Sara Martinez - Academia.edu (original) (raw)

Papers by Sara Martinez

Agriculture

The valorization of municipal solid waste (MSW) can serve as an organic amendment in agriculture ... more The valorization of municipal solid waste (MSW) can serve as an organic amendment in agriculture while reducing solid waste accumulation in the environment. This research aimed to evaluate the valorization of a bio-stabilized MSW amendment for the production of faba bean (Vicia faba L.) crop. For this purpose, biomass production and growth, as well as, seed yield and seed components, seed nutrient accumulation, plant pigments, soil properties, and microorganisms were evaluated in comparison with faba bean mineral fertilization in a greenhouse experiment. The results demonstrated that the bio-stabilized MSW amendment achieved similar biomass production, plant growth, seed yield, nitrogen and protein content, and pigment content as the mineral fertilization treatment. On the other hand, the organic fertilization did not exhibit significant effects on the yield components number of pods per plant, and number of seeds per pod, and nutrient accumulation in seeds with respect to mineral a...

Agriculture

The goal of this study was to provide quantitative agronomic data and environmental performance t... more The goal of this study was to provide quantitative agronomic data and environmental performance through a life cycle assessment of camelina in a crop rotation. For this purpose, camelina [Camelina sativa (L.) Crantz] was included in a crop rotation (camelina-barley [Hordeum vulgare (L.)]-camelina) fertilized with two organic fertilizers (dewatered sludge and composted sludge) during three growing seasons (2015–2018). Three treatments were considered in this experimental study of 0.018 ha: (1) Fertilization with composted sludge (15 t ha−1), (2) fertilization with dewatered sludge (35 t ha−1), and (3) control treatment without fertilization. Results showed that camelina’s yield was affected by climatic conditions, ranging from 0.9 to 1.4 t ha−1 in the first season (2015/2016) and the third season (2017/2018 and did not present significant differences between treatments. The yield components with a positive response to organic fertilization were number of silicles, number of seeds per...

Applied Sciences

This work presents an integrated thermal-electrical simulation model, capable of taking into acco... more This work presents an integrated thermal-electrical simulation model, capable of taking into account the thermal and electrical effects of the battery and photovoltaic panels for each instant of time in a given orbit and attitude. Using the physical equations that govern the thermal and electrical models involved during a CubeSat operation, the proposed integrated model can estimate the temperature and energy conditions of the battery, not only in an isolated way but also in considering the mutual effects on the system. Besides, special attention is given to photovoltaic panels used in the energy harvesting process, whose performance is affected by irradiance and temperature along the orbit. The integrated model can be useful for engineers when developing the subsystems of their CubeSats, taking into account, for example, the battery temperature control through a heater. Simulations were performed to illustrate the functioning of the proposed model with variations in the power requi...

International Journal of Digital Earth

Journal of Clinical Oncology

Applied Geography

Predictions about the spatial distribution of environmental impacts related to extractive industr... more Predictions about the spatial distribution of environmental impacts related to extractive industries have commonly assumed an inverse relationship between the severity of impact and distance from the site of extraction. However, because of the salience of water to both extractive industries and other livelihood strategies, many severe externalities of extractive development are experienced in areas hydrologically linked to the site of extraction , though these areas may not be those closest to mines themselves. This paper uses cadastral and remotely sensed data to model the spatial distribution of water, and extractive industries in Honduras and identify hydrological links between mines and downstream areas. Based on water availability, and the amount of upstream extractive development, it describes vulnerability to water-related risks from extractive industries in terms of severity as well as its concentration, measuring how local or spatially distributed are potential sources of impact. A consideration of risks experienced by agricultural producers indicates that small-scale farmers and large, commercial growers face distinctly different types of risk, and suggests that each group may pursue different strategies for mitigation. These strategies differ with respect to the spatial and administrative scales at which they would be pursued, as well as the degree to which they push for governance approaches focusing on spatially-defined, cadastral units of regulation or on broader regional and landscape impacts.

PloS one, 2018

Prior studies have reported inconsistencies in the baseline risk profile, comorbidity burden and ... more Prior studies have reported inconsistencies in the baseline risk profile, comorbidity burden and their association with clinical outcomes in women compared to men. More importantly, there is limited data around the sex differences and how these have changed over time in contemporary percutaneous coronary intervention (PCI) practice. We used the Nationwide Inpatient Sample to identify all PCI procedures based on ICD-9 procedure codes in the United States between 2004-2014 in adult patients. Descriptive statistics were used to describe sex-based differences in baseline characteristics and comorbidity burden of patients. Multivariable logistic regressions were used to investigate the association between these differences and in-hospital mortality, complications, length of stay and total hospital charges. Among 6,601,526 patients, 66% were men and 33% were women. Women were more likely to be admitted with diagnosis of NSTEMI (non-ST elevation acute myocardial infarction), were on averag...

Hematological oncology, Jan 28, 2018

Trabectedin is an FDA-approved DNA minor groove binder (MGB) that has activity against translocat... more Trabectedin is an FDA-approved DNA minor groove binder (MGB) that has activity against translocation-associated sarcomas. Lurbinectedin is a next-generation MGB with pre-clinical activity against myeloid leukemia cells. A dose-finding phase 1 clinical trial was performed in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with further assessment of safety and tolerability. Forty-two patients with relapsed/refractory AML/MDS received lurbinectedin administered as a 1-hour intravenous infusion in a 3+3 study design. Two dosing schedules were used: 3.5 mg, 5 mg, 7 mg, or 6 mg on days 1 and 8 or 2 mg, 3 mg, 1 mg, or 1.5 mg for 3 consecutive days on days 1 to 3. Three patients experienced dose-limiting toxicities (DLTs) of rhabdomyolysis (grade 4), hyperbilirubinemia (grade 3), and oral herpes (grade 3) with the days 1 and 8 schedule. Otherwise, adverse events (AEs) mainly consisted of gastrointestinal manifestations (n=11), febrile neutropenia/infections (n=...

Scientific reports, Jan 24, 2018

It is unclear how comorbidity influences rates and causes of unplanned readmissions following per... more It is unclear how comorbidity influences rates and causes of unplanned readmissions following percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database who were admitted to hospital between 2010 and 2014. The comorbidity burden as defined by the Charlson Comorbidity Index (CCI). Primary outcomes were 30-day readmission rates and causes of readmission according to comorbidity burden. A total of 2,294,346 PCI procedures were included the analysis. The patients in CCI = 0, 1, 2 and ≥3 were 842,272(36.7%), 701,476(30.6%), 347,537(15.1%) and 403,061(17.6%), respectively. 219,227(9.6%) had an unplanned readmission within 30 days and rates by CCI group were 6.6%, 8.6%, 11.4% and 15.9% for CCI groups 0, 1, 2 and ≥3, respectively. The CCI score was also associated with greater cost (cost of index PCI for not readmitted vs readmitted was CCI = 0 21,257vs21,257 vs 21,257vs19,764 and CCI ≥ 3 26,736vs26,736 vs 26,736vs27,723). Compared to patients with CCI = 0, greater CCI score ...

Current atherosclerosis reports, Jan 2, 2018

Peripheral arterial disease (PAD) is the third most common manifestation of cardiovascular diseas... more Peripheral arterial disease (PAD) is the third most common manifestation of cardiovascular disease (CVD), following coronary artery disease (CAD) and stroke. PAD remains underdiagnosed and under-treated in women. Women with PAD experience more atypical symptoms and poorer overall health status. The prevalence of PAD in women increases with age, such that more women than men have PAD after the age of 40 years. There is under-representation of PAD patients in clinical trials in general and women in particular. In this article, we address the lack of women participants in PAD trials. We then present a comprehensive overview of the epidemiology/risk factor profile, clinical features, treatment, and outcomes. PAD is prevalent in women and its global burden is on the rise despite a decline in global age-standardized death rate from CVD. The importance of this issue has been underlined by the American Heart Association's (AHA) "Call to Action" scientific statement on PAD in w...

The American journal of cardiology, Jan 12, 2018

It is unclear how age affects rates and causes of unplanned early readmissions after percutaneous... more It is unclear how age affects rates and causes of unplanned early readmissions after percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database in the United States from 2010 to 2014 and examined the impact of age on readmissions after PCI. The primary outcomes were age-specific 30-day rates and causes of unplanned readmissions. A total of 2,294,345 procedures were analyzed with a 9.6% unplanned readmission rate within 30 days. Unplanned readmissions were 8.1%, 8.1%, 9.5%, and 12.6% for age groups <55, 55.0 to 64.9, 65.0-74.9, and ≥75 years, respectively. With increasing age, there was an increase in the rate of noncardiac causes for readmissions (for ages <55, 55.0 to 64.9, and ≥75 years, the rates were 54.1%, 54.8%, 56.6%, and 57.1%, respectively; p <0.001). Older age was associated with an increased prevalence of infections (13.9% ≥75 years vs 7.7% <55 years), gastrointestinal disease (11.5% ≥75 years vs 9.5% <55 years), a...

The Science of the total environment, Jan 29, 2018

Over the past years, the implementation of urban and peri-urban orchards in cities has increased ... more Over the past years, the implementation of urban and peri-urban orchards in cities has increased and so has the environmental awareness regarding these systems. This study applied the environmental extended multi-regional input-output analysis to obtain the Environmental Footprint associated with an organic peri-urban orchard network in Spain. The total environmental impacts were calculated for seven organic peri-urban orchards identified as PUO1 to PUO7. PUO1, PUO4 and PUO6 presented the highest environmental impacts due to a higher consumption of (1) fuel, (2) plastics and (3) electricity in comparison to the other orchards. Approximately 70% of the overall impacts were indirect impacts generated in the supply chain. A more in-depth study of climate change impacts in the supply chain of the organic peri-urban orchard network revealed that the major hotspots were the sectors "extraction of crude petroleum" (29%) and "production of electricity by gas and coal" (3...

PASOS Revista de turismo y patrimonio cultural

Resumen: En el mercado turístico es frecuente el uso de promociones en precios con el fin de incr... more Resumen: En el mercado turístico es frecuente el uso de promociones en precios con el fin de incrementar las ventas de un producto. Sin embargo el uso de estas herramientas promocionales de forma indiscriminada puede afectar a la evaluación del consumidor de la compra y a los resultados empresariales a largo plazo. Este trabajo analiza el efecto de las promociones en precios sobre la evaluación del turista del producto adquirido y sobre su nivel de satisfacción, y está aplicado a la compra de un paquete turístico. Para realizar el análisis se lleva a cabo una investigación empírica enfocada en los turistas que han viajado desde España a los países de Sur América, Centro América y del Caribe a través de la compra de un paquete turístico. Los resultados indican que la calidad percibida en el viaje es la variable que tiene una mayor influencia en la formación de la satisfacción del turista. Además el efecto de las promociones en precios sobre la satisfacción es indirecto, negativo y tiene una forma no lineal.

Polish Journal of Environmental Studies

The application of sewage sludge as an organic amendment on crops can be one of the main sources ... more The application of sewage sludge as an organic amendment on crops can be one of the main sources of soil contamination by heavy metals. The accumulation of heavy metals can cause adverse effects on soils as well as present a potential risk for the environment [1-2]. Their toxicity depends on the dose applied and other factors, such as the pH of sewage sludge. Also, it is known that other micro-pollutants present in these wastes can cause

The American journal of cardiology, 2017

Frail patients are more prone to adverse events after cardiac surgery, particularly after implant... more Frail patients are more prone to adverse events after cardiac surgery, particularly after implantation of left ventricular assist devices. Thus, frailty assessment may help identify patients unlikely to benefit from left ventricular assist device therapy. The purpose was to establish a suitable measure of frailty in adults with end-stage heart failure. In a prospective cohort of 75 patients (age 58 ± 12 years) with end-stage heart failure, we assessed the association between frailty (5-component Fried criteria) and the composite primary outcome of inpatient mortality or prolonged length of stay, as well as extubation status, time on ventilator, discharge status, and long-term mortality. Fried frailty criteria were met in 44 (59%) patients, but there was no association with the primary outcome (p = 0.10). However, an abridged set of 3 criteria (exhaustion, inactivity, and grip strength) was predictive of the primary outcome (odds ratio 2.9, 95% confidence interval 1.1 to 7.4), and of...

Agriculture

The valorization of municipal solid waste (MSW) can serve as an organic amendment in agriculture ... more The valorization of municipal solid waste (MSW) can serve as an organic amendment in agriculture while reducing solid waste accumulation in the environment. This research aimed to evaluate the valorization of a bio-stabilized MSW amendment for the production of faba bean (Vicia faba L.) crop. For this purpose, biomass production and growth, as well as, seed yield and seed components, seed nutrient accumulation, plant pigments, soil properties, and microorganisms were evaluated in comparison with faba bean mineral fertilization in a greenhouse experiment. The results demonstrated that the bio-stabilized MSW amendment achieved similar biomass production, plant growth, seed yield, nitrogen and protein content, and pigment content as the mineral fertilization treatment. On the other hand, the organic fertilization did not exhibit significant effects on the yield components number of pods per plant, and number of seeds per pod, and nutrient accumulation in seeds with respect to mineral a...

Agriculture

The goal of this study was to provide quantitative agronomic data and environmental performance t... more The goal of this study was to provide quantitative agronomic data and environmental performance through a life cycle assessment of camelina in a crop rotation. For this purpose, camelina [Camelina sativa (L.) Crantz] was included in a crop rotation (camelina-barley [Hordeum vulgare (L.)]-camelina) fertilized with two organic fertilizers (dewatered sludge and composted sludge) during three growing seasons (2015–2018). Three treatments were considered in this experimental study of 0.018 ha: (1) Fertilization with composted sludge (15 t ha−1), (2) fertilization with dewatered sludge (35 t ha−1), and (3) control treatment without fertilization. Results showed that camelina’s yield was affected by climatic conditions, ranging from 0.9 to 1.4 t ha−1 in the first season (2015/2016) and the third season (2017/2018 and did not present significant differences between treatments. The yield components with a positive response to organic fertilization were number of silicles, number of seeds per...

Applied Sciences

This work presents an integrated thermal-electrical simulation model, capable of taking into acco... more This work presents an integrated thermal-electrical simulation model, capable of taking into account the thermal and electrical effects of the battery and photovoltaic panels for each instant of time in a given orbit and attitude. Using the physical equations that govern the thermal and electrical models involved during a CubeSat operation, the proposed integrated model can estimate the temperature and energy conditions of the battery, not only in an isolated way but also in considering the mutual effects on the system. Besides, special attention is given to photovoltaic panels used in the energy harvesting process, whose performance is affected by irradiance and temperature along the orbit. The integrated model can be useful for engineers when developing the subsystems of their CubeSats, taking into account, for example, the battery temperature control through a heater. Simulations were performed to illustrate the functioning of the proposed model with variations in the power requi...

International Journal of Digital Earth

Journal of Clinical Oncology

Applied Geography

Predictions about the spatial distribution of environmental impacts related to extractive industr... more Predictions about the spatial distribution of environmental impacts related to extractive industries have commonly assumed an inverse relationship between the severity of impact and distance from the site of extraction. However, because of the salience of water to both extractive industries and other livelihood strategies, many severe externalities of extractive development are experienced in areas hydrologically linked to the site of extraction , though these areas may not be those closest to mines themselves. This paper uses cadastral and remotely sensed data to model the spatial distribution of water, and extractive industries in Honduras and identify hydrological links between mines and downstream areas. Based on water availability, and the amount of upstream extractive development, it describes vulnerability to water-related risks from extractive industries in terms of severity as well as its concentration, measuring how local or spatially distributed are potential sources of impact. A consideration of risks experienced by agricultural producers indicates that small-scale farmers and large, commercial growers face distinctly different types of risk, and suggests that each group may pursue different strategies for mitigation. These strategies differ with respect to the spatial and administrative scales at which they would be pursued, as well as the degree to which they push for governance approaches focusing on spatially-defined, cadastral units of regulation or on broader regional and landscape impacts.

PloS one, 2018

Prior studies have reported inconsistencies in the baseline risk profile, comorbidity burden and ... more Prior studies have reported inconsistencies in the baseline risk profile, comorbidity burden and their association with clinical outcomes in women compared to men. More importantly, there is limited data around the sex differences and how these have changed over time in contemporary percutaneous coronary intervention (PCI) practice. We used the Nationwide Inpatient Sample to identify all PCI procedures based on ICD-9 procedure codes in the United States between 2004-2014 in adult patients. Descriptive statistics were used to describe sex-based differences in baseline characteristics and comorbidity burden of patients. Multivariable logistic regressions were used to investigate the association between these differences and in-hospital mortality, complications, length of stay and total hospital charges. Among 6,601,526 patients, 66% were men and 33% were women. Women were more likely to be admitted with diagnosis of NSTEMI (non-ST elevation acute myocardial infarction), were on averag...

Hematological oncology, Jan 28, 2018

Trabectedin is an FDA-approved DNA minor groove binder (MGB) that has activity against translocat... more Trabectedin is an FDA-approved DNA minor groove binder (MGB) that has activity against translocation-associated sarcomas. Lurbinectedin is a next-generation MGB with pre-clinical activity against myeloid leukemia cells. A dose-finding phase 1 clinical trial was performed in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with further assessment of safety and tolerability. Forty-two patients with relapsed/refractory AML/MDS received lurbinectedin administered as a 1-hour intravenous infusion in a 3+3 study design. Two dosing schedules were used: 3.5 mg, 5 mg, 7 mg, or 6 mg on days 1 and 8 or 2 mg, 3 mg, 1 mg, or 1.5 mg for 3 consecutive days on days 1 to 3. Three patients experienced dose-limiting toxicities (DLTs) of rhabdomyolysis (grade 4), hyperbilirubinemia (grade 3), and oral herpes (grade 3) with the days 1 and 8 schedule. Otherwise, adverse events (AEs) mainly consisted of gastrointestinal manifestations (n=11), febrile neutropenia/infections (n=...

Scientific reports, Jan 24, 2018

It is unclear how comorbidity influences rates and causes of unplanned readmissions following per... more It is unclear how comorbidity influences rates and causes of unplanned readmissions following percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database who were admitted to hospital between 2010 and 2014. The comorbidity burden as defined by the Charlson Comorbidity Index (CCI). Primary outcomes were 30-day readmission rates and causes of readmission according to comorbidity burden. A total of 2,294,346 PCI procedures were included the analysis. The patients in CCI = 0, 1, 2 and ≥3 were 842,272(36.7%), 701,476(30.6%), 347,537(15.1%) and 403,061(17.6%), respectively. 219,227(9.6%) had an unplanned readmission within 30 days and rates by CCI group were 6.6%, 8.6%, 11.4% and 15.9% for CCI groups 0, 1, 2 and ≥3, respectively. The CCI score was also associated with greater cost (cost of index PCI for not readmitted vs readmitted was CCI = 0 21,257vs21,257 vs 21,257vs19,764 and CCI ≥ 3 26,736vs26,736 vs 26,736vs27,723). Compared to patients with CCI = 0, greater CCI score ...

Current atherosclerosis reports, Jan 2, 2018

Peripheral arterial disease (PAD) is the third most common manifestation of cardiovascular diseas... more Peripheral arterial disease (PAD) is the third most common manifestation of cardiovascular disease (CVD), following coronary artery disease (CAD) and stroke. PAD remains underdiagnosed and under-treated in women. Women with PAD experience more atypical symptoms and poorer overall health status. The prevalence of PAD in women increases with age, such that more women than men have PAD after the age of 40 years. There is under-representation of PAD patients in clinical trials in general and women in particular. In this article, we address the lack of women participants in PAD trials. We then present a comprehensive overview of the epidemiology/risk factor profile, clinical features, treatment, and outcomes. PAD is prevalent in women and its global burden is on the rise despite a decline in global age-standardized death rate from CVD. The importance of this issue has been underlined by the American Heart Association's (AHA) "Call to Action" scientific statement on PAD in w...

The American journal of cardiology, Jan 12, 2018

It is unclear how age affects rates and causes of unplanned early readmissions after percutaneous... more It is unclear how age affects rates and causes of unplanned early readmissions after percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database in the United States from 2010 to 2014 and examined the impact of age on readmissions after PCI. The primary outcomes were age-specific 30-day rates and causes of unplanned readmissions. A total of 2,294,345 procedures were analyzed with a 9.6% unplanned readmission rate within 30 days. Unplanned readmissions were 8.1%, 8.1%, 9.5%, and 12.6% for age groups <55, 55.0 to 64.9, 65.0-74.9, and ≥75 years, respectively. With increasing age, there was an increase in the rate of noncardiac causes for readmissions (for ages <55, 55.0 to 64.9, and ≥75 years, the rates were 54.1%, 54.8%, 56.6%, and 57.1%, respectively; p <0.001). Older age was associated with an increased prevalence of infections (13.9% ≥75 years vs 7.7% <55 years), gastrointestinal disease (11.5% ≥75 years vs 9.5% <55 years), a...

The Science of the total environment, Jan 29, 2018

Over the past years, the implementation of urban and peri-urban orchards in cities has increased ... more Over the past years, the implementation of urban and peri-urban orchards in cities has increased and so has the environmental awareness regarding these systems. This study applied the environmental extended multi-regional input-output analysis to obtain the Environmental Footprint associated with an organic peri-urban orchard network in Spain. The total environmental impacts were calculated for seven organic peri-urban orchards identified as PUO1 to PUO7. PUO1, PUO4 and PUO6 presented the highest environmental impacts due to a higher consumption of (1) fuel, (2) plastics and (3) electricity in comparison to the other orchards. Approximately 70% of the overall impacts were indirect impacts generated in the supply chain. A more in-depth study of climate change impacts in the supply chain of the organic peri-urban orchard network revealed that the major hotspots were the sectors "extraction of crude petroleum" (29%) and "production of electricity by gas and coal" (3...

PASOS Revista de turismo y patrimonio cultural

Resumen: En el mercado turístico es frecuente el uso de promociones en precios con el fin de incr... more Resumen: En el mercado turístico es frecuente el uso de promociones en precios con el fin de incrementar las ventas de un producto. Sin embargo el uso de estas herramientas promocionales de forma indiscriminada puede afectar a la evaluación del consumidor de la compra y a los resultados empresariales a largo plazo. Este trabajo analiza el efecto de las promociones en precios sobre la evaluación del turista del producto adquirido y sobre su nivel de satisfacción, y está aplicado a la compra de un paquete turístico. Para realizar el análisis se lleva a cabo una investigación empírica enfocada en los turistas que han viajado desde España a los países de Sur América, Centro América y del Caribe a través de la compra de un paquete turístico. Los resultados indican que la calidad percibida en el viaje es la variable que tiene una mayor influencia en la formación de la satisfacción del turista. Además el efecto de las promociones en precios sobre la satisfacción es indirecto, negativo y tiene una forma no lineal.

Polish Journal of Environmental Studies

The application of sewage sludge as an organic amendment on crops can be one of the main sources ... more The application of sewage sludge as an organic amendment on crops can be one of the main sources of soil contamination by heavy metals. The accumulation of heavy metals can cause adverse effects on soils as well as present a potential risk for the environment [1-2]. Their toxicity depends on the dose applied and other factors, such as the pH of sewage sludge. Also, it is known that other micro-pollutants present in these wastes can cause

The American journal of cardiology, 2017

Frail patients are more prone to adverse events after cardiac surgery, particularly after implant... more Frail patients are more prone to adverse events after cardiac surgery, particularly after implantation of left ventricular assist devices. Thus, frailty assessment may help identify patients unlikely to benefit from left ventricular assist device therapy. The purpose was to establish a suitable measure of frailty in adults with end-stage heart failure. In a prospective cohort of 75 patients (age 58 ± 12 years) with end-stage heart failure, we assessed the association between frailty (5-component Fried criteria) and the composite primary outcome of inpatient mortality or prolonged length of stay, as well as extubation status, time on ventilator, discharge status, and long-term mortality. Fried frailty criteria were met in 44 (59%) patients, but there was no association with the primary outcome (p = 0.10). However, an abridged set of 3 criteria (exhaustion, inactivity, and grip strength) was predictive of the primary outcome (odds ratio 2.9, 95% confidence interval 1.1 to 7.4), and of...