Sara Mohammed - Academia.edu (original) (raw)

Papers by Sara Mohammed

The Scientific Journal of Al-Azhar Medical Faculty, Girls, 2021

Objective We have studied the variability of blood transfusion on hemodynamics and its complicati... more Objective We have studied the variability of blood transfusion on hemodynamics and its complications during cardiac surgeries at a single center in Egypt. Patients and methods A total of 35 patients of both sexes, with ages from 21 to 70 years, scheduled for open heart surgeries were prospectively enrolled in this observational study between December 2019 and June 2020. Hemodynamic variables, such as mean arterial blood pressure and heart rate were recorded before induction (T1), after endotracheal intubation (T2), immediately before cardiopulmonary bypass (CPB) (T3), 30 min into CPB (T4), 15 min after successful weaning (T5), after sternal closure (T6), and upon arrival in the ICU (T7). The total amount of administered blood and blood products transfused intraoperatively and on the first day postoperatively; the total amount of fluids administered, including the CPB prime volume; and the total intraoperative urine output were recorded. Moreover, the number of patients who needed in...

Microbiology Resource Announcements, 2019

Acinetobacter baumannii strain HUMV-3743 was obtained from wound exudate from an adult patient. H... more Acinetobacter baumannii strain HUMV-3743 was obtained from wound exudate from an adult patient. Here, we report its complete genome sequence using Illumina-based sequence analysis, which revealed a genome of 4 Mb, which includes 2 predicted plasmids of 78.9 and 107 kb. A total of 3,881 protein-coding genes are predicted from this assembly.

Journal of Digestive Endoscopy, 2017

ABSTRACTSchistosomiasis is prevalent in tropical and subtropical areas. It manifests as an acute ... more ABSTRACTSchistosomiasis is prevalent in tropical and subtropical areas. It manifests as an acute or chronic illness caused by the body’s reaction to the worms’ eggs. In view of its clinical similarity to various other diseases, the disorder may cause diagnostic errors. We present a case of a Sudanese man, who presented with fever, headache, fatigue, myalgia, excessive sweating, abdominal cramps, and a high eosinophil count on blood testing. He was diagnosed with a connective tissue disorder and was started on prednisolone, but 3 weeks later, he presented with rectal bleeding. Colonoscopy showed features of moderate distal colitis. Colonic biopsies revealed several viable schistosome ova associated with aggregates of eosinophils, compatible with active colonic schistosomiasis.

World Journal of Hepatology, 2016

Clinical trial registration statement: Not applicable, there were no interventions in this study.... more Clinical trial registration statement: Not applicable, there were no interventions in this study. Informed consent statement: All participants in the study or their legal guardian provided their informed consent before being enrolled in the study.

European Journal of Cancer, 2016

A high preoperative neutrophil-lymphocyte ratio (NLR) has been shown in several studies as a pred... more A high preoperative neutrophil-lymphocyte ratio (NLR) has been shown in several studies as a predictor of worse survival in many solid neoplasms, including esophageal cancer, but its impact remains unclear. The goal of this systematic review was to gain all the evidence about NLR in order to analyse its potential in predicting survival in esophageal cancer. Therefore, we conducted a systematic literature search of all relevant studies reporting data on NLR as prognostic marker in esophageal cancer patients. We considered overall survival (OS) as primary outcome, disease-free survival (DFS) and progression-free survival (PFS) as secondary outcomes. We included studies with a directly or indirectly available hazard ratio (HR), furthermore we used both fixed effect model and random effect model depending on heterogeneity. We included a total of 20 studies, published between 2011 and 2017, consisting of 6,457 patients. The NLR cutoff value ranges from 1.7 to 5. The HR for OS of all included studies was 1.60. The HR for DFS and PFS was 1.75 and 1.66 respectively. The survival sub-analysis about tumor characteristics, treatment modality, blood sample timing also confirmed NLR prognostic relevance with statistically significant results. The meta-analysis showed that high preoperative NLR is associated with worse survival in esophageal cancer, as shown in several solid tumors, but its use in the clinical practice is still underestimated. Highquality studies are needed to assess the most effective cutoff in survival prognostication and NLR relevance on postoperative complications.

The American Journal of Human Genetics, 2000

Wolfram syndrome, which is sometimes referred to as "DIDMOAD" (diabetes insipidus, diabetes melli... more Wolfram syndrome, which is sometimes referred to as "DIDMOAD" (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is an autosomal recessive neurodegenerative disorder for which only insulin-dependent diabetes mellitus and optic atrophy are necessary to make the diagnosis. Researchers have mapped Wolfram syndrome to chromosome 4p16.1, and, recently, a gene encoding a putative transmembrane protein has been cloned and mutations have been identified in patients. To pursue the possibility of locus heterogeneity, 16 patients from four different families were recruited. These patients, who have the Wolfram syndrome phenotype, also have additional features that have not previously been reported. There is an absence of diabetes insipidus in all affected family members. In addition, several patients have profound upper gastrointestinal ulceration and bleeding. With the use of three microsatellite markers (D4S432, D4S3023, and D4S2366) reported to be linked to the chromosome 4p16.1 locus, we significantly excluded linkage in three of the four families. The two affected individuals in one family showed homozygosity for all three markers from the region of linkage on chromosome 4p16.1. For the other three families, genetic heterogeneity for Wolfram syndrome was verified by demonstration of linkage to chromosome 4q22-24. In conclusion, we report the unique clinical findings and linkage-analysis results of 16 patients with Wolfram syndrome and provide further evidence for the genetic heterogeneity of this disorder. We also provide data on a new locus that plays a role in the etiology of insulin-dependent diabetes mellitus.

The Scientific Journal of Al-Azhar Medical Faculty, Girls, 2021

Objective We have studied the variability of blood transfusion on hemodynamics and its complicati... more Objective We have studied the variability of blood transfusion on hemodynamics and its complications during cardiac surgeries at a single center in Egypt. Patients and methods A total of 35 patients of both sexes, with ages from 21 to 70 years, scheduled for open heart surgeries were prospectively enrolled in this observational study between December 2019 and June 2020. Hemodynamic variables, such as mean arterial blood pressure and heart rate were recorded before induction (T1), after endotracheal intubation (T2), immediately before cardiopulmonary bypass (CPB) (T3), 30 min into CPB (T4), 15 min after successful weaning (T5), after sternal closure (T6), and upon arrival in the ICU (T7). The total amount of administered blood and blood products transfused intraoperatively and on the first day postoperatively; the total amount of fluids administered, including the CPB prime volume; and the total intraoperative urine output were recorded. Moreover, the number of patients who needed in...

Microbiology Resource Announcements, 2019

Acinetobacter baumannii strain HUMV-3743 was obtained from wound exudate from an adult patient. H... more Acinetobacter baumannii strain HUMV-3743 was obtained from wound exudate from an adult patient. Here, we report its complete genome sequence using Illumina-based sequence analysis, which revealed a genome of 4 Mb, which includes 2 predicted plasmids of 78.9 and 107 kb. A total of 3,881 protein-coding genes are predicted from this assembly.

Journal of Digestive Endoscopy, 2017

ABSTRACTSchistosomiasis is prevalent in tropical and subtropical areas. It manifests as an acute ... more ABSTRACTSchistosomiasis is prevalent in tropical and subtropical areas. It manifests as an acute or chronic illness caused by the body’s reaction to the worms’ eggs. In view of its clinical similarity to various other diseases, the disorder may cause diagnostic errors. We present a case of a Sudanese man, who presented with fever, headache, fatigue, myalgia, excessive sweating, abdominal cramps, and a high eosinophil count on blood testing. He was diagnosed with a connective tissue disorder and was started on prednisolone, but 3 weeks later, he presented with rectal bleeding. Colonoscopy showed features of moderate distal colitis. Colonic biopsies revealed several viable schistosome ova associated with aggregates of eosinophils, compatible with active colonic schistosomiasis.

World Journal of Hepatology, 2016

Clinical trial registration statement: Not applicable, there were no interventions in this study.... more Clinical trial registration statement: Not applicable, there were no interventions in this study. Informed consent statement: All participants in the study or their legal guardian provided their informed consent before being enrolled in the study.

European Journal of Cancer, 2016

A high preoperative neutrophil-lymphocyte ratio (NLR) has been shown in several studies as a pred... more A high preoperative neutrophil-lymphocyte ratio (NLR) has been shown in several studies as a predictor of worse survival in many solid neoplasms, including esophageal cancer, but its impact remains unclear. The goal of this systematic review was to gain all the evidence about NLR in order to analyse its potential in predicting survival in esophageal cancer. Therefore, we conducted a systematic literature search of all relevant studies reporting data on NLR as prognostic marker in esophageal cancer patients. We considered overall survival (OS) as primary outcome, disease-free survival (DFS) and progression-free survival (PFS) as secondary outcomes. We included studies with a directly or indirectly available hazard ratio (HR), furthermore we used both fixed effect model and random effect model depending on heterogeneity. We included a total of 20 studies, published between 2011 and 2017, consisting of 6,457 patients. The NLR cutoff value ranges from 1.7 to 5. The HR for OS of all included studies was 1.60. The HR for DFS and PFS was 1.75 and 1.66 respectively. The survival sub-analysis about tumor characteristics, treatment modality, blood sample timing also confirmed NLR prognostic relevance with statistically significant results. The meta-analysis showed that high preoperative NLR is associated with worse survival in esophageal cancer, as shown in several solid tumors, but its use in the clinical practice is still underestimated. Highquality studies are needed to assess the most effective cutoff in survival prognostication and NLR relevance on postoperative complications.

The American Journal of Human Genetics, 2000

Wolfram syndrome, which is sometimes referred to as "DIDMOAD" (diabetes insipidus, diabetes melli... more Wolfram syndrome, which is sometimes referred to as "DIDMOAD" (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is an autosomal recessive neurodegenerative disorder for which only insulin-dependent diabetes mellitus and optic atrophy are necessary to make the diagnosis. Researchers have mapped Wolfram syndrome to chromosome 4p16.1, and, recently, a gene encoding a putative transmembrane protein has been cloned and mutations have been identified in patients. To pursue the possibility of locus heterogeneity, 16 patients from four different families were recruited. These patients, who have the Wolfram syndrome phenotype, also have additional features that have not previously been reported. There is an absence of diabetes insipidus in all affected family members. In addition, several patients have profound upper gastrointestinal ulceration and bleeding. With the use of three microsatellite markers (D4S432, D4S3023, and D4S2366) reported to be linked to the chromosome 4p16.1 locus, we significantly excluded linkage in three of the four families. The two affected individuals in one family showed homozygosity for all three markers from the region of linkage on chromosome 4p16.1. For the other three families, genetic heterogeneity for Wolfram syndrome was verified by demonstration of linkage to chromosome 4q22-24. In conclusion, we report the unique clinical findings and linkage-analysis results of 16 patients with Wolfram syndrome and provide further evidence for the genetic heterogeneity of this disorder. We also provide data on a new locus that plays a role in the etiology of insulin-dependent diabetes mellitus.