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Papers by Sandra Renou

International Journal of Periodontics & Restorative Dentistry, May 1, 2022

This study was designed to assess the effect of enamel matrix derivative (Emdogain, Straumann) an... more This study was designed to assess the effect of enamel matrix derivative (Emdogain, Straumann) and alloplastic bone substitute (BoneCeramic, Straumann) on new bone formation in postextraction alveolar sockets. Twenty-one patients requiring anterior single-tooth extractions and subsequent implant placement were recruited and randomly assigned to one of three treatment groups. Postextraction sockets were filled with either an alloplastic bone substitute (BoneCeramic [BC]), BC combined with Emdogain (EMD+BC), or left to heal spontaneously (SO). Histologic and histomorphometric analyses of the results were performed at 6 months postextraction. A significant increase in the percentage of new bone tissue area was found in EMD+BC compared to SO and BC groups. These findings demonstrate that compared with BC or SO, EMD+BC allowed for better formation of new bone in postextraction sockets after 6 months of healing.

Introducción: La fisiopatología de la disfunción diastólica del ventrículo izquierdo incluye alte... more Introducción: La fisiopatología de la disfunción diastólica del ventrículo izquierdo incluye alteraciones de la relajación ventricular, rigidez elástica pasiva o una combinación de ambos mecanismos. Mediante el eco-Doppler es posible evaluar parámetros relacionados con la relajación ventricular, pero no de la rigidez elástica pasiva. El estrés parietal diastólico evalúa la rigidez elástica pasiva a través de la disminución de la compresión del miocardio al final de la diástole. Objetivo: Evaluar la rigidez elástica pasiva mediante el estrés parietal diastólico en pacientes con estenosis aórtica grave con fracción de eyección preservada y su relación con la presencia de insuficiencia cardíaca grado III-IV. Material y métodos: Se estudiaron 76 pacientes (edad promedio 67 ± 11 años) portadores de estenosis aórtica grave (índice de área valvular aórtica <0,6 cm2/m2) y fracción de eyección mayor o igual al 50%. El estrés parietal diastólico fue calculado como: (espesor sistólico de pa...

The International journal of oral & maxillofacial implants

Study of the implant-tissue interface is one of the fundamental issues in implantology, both odon... more Study of the implant-tissue interface is one of the fundamental issues in implantology, both odontologic and orthopedic. The characteristics of this interface will influence the success or failure of an implant. The aim of the present study was to evaluate histomorphometrically the capacity of different metals to osseointegrate employing laminar implants of zirconium, titanium, aluminum, and zirconium coated with diamond-like carbon. The experimental model herein allowed for the quantitative evaluation of the tissue-implant interface for different metals. The implants were placed in the tibiae of Wistar rats under anesthesia and allowed to remain in situ for a 30-day period. The interfaces of the zirconium and diamond-like coated zirconium implants exhibited better responses than the interface of titanium implants. Aluminum produced a local toxic effect, evidenced by osteoid formation.

International Journal of Oral and Maxillofacial Surgery, 2009

Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology... more Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology and dermatology. Its effect on bone repair has not been studied. The present study undertook a quantitative and qualitative evaluation of post-extraction bone healing in the presence of BS. Under intraperitoneal anesthesia, forty male Wistar rats, 80+/-5g body weight, underwent the extraction of both lower first molars. BS was placed in the right post-extraction socket (group E) and the contralateral socket served as control (group C). The animals were killed in groups immediately, 7, 14 and 30 days post-extraction. The mandibles were resected, radiographed and processed for embedding in paraffin. The mesial socket was sectioned along the bucco-lingual axis and stained with hematoxylin-eosin. Total tissue volume and trabecular bone volume of the apical third of the sockets were determined histomorphometrically. At 14 and 30 days post-extraction, group E exhibited bone tissue that resembled that of group C. Histomorphometric analyses showed no statistically significant differences between groups C and E. Bismuth subgallate did not interfere with post-extraction bone healing. Further studies will analyze the effect of this hemostatic agent on bone repair in aniticoagulated rats.

Clinical Oral Implants Research, 2001

The aim of the present study was to evaluate the osseointegration process under total body irradi... more The aim of the present study was to evaluate the osseointegration process under total body irradiation conditions (LD 50/30). Twenty Wistar rats (mean body weight: 90 g) were used. Under ethyl urethane intraperitoneal anesthesia (1 g/kg body weight), the animals were irradiated with a single 700 cGy dose (linear accelerator 6 Mev photons). Four days post irradiation, a titanium laminar implant was placed in the left tibia of each rat. Antibiotic therapy (ceftriaxone) was administered daily post implantation, to prevent infection by radiation. Fourteen days post implantation, the animals were killed by ether overdose. The tibiae were resected, radiographed and processed for embedding in methyl methacrylate. The results showed impaired osteogenesis and absence of osseointegration in experimental tibiae. This could be due to a direct action of total body irradiation on osteogenesis precursor cells. This effect would impair bone formation involved in peri-implant osseointegration processes in this experimental model.

The dimensions of the alveolar bone surrounding the tooth are not maintained post tooth-extractio... more The dimensions of the alveolar bone surrounding the tooth are not maintained post tooth-extraction probably as a consequence of the bone remodeling process and the biomechanical demands on bone. The use of biomaterials as bone substitutes in the post-tooth-extraction socket promotes bone repair, regardless of damage to bone structures during the surgical procedures. The aim of the present study was to evaluate the effectiveness of anorganic bovine bone matrix (ABBM) as a bone substitute, in an experimental model of post-tooth extraction bone healing in the rat. Radiographic follow-up was performed at 7, 14, and 30 days, and showed persistence of the biomaterial inside the experimental alveoli. At 14 and 30 days post-tooth extraction, particles surrounded by bone tissue were observed in the middle sector of the alveoli. The osteoconductive property of ABBM was demonstrated using the present experimental model of active osteogenesis, thus showing its usefulness as a bone substitute. P...

Nanomaterials

Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical... more Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (n = 10) and UNCD-coated (n = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tib...

Revista Argentina de Cardiología, 2018

Objetivos: Investigar cuál es el comportamiento de los stents de aleación de cromo cobalto ante l... more Objetivos: Investigar cuál es el comportamiento de los stents de aleación de cromo cobalto ante la sobrexpansión comparados con los stents de acero inoxidable. Material y Métodos: Se utilizaron 20 conejos neozelandeses que fueron alimentados con colesterol agregado en la dieta al 1%, y divididos en dos grupos. El grupo 1 (n = 10) recibió stents de cromo cobalto de 3 mm sobrexpandidos a 20 atmósferas, y el grupo 2 (n = 10), stents de 3,5 mm implantados a 10 atmósferas. Estos fueron comparados con una serie previa de 20 animales con stents de acero inoxidable, divididos en los mismos dos grupos. Un tercer grupo con dieta convencional fue utilizado como control. Se realizó ultrasonido intravascular (IVUS) para determinar el grado de retracción elástica y se analizó también el grado de simetría por medio de los "ángulos interstrut". Resultados: El grupo 1 de stents de cromo cobalto presentó un retroceso elástico de 0,11 ± 0,13 mm (3,21% de retracción) y el grupo 2, de 0,3 ± 0,...

Acta odontológica latinoamericana, 2015

Tooth loss leads to a decrease in alveolar bone volume, and consequently to the need for guided b... more Tooth loss leads to a decrease in alveolar bone volume, and consequently to the need for guided bone regeneration (GBR) techniques to restore bone anatomy, and the adequate choice of therapy. Fascia lata membrane (FLM) has been used in surgical procedures in neurology, orthopedics, otorhinolaryngology, cardiology, vascular surgery, gynecology, and dentistry for guided tissue regeneration. The aim of the present preliminary study was to evaluate bone tissue response in rat calvarial bone defects covered with human fascia lata membrane (FLM). Eight Wistar rats, 230g body weight, were subjected to bone surgery to create a 5x5mm long/ 1mm deep calvarial bone defect on either side of the median suture, using a piezoelectric scalpel and irrigation. The animals were treated according to the following protocol: Group I (GI): placement of a single layer of FLM (Biotar, Rosario, Prov. de Santa Fe, Argentina) to cover the defects; Group II (GII): double layer of FLM to cover the defects; Group...

Acta odontológica latinoamericana, 2010

In recent years there has been increasing interest in the choice of the best material for bone su... more In recent years there has been increasing interest in the choice of the best material for bone substitutes. Experimental models enable estimation of biological potential, efficacy and safety of a biomaterial before its clinical application. The aim of this study was to evaluate the response of a bone substitute, UNC bone matrix powder (MOeP-UNC), for repairing the post-extraction alveolus in Wistar rats. Rats' first lower molars were extracted. The right alveoli were filled with MOeP-UNC hydrated with physiological saline (Experimental Group, EG), and the left alveoli were used as Control Group (CG). Thirty days after extraction, the animals were killed and the samples processed. Histological sections were made in vestibular-lingual direction at the level of the mesial alveolus of the first inferior molar (Guglielmotti et al. J. Oral Maxillofac. Surg. 1985;43(5):359-364). Repair of the alveoli at 30 days after extraction was evaluated histologically. Repair of the alveolus was o...

Revista Argentina de Cardiologia

Comportamiento mecánico ante la sobrexpansión de stents de cromo-cobalto comparados con stents de... more Comportamiento mecánico ante la sobrexpansión de stents de cromo-cobalto comparados con stents de acero inoxidable, implantados en la aorta abdominal de conejos hipercolesterolémicos

RESUMEN Las dimensiones del hueso alveolar que rodea a la pieza den-taria, no se mantienen despué... more RESUMEN Las dimensiones del hueso alveolar que rodea a la pieza den-taria, no se mantienen después de la exodoncia. Este hecho sería consecuencia del proceso de remodelado óseo y del requerimien-to biomecánico. La utilización de biomateriales como sustitutos óseos en los alvéolos, facilitan o promueven la reparación ósea, inde pen dientemente que se haya producido traumatismo de las estructuras óseas durante la maniobra quirúrgica. El objetivo del presente estudio fue evaluar la efectividad de una matriz ósea esponjosa anorgánica (MOEA) como sustituto óseo, en un modelo experimental de reparación ósea en el alvéolo post-extracción en ratas. Se realizó el estudio radiográfico en los distintos tiempos experimentales: 7, 14 y 30 días, evidenciando la persistencia del biomaterial. A los 14 y 30 días post-exodoncia se eviden-ciaron las partículas rodeadas de tejido óseo en el sector medio del alvéolo. Es importante destacar que la utilización de (MOEA), como sustituto óseo en el alvéolo ...

Acta odontologica latinoamericana : AOL, 2018

The aim of this study was to evaluate thickening of the Schneiderian membrane and to determine it... more The aim of this study was to evaluate thickening of the Schneiderian membrane and to determine its association with periapical pathologies, using computerized cone beam tomography. An observational, analytical, cross-sectional retrospective study was conducted. A total 179 maxillary sinuses were evaluated using CBCT. The presence of sinus membrane thickening and its association with unhealthy teeth was analyzed. Results are shown as percentages with 95% confidence intervals (95%CI); Chi square test was used with a significance level of 5%.Sinus membrane thickening was detected in 70 cases (39%; 95%CI=32% to 46%) and no sinus membrane thickening was observed in 109 (61%; 95%CI = 54% to 68%) (p<0.05). The 70 cases showing sinus membrane thickening included 46 of odontogenic origin (66%; 95%CI = 54% to 76%) and 24 (34%; 95%CI = 24% to 46%) of non odontogenic origin (p<0.05). The frequency of odontogenic causes followed a heterogeneous distribution (p<0.05): penetrating caries,...

Journal of biomedical materials research. Part A, 2021

Bone is a hierarchical material that has inspired the design of biopolymer-derived biocomposites ... more Bone is a hierarchical material that has inspired the design of biopolymer-derived biocomposites for tissue engineering purposes. The present study sought to synthesize and perform the physicochemical characterization and biocompatibility of a collagen-silica-based biocomposite for potential application in bone tissue engineering. Ultrastructure, biodegradability, swelling behavior, and biocompatibility properties were analyzed to gain insight into the advantages and limitations to the use of this biomaterial as a bone substitute. Scanning electron microscopy analysis showed a packed-collagen fibril matrix and silica particles in the biocomposite three-dimensional structure. As shown by analysis of in vitro swelling behavior and biodegradability, it would seem that the material swelled soon after implantation and then suffered degradation. Biocompatibility properties were analyzed in vivo 14-days postimplantation using an experimental model in Wistar rats. The biocomposite was place...

El estudio del material del implante en relacion con el tejido vivo (hueso y/o medula) es de espe... more El estudio del material del implante en relacion con el tejido vivo (hueso y/o medula) es de especial importancia. En esta presentacion deseamos resumir una serie de datos experimentales obtenidos del estudio de diferentes materiales y condiciones que han posibilitado disponer de una metodologia que puede ser aplicada sobre un numero significativo de muestras, obteniendose medidas y datos a nivel microscopico y con valor estadistico

Revista Argentina de Cardiología, 2018

espanolIntroduccion: Investigar cual es el comportamiento de los stents de aleacion de cromo coba... more espanolIntroduccion: Investigar cual es el comportamiento de los stents de aleacion de cromo cobalto ante la sobrexpansion comparados con los stents de acero inoxidable. Material y Metodos: Se utilizaron 20 conejos neozelandeses que fueron alimentados con colesterol agregado en la dieta al 1%, y divididos en dos grupos. El grupo 1 (n = 10) recibio stents de cromo cobalto de 3 mm sobrexpandidos a 20 atmosferas, y el grupo 2 (n = 10), stents de 3,5 mm implantados a 10 atmosferas. Estos fueron comparados con una serie previa de 20 animales con stents de acero inoxidable, divididos en los mismos dos grupos. Un tercer grupo con dieta convencional fue utilizado como control. Se realizo ultrasonido intravascular (IVUS) para determinar el grado de retraccion elastica y se analizo tambien el grado de simetria por medio de los “angulos interstrut”. Resultados: El grupo 1 de stents de cromo cobalto presento un retroceso elastico de 0,11 ± 0,13 mm (3,21% de retraccion) y el grupo 2, de 0,3 ± 0,...

Acta odontologica latinoamericana : AOL, 2010

In recent years there has been increasing interest in the choice of the best material for bone su... more In recent years there has been increasing interest in the choice of the best material for bone substitutes. Experimental models enable estimation of biological potential, efficacy and safety of a biomaterial before its clinical application. The aim of this study was to evaluate the response of a bone substitute, UNC bone matrix powder (MOeP-UNC), for repairing the post-extraction alveolus in Wistar rats. Rats' first lower molars were extracted. The right alveoli were filled with MOeP-UNC hydrated with physiological saline (Experimental Group, EG), and the left alveoli were used as Control Group (CG). Thirty days after extraction, the animals were killed and the samples processed. Histological sections were made in vestibular-lingual direction at the level of the mesial alveolus of the first inferior molar (Guglielmotti et al. J. Oral Maxillofac. Surg. 1985;43(5):359-364). Repair of the alveoli at 30 days after extraction was evaluated histologically. Repair of the alveolus was o...

The dimensions of the alveolar bone surrounding the tooth are not maintained post tooth-extractio... more The dimensions of the alveolar bone surrounding the tooth are not maintained post tooth-extraction probably as a consequence of the bone remodeling process and the biomechanical demands on bone. The use of biomaterials as bone substitutes in the post-tooth-extraction socket promotes bone repair, regardless of damage to bone structures during the surgical procedures. The aim of the present study was to evaluate the effectiveness of anorganic bovine bone matrix (ABBM) as a bone substitute, in an experimental model of post-tooth extraction bone healing in the rat. Radiographic follow-up was performed at 7, 14, and 30 days, and showed persistence of the biomaterial inside the experimental alveoli. At 14 and 30 days post-tooth extraction, particles surrounded by bone tissue were observed in the middle sector of the alveoli. The osteoconductive property of ABBM was demonstrated using the present experimental model of active osteogenesis, thus showing its usefulness as a bone substitute. P...

Clinical Oral Implants Research

Journal of Biomaterials Science, Polymer Edition

International Journal of Periodontics & Restorative Dentistry, May 1, 2022

This study was designed to assess the effect of enamel matrix derivative (Emdogain, Straumann) an... more This study was designed to assess the effect of enamel matrix derivative (Emdogain, Straumann) and alloplastic bone substitute (BoneCeramic, Straumann) on new bone formation in postextraction alveolar sockets. Twenty-one patients requiring anterior single-tooth extractions and subsequent implant placement were recruited and randomly assigned to one of three treatment groups. Postextraction sockets were filled with either an alloplastic bone substitute (BoneCeramic [BC]), BC combined with Emdogain (EMD+BC), or left to heal spontaneously (SO). Histologic and histomorphometric analyses of the results were performed at 6 months postextraction. A significant increase in the percentage of new bone tissue area was found in EMD+BC compared to SO and BC groups. These findings demonstrate that compared with BC or SO, EMD+BC allowed for better formation of new bone in postextraction sockets after 6 months of healing.

Introducción: La fisiopatología de la disfunción diastólica del ventrículo izquierdo incluye alte... more Introducción: La fisiopatología de la disfunción diastólica del ventrículo izquierdo incluye alteraciones de la relajación ventricular, rigidez elástica pasiva o una combinación de ambos mecanismos. Mediante el eco-Doppler es posible evaluar parámetros relacionados con la relajación ventricular, pero no de la rigidez elástica pasiva. El estrés parietal diastólico evalúa la rigidez elástica pasiva a través de la disminución de la compresión del miocardio al final de la diástole. Objetivo: Evaluar la rigidez elástica pasiva mediante el estrés parietal diastólico en pacientes con estenosis aórtica grave con fracción de eyección preservada y su relación con la presencia de insuficiencia cardíaca grado III-IV. Material y métodos: Se estudiaron 76 pacientes (edad promedio 67 ± 11 años) portadores de estenosis aórtica grave (índice de área valvular aórtica <0,6 cm2/m2) y fracción de eyección mayor o igual al 50%. El estrés parietal diastólico fue calculado como: (espesor sistólico de pa...

The International journal of oral & maxillofacial implants

Study of the implant-tissue interface is one of the fundamental issues in implantology, both odon... more Study of the implant-tissue interface is one of the fundamental issues in implantology, both odontologic and orthopedic. The characteristics of this interface will influence the success or failure of an implant. The aim of the present study was to evaluate histomorphometrically the capacity of different metals to osseointegrate employing laminar implants of zirconium, titanium, aluminum, and zirconium coated with diamond-like carbon. The experimental model herein allowed for the quantitative evaluation of the tissue-implant interface for different metals. The implants were placed in the tibiae of Wistar rats under anesthesia and allowed to remain in situ for a 30-day period. The interfaces of the zirconium and diamond-like coated zirconium implants exhibited better responses than the interface of titanium implants. Aluminum produced a local toxic effect, evidenced by osteoid formation.

International Journal of Oral and Maxillofacial Surgery, 2009

Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology... more Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology and dermatology. Its effect on bone repair has not been studied. The present study undertook a quantitative and qualitative evaluation of post-extraction bone healing in the presence of BS. Under intraperitoneal anesthesia, forty male Wistar rats, 80+/-5g body weight, underwent the extraction of both lower first molars. BS was placed in the right post-extraction socket (group E) and the contralateral socket served as control (group C). The animals were killed in groups immediately, 7, 14 and 30 days post-extraction. The mandibles were resected, radiographed and processed for embedding in paraffin. The mesial socket was sectioned along the bucco-lingual axis and stained with hematoxylin-eosin. Total tissue volume and trabecular bone volume of the apical third of the sockets were determined histomorphometrically. At 14 and 30 days post-extraction, group E exhibited bone tissue that resembled that of group C. Histomorphometric analyses showed no statistically significant differences between groups C and E. Bismuth subgallate did not interfere with post-extraction bone healing. Further studies will analyze the effect of this hemostatic agent on bone repair in aniticoagulated rats.

Clinical Oral Implants Research, 2001

The aim of the present study was to evaluate the osseointegration process under total body irradi... more The aim of the present study was to evaluate the osseointegration process under total body irradiation conditions (LD 50/30). Twenty Wistar rats (mean body weight: 90 g) were used. Under ethyl urethane intraperitoneal anesthesia (1 g/kg body weight), the animals were irradiated with a single 700 cGy dose (linear accelerator 6 Mev photons). Four days post irradiation, a titanium laminar implant was placed in the left tibia of each rat. Antibiotic therapy (ceftriaxone) was administered daily post implantation, to prevent infection by radiation. Fourteen days post implantation, the animals were killed by ether overdose. The tibiae were resected, radiographed and processed for embedding in methyl methacrylate. The results showed impaired osteogenesis and absence of osseointegration in experimental tibiae. This could be due to a direct action of total body irradiation on osteogenesis precursor cells. This effect would impair bone formation involved in peri-implant osseointegration processes in this experimental model.

The dimensions of the alveolar bone surrounding the tooth are not maintained post tooth-extractio... more The dimensions of the alveolar bone surrounding the tooth are not maintained post tooth-extraction probably as a consequence of the bone remodeling process and the biomechanical demands on bone. The use of biomaterials as bone substitutes in the post-tooth-extraction socket promotes bone repair, regardless of damage to bone structures during the surgical procedures. The aim of the present study was to evaluate the effectiveness of anorganic bovine bone matrix (ABBM) as a bone substitute, in an experimental model of post-tooth extraction bone healing in the rat. Radiographic follow-up was performed at 7, 14, and 30 days, and showed persistence of the biomaterial inside the experimental alveoli. At 14 and 30 days post-tooth extraction, particles surrounded by bone tissue were observed in the middle sector of the alveoli. The osteoconductive property of ABBM was demonstrated using the present experimental model of active osteogenesis, thus showing its usefulness as a bone substitute. P...

Nanomaterials

Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical... more Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (n = 10) and UNCD-coated (n = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tib...

Revista Argentina de Cardiología, 2018

Objetivos: Investigar cuál es el comportamiento de los stents de aleación de cromo cobalto ante l... more Objetivos: Investigar cuál es el comportamiento de los stents de aleación de cromo cobalto ante la sobrexpansión comparados con los stents de acero inoxidable. Material y Métodos: Se utilizaron 20 conejos neozelandeses que fueron alimentados con colesterol agregado en la dieta al 1%, y divididos en dos grupos. El grupo 1 (n = 10) recibió stents de cromo cobalto de 3 mm sobrexpandidos a 20 atmósferas, y el grupo 2 (n = 10), stents de 3,5 mm implantados a 10 atmósferas. Estos fueron comparados con una serie previa de 20 animales con stents de acero inoxidable, divididos en los mismos dos grupos. Un tercer grupo con dieta convencional fue utilizado como control. Se realizó ultrasonido intravascular (IVUS) para determinar el grado de retracción elástica y se analizó también el grado de simetría por medio de los "ángulos interstrut". Resultados: El grupo 1 de stents de cromo cobalto presentó un retroceso elástico de 0,11 ± 0,13 mm (3,21% de retracción) y el grupo 2, de 0,3 ± 0,...

Acta odontológica latinoamericana, 2015

Tooth loss leads to a decrease in alveolar bone volume, and consequently to the need for guided b... more Tooth loss leads to a decrease in alveolar bone volume, and consequently to the need for guided bone regeneration (GBR) techniques to restore bone anatomy, and the adequate choice of therapy. Fascia lata membrane (FLM) has been used in surgical procedures in neurology, orthopedics, otorhinolaryngology, cardiology, vascular surgery, gynecology, and dentistry for guided tissue regeneration. The aim of the present preliminary study was to evaluate bone tissue response in rat calvarial bone defects covered with human fascia lata membrane (FLM). Eight Wistar rats, 230g body weight, were subjected to bone surgery to create a 5x5mm long/ 1mm deep calvarial bone defect on either side of the median suture, using a piezoelectric scalpel and irrigation. The animals were treated according to the following protocol: Group I (GI): placement of a single layer of FLM (Biotar, Rosario, Prov. de Santa Fe, Argentina) to cover the defects; Group II (GII): double layer of FLM to cover the defects; Group...

Acta odontológica latinoamericana, 2010

In recent years there has been increasing interest in the choice of the best material for bone su... more In recent years there has been increasing interest in the choice of the best material for bone substitutes. Experimental models enable estimation of biological potential, efficacy and safety of a biomaterial before its clinical application. The aim of this study was to evaluate the response of a bone substitute, UNC bone matrix powder (MOeP-UNC), for repairing the post-extraction alveolus in Wistar rats. Rats' first lower molars were extracted. The right alveoli were filled with MOeP-UNC hydrated with physiological saline (Experimental Group, EG), and the left alveoli were used as Control Group (CG). Thirty days after extraction, the animals were killed and the samples processed. Histological sections were made in vestibular-lingual direction at the level of the mesial alveolus of the first inferior molar (Guglielmotti et al. J. Oral Maxillofac. Surg. 1985;43(5):359-364). Repair of the alveoli at 30 days after extraction was evaluated histologically. Repair of the alveolus was o...

Revista Argentina de Cardiologia

Comportamiento mecánico ante la sobrexpansión de stents de cromo-cobalto comparados con stents de... more Comportamiento mecánico ante la sobrexpansión de stents de cromo-cobalto comparados con stents de acero inoxidable, implantados en la aorta abdominal de conejos hipercolesterolémicos

RESUMEN Las dimensiones del hueso alveolar que rodea a la pieza den-taria, no se mantienen despué... more RESUMEN Las dimensiones del hueso alveolar que rodea a la pieza den-taria, no se mantienen después de la exodoncia. Este hecho sería consecuencia del proceso de remodelado óseo y del requerimien-to biomecánico. La utilización de biomateriales como sustitutos óseos en los alvéolos, facilitan o promueven la reparación ósea, inde pen dientemente que se haya producido traumatismo de las estructuras óseas durante la maniobra quirúrgica. El objetivo del presente estudio fue evaluar la efectividad de una matriz ósea esponjosa anorgánica (MOEA) como sustituto óseo, en un modelo experimental de reparación ósea en el alvéolo post-extracción en ratas. Se realizó el estudio radiográfico en los distintos tiempos experimentales: 7, 14 y 30 días, evidenciando la persistencia del biomaterial. A los 14 y 30 días post-exodoncia se eviden-ciaron las partículas rodeadas de tejido óseo en el sector medio del alvéolo. Es importante destacar que la utilización de (MOEA), como sustituto óseo en el alvéolo ...

Acta odontologica latinoamericana : AOL, 2018

The aim of this study was to evaluate thickening of the Schneiderian membrane and to determine it... more The aim of this study was to evaluate thickening of the Schneiderian membrane and to determine its association with periapical pathologies, using computerized cone beam tomography. An observational, analytical, cross-sectional retrospective study was conducted. A total 179 maxillary sinuses were evaluated using CBCT. The presence of sinus membrane thickening and its association with unhealthy teeth was analyzed. Results are shown as percentages with 95% confidence intervals (95%CI); Chi square test was used with a significance level of 5%.Sinus membrane thickening was detected in 70 cases (39%; 95%CI=32% to 46%) and no sinus membrane thickening was observed in 109 (61%; 95%CI = 54% to 68%) (p<0.05). The 70 cases showing sinus membrane thickening included 46 of odontogenic origin (66%; 95%CI = 54% to 76%) and 24 (34%; 95%CI = 24% to 46%) of non odontogenic origin (p<0.05). The frequency of odontogenic causes followed a heterogeneous distribution (p<0.05): penetrating caries,...

Journal of biomedical materials research. Part A, 2021

Bone is a hierarchical material that has inspired the design of biopolymer-derived biocomposites ... more Bone is a hierarchical material that has inspired the design of biopolymer-derived biocomposites for tissue engineering purposes. The present study sought to synthesize and perform the physicochemical characterization and biocompatibility of a collagen-silica-based biocomposite for potential application in bone tissue engineering. Ultrastructure, biodegradability, swelling behavior, and biocompatibility properties were analyzed to gain insight into the advantages and limitations to the use of this biomaterial as a bone substitute. Scanning electron microscopy analysis showed a packed-collagen fibril matrix and silica particles in the biocomposite three-dimensional structure. As shown by analysis of in vitro swelling behavior and biodegradability, it would seem that the material swelled soon after implantation and then suffered degradation. Biocompatibility properties were analyzed in vivo 14-days postimplantation using an experimental model in Wistar rats. The biocomposite was place...

El estudio del material del implante en relacion con el tejido vivo (hueso y/o medula) es de espe... more El estudio del material del implante en relacion con el tejido vivo (hueso y/o medula) es de especial importancia. En esta presentacion deseamos resumir una serie de datos experimentales obtenidos del estudio de diferentes materiales y condiciones que han posibilitado disponer de una metodologia que puede ser aplicada sobre un numero significativo de muestras, obteniendose medidas y datos a nivel microscopico y con valor estadistico

Revista Argentina de Cardiología, 2018

espanolIntroduccion: Investigar cual es el comportamiento de los stents de aleacion de cromo coba... more espanolIntroduccion: Investigar cual es el comportamiento de los stents de aleacion de cromo cobalto ante la sobrexpansion comparados con los stents de acero inoxidable. Material y Metodos: Se utilizaron 20 conejos neozelandeses que fueron alimentados con colesterol agregado en la dieta al 1%, y divididos en dos grupos. El grupo 1 (n = 10) recibio stents de cromo cobalto de 3 mm sobrexpandidos a 20 atmosferas, y el grupo 2 (n = 10), stents de 3,5 mm implantados a 10 atmosferas. Estos fueron comparados con una serie previa de 20 animales con stents de acero inoxidable, divididos en los mismos dos grupos. Un tercer grupo con dieta convencional fue utilizado como control. Se realizo ultrasonido intravascular (IVUS) para determinar el grado de retraccion elastica y se analizo tambien el grado de simetria por medio de los “angulos interstrut”. Resultados: El grupo 1 de stents de cromo cobalto presento un retroceso elastico de 0,11 ± 0,13 mm (3,21% de retraccion) y el grupo 2, de 0,3 ± 0,...

Acta odontologica latinoamericana : AOL, 2010

In recent years there has been increasing interest in the choice of the best material for bone su... more In recent years there has been increasing interest in the choice of the best material for bone substitutes. Experimental models enable estimation of biological potential, efficacy and safety of a biomaterial before its clinical application. The aim of this study was to evaluate the response of a bone substitute, UNC bone matrix powder (MOeP-UNC), for repairing the post-extraction alveolus in Wistar rats. Rats' first lower molars were extracted. The right alveoli were filled with MOeP-UNC hydrated with physiological saline (Experimental Group, EG), and the left alveoli were used as Control Group (CG). Thirty days after extraction, the animals were killed and the samples processed. Histological sections were made in vestibular-lingual direction at the level of the mesial alveolus of the first inferior molar (Guglielmotti et al. J. Oral Maxillofac. Surg. 1985;43(5):359-364). Repair of the alveoli at 30 days after extraction was evaluated histologically. Repair of the alveolus was o...

The dimensions of the alveolar bone surrounding the tooth are not maintained post tooth-extractio... more The dimensions of the alveolar bone surrounding the tooth are not maintained post tooth-extraction probably as a consequence of the bone remodeling process and the biomechanical demands on bone. The use of biomaterials as bone substitutes in the post-tooth-extraction socket promotes bone repair, regardless of damage to bone structures during the surgical procedures. The aim of the present study was to evaluate the effectiveness of anorganic bovine bone matrix (ABBM) as a bone substitute, in an experimental model of post-tooth extraction bone healing in the rat. Radiographic follow-up was performed at 7, 14, and 30 days, and showed persistence of the biomaterial inside the experimental alveoli. At 14 and 30 days post-tooth extraction, particles surrounded by bone tissue were observed in the middle sector of the alveoli. The osteoconductive property of ABBM was demonstrated using the present experimental model of active osteogenesis, thus showing its usefulness as a bone substitute. P...

Clinical Oral Implants Research

Journal of Biomaterials Science, Polymer Edition