Sara Pellegrini - Academia.edu (original) (raw)

Papers by Sara Pellegrini

Research paper thumbnail of Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver

Mechanisms of Ageing and Development, 2014

Research paper thumbnail of A new questionnaire for food allergy

World Allergy Organization Journal, 2007

ABSTRACT An abstract is unavailable. This article is available as HTML full text and PDF.

Research paper thumbnail of The use of the Hirsch index in benchmarking hepatic surgery research

The American Journal of Surgery, 2013

BACKGROUND: The Hirsch index (h-index) is recognized as an effective way to summarize an individu... more BACKGROUND: The Hirsch index (h-index) is recognized as an effective way to summarize an individual's scientific research output. However, a benchmark for evaluating surgeon scientists in the field of hepatic surgery is still not available.

Research paper thumbnail of Safety of hepatic resection for colorectal metastases in the era of neo-adjuvant chemotherapy

Langenbeck's Archives of Surgery, 2012

Purpose The relationship between neo-adjuvant chemotherapy prior to hepatectomy in patients with ... more Purpose The relationship between neo-adjuvant chemotherapy prior to hepatectomy in patients with resectable colorectal liver metastases and post-operative morbidity still has to be clarified. Methods Data from 242 patients undergoing hepatectomy for colorectal liver metastases, judged resectable at first observation, were reviewed and their clinical outcome was related to neo-adjuvant chemotherapy (125 patients). Selection biases were outlined and properly handled by means of propensity score analysis. Results Post-operative death was 1.2% and morbidity 40.9%. Pre-operative chemotherapy was only apparently related to higher morbidity (P00.021): multivariate analysis identified extension of hepatectomy and intra-operative blood loss as independent prognostic variables (P<0.05). Patients receiving and not receiving neo-adjuvant chemotherapy were significantly different for several covariates, including extension of hepatectomy (P00.049). After propensity score adjustment, 94 patients were identified as having similar covariate distribution (standardized differences <|0.1|) except for neo-adjuvant treatment (47 patients for each group). In this matched sample, mortality was similar and post-operative complications were only slightly higher (hazard ratio01.38) in treated patients. A significantly higher need for fluid replacement was only observed in patients receiving neo-adjuvant chemotherapy (P00.038). Conclusions Neo-adjuvant chemotherapy showed a limited role in determining post-operative morbidity after hepatic resection and did not modify mortality.

Research paper thumbnail of What is the probability of being too old for salvage transplantation after hepatocellular carcinoma resection?

Digestive and Liver Disease, 2012

The strategy of salvage transplantation for patients with hepatocellular carcinoma is based on th... more The strategy of salvage transplantation for patients with hepatocellular carcinoma is based on the premise that tumour recurrence will be still transplantable at the time of recurrence. However, patients can not only present non-transplantable recurrence but can also be over the age limit accepted for transplantation. To measure the risk of being too old for salvage transplantation of patients resected for hepatocellular carcinoma within Milan criteria. A Markov simulation model was developed on the basis of published literature. The risk of being too old for salvage transplantation depends on the time-span between age at hepatic resection and age limit, and the expected median waiting-time. Patients resected at an age 2 or 3 years below the age limit carry a risk of being too old that overcomes the probability of receiving transplantation. Salvage strategy can cause harm that depends on the tumour characteristics and degree of portal hypertension, becoming maximal for patients with multiple tumours, clinical signs of portal hypertension and increased bilirubin levels. The best strategy to adopt should be balanced between the risk of being too old and the expected transplant benefit, but salvage strategy could be pursued if it did not turn into significant harm in comparison to primary transplantation.

Research paper thumbnail of Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver

Mechanisms of Ageing and Development, 2014

Research paper thumbnail of A new questionnaire for food allergy

World Allergy Organization Journal, 2007

ABSTRACT An abstract is unavailable. This article is available as HTML full text and PDF.

Research paper thumbnail of The use of the Hirsch index in benchmarking hepatic surgery research

The American Journal of Surgery, 2013

BACKGROUND: The Hirsch index (h-index) is recognized as an effective way to summarize an individu... more BACKGROUND: The Hirsch index (h-index) is recognized as an effective way to summarize an individual's scientific research output. However, a benchmark for evaluating surgeon scientists in the field of hepatic surgery is still not available.

Research paper thumbnail of Safety of hepatic resection for colorectal metastases in the era of neo-adjuvant chemotherapy

Langenbeck's Archives of Surgery, 2012

Purpose The relationship between neo-adjuvant chemotherapy prior to hepatectomy in patients with ... more Purpose The relationship between neo-adjuvant chemotherapy prior to hepatectomy in patients with resectable colorectal liver metastases and post-operative morbidity still has to be clarified. Methods Data from 242 patients undergoing hepatectomy for colorectal liver metastases, judged resectable at first observation, were reviewed and their clinical outcome was related to neo-adjuvant chemotherapy (125 patients). Selection biases were outlined and properly handled by means of propensity score analysis. Results Post-operative death was 1.2% and morbidity 40.9%. Pre-operative chemotherapy was only apparently related to higher morbidity (P00.021): multivariate analysis identified extension of hepatectomy and intra-operative blood loss as independent prognostic variables (P<0.05). Patients receiving and not receiving neo-adjuvant chemotherapy were significantly different for several covariates, including extension of hepatectomy (P00.049). After propensity score adjustment, 94 patients were identified as having similar covariate distribution (standardized differences <|0.1|) except for neo-adjuvant treatment (47 patients for each group). In this matched sample, mortality was similar and post-operative complications were only slightly higher (hazard ratio01.38) in treated patients. A significantly higher need for fluid replacement was only observed in patients receiving neo-adjuvant chemotherapy (P00.038). Conclusions Neo-adjuvant chemotherapy showed a limited role in determining post-operative morbidity after hepatic resection and did not modify mortality.

Research paper thumbnail of What is the probability of being too old for salvage transplantation after hepatocellular carcinoma resection?

Digestive and Liver Disease, 2012

The strategy of salvage transplantation for patients with hepatocellular carcinoma is based on th... more The strategy of salvage transplantation for patients with hepatocellular carcinoma is based on the premise that tumour recurrence will be still transplantable at the time of recurrence. However, patients can not only present non-transplantable recurrence but can also be over the age limit accepted for transplantation. To measure the risk of being too old for salvage transplantation of patients resected for hepatocellular carcinoma within Milan criteria. A Markov simulation model was developed on the basis of published literature. The risk of being too old for salvage transplantation depends on the time-span between age at hepatic resection and age limit, and the expected median waiting-time. Patients resected at an age 2 or 3 years below the age limit carry a risk of being too old that overcomes the probability of receiving transplantation. Salvage strategy can cause harm that depends on the tumour characteristics and degree of portal hypertension, becoming maximal for patients with multiple tumours, clinical signs of portal hypertension and increased bilirubin levels. The best strategy to adopt should be balanced between the risk of being too old and the expected transplant benefit, but salvage strategy could be pursued if it did not turn into significant harm in comparison to primary transplantation.