Sanela Zukic - Academia.edu (original) (raw)
Papers by Sanela Zukic
American Journal of Nephrology, 1996
Two apparently healthy adults were admitted because of acute muscle cramps, severe weakness, and ... more Two apparently healthy adults were admitted because of acute muscle cramps, severe weakness, and red urine excretion. Patient No. 1 developed the symptoms following intense exercise and patient No. 2 during a febrile infection. Both of them experienced such episodes in the past, but these were medically misinterpreted. Their present manifestations were accompanied by renal failure which subsided gradually and was found to be a result of rhabdomyolsis and myoglobinuria. Further investigations yielded a deficiency of carnitine palmitoyltransferase as a background to the acute muscular destruction. Examination of a sister of patient No. 2 who had a similar past history revealed the same metabolic disorder. Carnitine palmitoyltransferase deficiency, as a cause of nontraumatic rhabdomyolysis, is a distinct entity in the pathogenesis of acute renal failure. Our experience (3 patients within 2 years) makes us presume that this condition is not as rare as hitherto reported and should rather be considered in cases of 'nonhematuric' red urine and acute renal failure.
Cureus, 2022
Coronavirus disease 2019 (COVID-19) is primarily a disease of the respiratory system but severe a... more Coronavirus disease 2019 (COVID-19) is primarily a disease of the respiratory system but severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause several immune-related complications including different neurological disorders, such as myelopathy with paraparesis. In this atypical case a female patient with progressive spastic paraparesis after COVID-19 infection, brisk reflexes and positive Babinski sign, reduced vibratory sensation to the thoracic level, elevated immunoglobulin levels (IgG) in cerebrospinal fluid, but negative magnetic resonance imaging (MRI) of the brain and spine, is presented. A 57-year-old woman with spastic paraparesis and inability to walk was admitted to our neurological department. About four months before hospitalization, she started feeling numbness and tingling in the feet and lumbar spine area. Gradually, numbness and tingling ascended to the thoracic spine level Th7/8, and she developed weakness mostly in her legs. In the neurological exam she had spastic paraparesis. MRI of the brain, cervical and thoracic spine did not reveal any signal abnormality. Serological testing for SARS-CoV-2 was performed and results were highly positive IgG and IgM+IgA levels. The lumbar puncture finding confirmed the suspicion of immune-related complications after SARS-CoV-2 infection (intrathecal IgG synthesis). This case draws attention to spastic paraparesis or progressive MRI-negative myelitis after SARS-CoV-2 infection, which obviously has immune-mediated pathogenesis that happen in response to the virus or its antibodies. Similarities in spastic paraparesis after human T-lymphotropic virus (HTLV-1) or human immunodeficiency virus (HIV-1) and SARS-CoV-2 infections were observed. The patient had a good response to corticosteroid therapy and had good recovery.
Acta Myologica, 2021
Purpose Myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS) are two different diseases... more Purpose Myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS) are two different diseases. The coexistence of both of them is extremely rare and represents a diagnostic challenge which requires thoughtful interpretation of clinical characteristics. Case report We present the case of a 46-year-old Bosnian male who developed ALS five months after MG. Diagnosis of MG was based on elevated titers of anti-AchR antibodies, positive edrophonium test, and decremental responses on a repetitive nerve stimulation test while the diagnosis of ALS was based on clinical and neurophysiological findings: upper motor neuron signs in the lumbar region, lower motor neuron signs in the bulbar and cervical regions, generalized fasciculations and muscle atrophy and progressive asymetric muscle weakness together with active and chronic denervation in the cervical and lumbosacral region determined by electromyoneurography. Conclusions The coexistence of MG and ALS is rare and request an adequate int...
International Journal of Innovative Research in Medical Science, 2020
Marinacci anastomosis, also known as Ulnar-Median anastomosis, is an anastomosis in which the bra... more Marinacci anastomosis, also known as Ulnar-Median anastomosis, is an anastomosis in which the branch anastomotic originates proximally in the ulnar nerve and unites distally with the median nerve. A purpose of this study was to determine the incidence and the characteristics of Marinacci anastomosis in the Bosnian population. The 60 anterior forearms of fresh frozen adult cadavers were dissected in the Department of Pathology, University Clinical Centre Tuzla and the morgue of Tuzla during a time period of two years. The Marinacci anastomosis was evidenced in one male forearm in the right side behind the ulnar artery, following an transversal course of 5.2 cm until its connection with the median nerve in only one branch. The incidence of Marinacci anastomosis was 1.67%. Since this anastomosis can expalin some cases where injuries in the forearm nerves are not reflected in the hand muscles, it is important to study. Our study contributes to a limited research on the Marinacci anast...
Applied neuropsychology. Adult, Jan 10, 2017
Poststroke language disorders are frequent and include aphasia, alexia, agraphia, and acalculia. ... more Poststroke language disorders are frequent and include aphasia, alexia, agraphia, and acalculia. These disorders refer to an acquired inability to read, write and calculate. In this study, we evaluated the two year outcomes of writing and reading disorders in poststroke patients, the natural course, recovery and mortality. We evaluated all the patients with stroke who were admitted to the Department of Neurology, University Clinical Centre Tuzla in period of six months, who developed poststroke alexia, agraphia, acalculia, or different combinations of these language disorders. Outcome of these patients was evaluated again after 24 months. For clinical assessment of alexia, agraphia, and acalculia we used Minnesota Test for Differential Diagnosis of Aphasia. We investigated 59 (30.5%) of 193 stroke patients with alexia, agraphia, acalculia, and combinations. Outcome of these patients after 24 months was: 37 (62.7%) died, 13 (22%) fully recovered, and 9 (15.3%) of them retained the sa...
Acta Medica Saliniana, 2017
Acta Medica Saliniana, Jan 28, 2009
... married to Fatima Azapagić; they had four daughters and four sons12. Three of them have finis... more ... married to Fatima Azapagić; they had four daughters and four sons12. Three of them have finished the studies at Universities in Prague and Belgrade. The youngest daughter Hiba erbić (married erbić-Ramadanović), was the first Muslim woman enrolled to the School of ...
Acta Clinica Croatica, Mar 31, 2011
Post stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. ... more Post stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. There are different definitions of aphasias, but the most widely accepted neurologic and/or neuropsychological definition is that aphasia is a loss or impairment of verbal communication, which occurs as a consequence of brain dysfunction. It manifests as impairment of almost all verbal abilities, e.g., abnormal verbal expression, difficulties in understanding spoken or written language, repetition, naming, reading and writing. During the history, many classifications of aphasia syndromes were established. For practical use, classification of aphasias according to fluency, comprehension and abilities of naming it seems to be most suitable (nonfluent aphasias: Broca's, transcortical motor, global and mixed transcortical aphasia; fluent aphasias: anomic, conduction, Wernicke's, transcortical sensory, subcortical aphasia). Aphasia is a common consequence of left hemispheric lesion and most common neuropsychological consequence of stroke, with a prevalence of one-third of all stroke patients in acute phase, although there are reports on even higher figures. Many speech impairments have a tendency of spontaneous recovery. Spontaneous recovery is most remarkable in the first three months after stroke onset. Recovery of aphasias caused by ischemic stroke occurs earlier and it is most intensive in the first two weeks. In aphasias caused by hemorrhagic stroke, spontaneous recovery is slower and occurs from the fourth to the eighth week after stroke. The course and outcome of aphasia depend greatly on the type of aphasia. Regardless of the fact that a significant number of aphasias spontaneously improve, it is necessary to start treatment as soon as possible. The writing and reading disorders in stroke patients (alexias and agraphias) are more frequent than verified on routine examination, not only in less developed but also in large neurologic departments. Alexia is an acquired type of sensory aphasia where damage to the brain causes the patient to lose the ability to read. It is also called word blindness, text blindness or visual aphasia. Alexia refers to an acquired inability to read due to brain damage and must be distinguished from dyslexia, a developmental abnormality in which the individual is unable to learn to read, and from illiteracy, which reflects a poor educational background. Most aphasics are also alexic, but alexia may occur in the absence of aphasia and may occasionally be the sole disability resulting from specific brain lesions. There are different classifications of alexias. Traditionally, alexias are divided into three categories: pure alexia with agraphia, pure alexia without agraphia, and alexia associated with aphasia ('aphasic alexia'). Agraphia is defined as disruption of previously intact writing skills by brain damage. Writing involves several elements: language processing, spelling, visual perception, visuospatial orientation for graphic symbols, motor planning, and motor control of writing. A disturbance of any of these processes can impair writing. Agraphia may occur by itself or in association with aphasias, alexia, agnosia and apraxia. Agraphia can also result from 'peripheral' involvement of the motor act of writing. Like alexia, agraphia must be distinguished from illiteracy, where writing skills were never developed. Acalculia is a clinical syndrome of acquired deficits in mathematical calculation, either mentally or with paper and pencil. These language disturbances can be classified
Wallenbergs syndrome (also called lateral medullary syndrome and posterior inferior cerebel- lar ... more Wallenbergs syndrome (also called lateral medullary syndrome and posterior inferior cerebel- lar artery/PICA syndrome) is neurological condition caused by a stroke in the teritory of posterior inferi- or cerebellar artery vascularisation. In this report we presented a case of 45 years old women who was ad- mitted at our Clinic due to sudden onset of dizziness, nausea and vomiting, as well as nystagmus and un- steadiness gate. By computerized tomography (CT) of the brain it was visualized ishemic lesion in righ cer- ebellar hemisphere, but clinically also posible brainstem lesion (numbness of the rihgt side of the face, diffi - culties with swallowing) was confi rmed by magnetic resonance (MR) imaging of the brain. Th is case report emphasizes the importance of correlation between clinical fi ndings and anatomic localisation of lesions vi- sualized by CT and MR imaging.
Acta Medica Saliniana, 2014
ABSTRACT Background: Writing and reading disorders usually followed aphasias but frequency of aca... more ABSTRACT Background: Writing and reading disorders usually followed aphasias but frequency of acalculia, agraphia and alexia are not often studied. The aim of this study was to determine the frequency of these language disorders in acute stroke patients, and determine their relation to the type of stroke (ischemic/hemorrhag-ic) and lesion site (left/right hemisphere). Methods: It was analyzed 194 consecutive patients with acute first-ever stroke, hospitalized at the Department of Neurology, University Clinical Center Tuzla, in the period of six month. For clinical assessment of alexia, agraphia and acalculia it was used Minnesota Test for Differential Diagnosis ofAphasiàs. Results: The patients were evaluated in the first week of stroke onset, and 59 (30.40%) of them had alexia, agraphia and acalculia in different combinations of these disorders. The frequency of alexia, agraphia and acalculia among patients with stroke in the left (dominant) hemisphere was significantly higher (55.9%), comparing to those with right hemisphere stroke (37.7%) (χ2= 4.003; p=0.045). In 170 subjects with ischemic stroke, there were 53 (31.1%) cases of alexia, agraphia and acalculia, and 6 (42.8%) cases among 14 subjects with hemorrhagic stroke. There were no significant difference in frequency of alexia, agraphia and acalculia between hemorrhagic and ischemic stroke (χ2 =0.363; p=0.394). Conclusion: Results from this study provided evidence that alexia, agraphia and acalculia are frequent among stroke patients, presenting itself in one third of stroke cases. These language disorders were more common in patients with left hemisphere stroke, but there was no significant difference in dependency of type of stroke.
Book 2015 cal awareness of individuals. The basic integrative rule is that a human becomes a huma... more Book 2015 cal awareness of individuals. The basic integrative rule is that a human becomes a human only in relation to other humans , through mutual social empathy. IT understands disease and health as a 'quality of human life processes'. This determination emphasizes that health is not an unchangea-ble state, but rather a development, created by means of cooperation with others (Cvetko, after Petzold 2011). We think and work with clients from the point of view of pathogene-sis (together we investigate incriminating factors, critical life situations, pathogenic simulations, conflicts, disturbances, traumas). We give as much importance to salutogenesis by means of mutual discovery of our resources, protective factors , resistance, goals, coping strategies and individual creative styles. The process is designed through all life space development in the context and continuum. IT names 5 columns of identity: body, soul, spirit; social network; economic status, work and achieveme...
Aim: of this study was to evaluate incidence, prevalence, the most frequent first symptoms of the... more Aim: of this study was to evaluate incidence, prevalence, the most frequent first symptoms of the patients with multiple sclerosis (MS) in Tuzla-canton (Bosnia and Herzegovina), then forms of disease and time that passed from first symptom at disease onset until diagnose verification. Patients and Methods: The area of the Tuzla-canton (TC) is 2649 km 2. According to the last census done in 2013 in the area it was registered 477278 inhabitants. In this study it was analyzed medical records of hospitalized patients as well as records during follow-ups. Results: The number of analyzed MS patients in TC is 243. Average age of patients at the moment of diagnose verification was 35.1 (SD ±10.8) and it was more women (178; 73.2%). Disease prevalence on December 31, 2013 is 50.4/100000. Incidence for 2013 is 2.5/100000. The most frequent is relapsing-remitting form of MS (207; 85.1%), then secondary-progressive (30; 12.4%) and the list frequent is primary-progressive (6; 2.5%). From the fir...
Background and aims: Reinnervation after peripheral nerve injuries implies abnormal branching of ... more Background and aims: Reinnervation after peripheral nerve injuries implies abnormal branching of regenerating axons, modification of the original distribution of muscle innervation and compensatory activity in neighbouring nerves. These may lead to an abnormal function in muscles that require fine motor control, such as sphincters. We investigated if external anal sphincter (EAS) dysfunction leading to incontinence was related to pudendal nerve rein-nervation abnormalities. Methods: In 10 patients with fecal incontinence and 3 controls , we applied focal electrical stimuli with a monopolar needle inserted into one side and recorded responses in the other side. We hypothesized that the size of the contralate-ral responses would be an indirect measure of the amount of abnormal contralateral reinnervation. We also recorded EAS needle EMG activity and pudendal nerve latency. Results: 8 patients had abnormal needle EMG findings (denervation or significant jitter/blocking). Mean pudendal ...
Acta clinica Croatica, 2011
Post-stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. ... more Post-stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. There are different definitions of aphasias, but the most widely accepted neurologic and/or neuropsychological definition is that aphasia is a loss or impairment of verbal communication, which occurs as a consequence of brain dysfunction. It manifests as impairment of almost all verbal abilities, e.g., abnormal verbal expression, difficulties in understanding spoken or written language, repetition, naming, reading and writing. During the history, many classifications of aphasia syndromes were established. For practical use, classification of aphasias according to fluency, comprehension and abilities of naming it seems to be most suitable (nonfluent aphasias: Broca's, transcortical motor, global and mixed transcortical aphasia; fluent aphasias: anomic, conduction, Wernicke's, transcortical sensory, subcortical aphasia). Aphasia is a common consequence of left hemispheric lesion an...
American Journal of Nephrology, 1996
Two apparently healthy adults were admitted because of acute muscle cramps, severe weakness, and ... more Two apparently healthy adults were admitted because of acute muscle cramps, severe weakness, and red urine excretion. Patient No. 1 developed the symptoms following intense exercise and patient No. 2 during a febrile infection. Both of them experienced such episodes in the past, but these were medically misinterpreted. Their present manifestations were accompanied by renal failure which subsided gradually and was found to be a result of rhabdomyolsis and myoglobinuria. Further investigations yielded a deficiency of carnitine palmitoyltransferase as a background to the acute muscular destruction. Examination of a sister of patient No. 2 who had a similar past history revealed the same metabolic disorder. Carnitine palmitoyltransferase deficiency, as a cause of nontraumatic rhabdomyolysis, is a distinct entity in the pathogenesis of acute renal failure. Our experience (3 patients within 2 years) makes us presume that this condition is not as rare as hitherto reported and should rather be considered in cases of 'nonhematuric' red urine and acute renal failure.
Cureus, 2022
Coronavirus disease 2019 (COVID-19) is primarily a disease of the respiratory system but severe a... more Coronavirus disease 2019 (COVID-19) is primarily a disease of the respiratory system but severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause several immune-related complications including different neurological disorders, such as myelopathy with paraparesis. In this atypical case a female patient with progressive spastic paraparesis after COVID-19 infection, brisk reflexes and positive Babinski sign, reduced vibratory sensation to the thoracic level, elevated immunoglobulin levels (IgG) in cerebrospinal fluid, but negative magnetic resonance imaging (MRI) of the brain and spine, is presented. A 57-year-old woman with spastic paraparesis and inability to walk was admitted to our neurological department. About four months before hospitalization, she started feeling numbness and tingling in the feet and lumbar spine area. Gradually, numbness and tingling ascended to the thoracic spine level Th7/8, and she developed weakness mostly in her legs. In the neurological exam she had spastic paraparesis. MRI of the brain, cervical and thoracic spine did not reveal any signal abnormality. Serological testing for SARS-CoV-2 was performed and results were highly positive IgG and IgM+IgA levels. The lumbar puncture finding confirmed the suspicion of immune-related complications after SARS-CoV-2 infection (intrathecal IgG synthesis). This case draws attention to spastic paraparesis or progressive MRI-negative myelitis after SARS-CoV-2 infection, which obviously has immune-mediated pathogenesis that happen in response to the virus or its antibodies. Similarities in spastic paraparesis after human T-lymphotropic virus (HTLV-1) or human immunodeficiency virus (HIV-1) and SARS-CoV-2 infections were observed. The patient had a good response to corticosteroid therapy and had good recovery.
Acta Myologica, 2021
Purpose Myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS) are two different diseases... more Purpose Myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS) are two different diseases. The coexistence of both of them is extremely rare and represents a diagnostic challenge which requires thoughtful interpretation of clinical characteristics. Case report We present the case of a 46-year-old Bosnian male who developed ALS five months after MG. Diagnosis of MG was based on elevated titers of anti-AchR antibodies, positive edrophonium test, and decremental responses on a repetitive nerve stimulation test while the diagnosis of ALS was based on clinical and neurophysiological findings: upper motor neuron signs in the lumbar region, lower motor neuron signs in the bulbar and cervical regions, generalized fasciculations and muscle atrophy and progressive asymetric muscle weakness together with active and chronic denervation in the cervical and lumbosacral region determined by electromyoneurography. Conclusions The coexistence of MG and ALS is rare and request an adequate int...
International Journal of Innovative Research in Medical Science, 2020
Marinacci anastomosis, also known as Ulnar-Median anastomosis, is an anastomosis in which the bra... more Marinacci anastomosis, also known as Ulnar-Median anastomosis, is an anastomosis in which the branch anastomotic originates proximally in the ulnar nerve and unites distally with the median nerve. A purpose of this study was to determine the incidence and the characteristics of Marinacci anastomosis in the Bosnian population. The 60 anterior forearms of fresh frozen adult cadavers were dissected in the Department of Pathology, University Clinical Centre Tuzla and the morgue of Tuzla during a time period of two years. The Marinacci anastomosis was evidenced in one male forearm in the right side behind the ulnar artery, following an transversal course of 5.2 cm until its connection with the median nerve in only one branch. The incidence of Marinacci anastomosis was 1.67%. Since this anastomosis can expalin some cases where injuries in the forearm nerves are not reflected in the hand muscles, it is important to study. Our study contributes to a limited research on the Marinacci anast...
Applied neuropsychology. Adult, Jan 10, 2017
Poststroke language disorders are frequent and include aphasia, alexia, agraphia, and acalculia. ... more Poststroke language disorders are frequent and include aphasia, alexia, agraphia, and acalculia. These disorders refer to an acquired inability to read, write and calculate. In this study, we evaluated the two year outcomes of writing and reading disorders in poststroke patients, the natural course, recovery and mortality. We evaluated all the patients with stroke who were admitted to the Department of Neurology, University Clinical Centre Tuzla in period of six months, who developed poststroke alexia, agraphia, acalculia, or different combinations of these language disorders. Outcome of these patients was evaluated again after 24 months. For clinical assessment of alexia, agraphia, and acalculia we used Minnesota Test for Differential Diagnosis of Aphasia. We investigated 59 (30.5%) of 193 stroke patients with alexia, agraphia, acalculia, and combinations. Outcome of these patients after 24 months was: 37 (62.7%) died, 13 (22%) fully recovered, and 9 (15.3%) of them retained the sa...
Acta Medica Saliniana, 2017
Acta Medica Saliniana, Jan 28, 2009
... married to Fatima Azapagić; they had four daughters and four sons12. Three of them have finis... more ... married to Fatima Azapagić; they had four daughters and four sons12. Three of them have finished the studies at Universities in Prague and Belgrade. The youngest daughter Hiba erbić (married erbić-Ramadanović), was the first Muslim woman enrolled to the School of ...
Acta Clinica Croatica, Mar 31, 2011
Post stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. ... more Post stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. There are different definitions of aphasias, but the most widely accepted neurologic and/or neuropsychological definition is that aphasia is a loss or impairment of verbal communication, which occurs as a consequence of brain dysfunction. It manifests as impairment of almost all verbal abilities, e.g., abnormal verbal expression, difficulties in understanding spoken or written language, repetition, naming, reading and writing. During the history, many classifications of aphasia syndromes were established. For practical use, classification of aphasias according to fluency, comprehension and abilities of naming it seems to be most suitable (nonfluent aphasias: Broca's, transcortical motor, global and mixed transcortical aphasia; fluent aphasias: anomic, conduction, Wernicke's, transcortical sensory, subcortical aphasia). Aphasia is a common consequence of left hemispheric lesion and most common neuropsychological consequence of stroke, with a prevalence of one-third of all stroke patients in acute phase, although there are reports on even higher figures. Many speech impairments have a tendency of spontaneous recovery. Spontaneous recovery is most remarkable in the first three months after stroke onset. Recovery of aphasias caused by ischemic stroke occurs earlier and it is most intensive in the first two weeks. In aphasias caused by hemorrhagic stroke, spontaneous recovery is slower and occurs from the fourth to the eighth week after stroke. The course and outcome of aphasia depend greatly on the type of aphasia. Regardless of the fact that a significant number of aphasias spontaneously improve, it is necessary to start treatment as soon as possible. The writing and reading disorders in stroke patients (alexias and agraphias) are more frequent than verified on routine examination, not only in less developed but also in large neurologic departments. Alexia is an acquired type of sensory aphasia where damage to the brain causes the patient to lose the ability to read. It is also called word blindness, text blindness or visual aphasia. Alexia refers to an acquired inability to read due to brain damage and must be distinguished from dyslexia, a developmental abnormality in which the individual is unable to learn to read, and from illiteracy, which reflects a poor educational background. Most aphasics are also alexic, but alexia may occur in the absence of aphasia and may occasionally be the sole disability resulting from specific brain lesions. There are different classifications of alexias. Traditionally, alexias are divided into three categories: pure alexia with agraphia, pure alexia without agraphia, and alexia associated with aphasia ('aphasic alexia'). Agraphia is defined as disruption of previously intact writing skills by brain damage. Writing involves several elements: language processing, spelling, visual perception, visuospatial orientation for graphic symbols, motor planning, and motor control of writing. A disturbance of any of these processes can impair writing. Agraphia may occur by itself or in association with aphasias, alexia, agnosia and apraxia. Agraphia can also result from 'peripheral' involvement of the motor act of writing. Like alexia, agraphia must be distinguished from illiteracy, where writing skills were never developed. Acalculia is a clinical syndrome of acquired deficits in mathematical calculation, either mentally or with paper and pencil. These language disturbances can be classified
Wallenbergs syndrome (also called lateral medullary syndrome and posterior inferior cerebel- lar ... more Wallenbergs syndrome (also called lateral medullary syndrome and posterior inferior cerebel- lar artery/PICA syndrome) is neurological condition caused by a stroke in the teritory of posterior inferi- or cerebellar artery vascularisation. In this report we presented a case of 45 years old women who was ad- mitted at our Clinic due to sudden onset of dizziness, nausea and vomiting, as well as nystagmus and un- steadiness gate. By computerized tomography (CT) of the brain it was visualized ishemic lesion in righ cer- ebellar hemisphere, but clinically also posible brainstem lesion (numbness of the rihgt side of the face, diffi - culties with swallowing) was confi rmed by magnetic resonance (MR) imaging of the brain. Th is case report emphasizes the importance of correlation between clinical fi ndings and anatomic localisation of lesions vi- sualized by CT and MR imaging.
Acta Medica Saliniana, 2014
ABSTRACT Background: Writing and reading disorders usually followed aphasias but frequency of aca... more ABSTRACT Background: Writing and reading disorders usually followed aphasias but frequency of acalculia, agraphia and alexia are not often studied. The aim of this study was to determine the frequency of these language disorders in acute stroke patients, and determine their relation to the type of stroke (ischemic/hemorrhag-ic) and lesion site (left/right hemisphere). Methods: It was analyzed 194 consecutive patients with acute first-ever stroke, hospitalized at the Department of Neurology, University Clinical Center Tuzla, in the period of six month. For clinical assessment of alexia, agraphia and acalculia it was used Minnesota Test for Differential Diagnosis ofAphasiàs. Results: The patients were evaluated in the first week of stroke onset, and 59 (30.40%) of them had alexia, agraphia and acalculia in different combinations of these disorders. The frequency of alexia, agraphia and acalculia among patients with stroke in the left (dominant) hemisphere was significantly higher (55.9%), comparing to those with right hemisphere stroke (37.7%) (χ2= 4.003; p=0.045). In 170 subjects with ischemic stroke, there were 53 (31.1%) cases of alexia, agraphia and acalculia, and 6 (42.8%) cases among 14 subjects with hemorrhagic stroke. There were no significant difference in frequency of alexia, agraphia and acalculia between hemorrhagic and ischemic stroke (χ2 =0.363; p=0.394). Conclusion: Results from this study provided evidence that alexia, agraphia and acalculia are frequent among stroke patients, presenting itself in one third of stroke cases. These language disorders were more common in patients with left hemisphere stroke, but there was no significant difference in dependency of type of stroke.
Book 2015 cal awareness of individuals. The basic integrative rule is that a human becomes a huma... more Book 2015 cal awareness of individuals. The basic integrative rule is that a human becomes a human only in relation to other humans , through mutual social empathy. IT understands disease and health as a 'quality of human life processes'. This determination emphasizes that health is not an unchangea-ble state, but rather a development, created by means of cooperation with others (Cvetko, after Petzold 2011). We think and work with clients from the point of view of pathogene-sis (together we investigate incriminating factors, critical life situations, pathogenic simulations, conflicts, disturbances, traumas). We give as much importance to salutogenesis by means of mutual discovery of our resources, protective factors , resistance, goals, coping strategies and individual creative styles. The process is designed through all life space development in the context and continuum. IT names 5 columns of identity: body, soul, spirit; social network; economic status, work and achieveme...
Aim: of this study was to evaluate incidence, prevalence, the most frequent first symptoms of the... more Aim: of this study was to evaluate incidence, prevalence, the most frequent first symptoms of the patients with multiple sclerosis (MS) in Tuzla-canton (Bosnia and Herzegovina), then forms of disease and time that passed from first symptom at disease onset until diagnose verification. Patients and Methods: The area of the Tuzla-canton (TC) is 2649 km 2. According to the last census done in 2013 in the area it was registered 477278 inhabitants. In this study it was analyzed medical records of hospitalized patients as well as records during follow-ups. Results: The number of analyzed MS patients in TC is 243. Average age of patients at the moment of diagnose verification was 35.1 (SD ±10.8) and it was more women (178; 73.2%). Disease prevalence on December 31, 2013 is 50.4/100000. Incidence for 2013 is 2.5/100000. The most frequent is relapsing-remitting form of MS (207; 85.1%), then secondary-progressive (30; 12.4%) and the list frequent is primary-progressive (6; 2.5%). From the fir...
Background and aims: Reinnervation after peripheral nerve injuries implies abnormal branching of ... more Background and aims: Reinnervation after peripheral nerve injuries implies abnormal branching of regenerating axons, modification of the original distribution of muscle innervation and compensatory activity in neighbouring nerves. These may lead to an abnormal function in muscles that require fine motor control, such as sphincters. We investigated if external anal sphincter (EAS) dysfunction leading to incontinence was related to pudendal nerve rein-nervation abnormalities. Methods: In 10 patients with fecal incontinence and 3 controls , we applied focal electrical stimuli with a monopolar needle inserted into one side and recorded responses in the other side. We hypothesized that the size of the contralate-ral responses would be an indirect measure of the amount of abnormal contralateral reinnervation. We also recorded EAS needle EMG activity and pudendal nerve latency. Results: 8 patients had abnormal needle EMG findings (denervation or significant jitter/blocking). Mean pudendal ...
Acta clinica Croatica, 2011
Post-stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. ... more Post-stroke language disorders are frequent and include aphasia, alexia, agraphia and acalculia. There are different definitions of aphasias, but the most widely accepted neurologic and/or neuropsychological definition is that aphasia is a loss or impairment of verbal communication, which occurs as a consequence of brain dysfunction. It manifests as impairment of almost all verbal abilities, e.g., abnormal verbal expression, difficulties in understanding spoken or written language, repetition, naming, reading and writing. During the history, many classifications of aphasia syndromes were established. For practical use, classification of aphasias according to fluency, comprehension and abilities of naming it seems to be most suitable (nonfluent aphasias: Broca's, transcortical motor, global and mixed transcortical aphasia; fluent aphasias: anomic, conduction, Wernicke's, transcortical sensory, subcortical aphasia). Aphasia is a common consequence of left hemispheric lesion an...