Sara Ashraf - Academia.edu (original) (raw)
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Papers by Sara Ashraf
Cureus, 2019
Juvenile Parkinson's disease (JPD) is a rare movement disorder that presents before the age of 21... more Juvenile Parkinson's disease (JPD) is a rare movement disorder that presents before the age of 21 years. Kufor-Rekab syndrome (KRS) is one of the distinct types of JPD caused by the ATP13A2 mutation and inherited as an autosomal recessive. The pathogenesis of KRS is related to an interrelated metabolism of ATP13A2 with Mn+2 and Zn+2, bioenergetics of mitochondria, autophagy lysosomal dysfunction, and synuclein metabolism. Clinically, KRS has a variable phenotype and may present with pyramidal or extrapyramidal symptoms and cognitive impairment. Early diagnosis of KRS is important as most of these patients are levodoparesponsive and genetic counseling and screening is important for the whole family. We present a case of a 16-year-old boy who presented with tremors and walking difficulty. His physical examination showed an expressionless face, decrease in eye blink frequency, and slow vertical saccadic eye movements. His movements were slow. All laboratory investigations were normal, except the genetic study, which led to the diagnosis of KRS.
Optik, 2021
In this study, Sr 2 La 8-x (SiO 4) 6 O 2 :xSm 3+ (where x=(0.01 ≤ x ≤ 0.11)) phosphors were prepa... more In this study, Sr 2 La 8-x (SiO 4) 6 O 2 :xSm 3+ (where x=(0.01 ≤ x ≤ 0.11)) phosphors were prepared successfully via the sol-gel route. Their structural properties were evaluated through fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) measurements. The XRD patterns confirmed the purity of the prepared compound that had an average crystallite size of ~38.8 nm. From the FTIR spectra, various stretching and bending vibrations of the SiO 4 units were identified. The band observed at 540 cm − 1 was attributed to the normal vibration mode of La-O. The optical properties of the prepared phosphor were assessed through diffuse reflection spectroscopy and photoluminescence measurements. The diffuse reflectance spectrum exhibited seven peaks from the Sm 3+ ions corresponding to f-f transitions from the ground state, 6 H 5/2 , to the excited states, 6
Cureus, 2019
Juvenile Parkinson's disease (JPD) is a rare movement disorder that presents before the age of 21... more Juvenile Parkinson's disease (JPD) is a rare movement disorder that presents before the age of 21 years. Kufor-Rekab syndrome (KRS) is one of the distinct types of JPD caused by the ATP13A2 mutation and inherited as an autosomal recessive. The pathogenesis of KRS is related to an interrelated metabolism of ATP13A2 with Mn+2 and Zn+2, bioenergetics of mitochondria, autophagy lysosomal dysfunction, and synuclein metabolism. Clinically, KRS has a variable phenotype and may present with pyramidal or extrapyramidal symptoms and cognitive impairment. Early diagnosis of KRS is important as most of these patients are levodoparesponsive and genetic counseling and screening is important for the whole family. We present a case of a 16-year-old boy who presented with tremors and walking difficulty. His physical examination showed an expressionless face, decrease in eye blink frequency, and slow vertical saccadic eye movements. His movements were slow. All laboratory investigations were normal, except the genetic study, which led to the diagnosis of KRS.
Optik, 2021
In this study, Sr 2 La 8-x (SiO 4) 6 O 2 :xSm 3+ (where x=(0.01 ≤ x ≤ 0.11)) phosphors were prepa... more In this study, Sr 2 La 8-x (SiO 4) 6 O 2 :xSm 3+ (where x=(0.01 ≤ x ≤ 0.11)) phosphors were prepared successfully via the sol-gel route. Their structural properties were evaluated through fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) measurements. The XRD patterns confirmed the purity of the prepared compound that had an average crystallite size of ~38.8 nm. From the FTIR spectra, various stretching and bending vibrations of the SiO 4 units were identified. The band observed at 540 cm − 1 was attributed to the normal vibration mode of La-O. The optical properties of the prepared phosphor were assessed through diffuse reflection spectroscopy and photoluminescence measurements. The diffuse reflectance spectrum exhibited seven peaks from the Sm 3+ ions corresponding to f-f transitions from the ground state, 6 H 5/2 , to the excited states, 6