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Vilay Sanger

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Research paper thumbnail of Cerebrospinal Fluid and Plasma Procalcitonin for the Diagnosis of Neonatal Bacterial Meningitis

ObjectiveTo determine accuracy of cerebro-spinal fluid (CSF) procalcitonin (PCT) to diagnose neon... more ObjectiveTo determine accuracy of cerebro-spinal fluid (CSF) procalcitonin (PCT) to diagnose neonatal bacterial meningitis (NBM) among septic neonates and compare with other index tests.DesignProspective, cross-sectional, single-gate studySettingLevel-3 neonatal unitPatientsNeonates with suspected sepsis undergoing lumbar punctureIndex testsCSF PCT, leukocyte count and biochemistry; plasma PCT and CSF:plasma PCT ratioReference standards“Definite meningitis” defined by positive CSF culture and/or gram stain and/or broad-based primer 16S rDNA polymerase chain reaction. “Definite or probable meningitis” defined by definite meningitis or probable meningitis (based on cytochemistry cut-offs).ResultsOf 216 eligible neonates, 18 had “definite meningitis” and 37 “definite or probable meningitis”. Median (Q1, Q3) CSF PCT level was higher in “definite meningitis” compared to “no definite meningitis” [0.429 (0.123, 1.300) vs. 0.181 (0.119, 0.286) ng/ml respectively, p=0.028]. Likewise, it was ...

Research paper thumbnail of Cerebrospinal Fluid and Plasma Procalcitonin for the Diagnosis of Neonatal Bacterial Meningitis

ObjectiveTo determine accuracy of cerebro-spinal fluid (CSF) procalcitonin (PCT) to diagnose neon... more ObjectiveTo determine accuracy of cerebro-spinal fluid (CSF) procalcitonin (PCT) to diagnose neonatal bacterial meningitis (NBM) among septic neonates and compare with other index tests.DesignProspective, cross-sectional, single-gate studySettingLevel-3 neonatal unitPatientsNeonates with suspected sepsis undergoing lumbar punctureIndex testsCSF PCT, leukocyte count and biochemistry; plasma PCT and CSF:plasma PCT ratioReference standards“Definite meningitis” defined by positive CSF culture and/or gram stain and/or broad-based primer 16S rDNA polymerase chain reaction. “Definite or probable meningitis” defined by definite meningitis or probable meningitis (based on cytochemistry cut-offs).ResultsOf 216 eligible neonates, 18 had “definite meningitis” and 37 “definite or probable meningitis”. Median (Q1, Q3) CSF PCT level was higher in “definite meningitis” compared to “no definite meningitis” [0.429 (0.123, 1.300) vs. 0.181 (0.119, 0.286) ng/ml respectively, p=0.028]. Likewise, it was ...

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