Sandeep Mayer - Academia.edu (original) (raw)

Papers by Sandeep Mayer

Research paper thumbnail of Neurostimulation for fecal incontinence after correction of repair of imperforate anus

World journal of clinical cases, Jan 16, 2017

We are reporting the case of a 32-year-old female who had suffered from fecal incontinence (FI). ... more We are reporting the case of a 32-year-old female who had suffered from fecal incontinence (FI). She was born with an imperforate anus and a recto-vaginal fistula; she underwent repair at 6 mo of age. At 29 years of age, she was still fecally incontinent despite extensive pelvic floor reeducation. A magnetic resonance imaging and an anal electromyography were performed. Because her symptoms were considered to be probably due to extra-sphincteric implantation of the neo-anus, a redo was performed of the recto-neo-anal intra-sphincteric anastomosis. A neurostimulator device was subsequently implanted for persistent incontinence. Solid and liquid FI resolved, and her quality of life improved markedly. Combining surgery to correct the position of the neo-anus within the anal sphincter complex and neurostimulation could thus become a new approach in cases of refractory FI for patients with imperforate anus as a newborn. Follow-up into adulthood after pediatric imperforate anus surgery sh...

Research paper thumbnail of Image of the Month: Serous Cystadenoma of the Retroperitoneum

Journal of Obstetrics and Gynaecology Canada, 2017

Research paper thumbnail of Vasopressor use following traumatic injury – A single center retrospective study

PLOS ONE, Apr 27, 2017

Objectives Vasopressors are not recommended by current trauma guidelines, but recent reports indi... more Objectives Vasopressors are not recommended by current trauma guidelines, but recent reports indicate that they are commonly used. We aimed to describe the early hemodynamic management of trauma patients outside densely populated urban centers.

Research paper thumbnail of Incidental finding of synchronous bilateral ductal carcinoma in situ associated with gynecomastia in a 15-year-old obese boy: case report and review of the literature

Journal of Pediatric Surgery, 2011

Carcinoma of the breast is rarely encountered in the male population and is even less prevalent i... more Carcinoma of the breast is rarely encountered in the male population and is even less prevalent in the pediatric male population. Studies have suggested an association between male breast carcinoma and gynecomastia, but conflicting results have been shown. Only 3 cases of carcinoma in situ associated with bilateral gynecomastia during puberty have been described in the literature. Here, we present the case of a 15-year-old boy with bilateral gynecomastia who was found to have synchronous bilateral ductal carcinoma in situ.

Research paper thumbnail of Portal venous decompression with H-type mesocaval shunt using autologous vein graft: A North American experience

Journal of Pediatric Surgery, 2001

Research paper thumbnail of Lengthening technique for long gap esophageal atresia and early anastomosis

Journal of Pediatric Surgery, 2003

Research paper thumbnail of Childhood adrenocortical tumors: Case series and reevaluation of prognosis—A 24-year experience

Journal of Pediatric Surgery, 1997

Research paper thumbnail of Origins of the inhibiting effects of nasal CPAP on nonnutritive swallowing in newborn lambs

Journal of Applied Physiology, 2008

The present study investigated the mechanism by which continuous positive airway pressure (CPAP) ... more The present study investigated the mechanism by which continuous positive airway pressure (CPAP) suppresses nonnutritive swallowing (NNS) during quiet sleep (QS) in newborn lambs. Eighteen full-term lambs were chronically instrumented and evenly distributed into three separate groups to determine the extent to which modulation of NNS may be attributed to stimulation of upper airway and/or bronchopulmonary mechanoreceptors. Six lambs were tracheotomized, six other lambs underwent a two-step bilateral intrathoracic vagotomy, and the remaining six lambs underwent chronic laryngotracheal separation (isolated upper airway group). Forty-eight hours after surgery, each nonsedated lamb underwent polysomnographic recordings on three consecutive days. States of alertness, NNS and respiratory movements were recorded. Results demonstrate that a CPAP of 6 cmH2O inhibited NNS during QS while administered directly on the lower airways and that bivagotomy prevented this inhibition. However, application of CPAP on the upper airways only also inhibited NNS during QS. Finally, the application of a CPAP of 6 cmH2O had no systematic effect on NNS-breathing coordination (assessed by the respiratory phase preceding and following NNS). In conclusion, our results suggest that bronchopulmonary receptors are implicated in the inhibiting effects of nasal CPAP of 6 cmH2O on NNS in all our experimental conditions, whereas upper airway receptors are only implicated in certain conditions.

Research paper thumbnail of Mechanisms of active laryngeal closure during noninvasive intermittent positive pressure ventilation in nonsedated lambs

Journal of Applied Physiology, 2008

that a progressive increase in nasal intermittent positive pressure ventilation (nIPPV) leads to ... more that a progressive increase in nasal intermittent positive pressure ventilation (nIPPV) leads to active glottal closure in nonsedated, newborn lambs. The aim of the study was to determine whether the mechanisms involved in this glottal narrowing during nIPPV originate from upper airway receptors and/or from bronchopulmonary receptors. Two groups of newborn lambs were chronically instrumented for polysomnographic recording: the first group of five lambs underwent a two-step bilateral thoracic vagotomy using video-assisted thoracoscopic surgery (bilateral vagotomy group), while the second group, composed of six lambs, underwent chronic laryngotracheal separation (isolated upper airway group). A few days later, polysomnographic recordings were performed to assess glottal muscle electromyography during step increases in nIPPV (volume control mode). Results show that active glottal narrowing does not develop when nIPPV is applied on the upper airways only, and that this narrowing is prevented by bilateral vagotomy when nIPPV is applied on intact airways. In conclusion, active glottal narrowing in response to increasing nIPPV originates from bronchopulmonary receptors.

Research paper thumbnail of Management of acute pain in children: Safety and efficacy of a nurse-controlled algorithm for pain relief

Research paper thumbnail of Pain management after tonsillectomy: morphine is not enough

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2008

Tonsillectomy is usually done as day surgery, transferring to the parents most of the postoperati... more Tonsillectomy is usually done as day surgery, transferring to the parents most of the postoperative care. They often feel alone and incompetent in front of a child in pain. We developed a guide to help parents for both the evaluation and the management of postoperative pain. To improve pediatric posttonsillectomy pain management with the implementation of a parental guide and treatment algorithm. Eighty children (5-17 years) were recruited in this randomized clinical trial. Parents and children were assigned to one of the research groups: control or experimental. All received an identical prescription for acetaminophen (15 mg/kg) and morphine (0.3 mg/kg), information about the medication, a visual analogue scale (VAS), and index cards to be filled at home. The experimental group also received a treatment algorithm associating pain scores with analgesics. Pain scores for the control group and the experimental group were 5.3 and 4.7 on the day of surgery, 4.0 and 3.6 the next day, 2.2...

Research paper thumbnail of Neurostimulation for fecal incontinence after correction of repair of imperforate anus

World journal of clinical cases, Jan 16, 2017

We are reporting the case of a 32-year-old female who had suffered from fecal incontinence (FI). ... more We are reporting the case of a 32-year-old female who had suffered from fecal incontinence (FI). She was born with an imperforate anus and a recto-vaginal fistula; she underwent repair at 6 mo of age. At 29 years of age, she was still fecally incontinent despite extensive pelvic floor reeducation. A magnetic resonance imaging and an anal electromyography were performed. Because her symptoms were considered to be probably due to extra-sphincteric implantation of the neo-anus, a redo was performed of the recto-neo-anal intra-sphincteric anastomosis. A neurostimulator device was subsequently implanted for persistent incontinence. Solid and liquid FI resolved, and her quality of life improved markedly. Combining surgery to correct the position of the neo-anus within the anal sphincter complex and neurostimulation could thus become a new approach in cases of refractory FI for patients with imperforate anus as a newborn. Follow-up into adulthood after pediatric imperforate anus surgery sh...

Research paper thumbnail of Image of the Month: Serous Cystadenoma of the Retroperitoneum

Journal of Obstetrics and Gynaecology Canada, 2017

Research paper thumbnail of Vasopressor use following traumatic injury – A single center retrospective study

PLOS ONE, Apr 27, 2017

Objectives Vasopressors are not recommended by current trauma guidelines, but recent reports indi... more Objectives Vasopressors are not recommended by current trauma guidelines, but recent reports indicate that they are commonly used. We aimed to describe the early hemodynamic management of trauma patients outside densely populated urban centers.

Research paper thumbnail of Incidental finding of synchronous bilateral ductal carcinoma in situ associated with gynecomastia in a 15-year-old obese boy: case report and review of the literature

Journal of Pediatric Surgery, 2011

Carcinoma of the breast is rarely encountered in the male population and is even less prevalent i... more Carcinoma of the breast is rarely encountered in the male population and is even less prevalent in the pediatric male population. Studies have suggested an association between male breast carcinoma and gynecomastia, but conflicting results have been shown. Only 3 cases of carcinoma in situ associated with bilateral gynecomastia during puberty have been described in the literature. Here, we present the case of a 15-year-old boy with bilateral gynecomastia who was found to have synchronous bilateral ductal carcinoma in situ.

Research paper thumbnail of Portal venous decompression with H-type mesocaval shunt using autologous vein graft: A North American experience

Journal of Pediatric Surgery, 2001

Research paper thumbnail of Lengthening technique for long gap esophageal atresia and early anastomosis

Journal of Pediatric Surgery, 2003

Research paper thumbnail of Childhood adrenocortical tumors: Case series and reevaluation of prognosis—A 24-year experience

Journal of Pediatric Surgery, 1997

Research paper thumbnail of Origins of the inhibiting effects of nasal CPAP on nonnutritive swallowing in newborn lambs

Journal of Applied Physiology, 2008

The present study investigated the mechanism by which continuous positive airway pressure (CPAP) ... more The present study investigated the mechanism by which continuous positive airway pressure (CPAP) suppresses nonnutritive swallowing (NNS) during quiet sleep (QS) in newborn lambs. Eighteen full-term lambs were chronically instrumented and evenly distributed into three separate groups to determine the extent to which modulation of NNS may be attributed to stimulation of upper airway and/or bronchopulmonary mechanoreceptors. Six lambs were tracheotomized, six other lambs underwent a two-step bilateral intrathoracic vagotomy, and the remaining six lambs underwent chronic laryngotracheal separation (isolated upper airway group). Forty-eight hours after surgery, each nonsedated lamb underwent polysomnographic recordings on three consecutive days. States of alertness, NNS and respiratory movements were recorded. Results demonstrate that a CPAP of 6 cmH2O inhibited NNS during QS while administered directly on the lower airways and that bivagotomy prevented this inhibition. However, application of CPAP on the upper airways only also inhibited NNS during QS. Finally, the application of a CPAP of 6 cmH2O had no systematic effect on NNS-breathing coordination (assessed by the respiratory phase preceding and following NNS). In conclusion, our results suggest that bronchopulmonary receptors are implicated in the inhibiting effects of nasal CPAP of 6 cmH2O on NNS in all our experimental conditions, whereas upper airway receptors are only implicated in certain conditions.

Research paper thumbnail of Mechanisms of active laryngeal closure during noninvasive intermittent positive pressure ventilation in nonsedated lambs

Journal of Applied Physiology, 2008

that a progressive increase in nasal intermittent positive pressure ventilation (nIPPV) leads to ... more that a progressive increase in nasal intermittent positive pressure ventilation (nIPPV) leads to active glottal closure in nonsedated, newborn lambs. The aim of the study was to determine whether the mechanisms involved in this glottal narrowing during nIPPV originate from upper airway receptors and/or from bronchopulmonary receptors. Two groups of newborn lambs were chronically instrumented for polysomnographic recording: the first group of five lambs underwent a two-step bilateral thoracic vagotomy using video-assisted thoracoscopic surgery (bilateral vagotomy group), while the second group, composed of six lambs, underwent chronic laryngotracheal separation (isolated upper airway group). A few days later, polysomnographic recordings were performed to assess glottal muscle electromyography during step increases in nIPPV (volume control mode). Results show that active glottal narrowing does not develop when nIPPV is applied on the upper airways only, and that this narrowing is prevented by bilateral vagotomy when nIPPV is applied on intact airways. In conclusion, active glottal narrowing in response to increasing nIPPV originates from bronchopulmonary receptors.

Research paper thumbnail of Management of acute pain in children: Safety and efficacy of a nurse-controlled algorithm for pain relief

Research paper thumbnail of Pain management after tonsillectomy: morphine is not enough

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2008

Tonsillectomy is usually done as day surgery, transferring to the parents most of the postoperati... more Tonsillectomy is usually done as day surgery, transferring to the parents most of the postoperative care. They often feel alone and incompetent in front of a child in pain. We developed a guide to help parents for both the evaluation and the management of postoperative pain. To improve pediatric posttonsillectomy pain management with the implementation of a parental guide and treatment algorithm. Eighty children (5-17 years) were recruited in this randomized clinical trial. Parents and children were assigned to one of the research groups: control or experimental. All received an identical prescription for acetaminophen (15 mg/kg) and morphine (0.3 mg/kg), information about the medication, a visual analogue scale (VAS), and index cards to be filled at home. The experimental group also received a treatment algorithm associating pain scores with analgesics. Pain scores for the control group and the experimental group were 5.3 and 4.7 on the day of surgery, 4.0 and 3.6 the next day, 2.2...