Saud Omani - Academia.edu (original) (raw)

Papers by Saud Omani

Mediators of Inflammation

Objectives. Inflammatory mediators are associated with many chronic diseases; however, their role... more Objectives. Inflammatory mediators are associated with many chronic diseases; however, their role in metabolic syndrome (Met-S) is not well documented. We therefore aimed to compare the serum markers of inflammation including C-reactive protein (CRP), myeloperoxidase (MPO), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α), and TNF-β in young military recruits with and without Met-S. We hypothesized that any significant change in inflammatory markers between the two groups would indicate the role of inflammation in Met-S that would help in future directions for screening and treatment of Met-S. Design and Methods. A total of 2010 adult men, aged 18-30 years, were divided into two groups: with Met-S ( N = 488 ) and without Met-S ( N = 1522 ), according to the International Diabetes Federation definition. We compared the serum levels of inflammatory biomarkers between the two groups. We also studied the correlations between the inflammatory markers and the components of Met-S...

Open Medicine, 2022

The risk factors associated with metabolic syndrome (Met-S) including hypertension, hyperglycemia... more The risk factors associated with metabolic syndrome (Met-S) including hypertension, hyperglycemia, central obesity, and dyslipidemia are preventable, particularly at their early stage. There are limited data available on the association between Met-S and preventable risk factors in young adults. We randomly selected 2,010 Saudis aged 18–30 years, who applied to be recruited in military colleges. All the procedures followed the guidelines of International Diabetes Federation. The results showed that out of 2,010 subjects, 4088 were affected with Met-S. The commonest risk factors were high blood sugar (63.6%), high systolic and diastolic blood pressures (63.3 and 37.3%), and high body mass index (57.5%). The prevalence of prediabetes and diabetes were 55.2 and 8.4%, respectively. Obesity, diabetes, hypertension, and hypertriglyceridemia were significantly associated with Met-S. The frequency of smoking was significantly linked with the development of Met-S. The prevalence of Met-S was...

Introduction: The use of mobile phones inside hospitals is a subject of controversy because it ma... more Introduction: The use of mobile phones inside hospitals is a subject of controversy because it may improve the quality of healthcare but also can transmit health care associated infections. Methodology: A cross-sectional study was conducted to screen a total of 426 mobile phones including (274) used by patients, companions, visitors and (152) used by health care workers for microbial pathogens which serve as a reservoir for hospital acquired infections (HAIs) and to assess the effectiveness of simple cleaning with clinical wipes impregnated with 70% isopropyl alcohol for decontamination at a tertiary hospital in Saudi Arabia. Results: Significantly higher rates of pathogens that might be associated with HAIs were found in mobile phones of patients' groups (n=258) versus the health care workers' (n=106) (97.2% vs 71.1% respectively; p≤0.009). Mobile phones owned by patients accounted for the highest rate of isolates (211; 29.3%) followed by companions (150; 20.9%), visitors (...

Journal of Toxicology, 2014

The potential effect of camel milk (CM) against gentamicin (GM) induced biochemical changes in th... more The potential effect of camel milk (CM) against gentamicin (GM) induced biochemical changes in the rat serum was evaluated. Four groups of six albino rats were used for control, CM fed, injected with GM(i.p.), and then fed and injected with GM. The results showed that the administration of GM significantly altered the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activity in rat serum. CM restored these parameters to almost their normal range in group IV. Additionally, the present study showed that injection of rats with gentamicin caused an increase in malondialdehyde (MDA) and myeloperoxidase (MPO) activity while the antioxidant enzymes like superoxide dismutase (SOD) and glutathione s-transferase (GST) activity decreased significantly (P≤0.05). Administration of CM significantly (P≤0.05) inhibited the formation of MDA and activity of MPO and upregulated the antioxidant enzymes (SOD and GST) ...

European Journal of Drug Metabolism and Pharmacokinetics, 2014

The 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors known as &... more The 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors known as "statins" are widely prescribed for the management of dyslipidemia. In spite of their muscle toxicity, use of statins has alarmingly increased worldwide. A recent report suggests that vitamin D (VD) levels are closely associated with lipid lowering activity and muscular toxicity of statins. However, data are limited and inconclusive. The present study was undertaken to investigate the effect of VD supplementation on the bioavailability and lipid lowering effect of simvastatin (ST). Adult Sprague-Dawley male rats (250 ± 10 g) were divided into four groups including control, ST (100 mg/kg/day), VD (100 μg/kg/day) and ST + VD group, respectively. After the dosing period of 8 days the animals were sacrificed and the blood was collected for the analysis of ST, its active metabolite simvastatin acid (STA), total cholesterol, triglyceride and liver enzymes including aspartate transaminase and alanine transaminase. The result of this study showed a significant decrease in the level of cholesterol and triglyceride in ST alone treated group, whereas VD alone failed to alter the blood lipid levels. Concomitant treatment with VD produced significant decrease in the bioavailability of ST and STA. However, there was no significant difference in the level of cholesterol in ST alone and in ST + VD treated group. Our results on the liver enzyme suggest that ST alone or in combination with VD does not produce any hepatotoxicity. Further studies using VD along with various statins for a longer duration are suggested.

Copyright © 2014 Abdulrahman K. Al-Asmari et al. This is an open access article distributed under... more Copyright © 2014 Abdulrahman K. Al-Asmari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The potential effect of camel milk (CM) against gentamicin (GM) induced biochemical changes in the rat serum was evaluated. Four groups of six albino rats were used for control, CM fed, injected with GM(i.p.), and then fed and injected with GM.The results showed that the administration of GM significantly altered the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activity in rat serum. CM restored these parameters to almost their normal range in group IV. Additionally, the present study showed that injection of rats with gentamicin caused an increase in malondialdehyde (MDA) andmyeloperoxidase (MPO) activitywhile the antioxidant enzymes...

Feasibility and safety of day-surgery laparoscopic cholecystectomy:

Saudi Medical Journal, 2012

Backgrounds/Aims: We report our experience with day-surgery laparoscopic cholecystectomy and asse... more Backgrounds/Aims: We report our experience with day-surgery laparoscopic cholecystectomy and assess its feasibility and safety. Methods: Data was collected on all the patients who underwent day-surgery laparoscopic cholecystectomy between February 2009 and February 2014 at Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. All patients had symptomatic cholelithiasis that was proven on imaging studies with clearance of the common bile duct. The patient biographical data (age, gender, American Society of Anaesthesiology status, medical comorbidities) and surgical outcomes were then obtained. There was an evaluation of the success rate of day-surgery laparoscopic cholecystectomy, reasons for unexpected admission, and the re-admission rate. Results: A total of 1,140 patients were included in this study. The success rate for day-surgery laparoscopic cholecystectomy was 96%. The reasons for unexpected hospital admission for 46 patients (4%) included persistent abdominal...

Saudi Medical Journal, 2010

International journal of clinical and experimental medicine, 2014

Minocycline (MCN), a semi-synthetic tetracycline derivative possesses pleiotropic effects and pro... more Minocycline (MCN), a semi-synthetic tetracycline derivative possesses pleiotropic effects and provides protection against a number of disease models. However its effect on gastric ulcers has not been studied. The present investigation was undertaken, to study the gastro-protective potential of MCN in experimentally induced gastric ulcers in rats. MCN (10, 30, 100 mg/Kg) was tested for gastric secretion and antiulcer activity in different groups of Wistar rats. Gastric secretion and acidity studies were performed in pylorus ligated rats while indices of gastric ulcers were measured in ethanol (1 ml-100%) and indomethacin (30 mg/kg), induced gastric ulcers. Histological changes and the levels of gastric wall mucus, malondialdehyde (MDA), non-protein sulfhydryl (NP-SH), and myeloperoxidase (MPO), were used to assess ethanol induced gastric mucosal injuries. Exposure of rats to ulcerogens resulted in gastric mucosal injury and a significant increase in the indices of ulcer. MCN conferre...

Dodonaea viscosa (Family sapindaceae) is an evergreen medicinal plant with woody perennial shrub ... more Dodonaea viscosa (Family sapindaceae) is an evergreen medicinal plant with woody perennial shrub widely distributed throughout the tropics. In Saudi Arabia, it is found in Hijaz region, Eastern region and Southern part. Various plant parts such as stem, leaves, seeds, roots, bark and aerial parts are used in traditional system of medicine. The leaves of this plant has been used to treat various ailments like sore throat, wounds, fever, piles, malaria, angina, cold, arthritis, sinusitis, flu and boils. It is also used as dressing for skin diseases of the head and face. In addition to this, leaves extract has been reported to have antibacterial activity against Staphylococcus aureus, Micrococcus luteus, Escherichia coli and Pseudomonas aeruginosa. Other pharmacological activity viz antinociceptive, antiulcer, wound healing, antioxidant, anti-inflammatory, neurological, antidiabetic, anti-diarrheal, antihyperlipidemic and hepatoprotective activity has also been reported. The present re...

Introduction: Antibiotic resistance is a problem of deep scientific concern both in hospital and ... more Introduction: Antibiotic resistance is a problem of deep scientific concern both in hospital and community Settings. The patient environment in healthcare settings has continually proven to harbor a reservoir of potentially harmful, and even lethal multidrug-resistant organisms (MDRO). Methodology: A cross sectional study was carried out to investigate the prevalence of multidrug resistant producing pathogens contaminated mobile phones (MPs) used by patient, companions, visitors and Heath. Results: Out of 426 mobile phones enrolled, a total of 163 isolates linked to hospital acquired infection were recovered. This study revealed high prevalence of multidrugresistant isolates reaching (71.8%), whereas Extended-spectrum betalactamases (ESBLs) producing K. pneumoniae, E. coli and MRSA accounted (27.6%) of the isolates. E. cloacae (88.9%) and S. aureus (85.7%) were found to be the principle MDRO. Likewise 76% of A. baumannii, K. pneumonia and E. coli were MDRO. High prevalence rate of r...

The role of the Hospitalist has evolved to meet the challenges and demands of modern medical prac... more The role of the Hospitalist has evolved to meet the challenges and demands of modern medical practice and primary care. In 1999, Wachter 1 proposed the definition “a physician who spends at least 25% of his or her professional time serving as the physicianof-record for inpatients, during which time he or she accepts “hands-off” of hospitalized patients from primary care providers, returning the patients to their primary care providers at the time of discharge.” However, this has now greatly evolved into the Society of Hospital Medicine’s current definition “Physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient care, teaching, research, and leadership related to hospital medicine.” 2 Most Hospitalists are board certified internists, pediatricians, and family practitioners by training, specializing in providing continuity of primary and acute care to inpatients from admission to discharge. The specialty is or...

Mediators of Inflammation

Objectives. Inflammatory mediators are associated with many chronic diseases; however, their role... more Objectives. Inflammatory mediators are associated with many chronic diseases; however, their role in metabolic syndrome (Met-S) is not well documented. We therefore aimed to compare the serum markers of inflammation including C-reactive protein (CRP), myeloperoxidase (MPO), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α), and TNF-β in young military recruits with and without Met-S. We hypothesized that any significant change in inflammatory markers between the two groups would indicate the role of inflammation in Met-S that would help in future directions for screening and treatment of Met-S. Design and Methods. A total of 2010 adult men, aged 18-30 years, were divided into two groups: with Met-S ( N = 488 ) and without Met-S ( N = 1522 ), according to the International Diabetes Federation definition. We compared the serum levels of inflammatory biomarkers between the two groups. We also studied the correlations between the inflammatory markers and the components of Met-S...

Open Medicine, 2022

The risk factors associated with metabolic syndrome (Met-S) including hypertension, hyperglycemia... more The risk factors associated with metabolic syndrome (Met-S) including hypertension, hyperglycemia, central obesity, and dyslipidemia are preventable, particularly at their early stage. There are limited data available on the association between Met-S and preventable risk factors in young adults. We randomly selected 2,010 Saudis aged 18–30 years, who applied to be recruited in military colleges. All the procedures followed the guidelines of International Diabetes Federation. The results showed that out of 2,010 subjects, 4088 were affected with Met-S. The commonest risk factors were high blood sugar (63.6%), high systolic and diastolic blood pressures (63.3 and 37.3%), and high body mass index (57.5%). The prevalence of prediabetes and diabetes were 55.2 and 8.4%, respectively. Obesity, diabetes, hypertension, and hypertriglyceridemia were significantly associated with Met-S. The frequency of smoking was significantly linked with the development of Met-S. The prevalence of Met-S was...

Introduction: The use of mobile phones inside hospitals is a subject of controversy because it ma... more Introduction: The use of mobile phones inside hospitals is a subject of controversy because it may improve the quality of healthcare but also can transmit health care associated infections. Methodology: A cross-sectional study was conducted to screen a total of 426 mobile phones including (274) used by patients, companions, visitors and (152) used by health care workers for microbial pathogens which serve as a reservoir for hospital acquired infections (HAIs) and to assess the effectiveness of simple cleaning with clinical wipes impregnated with 70% isopropyl alcohol for decontamination at a tertiary hospital in Saudi Arabia. Results: Significantly higher rates of pathogens that might be associated with HAIs were found in mobile phones of patients' groups (n=258) versus the health care workers' (n=106) (97.2% vs 71.1% respectively; p≤0.009). Mobile phones owned by patients accounted for the highest rate of isolates (211; 29.3%) followed by companions (150; 20.9%), visitors (...

Journal of Toxicology, 2014

The potential effect of camel milk (CM) against gentamicin (GM) induced biochemical changes in th... more The potential effect of camel milk (CM) against gentamicin (GM) induced biochemical changes in the rat serum was evaluated. Four groups of six albino rats were used for control, CM fed, injected with GM(i.p.), and then fed and injected with GM. The results showed that the administration of GM significantly altered the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activity in rat serum. CM restored these parameters to almost their normal range in group IV. Additionally, the present study showed that injection of rats with gentamicin caused an increase in malondialdehyde (MDA) and myeloperoxidase (MPO) activity while the antioxidant enzymes like superoxide dismutase (SOD) and glutathione s-transferase (GST) activity decreased significantly (P≤0.05). Administration of CM significantly (P≤0.05) inhibited the formation of MDA and activity of MPO and upregulated the antioxidant enzymes (SOD and GST) ...

European Journal of Drug Metabolism and Pharmacokinetics, 2014

The 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors known as &... more The 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitors known as "statins" are widely prescribed for the management of dyslipidemia. In spite of their muscle toxicity, use of statins has alarmingly increased worldwide. A recent report suggests that vitamin D (VD) levels are closely associated with lipid lowering activity and muscular toxicity of statins. However, data are limited and inconclusive. The present study was undertaken to investigate the effect of VD supplementation on the bioavailability and lipid lowering effect of simvastatin (ST). Adult Sprague-Dawley male rats (250 ± 10 g) were divided into four groups including control, ST (100 mg/kg/day), VD (100 μg/kg/day) and ST + VD group, respectively. After the dosing period of 8 days the animals were sacrificed and the blood was collected for the analysis of ST, its active metabolite simvastatin acid (STA), total cholesterol, triglyceride and liver enzymes including aspartate transaminase and alanine transaminase. The result of this study showed a significant decrease in the level of cholesterol and triglyceride in ST alone treated group, whereas VD alone failed to alter the blood lipid levels. Concomitant treatment with VD produced significant decrease in the bioavailability of ST and STA. However, there was no significant difference in the level of cholesterol in ST alone and in ST + VD treated group. Our results on the liver enzyme suggest that ST alone or in combination with VD does not produce any hepatotoxicity. Further studies using VD along with various statins for a longer duration are suggested.

Copyright © 2014 Abdulrahman K. Al-Asmari et al. This is an open access article distributed under... more Copyright © 2014 Abdulrahman K. Al-Asmari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The potential effect of camel milk (CM) against gentamicin (GM) induced biochemical changes in the rat serum was evaluated. Four groups of six albino rats were used for control, CM fed, injected with GM(i.p.), and then fed and injected with GM.The results showed that the administration of GM significantly altered the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activity in rat serum. CM restored these parameters to almost their normal range in group IV. Additionally, the present study showed that injection of rats with gentamicin caused an increase in malondialdehyde (MDA) andmyeloperoxidase (MPO) activitywhile the antioxidant enzymes...

Feasibility and safety of day-surgery laparoscopic cholecystectomy:

Saudi Medical Journal, 2012

Backgrounds/Aims: We report our experience with day-surgery laparoscopic cholecystectomy and asse... more Backgrounds/Aims: We report our experience with day-surgery laparoscopic cholecystectomy and assess its feasibility and safety. Methods: Data was collected on all the patients who underwent day-surgery laparoscopic cholecystectomy between February 2009 and February 2014 at Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia. All patients had symptomatic cholelithiasis that was proven on imaging studies with clearance of the common bile duct. The patient biographical data (age, gender, American Society of Anaesthesiology status, medical comorbidities) and surgical outcomes were then obtained. There was an evaluation of the success rate of day-surgery laparoscopic cholecystectomy, reasons for unexpected admission, and the re-admission rate. Results: A total of 1,140 patients were included in this study. The success rate for day-surgery laparoscopic cholecystectomy was 96%. The reasons for unexpected hospital admission for 46 patients (4%) included persistent abdominal...

Saudi Medical Journal, 2010

International journal of clinical and experimental medicine, 2014

Minocycline (MCN), a semi-synthetic tetracycline derivative possesses pleiotropic effects and pro... more Minocycline (MCN), a semi-synthetic tetracycline derivative possesses pleiotropic effects and provides protection against a number of disease models. However its effect on gastric ulcers has not been studied. The present investigation was undertaken, to study the gastro-protective potential of MCN in experimentally induced gastric ulcers in rats. MCN (10, 30, 100 mg/Kg) was tested for gastric secretion and antiulcer activity in different groups of Wistar rats. Gastric secretion and acidity studies were performed in pylorus ligated rats while indices of gastric ulcers were measured in ethanol (1 ml-100%) and indomethacin (30 mg/kg), induced gastric ulcers. Histological changes and the levels of gastric wall mucus, malondialdehyde (MDA), non-protein sulfhydryl (NP-SH), and myeloperoxidase (MPO), were used to assess ethanol induced gastric mucosal injuries. Exposure of rats to ulcerogens resulted in gastric mucosal injury and a significant increase in the indices of ulcer. MCN conferre...

Dodonaea viscosa (Family sapindaceae) is an evergreen medicinal plant with woody perennial shrub ... more Dodonaea viscosa (Family sapindaceae) is an evergreen medicinal plant with woody perennial shrub widely distributed throughout the tropics. In Saudi Arabia, it is found in Hijaz region, Eastern region and Southern part. Various plant parts such as stem, leaves, seeds, roots, bark and aerial parts are used in traditional system of medicine. The leaves of this plant has been used to treat various ailments like sore throat, wounds, fever, piles, malaria, angina, cold, arthritis, sinusitis, flu and boils. It is also used as dressing for skin diseases of the head and face. In addition to this, leaves extract has been reported to have antibacterial activity against Staphylococcus aureus, Micrococcus luteus, Escherichia coli and Pseudomonas aeruginosa. Other pharmacological activity viz antinociceptive, antiulcer, wound healing, antioxidant, anti-inflammatory, neurological, antidiabetic, anti-diarrheal, antihyperlipidemic and hepatoprotective activity has also been reported. The present re...

Introduction: Antibiotic resistance is a problem of deep scientific concern both in hospital and ... more Introduction: Antibiotic resistance is a problem of deep scientific concern both in hospital and community Settings. The patient environment in healthcare settings has continually proven to harbor a reservoir of potentially harmful, and even lethal multidrug-resistant organisms (MDRO). Methodology: A cross sectional study was carried out to investigate the prevalence of multidrug resistant producing pathogens contaminated mobile phones (MPs) used by patient, companions, visitors and Heath. Results: Out of 426 mobile phones enrolled, a total of 163 isolates linked to hospital acquired infection were recovered. This study revealed high prevalence of multidrugresistant isolates reaching (71.8%), whereas Extended-spectrum betalactamases (ESBLs) producing K. pneumoniae, E. coli and MRSA accounted (27.6%) of the isolates. E. cloacae (88.9%) and S. aureus (85.7%) were found to be the principle MDRO. Likewise 76% of A. baumannii, K. pneumonia and E. coli were MDRO. High prevalence rate of r...

The role of the Hospitalist has evolved to meet the challenges and demands of modern medical prac... more The role of the Hospitalist has evolved to meet the challenges and demands of modern medical practice and primary care. In 1999, Wachter 1 proposed the definition “a physician who spends at least 25% of his or her professional time serving as the physicianof-record for inpatients, during which time he or she accepts “hands-off” of hospitalized patients from primary care providers, returning the patients to their primary care providers at the time of discharge.” However, this has now greatly evolved into the Society of Hospital Medicine’s current definition “Physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient care, teaching, research, and leadership related to hospital medicine.” 2 Most Hospitalists are board certified internists, pediatricians, and family practitioners by training, specializing in providing continuity of primary and acute care to inpatients from admission to discharge. The specialty is or...