Sari Edi Cahyaningrum - Academia.edu (original) (raw)

Papers by Sari Edi Cahyaningrum

Composite hydroxyapatite-collagen-chitosan as bone graft materials for bone fracture has been syn... more Composite hydroxyapatite-collagen-chitosan as bone graft materials for bone fracture has been synthesized using exsitu method. Combining the advantages of hydroxyapatite with chitosan and collagen as composites bone material that it show good biocompatibility and can bond with surrounding host tissues inherent from hydroxyapatite. In this research hydroxyapaptite was synthesized from cow bone with calcination method. The main of this research is to determine the chemical and physics characteristics from the bone graft. The analysis data from Spectra IR indicated vibration of OH-, PO4 3and CO3 2from hydroxyapatite, also-NH2, C=O and C-H from collagen and chitosan along with the peak wave number shifting. The result from SEM characterization was indicated surface morphology formed mineral apatite layer with rough crystal.

Kitosan merupakan turunan kitin yang dapat diisolasi dari kulit udang, rajungan, kepiting, dan ku... more Kitosan merupakan turunan kitin yang dapat diisolasi dari kulit udang, rajungan, kepiting, dan kulit serangga lainnya. Kitosan menunjukkan sifat mampu menghambat pertumbuhan jamur dan bakteri yang bersifat patogen dan menyebabkan resistensi tumbuhan terhadap infeksi jamur dan virus. Produk ini berpotensi untuk menekan pertumbuhan jamur. Berdasarkan hal tersebut kitosan dapat digunakan sebagai alternatif lain bahan pengawet alami untuk mengurangi penggunaan formalin yang dapat meracuni tubuh manusia. Penelitian ini bertujuan untuk melakukan pelatihan kitosan sebagai pengawet alami serta menggunakannya pada industri tahu di Desa Tambak Sumur Sidoarjo untuk meningkatkan mutu dan menambah masa simpan tahu. Hasil kegiatan menunjukkan bahwa, tahu mempunyai tekstur yang lebih kenyal, tidak mudah hancur, mempunyai aroma dan rasa yang lebih gurih dan lebih mengembang apabila digoreng dibandingkan dengan tahu tanpa penambahan kitosan. Berdasarkan hasil angket, responden menyatakan lebih menyukai tahu dengan tambahan kitosandan terbukti bahwa kitosan dapat meningkatkan daya simpan tahu sampai dengan 3 hari lebih lama dibandingkan tahu tanpa penambahan kitosan.

Journal of physics, Jul 1, 2020

One of the data used as a benchmark for determining the progress of a university can be seen from... more One of the data used as a benchmark for determining the progress of a university can be seen from the productivity of research and community service. The research objectives are to (1) analyze Unesa lecturer research based on the distribution of faculties/departments/study programs; (2) analyzing trends in the research focus of Unesa lecturers; (3) analyzing the achievement of Unesa lecturer research outcomes compared with the target research outcomes; and (4) analyzing the profile of the service to the Unesa lecturer community based on the distribution of faculties/departments/study programs. The reference used in analyzing is from 2015-2019. The development model used is the Waterfall model with a linear development system. The research subject used was the procedure of developing Sistem Informasi Riset dan Pengabdian Kepada Masyarakat (SIRIP) in Higher Education. Data analysis techniques were carried out in three stages, namely pre-development, development, and post-development. Based on the results and discussion, the conclusions in this study are as follows. The results of the trial of Sistem Informasi Riset dan Pengabdian Kepada Masyarakat (SIRIP) using the black box testing method in accordance with 18 functional requirements of the system can run successfully. The profile of research in Unesa from 2015-2019 experienced a significant increase and decrease (fluctuation). The number of research titles funded from 2015-2019 was as many as 250 titles, 585 titles, 700 titles, 480 titles, and 447 titles. Meanwhile, the number of community service titles funded from 2015-2019 was 46 titles, 51 titles, 29 titles, 22 titles, and 338 titles, respectively.

Rasayan journal of Chemistry, 2020

This study was aimed to encapsulation metformin, the diabetes melittus type 2 drugs. In this stud... more This study was aimed to encapsulation metformin, the diabetes melittus type 2 drugs. In this study, chitosan-alginat and tween 80 composites were used as matrix encapsulation. The chitosan was mixed with variation of the composition of metformin-calcium alginate-tween 80. The effectivity of encapsulation was evaluated from surface morphology, functional group, % drug encapsulation efficiency and effect soaked on stability encapsulation. The metformin encapsulated was characterized to analysis of the functional group and particle size. The results showed that the metformin encapsulated a slightly rough surface with a good appearance. The drug encapsulation efficiency was about 7.06 to 30.32 %.

Indonesian Journal of Chemistry, Mar 30, 2015

Sari Edi Cahyaningrum et al.

Eurasian Journal of Analytical Chemistry, 2019

Laboratory waste can take the form of organic and inorganic materials if it accumulates, it can b... more Laboratory waste can take the form of organic and inorganic materials if it accumulates, it can be harm the surrounding environment such as soil, water and plants. Some heavy metals are discharged without prior processing so it is feared that they can cause environmental pollution. The purpose of this research was to identify heavy metals from the laboratory activities waste and reduce that heavy metals using activated carbon and bentonite. The adsorption method using adsorbents such as activated carbon and bentonite is widely used to reduce metal contamination in waste and for analysis of heavy metal content in this research we used an atomic absorption spectrophotometer. The results of the analysis show the presence of several heavy metals such as Pb, Cu, Ag, Co, Cd, Cr and Hg. Identified laboratory waste results are quite high at 35 g/L for Cu, 1200 ppm for Pb metal and 220 ppm Ag. Adsorption using carbon and bentonite showed a reduction of Cu in the laboratory waste of 90.8 and ...

Bacteria isolated from mud field in the Ketintang Surabaya area showed chitinolytic activity in m... more Bacteria isolated from mud field in the Ketintang Surabaya area showed chitinolytic activity in media containing 0,4 % colloidal chitin. Morphological and phisiological characteristic showed Gram negative, rod-shape kokoid, can produce acid from mannitol, sucrose, sorbitol, innositol also able to oxidize glucose. Based on the nucleotide sequence of 16S-rRNA gene showed 98 % genetic relationship to Pseudomonas sp. Molecular weight chitinase determination by SDS-PAGE and zymogram have size 26.1 and 29.0 kDa. Extraselluler chitinase can showed inhibition of growth of Aspergillus parasiticus fungi that are pathogenic on rice and potatoes.

In this study, removal of Mg(II) and Ca(II) metals ions from aqueous solution by adsorption was i... more In this study, removal of Mg(II) and Ca(II) metals ions from aqueous solution by adsorption was investigated. The chitosan-alginate membrane was used as adsorbents. Chitosan was prepared from shrimp wastes. Parameters investigated in this work such as medium of pH, adsorption rate (k1), energies (E) and capacity of adsorption (b). The kinetic model of first order reaching equilibrium and pseudo order 2nd Ho adsorption were applied to estimate the adsorption rate, whereas the isotherm adsorption Langmuir and Freundlich models were employed in the determination of the energy and the capacity in adsorption. The optimum pH of adsorption Mg(II) and Ca(II) metal ion process on chitosan-alginate membrane were pH around 7.0. Adsorption Mg(II) and Ca(II) metal ions on chitosan-alginate membrane tend followed kinetic model of first order adsorption reaching equilibrium. Mg(II) and Ca(II) metal ions adsorbed on chitosan-alginate membrane tend followed the Langmuir isotherm adsorption model and...

Folia Medica Indonesiana

Highlights: This research analyzed a previously understudied subject in Surabaya, Indonesia, and ... more Highlights: This research analyzed a previously understudied subject in Surabaya, Indonesia, and discovered knockdown resistance (kdr) mutations in Aedes albopictus. The findings of this study can prompt further research, including bioassay testing and the development of more potent insecticides. Abstarct : Dengue hemorrhagic fever (DHF) has been endemic in Indonesia for decades. Insecticides are necessary to manage the transmission of the dengue virus. However, prolonged use of insecticides can lead to insecticide resistance. This study aimed to examine the genotype of mosquitoes using the allele-specific polymerase chain reaction (ASPCR) method. The ASPCR method was chosen for genotype detection due to its high sensitivity, affordability, and ease of design. Five mosquitoes were collected from human habitation in four different areas of Surabaya, Indonesia, namely Kranggan, Ulul Azmi Mosque, Ploso, and Kalijudan. Among them, three samples were identified as Aedes albopictus (A1, A...

Jurnal Penelitian Pendidikan IPA

This research aimed to describe the effectiveness of differentiated learning materials oriented t... more This research aimed to describe the effectiveness of differentiated learning materials oriented toward the nature of science (NoS) to improve students’ scientific literacy skills. The research type is quasi-experiment with one group pretest-posttest design. The research was given to 31 students in VIII-A class of Junior High School 16 Gresik. The effectiveness of differentiated learning materials oriented toward the nature of science (NoS) was obtained from the scientific literacy skills test and student response questionnaire. The student’s scientific literacy skills test showed an improvement in gain score between the pretest and posttest scores of 0.64, which is in the medium category; besides that, most students gave positive responses to the learning materials seen from the percentage of interest in learning materials 84.68% (very interested). The data obtained showed that differentiated learning materials oriented toward the nature of science were effective as learning materia...

Unesa Journal of Chemistry

Tulang sapi memiliki kandungan hidroksiapatit cukup tinggi, sehingga berpotensi sebagai prekursor... more Tulang sapi memiliki kandungan hidroksiapatit cukup tinggi, sehingga berpotensi sebagai prekursor material dalam sintesis hidroksiapatit. Tulang sapi memiliki komposisi anorganik yang terdiri dari 93% hidroksiapatit dan 7% β-TCP. Hidroksiapatit merupakan biomaterial dengan struktur heksagonal yang dapat dimanfaatkan sebagai implan tulang. Penelitian ini bertujuan untuk mengetahui hasil karakterisasi secara kimia (gugus fungsional dan fasa) maupun fisika (kristalinitas) sintesis hidroksiapatit dari tulang sapi. Tulang sapi dipreparasi dengan cara direbus, dicuci dengan aquades, lalu direndam dengan larutan H2O2 selama 5 jam sehingga dihasilkan tulang sapi bebas lemak berwarna putih. Hidroksiapatit diperoleh dari hasil kalsinasi tulang sapi menggunakan furnace dengan suhu 900⁰C selama 6 jam. Kalsinasi dilakukan dengan tujuan untuk mendapatkan hidroksiapatit dari tulang sapi dan untuk menghilangkan senyawa organik yang tidak dibutuhkan dalam tulang manusia. Rendemen yang dihasilkan pad...

Indonesian Journal of Chemical Science

The formation of dental caries is the result of the activity of Streptococcus mutans bacteria. Va... more The formation of dental caries is the result of the activity of Streptococcus mutans bacteria. Various attempts have been done to prevent dental caries. One of them is using oral preparations containing antibacterial compounds Hydroxyapatite-NanoSilver which is an active ingredient that can provide antimicrobial effects to prevent dental caries. This study aims to synthesize and characterize nanosilver hydroxyapatite as an antibacterial that causes dental caries. Physicochemical characterization and antibacterial test towards Streptococcus mutans bacteria with the active ingredient hydroxyapatite-nanosilver. In this study, hydroxyapatite-nanosilver materials with variations in nanosilver concentration of 4 ppm were used; 7 ppm; 10 ppm; 13 ppm; and 15 ppm. The results of FT-IR characterization showed the functional groups O-H, C=O, CO32-, and PO43-. The results of the PSA test showed that the hydroxyapatite-nanosilver formulation with a concentration of 10 ppm had the smallest nanopa...

RASAYAN Journal of Chemistry

This study was a purpose to determine the kinetic release of metformin encapsulated in chitosan a... more This study was a purpose to determine the kinetic release of metformin encapsulated in chitosan alginate and to determine the antidiabetic effectiveness by in vivo study. Encapsulation of metformin was carried out by using alginate and chitosan polymers with CaCl2 as a crosslinking agent and Tween 80 as a surfactant. A total of 30 mice were divided into 6 groups, namely the normal group with distilled water, the positive control group with metformin without encapsulation, the negative control group with Na-CMC (without drug treatment), and the treatment group (encapsulated drug with a composition of 1:1; 1:2; and 1:3). Substances used for diabetes include intraperitoneally induced alloxan monohydrate. The results showed the release of metformin in pH 1.2 of the gastric physiological solution. The mechanism is followed the Korsmeyer Peppas equation. In the intestinal physiological solution pH, 7.4 followed the Higuchi equation with the mechanism was an erosion. The analysis of surfac...

RASAYAN Journal of Chemistry, 2021

One way of the release control of the glibenclamide is the process of encapsulation using a blend... more One way of the release control of the glibenclamide is the process of encapsulation using a blend of calcium alginate-chitosan polymer with the addition of tween 80 surfactants. The resulting microparticles were analyzed for encapsulation efficiency, dissolution test in gastric and artificial intestinal pH solutions, functional groups, and surface morphology. The encapsulation efficiency showed that the Tween 80 with a concentration of 4% can produce the highestencapsulation efficiency of 65,2568%. The kinetic release of glibenclamide encapsulated on intestinal medium showed that the amount of glibenclamide dissolved in the gastric medium is lower than in the intestinal medium so that it can prevent gastric irritation by the mechanism of glibenclamide release through a combination of diffusion and erosion. The FT-IR spectra of the glibenclamide, alginate, chitosan, and glibenclamideencapsulated on the matrix showed that glibenclamide is only trapped physically in the alginatechitosan matrix. SEM test results show that the surface morphology of the glibenclamide is encapsulated smooth, porous small and there is no agglomeration.

Coronavirus disease- 19 (Covid-19) adalah penyakit yang memberikan resiko kematian yang sangat ti... more Coronavirus disease- 19 (Covid-19) adalah penyakit yang memberikan resiko kematian yang sangat tinggi. Alternatif pencegahan adalah dengan konsumsi susu kedelai berempah karena dapat meningkatkan imun dan kaya antioksidan. Kegiatan ini bertujuan untuk (1) memberikan pengetahuan tentang Covid-19 dan cara penanggulangannya, (2) memberikan keterampilan pembuatan sari kedelai berempah, dan (3) melakukan sosialisasi produk kepada masyarakat oleh peserta latih. Metode pelatihan dilakukan secara daring dan diunggah melalui youtube https://youtu.be/mb_6H2biczA , dilanjutkan praktek mandiri dan sosialisasi produk hasil praktek mandiri kepada masyarakat sekitar. Hasil kegiatan menunjukkan peserta latih memberikan respon bahwa materi pengetahuan tentang Covid-19 dan cara pembuatan sari kedelai adalah penting dan cara penyajiannya sangat menarik. Sebanyak 86.7 % peserta menyatakan bahwa materi adalah baru, dan 60% peserta menjawab akan mempraktekkan hasil pelatihan. Satu orang peserta telah mam...

Proceedings of the National Seminar on Chemistry 2019 (SNK-19), 2019

This research aimed to study the effect of concentration calcium alginate on metformine encapsula... more This research aimed to study the effect of concentration calcium alginate on metformine encapsulation processes and investigated characteristic of metformine encapsulation. The encapsulation of metformine performed using chitosan and calcium alginate polymers with calcium chloride as crosslink agent. The concentrations of calcium alginate were varieties 0.5%; 1.0%; 1.5%; 2.0%; 2.5%; and 3.0% (w/v). The results showed that the highest encapsulation efficiency of metformine on concentration of alginate 2.0% (w/v) and the lowest in the alginate 0% (w/v), respectively by 80.51% and 55.94%. Encapsulation resulted with the highest the spectra FTIR analysis showed that there is vibration in 1497.91 cm-1 that indicated interaction between the carboxyl functional group of alginate and the amine functional group of chitosan

The viability of using ultra fitration membranes made by blending 85% deacetylated chitosan and s... more The viability of using ultra fitration membranes made by blending 85% deacetylated chitosan and sodium alginate biopolymers with glutaraldehyde crosslink agent for separation uric acid was investigated. The membranes were characterized by FTIR to verify the polyion complex formation, SEM for observe morphology, tensile testing for mechanical stability and the ability of membrane in filtering uric acid. The results showed that surface and pore size that membrane in range of ultra filtration membrane and did not reveal any new functional groups so that the membrane formation occurred only electrostatic interaction. This membrane was able to filter out uric acid concentration of 90 mg/l, with the amount of uric acid filtered 48.23 mg/l.

Proceedings of the Seminar Nasional Kimia - National Seminar on Chemistry (SNK 2018), 2018

Hydroxyapatite (HAp) is the main material of bone structure which has chemical formula Ca10(PO4)6... more Hydroxyapatite (HAp) is the main material of bone structure which has chemical formula Ca10(PO4)6(OH)2. In this research, HAp synthesis use precursor calcium from crab shells and phosphate from H3PO4. Phosphate addition is done in single drop and wise drop. The calcinations of crab shell were done at 1000 °C for 5 hours. The FTIR analysis showed that there were functional groups of OH, CO3 2-, PO4 3and Ca-O. The XRD analysis of HAp showed that synthesis with wish drop method has the main phase of HAp and second phase is apatite carbonate. HAp that synthesized by single drop besides produce those phase also produce tricalcium bis(orthophosphate) phase. The synthesized HAp using the wise drop method has a larger surface area and pore volume but has a smaller pore size than that synthesis by using single drop method. The analyze morphology showed that HAp that synthesis using the wise drop method there is an agglomeration in morphology and the synthesis using single drop method has a smooth morphology with pores spread evenly