Sanket Gudekar - Academia.edu (original) (raw)

Papers by Sanket Gudekar

Indian Journal of Pharmaceutical Sciences, 2006

A reversed phase high performance liquid chromatographic method has been developed using Shimadzu... more A reversed phase high performance liquid chromatographic method has been developed using Shimadzu HPLC-VP series, LC-10 ATV pump, SPD10 AVP and C8 column, for simultaneous determination of pseudoephedrine hydrochloride and cetrizine hydrochloride in three marketed tablet formulations (extended release). The mobile phase consists of phosphate buffer of pH 7.0 and acetonitrile HPLC grade in the ratio of 1:1. The flow rate was maintained at 1 ml/min and the ultraviolet detection was done at 242 nm, which is the isosbestic point. Linearity coefficients, assay values, recovery studies and repeatability studies showed that the method is accurate and precise. * n = 9; PEH is pseudo ephedrine hydrochloride and CEH is cetrizine hydrochloride. *Values are mean of three determinations; PEH is pseudo ephedrine hydrochloride and CEH is cetrizine hydrochloride. Brand A-Alerid, Brand B-Cetrizet, Brand C-Zyncet.

This paper describes the simple, economic, selective, and precise RP-HPLC method for the simultan... more This paper describes the simple, economic, selective, and precise RP-HPLC method for the simultaneous determination of Amlodipine, Telmisartan, Hydrochlorothiazide, Atenolol and Losartan either as single or in combination with each other. The proposed method utilizes Inertsil C18 column (100 mm, 4.6 mm id., 5 µm) and the separation was achieved by using gradient method. Mobile phase-A contains 0.1% Orthophosphoric acid and Mobile phase-B comprised of a mixture of Acetonitrile and Methanol in the ratio of 95:5 v/v, with flow rate of 1.5 mL/min and column temperature was maintained at 40 0 C. Quantitation was achieved with UV detection at 217 nm. The method was linear over wide concentration range of 0.08-0.12 mg/mL for Atenolol, 0.020.03 mg/mL for Hydrochlorothiazide, 0.064- 0.096 mg/mL for Telmisartan, 0.008-0.012 mg/mL for Amlodipine and 0.08-0.12 mg/mL for Losartan. The method was validated for specificity, linearity, robustness, precision and accuracy. Method is specific for acti...

La presente invention concerne des procedes de preparation d'un antagoniste du recepteur endo... more La presente invention concerne des procedes de preparation d'un antagoniste du recepteur endothelial. La presente invention concerne en particulier la synthese de 4-tert-butyl-n-[ 6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl ] benzene sulfonamide (bosentan).

N-alkylation of 2,6-diethyl aniline and its derivatives using various aldehydes by Pd/C catalyst ... more N-alkylation of 2,6-diethyl aniline and its derivatives using various aldehydes by Pd/C catalyst in aqueous 2propanol solvent using ammonium formate as insitu hydrogen donor facilitate the formation of N-ethyl-2,6-diethyl aniline and its derivatives which is the simple method of formation of this compound. The reaction proceeds smoothly and selectively with excellent yield at room temperature .Our method presents a facile, economical and environmentally benign alternative for reductive amination.

Bosentan Monohydrate(1), is the first of a new drug class, anEndothelinreceptor antagonist and be... more Bosentan Monohydrate(1), is the first of a new drug class, anEndothelinreceptor antagonist and belongs to of highly substituted pyrimidine derivatives with no c hiral centres used for treatment of pulmonary arter ial hypertension(PAH).One of the known impurity in Bose ntan Monohydrate is,N,N’-(ethane-1,2diyl{oxy[5-(2methoxy)-2,2’-bipyrimidine-6,4-diyl]})bis(4-tert-bu tylbenzenesulphonamide(Dimer)(2), is formed during the laboratory optimization and later during its bulk s ynthesis. This impurity is synthesi zed by novel method and characterised it by H-NMR, I.R., & Mass Spectroscopy.

La presente invention concerne le domaine de la synthese organique et concerne la synthese d'... more La presente invention concerne le domaine de la synthese organique et concerne la synthese d'intermediaires specifiques adaptes a la preparation de composes de la triazolopyrimidine tels que le ticagrelor.

An RP-HPLC method for the simultaneous determination of Paracetamol, Guaifenesin, Ambroxol, Pheny... more An RP-HPLC method for the simultaneous determination of Paracetamol, Guaifenesin, Ambroxol, Phenylephrine Hydrochloride, and Chlorpheniramine Maleate in tablets was developed and validated as per ICH & FDA guidelines. The separation was achieved with a 228 mm x 4.6 mm, 5 µm C18 column, by using a simple linear gradient. The mobile phase A was 0.01M sodium perchlorate, monohydrate, pH 3.0 and mobile phase B was Acetonitrile. The flow rate was 1.5 mL/min and column temperature was maintained at 25ᵒC. The gradient separation was achieved within 15 minutes. The linearity of the proposed method was investigated in the range 0.0008-0.0012 mg/mL (r2= 0.999) for Phenylephrine, 0.04-0.06 mg/mL (r2= 0.999) for Paracetamol, 0.008-0.012 mg/mL (r2= 1.000) for Guaifenesin, 0.0024-0.0036 mg/mL (r2= 1.000) for Ambroxol, and 0.00016-0.00024 mg/mL (r2= 1.000) for Chlorpheniramine. Blank and placebo did not disturb the detection of Paracetamol, Guaifenesin, Ambroxol, Phenylephrine, and Chlorpheniramin...

Indian Journal of Pharmaceutical Sciences, 2006

A reversed phase high performance liquid chromatographic method has been developed using Shimadzu... more A reversed phase high performance liquid chromatographic method has been developed using Shimadzu HPLC-VP series, LC-10 ATV pump, SPD10 AVP and C8 column, for simultaneous determination of pseudoephedrine hydrochloride and cetrizine hydrochloride in three marketed tablet formulations (extended release). The mobile phase consists of phosphate buffer of pH 7.0 and acetonitrile HPLC grade in the ratio of 1:1. The flow rate was maintained at 1 ml/min and the ultraviolet detection was done at 242 nm, which is the isosbestic point. Linearity coefficients, assay values, recovery studies and repeatability studies showed that the method is accurate and precise. * n = 9; PEH is pseudo ephedrine hydrochloride and CEH is cetrizine hydrochloride. *Values are mean of three determinations; PEH is pseudo ephedrine hydrochloride and CEH is cetrizine hydrochloride. Brand A-Alerid, Brand B-Cetrizet, Brand C-Zyncet.

This paper describes the simple, economic, selective, and precise RP-HPLC method for the simultan... more This paper describes the simple, economic, selective, and precise RP-HPLC method for the simultaneous determination of Amlodipine, Telmisartan, Hydrochlorothiazide, Atenolol and Losartan either as single or in combination with each other. The proposed method utilizes Inertsil C18 column (100 mm, 4.6 mm id., 5 µm) and the separation was achieved by using gradient method. Mobile phase-A contains 0.1% Orthophosphoric acid and Mobile phase-B comprised of a mixture of Acetonitrile and Methanol in the ratio of 95:5 v/v, with flow rate of 1.5 mL/min and column temperature was maintained at 40 0 C. Quantitation was achieved with UV detection at 217 nm. The method was linear over wide concentration range of 0.08-0.12 mg/mL for Atenolol, 0.020.03 mg/mL for Hydrochlorothiazide, 0.064- 0.096 mg/mL for Telmisartan, 0.008-0.012 mg/mL for Amlodipine and 0.08-0.12 mg/mL for Losartan. The method was validated for specificity, linearity, robustness, precision and accuracy. Method is specific for acti...

La presente invention concerne des procedes de preparation d'un antagoniste du recepteur endo... more La presente invention concerne des procedes de preparation d'un antagoniste du recepteur endothelial. La presente invention concerne en particulier la synthese de 4-tert-butyl-n-[ 6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl ] benzene sulfonamide (bosentan).

N-alkylation of 2,6-diethyl aniline and its derivatives using various aldehydes by Pd/C catalyst ... more N-alkylation of 2,6-diethyl aniline and its derivatives using various aldehydes by Pd/C catalyst in aqueous 2propanol solvent using ammonium formate as insitu hydrogen donor facilitate the formation of N-ethyl-2,6-diethyl aniline and its derivatives which is the simple method of formation of this compound. The reaction proceeds smoothly and selectively with excellent yield at room temperature .Our method presents a facile, economical and environmentally benign alternative for reductive amination.

Bosentan Monohydrate(1), is the first of a new drug class, anEndothelinreceptor antagonist and be... more Bosentan Monohydrate(1), is the first of a new drug class, anEndothelinreceptor antagonist and belongs to of highly substituted pyrimidine derivatives with no c hiral centres used for treatment of pulmonary arter ial hypertension(PAH).One of the known impurity in Bose ntan Monohydrate is,N,N’-(ethane-1,2diyl{oxy[5-(2methoxy)-2,2’-bipyrimidine-6,4-diyl]})bis(4-tert-bu tylbenzenesulphonamide(Dimer)(2), is formed during the laboratory optimization and later during its bulk s ynthesis. This impurity is synthesi zed by novel method and characterised it by H-NMR, I.R., & Mass Spectroscopy.

La presente invention concerne le domaine de la synthese organique et concerne la synthese d'... more La presente invention concerne le domaine de la synthese organique et concerne la synthese d'intermediaires specifiques adaptes a la preparation de composes de la triazolopyrimidine tels que le ticagrelor.

An RP-HPLC method for the simultaneous determination of Paracetamol, Guaifenesin, Ambroxol, Pheny... more An RP-HPLC method for the simultaneous determination of Paracetamol, Guaifenesin, Ambroxol, Phenylephrine Hydrochloride, and Chlorpheniramine Maleate in tablets was developed and validated as per ICH & FDA guidelines. The separation was achieved with a 228 mm x 4.6 mm, 5 µm C18 column, by using a simple linear gradient. The mobile phase A was 0.01M sodium perchlorate, monohydrate, pH 3.0 and mobile phase B was Acetonitrile. The flow rate was 1.5 mL/min and column temperature was maintained at 25ᵒC. The gradient separation was achieved within 15 minutes. The linearity of the proposed method was investigated in the range 0.0008-0.0012 mg/mL (r2= 0.999) for Phenylephrine, 0.04-0.06 mg/mL (r2= 0.999) for Paracetamol, 0.008-0.012 mg/mL (r2= 1.000) for Guaifenesin, 0.0024-0.0036 mg/mL (r2= 1.000) for Ambroxol, and 0.00016-0.00024 mg/mL (r2= 1.000) for Chlorpheniramine. Blank and placebo did not disturb the detection of Paracetamol, Guaifenesin, Ambroxol, Phenylephrine, and Chlorpheniramin...