Elemental analyses, IR spectra, magnetic susceptibilities by using Faraday Balance, molar conductance by using Genway 4200 conductivity meter. Metal estimation by using Alpha 4 Atomic Absorption Spectrophotometer. Thin layer chromatography was carried out using TLC plate coated with silica gel. Results: The results of the elemental analyses are in good agreement with those calculated for the suggested formulae, 1:2 (M:L) solid chelates are isolated and found to have the general formulae [(ML2)] X2; M¼Co (II), Ni (II) and Cu (II) (X¼Cl). The IR spectra revealed that the ligand L is a neutral tridentate ligand. It coordinated to the metal ions via the nitrogen of the amines and sulphur atom. The molar conductance values of the Co (II), Ni (II), and Cu (II) complexes were relatively low, indicating the non-electrolytic nature of these complexes. The ligand and metal complexes show antimicrobial effect against the tested organism species except against molds of penicillin and Aspergillus. Niesseria gonorrhoea was probably the most sensitive organism to the 2, 5-Diamino-1, 3, 4-Thiadizole and its metal complexes. Metal complexes showed greater activity against some of the micro-organisms compared to the parent compounds. Conclusion: In this paper we conclude from combined results of the chemical and physical analysis that the ligand (2, 5-diamino-1, 3, 4-thiadiazole) coordinated with Cu, Co and Ni. The metal complexes possess better physical properties than the parent compound. Metal complex of 2,5-diamino-1,3,4-thiadiazole would be a better therapeutic drug for antibacterial treatment.

Journal of Pharmacy Research, 2013

ABSTRACT Aim: Pyrimidine and their derivatives play the vital role in the field of drugs and agri... more ABSTRACT Aim: Pyrimidine and their derivatives play the vital role in the field of drugs and agricultural chemicals. In recent decades, a large no. of pharmacological studies has been done on Pyrimidine and their derivatives. But still more research is required in order to necessity of biological compounds. “The Chalcone is an aromatic compound that forms the central core for different necessity of biological compounds. The Chalcone is synthesized by an aldol, condensation of 4-methoxy acetophenone with m-phenoxy benzaldehydes in the presence of a catalyst that is treated with thiourea to provide Pyrimidine. The Pyrimidine treated with substituted N-1,3-benzothiazole-2-yl-2-chloro amide gives a compound”. Methods: Elemental analysis, IR, H NMR, C NMR melting point, Thin layer chromatography (TLC) plates (silica gel G) is used to determine the purity of the compounds. Result: Antimicrobial activity: All the synthesized compounds screened against four different strains, viz two Gram þve bacteria (Staphylococcus aureus & Streptococcus pyogenes) and two Gram �ve bacteria (Escherichia coli & Pseudomonas aeruginosa), analyzed with standard drugs ampicillin, chloramphenicol, ciprofloxacin, & norfloxacin. Antifungal activities: All the synthesized compounds screened against Candida albicans, and Aspergillus niger organisms, analyzed with standard drugs nystatin and griseofulvin. Conclusion: In this paper we focused on the reactions, synthesis, spectral analysis and Microbial activities of Pyrimidine based benzothiazole derivatives. The method gives excellent than previously reported literature. Some of the compounds were effective as antimicrobial and antifungal agents.

Biochemical Pharmacology, 1998

Chemotherapy of malignant melanoma is still a great challenge, as no effective drugs are availabl... more Chemotherapy of malignant melanoma is still a great challenge, as no effective drugs are available. The development of melanogenesis-based drugs is a promising area of research because melanogenesis is a unique biochemical pathway operating only in melanoma cells (and their normal counterparts) so that the tumour can be targeted. We have been using cysteinylphenol, a sulphur-containing analogue of tyrosine, and derivatives for that purpose. N-Acetyl-4-S-cysteaminylphenol was found to have the best antimelanoma effect in cell culture systems and in mice bearing B16 melanoma tumours. It also caused depigmentation of the skin, suggesting the possibility of use as a hypopigmenting agent. To improve the efficiency of the drug, we thought of replacing the acetyl group in N-acetyl-4-S-cysteaminylphenol with a propionyl group in the hope that increased hydrophobicity would increase the cellular uptake of the drug. N-Propionyl-4-S-cysteaminylphenol was synthesized by condensing 4-hydroxythiophenol with 2-ethyl-2-oxazoline. The drug showed both cytostatic and cytocidal effects in a human melanotic melanoma cell line. The drug was found to be a good depigmenting agent for the black hair follicles of C57 black mice when given s.c. for 14 days. A 10-day treatment with N-propionyl-4-S-cysteaminylphenol at 300 mg/kg body weight reduced the growth rate of B16 melanoma s.c. tumours in mice by 36%. The propionyl derivative was found to increase the life span of mice bearing melanoma more effectively than did the acetyl derivative.

Journal of Asian and African Studies, 2021

This article explores the lived experiences of some Indian migrant workers (MW) during the first ... more This article explores the lived experiences of some Indian migrant workers (MW) during the first COVID-19 pandemic nationwide lockdown, investigating their plights from a social identity perspective. It analyses crises associated with the COVID-19 pandemic, and with hunger and starvation. Drawing on a qualitative study conducted with twelve participants in the city of Pune in the Western Indian state of Maharashtra, the findings suggest that the participants’ plights have been exacerbated by the COVID-19 pandemic. The findings indicate the need for policy responses to focus on addressing conditions of work, terms of employment and access to necessities for Indian MW, including ensuring conditions for a prompt job-ready recovery and mental health care after the COVID-19 pandemic.