Jacinta Santos - Academia.edu (original) (raw)
Papers by Jacinta Santos
Archives of Endocrinology and Metabolism
Objectives: Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therap... more Objectives: Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therapy response in patients with cT1 and cT2 papillary thyroid carcinoma (PTC). Subjects and methods: Retrospective study of 970 consecutive patients, who underwent surgery for PTC between 2000 and 2016. All patients had: tumours ≤ 4 cm, apparent complete tumour resection, without clinically apparent lymph node or distant metastasis at diagnosis and nonaggressive histologic variant. Results: Based on the finding of MEE, 175 (18.0%) patients were upstaged to T3. They were older (53.9 versus 50.6 years; P = 0.004) and were more prone to have multifocal tumours (38.2% versus 24.8%; P = 0.001). Radioiodine ablation therapy (RAI) was administered more often to MEE patients (92% versus 40.5%; P < 0.001), as well as prophylactic lymph node resection (35.4% versus 28.6%, P = 0.048). They were more likely to have biochemical incomplete response (4% versus 0.3%; P = 0.03) at the end of the follow-up period. There was no significant association between MEE and recurrence rate, persistence of disease or disease-specific mortality. Conclusion: These results support the changes made to the latest edition of the TNM staging system, regarding MEE. Although incomplete biochemical response is more common in these patients, it does not seem to affect their prognosis.
International Journal of Endocrinology
Introduction. The diagnostic value of calcitonin (CT) measurement in fine-needle aspirate washout... more Introduction. The diagnostic value of calcitonin (CT) measurement in fine-needle aspirate washout (FNA-CT) for medullary thyroid cancer (MTC) lymph node (LN) metastases remains to be determined. It may increase the diagnostic sensitivity, but data on this subject is sparse. Objective. Our study aimed to evaluate the utility of FNA-CT in the diagnosis of LN metastases of MTC. Methods. We retrospectively investigated, in our institutional database, 69 consecutive FNA LN cytology from 42 patients who underwent FNA cytology and CT measurement in needle washout for suspicious LN between 2012 and 2017. Results. From the total of 69 FNA, 30 (43.4%) were performed in patients with personal history of MTC. MTC was detected in 19 FNA cytology (27.5%), and CT was detectable in needle washout in 23 cases (median = 2014 pg/mL; interquartile range = 490–15111 pg/mL). Based on the combined results of FNA-CT and FNA cytology, LN surgical resection was performed in 33 cases (47.8%). Histology report...
Journal of the Endocrine Society
Endocrinology, diabetes & metabolism case reports, 2018
Gastric neuroendocrine neoplasms (GNENs) are classified into three types according to their aetio... more Gastric neuroendocrine neoplasms (GNENs) are classified into three types according to their aetiology. We present a clinical case of a female patient of 66 years and a well-differentiated (grade 2), type 3 GNEN with late liver metastasis (LM). The patient underwent surgical excision of a gastric lesion at 50 years of age, without any type of follow-up. Sixteen years later, she was found to have a neuroendocrine tumour (NET) metastatic to the liver. The histological review of the gastric lesion previously removed confirmed that it was a NET measuring 8 mm, pT1NxMx (Ki67 = 4%). Ga-DOTANOC PET/CT reported two LM and a possible pancreatic tumour/gastric adenopathy. Biopsies of the lesion were repeatedly inconclusive. She had a high chromogranin A, normal gastrin levels and negative anti-parietal cell and intrinsic factor antibodies, which is suggestive of type 3 GNEN. She underwent total gastrectomy and liver segmentectomies (segment IV and VII) with proven metastasis in two perigastric...
The Endocrine Society's 93rd Annual Meeting & Expo, June 4–7, 2011 - Boston, 2011
Endocrine Abstracts, 2016
Endocrine …, 2008
We describe the case of a 33 years old female patient with full-blown clinical picture (weight ex... more We describe the case of a 33 years old female patient with full-blown clinical picture (weight excess, hirsutism, hypertension, muscular weakness, moon facies, buffalo hump and supraclavicular fat pads) since about a year. Repeated FUC showed fluctuating values 112, 200 and 68 ...
Endocrine …, 2010
1 Serviço de Endocrinologia, Diabetes e Metabolismo dos Hospitais da Universidade de Coimbra-EPE,... more 1 Serviço de Endocrinologia, Diabetes e Metabolismo dos Hospitais da Universidade de Coimbra-EPE, Coimbra, Portugal; 2 Serviço de Endocrinologia do Instituto Português de Oncologia Francisco Gentil de Coimbra-EPE, Coimbra, Portugal; 3 Serviço de Neurocirurgia dos ...
Endocrine …, 2010
Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroi... more Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroid hormone (PTH), typically leading to hypercalcaemia. This disorder is more common than previously expected, since it is frequently diagnosed in asymptomatic patients.
Endocrine …, 2010
Introduction: The association of autoimmune diseases in the same individual is common. It is well... more Introduction: The association of autoimmune diseases in the same individual is common. It is well documented that Graves' disease (GD) is associated to various autoimmune diseases, including: pernicious anemia, vitiligo, type 1 diabetes, Addison's disease, systemic ...
Endocrine …, 2009
Background: Insulinomas are rare neuroendocrine tumours (4 cases/million patients per year), repr... more Background: Insulinomas are rare neuroendocrine tumours (4 cases/million patients per year), representing an important cause of hyperinsulinemia. Usually are benign and sporadic, but can be part of multiple endocrine neoplasias. To establish the diagnosis it is ...
Clinical report: In December 2007, a 34 years-old women presented with palpitations and tachycard... more Clinical report: In December 2007, a 34 years-old women presented with palpitations and tachycardia, but normal blood pressure. She had a previous history of surgeries, performed in another hospital: left adrenalectomy due to pheochromocytoma, spinal and cerebellar ...
J Appl Oral Sci, Sep 1, 2004
Brazilian Dental Journal, Apr 1, 2009
Archives of Endocrinology and Metabolism
Objectives: Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therap... more Objectives: Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therapy response in patients with cT1 and cT2 papillary thyroid carcinoma (PTC). Subjects and methods: Retrospective study of 970 consecutive patients, who underwent surgery for PTC between 2000 and 2016. All patients had: tumours ≤ 4 cm, apparent complete tumour resection, without clinically apparent lymph node or distant metastasis at diagnosis and nonaggressive histologic variant. Results: Based on the finding of MEE, 175 (18.0%) patients were upstaged to T3. They were older (53.9 versus 50.6 years; P = 0.004) and were more prone to have multifocal tumours (38.2% versus 24.8%; P = 0.001). Radioiodine ablation therapy (RAI) was administered more often to MEE patients (92% versus 40.5%; P < 0.001), as well as prophylactic lymph node resection (35.4% versus 28.6%, P = 0.048). They were more likely to have biochemical incomplete response (4% versus 0.3%; P = 0.03) at the end of the follow-up period. There was no significant association between MEE and recurrence rate, persistence of disease or disease-specific mortality. Conclusion: These results support the changes made to the latest edition of the TNM staging system, regarding MEE. Although incomplete biochemical response is more common in these patients, it does not seem to affect their prognosis.
International Journal of Endocrinology
Introduction. The diagnostic value of calcitonin (CT) measurement in fine-needle aspirate washout... more Introduction. The diagnostic value of calcitonin (CT) measurement in fine-needle aspirate washout (FNA-CT) for medullary thyroid cancer (MTC) lymph node (LN) metastases remains to be determined. It may increase the diagnostic sensitivity, but data on this subject is sparse. Objective. Our study aimed to evaluate the utility of FNA-CT in the diagnosis of LN metastases of MTC. Methods. We retrospectively investigated, in our institutional database, 69 consecutive FNA LN cytology from 42 patients who underwent FNA cytology and CT measurement in needle washout for suspicious LN between 2012 and 2017. Results. From the total of 69 FNA, 30 (43.4%) were performed in patients with personal history of MTC. MTC was detected in 19 FNA cytology (27.5%), and CT was detectable in needle washout in 23 cases (median = 2014 pg/mL; interquartile range = 490–15111 pg/mL). Based on the combined results of FNA-CT and FNA cytology, LN surgical resection was performed in 33 cases (47.8%). Histology report...
Journal of the Endocrine Society
Endocrinology, diabetes & metabolism case reports, 2018
Gastric neuroendocrine neoplasms (GNENs) are classified into three types according to their aetio... more Gastric neuroendocrine neoplasms (GNENs) are classified into three types according to their aetiology. We present a clinical case of a female patient of 66 years and a well-differentiated (grade 2), type 3 GNEN with late liver metastasis (LM). The patient underwent surgical excision of a gastric lesion at 50 years of age, without any type of follow-up. Sixteen years later, she was found to have a neuroendocrine tumour (NET) metastatic to the liver. The histological review of the gastric lesion previously removed confirmed that it was a NET measuring 8 mm, pT1NxMx (Ki67 = 4%). Ga-DOTANOC PET/CT reported two LM and a possible pancreatic tumour/gastric adenopathy. Biopsies of the lesion were repeatedly inconclusive. She had a high chromogranin A, normal gastrin levels and negative anti-parietal cell and intrinsic factor antibodies, which is suggestive of type 3 GNEN. She underwent total gastrectomy and liver segmentectomies (segment IV and VII) with proven metastasis in two perigastric...
The Endocrine Society's 93rd Annual Meeting & Expo, June 4–7, 2011 - Boston, 2011
Endocrine Abstracts, 2016
Endocrine …, 2008
We describe the case of a 33 years old female patient with full-blown clinical picture (weight ex... more We describe the case of a 33 years old female patient with full-blown clinical picture (weight excess, hirsutism, hypertension, muscular weakness, moon facies, buffalo hump and supraclavicular fat pads) since about a year. Repeated FUC showed fluctuating values 112, 200 and 68 ...
Endocrine …, 2010
1 Serviço de Endocrinologia, Diabetes e Metabolismo dos Hospitais da Universidade de Coimbra-EPE,... more 1 Serviço de Endocrinologia, Diabetes e Metabolismo dos Hospitais da Universidade de Coimbra-EPE, Coimbra, Portugal; 2 Serviço de Endocrinologia do Instituto Português de Oncologia Francisco Gentil de Coimbra-EPE, Coimbra, Portugal; 3 Serviço de Neurocirurgia dos ...
Endocrine …, 2010
Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroi... more Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroid hormone (PTH), typically leading to hypercalcaemia. This disorder is more common than previously expected, since it is frequently diagnosed in asymptomatic patients.
Endocrine …, 2010
Introduction: The association of autoimmune diseases in the same individual is common. It is well... more Introduction: The association of autoimmune diseases in the same individual is common. It is well documented that Graves' disease (GD) is associated to various autoimmune diseases, including: pernicious anemia, vitiligo, type 1 diabetes, Addison's disease, systemic ...
Endocrine …, 2009
Background: Insulinomas are rare neuroendocrine tumours (4 cases/million patients per year), repr... more Background: Insulinomas are rare neuroendocrine tumours (4 cases/million patients per year), representing an important cause of hyperinsulinemia. Usually are benign and sporadic, but can be part of multiple endocrine neoplasias. To establish the diagnosis it is ...
Clinical report: In December 2007, a 34 years-old women presented with palpitations and tachycard... more Clinical report: In December 2007, a 34 years-old women presented with palpitations and tachycardia, but normal blood pressure. She had a previous history of surgeries, performed in another hospital: left adrenalectomy due to pheochromocytoma, spinal and cerebellar ...
J Appl Oral Sci, Sep 1, 2004
Brazilian Dental Journal, Apr 1, 2009