Sanghamitra Burman - Academia.edu (original) (raw)

Papers by Sanghamitra Burman

Research paper thumbnail of Cataract surgery in high risk corneas

Journal of Clinical & Experimental Ophthalmology, Jun 15, 2018

Research paper thumbnail of For Ocular

limbal stem cell transplantation

Research paper thumbnail of 295 Publications 3,080 Citations

Cultivated limbal stem cell transplantation for ocular surface reconstruction

Research paper thumbnail of Cataract surgery in Stevens-Johnson syndrome

Journal of Cataract and Refractive Surgery, 2005

Cataract surgery can be safely performed in patients with Stevens-Johnson syndrome (SJS) with vis... more Cataract surgery can be safely performed in patients with Stevens-Johnson syndrome (SJS) with visually significant cataracts. Maintaining ocular surface integrity improves the prognosis of cataract surgery in this high-risk population. We present the outcome of cataract surgery in a retrospective chart review of 3 eyes in 2 patients with SJS. Uneventful extracapsular cataract extraction with intraocular lens implantation was performed. Follow-up ranged from 3 to 24 months. The visual acuity and ocular surface integrity were reviewed. The preoperative visual acuity was counting fingers at 1 meter in all 3 eyes. The best corrected visual acuity (BCVA) improved to 20/40 in 2 eyes and 20/50 in 1 eye postoperatively. A drop in BCVA ranging from 20/100 to 20/200 was noted during follow-up.

Research paper thumbnail of Iconographies supplémentaires de l'article : Polycystic Echinococcosis of the Orbit

Research paper thumbnail of Cataract surgery in patients with Mooren's ulcer

Journal of Cataract & Refractive Surgery, 2005

Methods: In this interventional case series, the medical records of 6 patients with Mooren's ulce... more Methods: In this interventional case series, the medical records of 6 patients with Mooren's ulcer who had cataract surgery were retrospectively reviewed. Five patients had uneventful extracapsular cataract extraction with intraocular lens (IOL) implantation, and 1 patient had phacoemulsification with IOL implantation. The visual acuity and postoperative course of the patients were reviewed. The patients were followed to detect, and if present treat, a recurrence of Mooren's ulcer. Results: The follow-up ranged from 3 months to 2 years. The preoperative visual acuity ranged from 20/60 to hand movements. Postoperatively, the best corrected visual acuity improved to 20/20 to counting fingers close to face. Mooren's ulcer recurred 8 months after surgery in 1 patient and was treated appropriately. Conclusions: Results indicate that cataract surgery can be safe in patients with Mooren's ulcer and visually significant cataract. Performing surgery in a quiet, noninflamed eye improves the prognosis in these cases.

Research paper thumbnail of Cultivated limbal stem cell transplantation for ocular surface reconstruction

Clinical ophthalmology (Auckland, N.Z.), 2008

Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as v... more Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as vascularized conjunctivalization, keratinization, corneal scarring, and corneal opacification, collectively described as limbal stem cell deficiency (LSCD). Limbal stem cell deficiency may occur as a result of depletion of stem cells or destruction of their stromal niche. In such cases, apart from conventional corneal transplantation, limbal stem cell transplantation would be needed to restore vision. Limbal stem cells may be replenished by autologous limbal transplants from the healthy fellow eye in unilateral cases, and allografts from living related donors or cadaveric donors in bilateral cases. The induction of iatrogenic LSCD and its sequelae in donor eyes have motivated researchers to cultivate sheets of limbal epithelium ex vivo, from small fragments of donor tissue for the purpose of ocular surface reconstruction.

Research paper thumbnail of Non-contact lens related Acanthamoeba keratitis

Indian Journal of Ophthalmology, 2017

The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment... more The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment of Acanthamoeba keratitis (AK) with special focus on the disease in nonusers of contact lenses (CLs). This study was a perspective based on authors' experience and review of published literature. AK accounts for 2% of microbiology-proven cases of keratitis. Trauma and exposure to contaminated water are the main predisposing factors for the disease. Association with CLs is seen only in small fraction of cases. Contrary to classical description experience in India suggests that out of proportion pain, ring infiltrate, and radial keratoneuritis are seen in less than a third of cases. Majority of cases present with diffuse infiltrate, mimicking herpes simplex or fungal keratitis. The diagnosis can be confirmed by microscopic examination of corneal scraping material and culture on nonnutrient agar with an overlay of Escherichia coli. Confocal microscopy can help diagnosis in patients with deep infiltrate; however, experience with technique and interpretation of images influences its true value. Primary treatment of the infection is biguanides with or without diamidines. Most patients respond to medical treatment. Corticosteroids play an important role in the management and can be used when indicated after due consideration to established protocols. Surgery is rarely needed in patients where definitive management is initiated within 3 weeks of onset of symptoms. Lamellar keratoplasty has been shown to have good outcome in cases needing surgery. Since the clinical features of AK in nonusers of CL are different, it will be important for ophthalmologists to be aware of the scenario wherein to suspect this infection. Medical treatment is successful if the disease is diagnosed early and management is initiated soon.

Research paper thumbnail of Chapter-03 Surgery for Ocular Surface Reconstruction

Mastering Phacoemulsification in Difficult Situations, 2008

Research paper thumbnail of Isolated giant xanthogranuloma of the orbit

Indian journal of …, 2007

Xanthogranuloma is an uncommon tumor in the orbit and is usually associated with systemic disease... more Xanthogranuloma is an uncommon tumor in the orbit and is usually associated with systemic diseases or blood abnormalities. We report an extremely rare presentation of isolated orbital xanthogranuloma unassociated with any systemic disease, hematological or biochemical ...

Research paper thumbnail of Ophthalmic applications of preserved human amniotic membrane: A review of current indications

Cell and Tissue Banking, 2004

Preserved human amniotic membrane (AM) is currently being used for a wide spectrum of ocular surf... more Preserved human amniotic membrane (AM) is currently being used for a wide spectrum of ocular surface disorders. The AM has a basement membrane, which promotes epithelial cell migration and adhesion. The presence of a unique avascular stromal matrix reduces inflammation, neovascularization and fibrosis. The basic tenets of amniotic membrane transplantation (AMT) are to promote re-epithelialization, to reconstruct the ocular surface and to provide symptomatic relief from surface aberrations. AMT is a useful technique for reconstruction of surface defects resulting from removal of surface tumors and symblephara. AMT has effectively restored a stable corneal epithelium in eyes with, persistent epithelial defects and corneal ulcers. In the setting of acute ocular burns and SJS, AMT has satisfactorily reduced scarring and inflammation. AMT alone may be an effective alternative for partial limbal stem cell deficiency. However remarkable improvements in surface stability have resulted from concurrent AMT and limbal stem cell transplantation, wherein the limbal grafts are obtained from the normal fellow eye, living relative or cadaveric eye. In severe or bilateral cases, well being of the donor eye is a major concern. Currently, the most unique application of preserved human AM in ophthalmology is its use as a substrate for ex-vivo expansion of corneal and conjunctival epithelium. In this novel technique of tissue engineering, epithelial stem cells can be safely harvested and expanded on denuded AM. The resultant composite cultured tissue has been successfully transplanted to restore vision, as well as the structure and function of damaged ocular surfaces.

Research paper thumbnail of Cultivated limbal stem cell transplantation for ocular surface reconstruction

Clinical ophthalmology (Auckland, N.Z.), 2008

Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as v... more Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as vascularized conjunctivalization, keratinization, corneal scarring, and corneal opacification, collectively described as limbal stem cell deficiency (LSCD). Limbal stem cell deficiency may occur as a result of depletion of stem cells or destruction of their stromal niche. In such cases, apart from conventional corneal transplantation, limbal stem cell transplantation would be needed to restore vision. Limbal stem cells may be replenished by autologous limbal transplants from the healthy fellow eye in unilateral cases, and allografts from living related donors or cadaveric donors in bilateral cases. The induction of iatrogenic LSCD and its sequelae in donor eyes have motivated researchers to cultivate sheets of limbal epithelium ex vivo, from small fragments of donor tissue for the purpose of ocular surface reconstruction.

Research paper thumbnail of Ocular surface squamous neoplasia in Papillon–Lefevre syndrome

PURPOSE: To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with P... more PURPOSE: To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with Papillon-Lefevre syndrome. DESIGN: Interventional case report. METHODS: A 14-year-old boy presented with a progressively growing limbal lesion in the right eye for 2 months. He had associated erythematous scaly lesions on the elbows, knees, and feet with periodontosis suggestive of Papillon-Lefevre syndrome. An excision biopsy of the limbal tumor and a skin biopsy was performed. RESULTS: The limbal tumor showed features of carcinoma in situ with clear margins. The skin biopsy showed epidermal hyperplasia and hyperkeratosis with perivascular infiltrates, consistent with Papillon-Lefevre syndrome. CONCLUSIONS: Ocular surface squamous neoplasia may occur in patients with Papillon-Lefevre syndrome, an association that to the best of our knowledge has not been previously reported. (Am J Ophthalmol 2005;139: 207-209.

Research paper thumbnail of Neoadjuvant Chemotherapy in the Management of Sebaceous Gland Carcinoma of the Eyelid With Regional Lymph Node Metastasis

Ophthalmic Plastic and Reconstructive Surgery, 2005

A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower ey... more A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower eyelid with orbital extension and regional lymph node metastasis was treated with neoadjuvant chemotherapy, using a combination of carboplatin and 5-fluorouracil. Eyelid-sparing orbital exenteration was performed after 3 cycles of chemotherapy, followed by radiotherapy to the regional lymph nodes. Subsequently, 3 cycles of adjuvant chemotherapy were administered. Significant eyelid and orbital tumor volume reduction was achieved with neoadjuvant chemotherapy, making eyelid-sparing orbital exenteration possible. Chemotherapy also spared the patient from radical neck dissection. The patient had limited morbidity and was free of local, regional, and systemic disease at 26 months of follow-up.

Research paper thumbnail of Ophthalmic applications of preserved human amniotic membrane: A review of current indications

Cell and Tissue Banking, 2004

Preserved human amniotic membrane (AM) is currently being used for a wide spectrum of ocular surf... more Preserved human amniotic membrane (AM) is currently being used for a wide spectrum of ocular surface disorders. The AM has a basement membrane, which promotes epithelial cell migration and adhesion. The presence of a unique avascular stromal matrix reduces inflammation, neovascularization and fibrosis. The basic tenets of amniotic membrane transplantation (AMT) are to promote re-epithelialization, to reconstruct the ocular surface and to provide symptomatic relief from surface aberrations. AMT is a useful technique for reconstruction of surface defects resulting from removal of surface tumors and symblephara. AMT has effectively restored a stable corneal epithelium in eyes with, persistent epithelial defects and corneal ulcers. In the setting of acute ocular burns and SJS, AMT has satisfactorily reduced scarring and inflammation. AMT alone may be an effective alternative for partial limbal stem cell deficiency. However remarkable improvements in surface stability have resulted from concurrent AMT and limbal stem cell transplantation, wherein the limbal grafts are obtained from the normal fellow eye, living relative or cadaveric eye. In severe or bilateral cases, well being of the donor eye is a major concern. Currently, the most unique application of preserved human AM in ophthalmology is its use as a substrate for ex-vivo expansion of corneal and conjunctival epithelium. In this novel technique of tissue engineering, epithelial stem cells can be safely harvested and expanded on denuded AM. The resultant composite cultured tissue has been successfully transplanted to restore vision, as well as the structure and function of damaged ocular surfaces.

Research paper thumbnail of Cataract surgery in patients with Mooren's ulcer

Journal of Cataract & Refractive Surgery, 2005

Methods: In this interventional case series, the medical records of 6 patients with Mooren's ulce... more Methods: In this interventional case series, the medical records of 6 patients with Mooren's ulcer who had cataract surgery were retrospectively reviewed. Five patients had uneventful extracapsular cataract extraction with intraocular lens (IOL) implantation, and 1 patient had phacoemulsification with IOL implantation. The visual acuity and postoperative course of the patients were reviewed. The patients were followed to detect, and if present treat, a recurrence of Mooren's ulcer.

Research paper thumbnail of Amniotic membrane transplantation: A review of current indications in the management of ophthalmic disorders

Indian Journal of Ophthalmology, 2007

Research paper thumbnail of Polycystic Echinococcosis of the Orbit

American Journal of Ophthalmology, 2005

2. Reid SN, Yamashita C, Farber DB. Retinoschisin, a photoreceptor-secreted protein, and its inte... more 2. Reid SN, Yamashita C, Farber DB. Retinoschisin, a photoreceptor-secreted protein, and its interaction with bipolar and muller cells. PURPOSE: To report a case of polycystic echinococcosis of the orbit caused by Echinococcus oligarthrus. DESIGN: Interventional case report METHODS: A 14-year-old girl presented with a massive proptosis of the right eye of 9 years duration and loss of vision. The eye was phthisic, and a cystic mass was palpable. Computed tomography scan showed closely packed multiple orbital cysts with destruction of the medial orbital wall. Surgical exploration was performed. RESULTS: The phthisic eye was enucleated. Dissection of the outer fibrous capsule yielded approximately 30 intact translucent white cysts of various sizes that were suggestive of polycystic echinococcosis. The diagnosis of echinococcosis was confirmed on histopathologic evaluation. The specific diagnosis of E oligarthrus was made on the basis of the presence of straight-backed hooks and central guards. CONCLUSION: Polycystic echinococcosis of the orbit caused by E oligarthrus is rare. It may be an entirely new entity or hitherto unrecognized form of orbital echinococcosis. (Am J Ophthalmol 2005;140:561-563. PURPOSE: To assess the role of systemic non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of inflammatory cystoid macular edema (iCME). DESIGN: Pilot study. METHODS: We included 66 patients with iCME and treated them with naproxen (2 ؋ 250 mg daily; n ‫؍‬ 28) or rofecoxib (1 ؋ 25 mg daily; n ‫؍‬ 38). After 4 months of therapy, visual acuity and inflammation activity were measured. We evaluated the grade of CME, retinal vasculitis, and papillary leakage with fluorescein angiography. RESULTS: No clear effect of NSAIDs on iCME, visual acuity, and intraocular inflammation was observed. A beneficial effect was noted in less than 8% of the affected eyes. The drop-out rate after 4 months of treatment was 52%, because of adverse effects or inefficacy of the treatment. Improvement of visual acuity was slightly better in patients who were treated with naproxen compared with rofecoxib (P < .05). CONCLUSION: Systemic NSAIDs have a limited role (if any) in the treatment of iCME. (Am J Ophthalmol 2005;140:563-564.

Research paper thumbnail of Ocular surface squamous neoplasia in Papillon–Lefevre syndrome

American Journal of Ophthalmology, 2005

PURPOSE: To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with P... more PURPOSE: To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with Papillon-Lefevre syndrome. DESIGN: Interventional case report. METHODS: A 14-year-old boy presented with a progressively growing limbal lesion in the right eye for 2 months. He had associated erythematous scaly lesions on the elbows, knees, and feet with periodontosis suggestive of Papillon-Lefevre syndrome. An excision biopsy of the limbal tumor and a skin biopsy was performed. RESULTS: The limbal tumor showed features of carcinoma in situ with clear margins. The skin biopsy showed epidermal hyperplasia and hyperkeratosis with perivascular infiltrates, consistent with Papillon-Lefevre syndrome. CONCLUSIONS: Ocular surface squamous neoplasia may occur in patients with Papillon-Lefevre syndrome, an association that to the best of our knowledge has not been previously reported. (Am J Ophthalmol 2005;139: 207-209.

Research paper thumbnail of Cataract surgery in Stevens-Johnson syndrome

Journal of Cataract & Refractive Surgery, 2005

Research paper thumbnail of Cataract surgery in high risk corneas

Journal of Clinical & Experimental Ophthalmology, Jun 15, 2018

Research paper thumbnail of For Ocular

limbal stem cell transplantation

Research paper thumbnail of 295 Publications 3,080 Citations

Cultivated limbal stem cell transplantation for ocular surface reconstruction

Research paper thumbnail of Cataract surgery in Stevens-Johnson syndrome

Journal of Cataract and Refractive Surgery, 2005

Cataract surgery can be safely performed in patients with Stevens-Johnson syndrome (SJS) with vis... more Cataract surgery can be safely performed in patients with Stevens-Johnson syndrome (SJS) with visually significant cataracts. Maintaining ocular surface integrity improves the prognosis of cataract surgery in this high-risk population. We present the outcome of cataract surgery in a retrospective chart review of 3 eyes in 2 patients with SJS. Uneventful extracapsular cataract extraction with intraocular lens implantation was performed. Follow-up ranged from 3 to 24 months. The visual acuity and ocular surface integrity were reviewed. The preoperative visual acuity was counting fingers at 1 meter in all 3 eyes. The best corrected visual acuity (BCVA) improved to 20/40 in 2 eyes and 20/50 in 1 eye postoperatively. A drop in BCVA ranging from 20/100 to 20/200 was noted during follow-up.

Research paper thumbnail of Iconographies supplémentaires de l'article : Polycystic Echinococcosis of the Orbit

Research paper thumbnail of Cataract surgery in patients with Mooren's ulcer

Journal of Cataract & Refractive Surgery, 2005

Methods: In this interventional case series, the medical records of 6 patients with Mooren's ulce... more Methods: In this interventional case series, the medical records of 6 patients with Mooren's ulcer who had cataract surgery were retrospectively reviewed. Five patients had uneventful extracapsular cataract extraction with intraocular lens (IOL) implantation, and 1 patient had phacoemulsification with IOL implantation. The visual acuity and postoperative course of the patients were reviewed. The patients were followed to detect, and if present treat, a recurrence of Mooren's ulcer. Results: The follow-up ranged from 3 months to 2 years. The preoperative visual acuity ranged from 20/60 to hand movements. Postoperatively, the best corrected visual acuity improved to 20/20 to counting fingers close to face. Mooren's ulcer recurred 8 months after surgery in 1 patient and was treated appropriately. Conclusions: Results indicate that cataract surgery can be safe in patients with Mooren's ulcer and visually significant cataract. Performing surgery in a quiet, noninflamed eye improves the prognosis in these cases.

Research paper thumbnail of Cultivated limbal stem cell transplantation for ocular surface reconstruction

Clinical ophthalmology (Auckland, N.Z.), 2008

Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as v... more Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as vascularized conjunctivalization, keratinization, corneal scarring, and corneal opacification, collectively described as limbal stem cell deficiency (LSCD). Limbal stem cell deficiency may occur as a result of depletion of stem cells or destruction of their stromal niche. In such cases, apart from conventional corneal transplantation, limbal stem cell transplantation would be needed to restore vision. Limbal stem cells may be replenished by autologous limbal transplants from the healthy fellow eye in unilateral cases, and allografts from living related donors or cadaveric donors in bilateral cases. The induction of iatrogenic LSCD and its sequelae in donor eyes have motivated researchers to cultivate sheets of limbal epithelium ex vivo, from small fragments of donor tissue for the purpose of ocular surface reconstruction.

Research paper thumbnail of Non-contact lens related Acanthamoeba keratitis

Indian Journal of Ophthalmology, 2017

The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment... more The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment of Acanthamoeba keratitis (AK) with special focus on the disease in nonusers of contact lenses (CLs). This study was a perspective based on authors&amp;amp;amp;amp;amp;amp;amp;amp;#39; experience and review of published literature. AK accounts for 2% of microbiology-proven cases of keratitis. Trauma and exposure to contaminated water are the main predisposing factors for the disease. Association with CLs is seen only in small fraction of cases. Contrary to classical description experience in India suggests that out of proportion pain, ring infiltrate, and radial keratoneuritis are seen in less than a third of cases. Majority of cases present with diffuse infiltrate, mimicking herpes simplex or fungal keratitis. The diagnosis can be confirmed by microscopic examination of corneal scraping material and culture on nonnutrient agar with an overlay of Escherichia coli. Confocal microscopy can help diagnosis in patients with deep infiltrate; however, experience with technique and interpretation of images influences its true value. Primary treatment of the infection is biguanides with or without diamidines. Most patients respond to medical treatment. Corticosteroids play an important role in the management and can be used when indicated after due consideration to established protocols. Surgery is rarely needed in patients where definitive management is initiated within 3 weeks of onset of symptoms. Lamellar keratoplasty has been shown to have good outcome in cases needing surgery. Since the clinical features of AK in nonusers of CL are different, it will be important for ophthalmologists to be aware of the scenario wherein to suspect this infection. Medical treatment is successful if the disease is diagnosed early and management is initiated soon.

Research paper thumbnail of Chapter-03 Surgery for Ocular Surface Reconstruction

Mastering Phacoemulsification in Difficult Situations, 2008

Research paper thumbnail of Isolated giant xanthogranuloma of the orbit

Indian journal of …, 2007

Xanthogranuloma is an uncommon tumor in the orbit and is usually associated with systemic disease... more Xanthogranuloma is an uncommon tumor in the orbit and is usually associated with systemic diseases or blood abnormalities. We report an extremely rare presentation of isolated orbital xanthogranuloma unassociated with any systemic disease, hematological or biochemical ...

Research paper thumbnail of Ophthalmic applications of preserved human amniotic membrane: A review of current indications

Cell and Tissue Banking, 2004

Preserved human amniotic membrane (AM) is currently being used for a wide spectrum of ocular surf... more Preserved human amniotic membrane (AM) is currently being used for a wide spectrum of ocular surface disorders. The AM has a basement membrane, which promotes epithelial cell migration and adhesion. The presence of a unique avascular stromal matrix reduces inflammation, neovascularization and fibrosis. The basic tenets of amniotic membrane transplantation (AMT) are to promote re-epithelialization, to reconstruct the ocular surface and to provide symptomatic relief from surface aberrations. AMT is a useful technique for reconstruction of surface defects resulting from removal of surface tumors and symblephara. AMT has effectively restored a stable corneal epithelium in eyes with, persistent epithelial defects and corneal ulcers. In the setting of acute ocular burns and SJS, AMT has satisfactorily reduced scarring and inflammation. AMT alone may be an effective alternative for partial limbal stem cell deficiency. However remarkable improvements in surface stability have resulted from concurrent AMT and limbal stem cell transplantation, wherein the limbal grafts are obtained from the normal fellow eye, living relative or cadaveric eye. In severe or bilateral cases, well being of the donor eye is a major concern. Currently, the most unique application of preserved human AM in ophthalmology is its use as a substrate for ex-vivo expansion of corneal and conjunctival epithelium. In this novel technique of tissue engineering, epithelial stem cells can be safely harvested and expanded on denuded AM. The resultant composite cultured tissue has been successfully transplanted to restore vision, as well as the structure and function of damaged ocular surfaces.

Research paper thumbnail of Cultivated limbal stem cell transplantation for ocular surface reconstruction

Clinical ophthalmology (Auckland, N.Z.), 2008

Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as v... more Severe damage to cell repair mechanisms of the limbal region can lead to many disorders such as vascularized conjunctivalization, keratinization, corneal scarring, and corneal opacification, collectively described as limbal stem cell deficiency (LSCD). Limbal stem cell deficiency may occur as a result of depletion of stem cells or destruction of their stromal niche. In such cases, apart from conventional corneal transplantation, limbal stem cell transplantation would be needed to restore vision. Limbal stem cells may be replenished by autologous limbal transplants from the healthy fellow eye in unilateral cases, and allografts from living related donors or cadaveric donors in bilateral cases. The induction of iatrogenic LSCD and its sequelae in donor eyes have motivated researchers to cultivate sheets of limbal epithelium ex vivo, from small fragments of donor tissue for the purpose of ocular surface reconstruction.

Research paper thumbnail of Ocular surface squamous neoplasia in Papillon–Lefevre syndrome

PURPOSE: To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with P... more PURPOSE: To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with Papillon-Lefevre syndrome. DESIGN: Interventional case report. METHODS: A 14-year-old boy presented with a progressively growing limbal lesion in the right eye for 2 months. He had associated erythematous scaly lesions on the elbows, knees, and feet with periodontosis suggestive of Papillon-Lefevre syndrome. An excision biopsy of the limbal tumor and a skin biopsy was performed. RESULTS: The limbal tumor showed features of carcinoma in situ with clear margins. The skin biopsy showed epidermal hyperplasia and hyperkeratosis with perivascular infiltrates, consistent with Papillon-Lefevre syndrome. CONCLUSIONS: Ocular surface squamous neoplasia may occur in patients with Papillon-Lefevre syndrome, an association that to the best of our knowledge has not been previously reported. (Am J Ophthalmol 2005;139: 207-209.

Research paper thumbnail of Neoadjuvant Chemotherapy in the Management of Sebaceous Gland Carcinoma of the Eyelid With Regional Lymph Node Metastasis

Ophthalmic Plastic and Reconstructive Surgery, 2005

A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower ey... more A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower eyelid with orbital extension and regional lymph node metastasis was treated with neoadjuvant chemotherapy, using a combination of carboplatin and 5-fluorouracil. Eyelid-sparing orbital exenteration was performed after 3 cycles of chemotherapy, followed by radiotherapy to the regional lymph nodes. Subsequently, 3 cycles of adjuvant chemotherapy were administered. Significant eyelid and orbital tumor volume reduction was achieved with neoadjuvant chemotherapy, making eyelid-sparing orbital exenteration possible. Chemotherapy also spared the patient from radical neck dissection. The patient had limited morbidity and was free of local, regional, and systemic disease at 26 months of follow-up.

Research paper thumbnail of Ophthalmic applications of preserved human amniotic membrane: A review of current indications

Cell and Tissue Banking, 2004

Preserved human amniotic membrane (AM) is currently being used for a wide spectrum of ocular surf... more Preserved human amniotic membrane (AM) is currently being used for a wide spectrum of ocular surface disorders. The AM has a basement membrane, which promotes epithelial cell migration and adhesion. The presence of a unique avascular stromal matrix reduces inflammation, neovascularization and fibrosis. The basic tenets of amniotic membrane transplantation (AMT) are to promote re-epithelialization, to reconstruct the ocular surface and to provide symptomatic relief from surface aberrations. AMT is a useful technique for reconstruction of surface defects resulting from removal of surface tumors and symblephara. AMT has effectively restored a stable corneal epithelium in eyes with, persistent epithelial defects and corneal ulcers. In the setting of acute ocular burns and SJS, AMT has satisfactorily reduced scarring and inflammation. AMT alone may be an effective alternative for partial limbal stem cell deficiency. However remarkable improvements in surface stability have resulted from concurrent AMT and limbal stem cell transplantation, wherein the limbal grafts are obtained from the normal fellow eye, living relative or cadaveric eye. In severe or bilateral cases, well being of the donor eye is a major concern. Currently, the most unique application of preserved human AM in ophthalmology is its use as a substrate for ex-vivo expansion of corneal and conjunctival epithelium. In this novel technique of tissue engineering, epithelial stem cells can be safely harvested and expanded on denuded AM. The resultant composite cultured tissue has been successfully transplanted to restore vision, as well as the structure and function of damaged ocular surfaces.

Research paper thumbnail of Cataract surgery in patients with Mooren's ulcer

Journal of Cataract & Refractive Surgery, 2005

Methods: In this interventional case series, the medical records of 6 patients with Mooren's ulce... more Methods: In this interventional case series, the medical records of 6 patients with Mooren's ulcer who had cataract surgery were retrospectively reviewed. Five patients had uneventful extracapsular cataract extraction with intraocular lens (IOL) implantation, and 1 patient had phacoemulsification with IOL implantation. The visual acuity and postoperative course of the patients were reviewed. The patients were followed to detect, and if present treat, a recurrence of Mooren's ulcer.

Research paper thumbnail of Amniotic membrane transplantation: A review of current indications in the management of ophthalmic disorders

Indian Journal of Ophthalmology, 2007

Research paper thumbnail of Polycystic Echinococcosis of the Orbit

American Journal of Ophthalmology, 2005

2. Reid SN, Yamashita C, Farber DB. Retinoschisin, a photoreceptor-secreted protein, and its inte... more 2. Reid SN, Yamashita C, Farber DB. Retinoschisin, a photoreceptor-secreted protein, and its interaction with bipolar and muller cells. PURPOSE: To report a case of polycystic echinococcosis of the orbit caused by Echinococcus oligarthrus. DESIGN: Interventional case report METHODS: A 14-year-old girl presented with a massive proptosis of the right eye of 9 years duration and loss of vision. The eye was phthisic, and a cystic mass was palpable. Computed tomography scan showed closely packed multiple orbital cysts with destruction of the medial orbital wall. Surgical exploration was performed. RESULTS: The phthisic eye was enucleated. Dissection of the outer fibrous capsule yielded approximately 30 intact translucent white cysts of various sizes that were suggestive of polycystic echinococcosis. The diagnosis of echinococcosis was confirmed on histopathologic evaluation. The specific diagnosis of E oligarthrus was made on the basis of the presence of straight-backed hooks and central guards. CONCLUSION: Polycystic echinococcosis of the orbit caused by E oligarthrus is rare. It may be an entirely new entity or hitherto unrecognized form of orbital echinococcosis. (Am J Ophthalmol 2005;140:561-563. PURPOSE: To assess the role of systemic non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of inflammatory cystoid macular edema (iCME). DESIGN: Pilot study. METHODS: We included 66 patients with iCME and treated them with naproxen (2 ؋ 250 mg daily; n ‫؍‬ 28) or rofecoxib (1 ؋ 25 mg daily; n ‫؍‬ 38). After 4 months of therapy, visual acuity and inflammation activity were measured. We evaluated the grade of CME, retinal vasculitis, and papillary leakage with fluorescein angiography. RESULTS: No clear effect of NSAIDs on iCME, visual acuity, and intraocular inflammation was observed. A beneficial effect was noted in less than 8% of the affected eyes. The drop-out rate after 4 months of treatment was 52%, because of adverse effects or inefficacy of the treatment. Improvement of visual acuity was slightly better in patients who were treated with naproxen compared with rofecoxib (P < .05). CONCLUSION: Systemic NSAIDs have a limited role (if any) in the treatment of iCME. (Am J Ophthalmol 2005;140:563-564.

Research paper thumbnail of Ocular surface squamous neoplasia in Papillon–Lefevre syndrome

American Journal of Ophthalmology, 2005

PURPOSE: To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with P... more PURPOSE: To report the occurrence of ocular surface squamous neoplasia (OSSN) in a patient with Papillon-Lefevre syndrome. DESIGN: Interventional case report. METHODS: A 14-year-old boy presented with a progressively growing limbal lesion in the right eye for 2 months. He had associated erythematous scaly lesions on the elbows, knees, and feet with periodontosis suggestive of Papillon-Lefevre syndrome. An excision biopsy of the limbal tumor and a skin biopsy was performed. RESULTS: The limbal tumor showed features of carcinoma in situ with clear margins. The skin biopsy showed epidermal hyperplasia and hyperkeratosis with perivascular infiltrates, consistent with Papillon-Lefevre syndrome. CONCLUSIONS: Ocular surface squamous neoplasia may occur in patients with Papillon-Lefevre syndrome, an association that to the best of our knowledge has not been previously reported. (Am J Ophthalmol 2005;139: 207-209.

Research paper thumbnail of Cataract surgery in Stevens-Johnson syndrome

Journal of Cataract & Refractive Surgery, 2005